Lara A Ray

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects
    Lara A Ray
    Brown University, Center for Alcohol and Addiction Studies, USA
    Addict Biol 14:238-44. 2009
  2. pmc The factor structure and severity of DSM-IV alcohol abuse and dependence symptoms in psychiatric outpatients
    Lara A Ray
    Center for Alcohol and Addiction Studies, Box G S121 4, Brown University, Providence, Rhode Island 02912, USA
    J Stud Alcohol Drugs 69:496-9. 2008
  3. pmc Diagnostic orphans for alcohol use disorders in a treatment-seeking psychiatric sample
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    Drug Alcohol Depend 96:187-91. 2008
  4. ncbi Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study
    Lara A Ray
    Department of Psychology, University of Colorado at Boulder, Boulder, Colorado, USA
    Arch Gen Psychiatry 64:1069-77. 2007
  5. ncbi Examining the heritability of a laboratory-based smoking endophenotype: initial results from an experimental twin study
    Lara A Ray
    Department of Psychology and Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, United States of America
    Twin Res Hum Genet 10:546-53. 2007
  6. ncbi The relationship between prospective self-rating of alcohol sensitivity and craving and experimental results from two alcohol challenge studies
    Lara A Ray
    University of Colorado, Department of Psychology, Boulder, CO, USA
    J Stud Alcohol Drugs 68:379-84. 2007
  7. doi Effects of naltrexone during the descending limb of the blood alcohol curve
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA Lara
    Am J Addict 17:257-64. 2008
  8. pmc Alcohol demand, delayed reward discounting, and craving in relation to drinking and alcohol use disorders
    James MacKillop
    Department of Psychology, University of Georgia, and Center for Alcohol and Addiction Studies, Brown University, USA
    J Abnorm Psychol 119:106-14. 2010
  9. pmc Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University and Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    J Abnorm Psychol 119:115-25. 2010
  10. doi A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving
    Lara A Ray
    Department of Psychology, University of California Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 217:341-51. 2011

Research Grants

Detail Information

Publications51

  1. pmc The dopamine D Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects
    Lara A Ray
    Brown University, Center for Alcohol and Addiction Studies, USA
    Addict Biol 14:238-44. 2009
    ..These findings may also help elucidate the specific pathways of risk associated with genetic influences on alcohol use and abuse phenotypes...
  2. pmc The factor structure and severity of DSM-IV alcohol abuse and dependence symptoms in psychiatric outpatients
    Lara A Ray
    Center for Alcohol and Addiction Studies, Box G S121 4, Brown University, Providence, Rhode Island 02912, USA
    J Stud Alcohol Drugs 69:496-9. 2008
    ..The goal of the present study was to examine the factor structure and estimated severity of alcohol-use disorder (AUD) symptoms in a sample of treatment-seeking psychiatric outpatients...
  3. pmc Diagnostic orphans for alcohol use disorders in a treatment-seeking psychiatric sample
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    Drug Alcohol Depend 96:187-91. 2008
    ..Taken together, these results generally do not support combining diagnostic orphans to individuals with alcohol abuse...
  4. ncbi Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study
    Lara A Ray
    Department of Psychology, University of Colorado at Boulder, Boulder, Colorado, USA
    Arch Gen Psychiatry 64:1069-77. 2007
    ..However, the mechanism by which naltrexone may be differentially effective as a function of the OPRM1 genotype is unclear...
  5. ncbi Examining the heritability of a laboratory-based smoking endophenotype: initial results from an experimental twin study
    Lara A Ray
    Department of Psychology and Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, United States of America
    Twin Res Hum Genet 10:546-53. 2007
    ..To the best of our knowledge, this is the first study to examine the genetic basis of a laboratory smoking endophenotype, in this case tension reduction after smoking. Implications for genetic association studies are discussed...
  6. ncbi The relationship between prospective self-rating of alcohol sensitivity and craving and experimental results from two alcohol challenge studies
    Lara A Ray
    University of Colorado, Department of Psychology, Boulder, CO, USA
    J Stud Alcohol Drugs 68:379-84. 2007
    ....
  7. doi Effects of naltrexone during the descending limb of the blood alcohol curve
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA Lara
    Am J Addict 17:257-64. 2008
    ..Additionally, these results highlight the potential utility of considering limb of blood alcohol curve when examining the mechanisms of action of pharmacotherapies thought to alter subjective responses to alcohol...
  8. pmc Alcohol demand, delayed reward discounting, and craving in relation to drinking and alcohol use disorders
    James MacKillop
    Department of Psychology, University of Georgia, and Center for Alcohol and Addiction Studies, Brown University, USA
    J Abnorm Psychol 119:106-14. 2010
    ..These findings further emphasize the relevance of behavioral economic indices of motivation to AUDs and the potential importance of craving for alcohol in this relationship...
  9. pmc Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University and Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    J Abnorm Psychol 119:115-25. 2010
    ..This study extends findings on subjective intoxication, urge to drink, and their genetic bases from controlled laboratory to naturalistic settings...
  10. doi A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving
    Lara A Ray
    Department of Psychology, University of California Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 217:341-51. 2011
    ....
  11. ncbi Pharmacological effects of naltrexone and intravenous alcohol on craving for cigarettes among light smokers: a pilot study
    Lara A Ray
    Department of Psychology, University of Colorado at Boulder, Muenzinger Psychology Building, 345 UCB, Boulder, CO 80309 0345, USA
    Psychopharmacology (Berl) 193:449-56. 2007
    ..Although naltrexone has been widely researched in the context of drinking and smoking behaviors, with each substance studied separately, little is known about the effects of naltrexone on craving for cigarettes during alcohol intoxication...
  12. doi Behavioral economic analysis of cue-elicited craving for alcohol
    James MacKillop
    Department of Psychology, University of Georgia, Athens, GA 30602, USA
    Addiction 105:1599-607. 2010
    ..The current study tested this hypothesis via a multidimensional assessment of alcohol demand over the course of an alcohol cue reactivity procedure...
  13. pmc Anhedonia and amotivation in psychiatric outpatients with fully remitted stimulant use disorder
    Adam M Leventhal
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
    Am J Addict 17:218-23. 2008
    ..These findings suggest that anhedonia may be a preexisting risk factor or protracted effect of stimulant misuse...
  14. pmc Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 37:E116-24. 2013
    ..A secondary aim of this study is to examine alcoholism severity as a predictor of subjective responses to alcohol...
  15. pmc Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study
    Lara A Ray
    Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 37:445-55. 2012
    ..These findings help further delineate the biobehavioral mechanisms of naltrexone and its pharmacogenetics...
  16. pmc Clinical correlates of desire for treatment for current alcohol dependence among patients with a primary psychiatric disorder
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Am J Drug Alcohol Abuse 37:105-10. 2011
    ....
  17. doi The effects of drinking goal on treatment outcome for alcoholism
    Spencer Bujarski
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    J Consult Clin Psychol 81:13-22. 2013
    ..The objective in this study was to elucidate the contribution of drinking goal to treatment outcome in the context of specific behavioral and pharmacological interventions...
  18. pmc Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication
    Lara A Ray
    Department of Psychology, University of California Los Angeles, CA 90095 1563, USA
    Alcohol Clin Exp Res 33:2154-61. 2009
    ..The goal of this study was to examine the latent structure among measures of alcohol-induced subjective feelings of intoxication from a behavioral pharmacology perspective...
  19. doi The effects of varenicline on stress-induced and cue-induced craving for cigarettes
    Lara A Ray
    Department of Psychology, University of California Los Angeles, CA, USA
    Drug Alcohol Depend 131:136-42. 2013
    ....
  20. pmc Understanding naltrexone mechanism of action and pharmacogenetics in Asian Americans via behavioral economics: a preliminary study
    Spencer Bujarski
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Exp Clin Psychopharmacol 20:181-90. 2012
    ..This preliminary report provides further evidence for the effectiveness of naltrexone and supports the utility of a behavioral economic approach to alcoholism pharmacotherapy development...
  21. pmc The neuroeconomics of nicotine dependence: a preliminary functional magnetic resonance imaging study of delay discounting of monetary and cigarette rewards in smokers
    James MacKillop
    Department of Psychology, University of Georgia, Athens, GA, USA
    Psychiatry Res 202:20-9. 2012
    ..These findings provide initial evidence in support of applying a neuroeconomic approach to understanding nicotine dependence...
  22. pmc A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers
    Lara A Ray
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    Exp Clin Psychopharmacol 17:122-9. 2009
    ..Genes underlying glutamatergic neurotransmission, such as the GRIK1 gene, may help predict heterogeneity in topiramate-induced side effects. Future studies in larger samples are needed to more fully establish these preliminary findings...
  23. pmc Effects of naltrexone on cortisol levels in heavy drinkers
    Lara A Ray
    Department of Psychology, University of California Los Angeles UCLA, Los Angeles, CA 90095 1563, USA
    Pharmacol Biochem Behav 91:489-94. 2009
    ..These results suggest that naltrexone alters cortisol levels in heavy drinkers and that its effects on subjective responses to alcohol may be related, in part, to naltrexone's ability to activate the HPA-axis...
  24. pmc Craving and subjective responses to alcohol administration: validation of the desires for alcohol questionnaire in the human laboratory
    Kelly E Courtney
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
    J Stud Alcohol Drugs 74:797-802. 2013
    ..This study addresses this gap in the literature by testing the relationship between subjective responses to alcohol during alcohol administration and DAQ scores assessed 1 month later...
  25. ncbi Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation
    Lara A Ray
    Department of Psychology, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 34:1479-87. 2010
    ....
  26. pmc Refining the depression-nicotine dependence link: patterns of depressive symptoms in psychiatric outpatients with current, past, and no history of nicotine dependence
    Adam M Leventhal
    Center for Alcohol and Addiction Studies, Brown Medical School, Brown University, Providence, RI 02912, USA
    Addict Behav 34:297-303. 2009
    ..Certain vegetative, melancholic and dysphoric depressive symptoms are closely associated with nicotine dependence and could play an important etiological role in depression-nicotine dependence comorbidity...
  27. ncbi A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans
    Lara A Ray
    University of Colorado, Boulder, CO 80309 0345, USA
    Alcohol Clin Exp Res 28:1789-95. 2004
    ..The goal of this study was to test whether the A118G polymorphism is associated with sensitivity to the effects of alcohol...
  28. pmc Relations between anhedonia and smoking motivation
    Adam M Leventhal
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Nicotine Tob Res 11:1047-54. 2009
    ....
  29. pmc Quetiapine improves response inhibition in alcohol dependent patients: a placebo-controlled pilot study
    Nathasha Moallem
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Pharmacol Biochem Behav 100:490-3. 2012
    ....
  30. pmc Latent structure of facets of alcohol reinforcement from a behavioral economic demand curve
    James MacKillop
    Department of Psychology, University of Georgia, Athens, GA, 30602, USA
    Psychopharmacology (Berl) 203:33-40. 2009
    ..Demand curves provide a multidimensional assessment of reinforcement, but the relationships among the various indices of reinforcement have been largely unstudied...
  31. doi Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, 90095 1563, USA
    Alcohol Clin Exp Res 35:166-74. 2011
    ....
  32. pmc Posttraumatic stress disorder with and without alcohol use disorders: diagnostic and clinical correlates in a psychiatric sample
    Lara A Ray
    University of California Los Angeles, Department of Psychology, Los Angeles, CA, USA
    Psychiatry Res 170:278-81. 2009
    ..PTSD+AUD patients were more likely to meet criteria for Borderline and Antisocial Personality Disorders. Emotion dysregulation may help account for the relationship between PTSD and AUD...
  33. doi Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Subst Use Misuse 45:1742-65. 2010
    ....
  34. doi Sex moderates stress reactivity in heavy drinkers
    Emily E Hartwell
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Addict Behav 38:2643-6. 2013
    ..If supported by future studies, these initial findings may help advance understanding of the mechanisms of stress and mood regulation as central to alcoholism liability and recovery in females...
  35. pmc Dimensions of impulsivity among heavy drinkers, smokers, and heavy drinking smokers: singular and combined effects
    Nathasha R Moallem
    University of California, Los Angeles, Department of Psychology, CA 90095 1563, USA
    Addict Behav 37:871-4. 2012
    ..Future studies should examine these constructs longitudinally, as well as incorporate genetic and/or a neuroimaging component to these group comparisons in order to ascertain the biological bases of these behavioral findings...
  36. pmc Associations among GABRG1, level of response to alcohol, and drinking behaviors
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 33:1382-90. 2009
    ....
  37. ncbi Risk factors for alcohol misuse: examining heart rate reactivity to alcohol, alcohol sensitivity, and personality constructs
    Lara A Ray
    University of Colorado at Boulder, Department of Psychology, CO 80309 0345, United States
    Addict Behav 31:1959-73. 2006
    ....
  38. pmc The neuroeconomics of alcohol demand: an initial investigation of the neural correlates of alcohol cost-benefit decision making in heavy drinking men
    James MacKillop
    1 Department of Psychology, University of Georgia, Athens, GA, USA 2 Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA
    Neuropsychopharmacology 39:1988-95. 2014
    ....
  39. doi A prospective study of stress and alcohol craving in heavy drinkers
    Molly A Tartter
    Department of Psychology, University of California, Los Angeles, CA, USA
    Pharmacol Biochem Behav 101:625-31. 2012
    ..The current study supports and extends laboratory research describing phenotypes of stress-induced alcohol craving...
  40. ncbi Alcohol use and protective sexual behaviors among high-risk adolescents
    Angela Bryan
    Department of Psychology, 345 UCB, University of Colorado, Boulder, CO 80309 0345, USA
    J Stud Alcohol Drugs 68:327-35. 2007
    ..The following potential moderators were examined: sex-related alcohol expectancies, gender, relationship type, level of alcohol use, and impulsive sensation seeking...
  41. pmc Delayed reward discounting and addictive behavior: a meta-analysis
    James MacKillop
    Department of Psychology, University of Georgia, Athens, GA 30602, USA
    Psychopharmacology (Berl) 216:305-21. 2011
    ..To synthesize the findings across the literature, the current review is a meta-analysis of studies comparing DRD between criterion groups exhibiting addictive behavior and control groups...
  42. pmc Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Alcohol Clin Exp Res 33:1539-44. 2009
    ..Heavy drinking may increase blood glucose levels. Moreover, in alcohol-dependent subjects, glucose may play a putative role in alcohol preference...
  43. doi Quetiapine for the treatment of alcoholism: scientific rationale and review of the literature
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Drug Alcohol Rev 29:568-75. 2010
    ....
  44. pmc Fronto-striatal functional connectivity during response inhibition in alcohol dependence
    Kelly E Courtney
    Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Addict Biol 18:593-604. 2013
    ..These findings suggest that the fronto-striatal pathway underlying response inhibition is weakened as alcoholism progresses...
  45. pmc The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review
    Lara A Ray
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Alcohol Clin Exp Res 36:385-94. 2012
    ..Together, these lines of research seek to elucidate the effects of this functional polymorphism on alcoholism etiology and treatment response...
  46. ncbi Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics
    Lara A Ray
    Department of Psychology, University of California Los Angeles, CA 90095 1563, USA
    CNS Neurol Disord Drug Targets 9:13-22. 2010
    ..Limitations and future directions in the research and practice of naltrexone for alcoholism are also outlined...
  47. ncbi Predictors of smoking lapse in a human laboratory paradigm
    Daniel J O Roche
    Department of Psychology, University of California, 1285 Franz Hall, Box 951563, Los Angeles, CA, 90095 1563, USA
    Psychopharmacology (Berl) 231:2889-97. 2014
    ....
  48. pmc Modeling alcohol use disorder severity: an integrative structural equation modeling approach
    Nathasha R Moallem
    Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA
    Front Psychiatry 4:75. 2013
    ..Clinically, this approach to AUD severity can be used to inform treatment planning and ultimately to improve outcomes. ..
  49. doi Further validation of a cigarette purchase task for assessing the relative reinforcing efficacy of nicotine in college smokers
    James MacKillop
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Exp Clin Psychopharmacol 16:57-65. 2008
    ..Theoretical implications of the findings, limitations, and future directions are also discussed...
  50. pmc Cognitive-behavioral treatment with adult alcohol and illicit drug users: a meta-analysis of randomized controlled trials
    Molly Magill
    Center for Alcohol and Addiction Studies, Brown University, Box G S121 4, Providence, Rhode Island 02912, USA
    J Stud Alcohol Drugs 70:516-27. 2009
    ..The aims were to provide an overall picture of CBT treatment efficacy and to identify client or treatment factors predictive of CBT effect magnitude...
  51. pmc The Effects of Naltrexone Among Alcohol Non-Abstainers: Results from the COMBINE Study
    Lara A Ray
    Department of Psychology, University of California at Los Angeles Los Angeles, CA, USA
    Front Psychiatry 1:26. 2010
    ..Naltrexone may be effective in the context of controlled-drinking approaches, even among very frequent drinkers...

Research Grants1

  1. Genetic Correlates of Alcohol Use Disorders
    Lara Ray; Fiscal Year: 2006
    ..abstract_text> ..