Chanika Phornphutkul

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Insulin-like growth factor-I signaling is modified during chondrocyte differentiation
    Chanika Phornphutkul
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Endocrinol 183:477-86. 2004
  2. ncbi request reprint The role of insulin in chondrogenesis
    Chanika Phornphutkul
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Mol Cell Endocrinol 249:107-15. 2006
  3. pmc mTOR signaling contributes to chondrocyte differentiation
    Chanika Phornphutkul
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    Dev Dyn 237:702-12. 2008
  4. pmc The effect of rapamycin on bone growth in rabbits
    Chanika Phornphutkul
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Orthop Res 27:1157-61. 2009
  5. pmc Disorders of the growth plate
    Chanika Phornphutkul
    Department of Pediatrics, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Curr Opin Endocrinol Diabetes Obes 16:430-4. 2009
  6. pmc Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling
    Mimi S Kim
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Endocrinol Metab 296:E1374-82. 2009
  7. pmc The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells
    Tecla M Temu
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Am J Physiol Endocrinol Metab 299:E325-34. 2010
  8. pmc The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats
    Jennifer A Sanders
    Dept of Pediatrics, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 295:C406-13. 2008
  9. ncbi request reprint Exacerbation of the ochronosis of alkaptonuria due to renal insufficiency and improvement after renal transplantation
    Wendy J Introne
    Section on Human Biochemical Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1851, USA
    Mol Genet Metab 77:136-42. 2002

Collaborators

  • PHILIP GRUPPUSO
  • Jennifer A Sanders
  • Tecla M Temu
  • Ke Ying Wu
  • Mimi S Kim
  • Wendy J Introne
  • Qian Chen
  • Valerie Auyeung
  • Kevin McLaughlin
  • Diana Fitzpatrick
  • William A Gahl
  • Isa Bernardini

Detail Information

Publications9

  1. ncbi request reprint Insulin-like growth factor-I signaling is modified during chondrocyte differentiation
    Chanika Phornphutkul
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Endocrinol 183:477-86. 2004
    ..We conclude that IGF-I promotes both proliferation and differentiation of chondrocytes and that the differentiation effects of IGF-I may require uncoupling of signaling to the ERK pathway...
  2. ncbi request reprint The role of insulin in chondrogenesis
    Chanika Phornphutkul
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Mol Cell Endocrinol 249:107-15. 2006
    ..These results support assignment of a physiological role for this hormone in linear bone growth...
  3. pmc mTOR signaling contributes to chondrocyte differentiation
    Chanika Phornphutkul
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    Dev Dyn 237:702-12. 2008
    ..Our findings support the hypothesis that nutrients, acting through mTOR, directly influence chondrocyte differentiation and long bone growth...
  4. pmc The effect of rapamycin on bone growth in rabbits
    Chanika Phornphutkul
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Orthop Res 27:1157-61. 2009
    ..and suggest that the possible inhibitory effects of rapamycin on skeletal growth warrant further attention before its use in children...
  5. pmc Disorders of the growth plate
    Chanika Phornphutkul
    Department of Pediatrics, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Curr Opin Endocrinol Diabetes Obes 16:430-4. 2009
    ..To summarize the recent advances in our understanding of the majors genes involved in chondrogenesis and their molecular mechanisms...
  6. pmc Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling
    Mimi S Kim
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Endocrinol Metab 296:E1374-82. 2009
    ..Thus nutrient restriction appears to directly modulate bone growth through unidentified mTOR-independent mechanisms in addition to the well-characterized mTOR nutrient-sensing pathway...
  7. pmc The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells
    Tecla M Temu
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Am J Physiol Endocrinol Metab 299:E325-34. 2010
    ....
  8. pmc The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats
    Jennifer A Sanders
    Dept of Pediatrics, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 295:C406-13. 2008
    ..Furthermore, the well-characterized effects of rapamycin in tissue culture systems are not recapitulated in the asynchronous cell proliferation that accompanies normal growth and tissue remodeling...
  9. ncbi request reprint Exacerbation of the ochronosis of alkaptonuria due to renal insufficiency and improvement after renal transplantation
    Wendy J Introne
    Section on Human Biochemical Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1851, USA
    Mol Genet Metab 77:136-42. 2002
    ....