Elena Oancea

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc TRPM1 forms ion channels associated with melanin content in melanocytes
    Elena Oancea
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 2:ra21. 2009
  2. ncbi request reprint UV light phototransduction depolarizes human melanocytes
    Nicholas W Bellono
    Department of Molecular Pharmacology, Physiology, and Biotechnology Brown University Providence, RI USA
    Channels (Austin) 7:243-8. 2013
  3. ncbi request reprint TRPM1: new trends for an old TRP
    Elena Oancea
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI, USA
    Adv Exp Med Biol 704:135-45. 2011
  4. pmc Melanosomal dynamics assessed with a live-cell fluorescent melanosomal marker
    Jan M Bruder
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 7:e43465. 2012
  5. pmc UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes
    Nicholas W Bellono
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 110:2383-8. 2013
  6. pmc UVA phototransduction drives early melanin synthesis in human melanocytes
    Nadine L Wicks
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Curr Biol 21:1906-11. 2011
  7. ncbi request reprint TRPC5 is a regulator of hippocampal neurite length and growth cone morphology
    Anna Greka
    Howard Hughes Medical Institute, Children s Hospital and Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 6:837-45. 2003
  8. ncbi request reprint Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow
    Elena Oancea
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 98:245-53. 2006
  9. ncbi request reprint Mechanism of persistent protein kinase D1 translocation and activation
    Elena Oancea
    HHMI, Children s Hospital, Harvard Medical School, 1309 Enders Building, 320 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 4:561-74. 2003
  10. ncbi request reprint Opsin expression in human epidermal skin
    Kirk Haltaufderhyde
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI
    Photochem Photobiol 91:117-23. 2015

Collaborators

  • David E Clapham
  • Anna Greka
  • Igor Splawski
  • Joris Vriens
  • Nicholas W Bellono
  • Nadine L Wicks
  • Julia A Najera
  • Kirk Haltaufderhyde
  • Jan M Bruder
  • Jonathan M Ciriello
  • Rana N Ozdeşlik
  • Laura G Kammel
  • Anita L Zimmerman
  • Zachary A Pfeiffer
  • Diana M Horrigan
  • Benjamin Flaherty
  • Jason W Chan

Detail Information

Publications11

  1. pmc TRPM1 forms ion channels associated with melanin content in melanocytes
    Elena Oancea
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 2:ra21. 2009
    ..We propose that TRPM1 is an ion channel whose function is critical to normal melanocyte pigmentation and is thus a potential target for pigmentation disorders...
  2. ncbi request reprint UV light phototransduction depolarizes human melanocytes
    Nicholas W Bellono
    Department of Molecular Pharmacology, Physiology, and Biotechnology Brown University Providence, RI USA
    Channels (Austin) 7:243-8. 2013
    ..Thus, the cellular depolarization induced by UVR phototransduction in melanocytes is likely to be a critical signaling mechanism necessary for the protective response represented by increased melanin content...
  3. ncbi request reprint TRPM1: new trends for an old TRP
    Elena Oancea
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI, USA
    Adv Exp Med Biol 704:135-45. 2011
    ..This review will summarize and discuss our present knowledge of TRPM1: its discovery, expression, regulation, and proposed functions in skin and eye...
  4. pmc Melanosomal dynamics assessed with a live-cell fluorescent melanosomal marker
    Jan M Bruder
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 7:e43465. 2012
    ....
  5. pmc UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes
    Nicholas W Bellono
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 110:2383-8. 2013
    ..Our results show that TRPA1 is essential for a unique extraocular phototransduction pathway in human melanocytes that is activated by physiological doses of UVR and results in early melanin synthesis...
  6. pmc UVA phototransduction drives early melanin synthesis in human melanocytes
    Nadine L Wicks
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Curr Biol 21:1906-11. 2011
    ..Our findings identify a novel UVA-sensitive signaling pathway in melanocytes that leads to calcium mobilization and melanin synthesis and may underlie the mechanism of IPD in human skin...
  7. ncbi request reprint TRPC5 is a regulator of hippocampal neurite length and growth cone morphology
    Anna Greka
    Howard Hughes Medical Institute, Children s Hospital and Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 6:837-45. 2003
    ..Dominant-negative TRPC5 expression allowed significantly longer neurites and filopodia to form. We conclude that TRPC5 channels are important components of the mechanism controlling neurite extension and growth cone morphology...
  8. ncbi request reprint Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow
    Elena Oancea
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 98:245-53. 2006
    ..In vascular smooth muscle cells, but not in several types of endothelial cells, fluid flow increased endogenous native TRPM7 current amplitude. We hypothesize that TRPM7 plays a role in pathological response to vessel wall injury...
  9. ncbi request reprint Mechanism of persistent protein kinase D1 translocation and activation
    Elena Oancea
    HHMI, Children s Hospital, Harvard Medical School, 1309 Enders Building, 320 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 4:561-74. 2003
    ..We incorporate the kinetics of PKD1 translocation into a three-state model that suggests how PKD1 binding to DAG and Galphaq uniquely encodes frequency-dependent PKD1 signaling...
  10. ncbi request reprint Opsin expression in human epidermal skin
    Kirk Haltaufderhyde
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI
    Photochem Photobiol 91:117-23. 2015
    ..Our results demonstrate that opsins are expressed in epidermal skin cells and suggest that they might initiate light-induced signaling pathways, possibly contributing to UVR phototransduction. ..
  11. pmc UV light activates a Gαq/11-coupled phototransduction pathway in human melanocytes
    Nicholas W Bellono
    Department of Molecular Pharmacology, Physiology, and Biotechnology, and 2 Department of Neuroscience, Brown University, Providence, RI 02192
    J Gen Physiol 143:203-14. 2014
    ..We propose that melanocytes use a UVR phototransduction mechanism that involves the activation of a Gαq/11-dependent phosphoinositide cascade, and resembles light phototransduction cascades of the eye. ..