Steven Moss

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Human immune responses to H. pylori HLA Class II epitopes identified by immunoinformatic methods
    Songhua Zhang
    Division of Gastroenterology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 9:e94974. 2014
  2. pmc Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer
    S Wen
    Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Oncogene 31:1771-80. 2012
  3. pmc Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis
    Steven F Moss
    Department of Medicine, Gastroenterology Division, Rhode Island Hospital, 593 Eddy Street, APC 414, Providence, RI 02903, USA
    Clin Cancer Res 14:4161-7. 2008
  4. ncbi request reprint Helicobacter and gastric malignancies
    Steven F Moss
    Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Helicobacter 12:23-30. 2007
  5. ncbi request reprint Mechanisms of disease: Inflammation and the origins of cancer
    Steven F Moss
    Rhode Island Hospital and Department of Medicine, Brown University, Providence, Rhode Island 02903, USA
    Nat Clin Pract Oncol 2:90-7; quiz 1 p following 113. 2005
  6. pmc HelicoVax: epitope-based therapeutic Helicobacter pylori vaccination in a mouse model
    Steven F Moss
    Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA steven
    Vaccine 29:2085-91. 2011
  7. pmc Helicobacter pylori virulence factors in gastric carcinogenesis
    Sicheng Wen
    Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Cancer Lett 282:1-8. 2009
  8. ncbi request reprint p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice
    Noriyoshi Kuzushita
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
    Gastroenterology 129:1544-56. 2005
  9. ncbi request reprint Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis
    Hangxiu Xu
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 64:8521-5. 2004
  10. ncbi request reprint Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells
    Hidetoshi Eguchi
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Cancer Res 63:4739-46. 2003

Research Grants

  1. H pylori mediated gastric carcinogenesis
    Steven Moss; Fiscal Year: 2002
  2. p27 & apoptosis resistance in gastric cancer
    Steven Moss; Fiscal Year: 2006
  3. p27 & apoptosis resistance in gastric cancer
    Steven Moss; Fiscal Year: 2007
  4. p27 & apoptosis resistance in gastric cancer
    Steven Moss; Fiscal Year: 2009
  5. p27 & apoptosis resistance in gastric cancer
    Steven F Moss; Fiscal Year: 2010
  6. p27 & apoptosis resistance in gastric cancer
    Steven Moss; Fiscal Year: 2009

Collaborators

Detail Information

Publications24

  1. pmc Human immune responses to H. pylori HLA Class II epitopes identified by immunoinformatic methods
    Songhua Zhang
    Division of Gastroenterology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 9:e94974. 2014
    ..This information will improve understanding of the complex immune response to H. pylori, aiding rational epitope-driven vaccine design as well as helping identify other H. pylori epitopes with potentially immunoregulatory effects. ..
  2. pmc Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer
    S Wen
    Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Oncogene 31:1771-80. 2012
    ..Cytoplasmic mislocalization of p27 induced by H. pylori may be an important mechanistic link between H. pylori infection and gastric carcinogenesis...
  3. pmc Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis
    Steven F Moss
    Department of Medicine, Gastroenterology Division, Rhode Island Hospital, 593 Eddy Street, APC 414, Providence, RI 02903, USA
    Clin Cancer Res 14:4161-7. 2008
    ..We have examined GKN1 and GKN2 protein expression in a large gastric cancer series, correlated expression with tumor subtype, and evaluated their utility as prognostic biomarkers...
  4. ncbi request reprint Helicobacter and gastric malignancies
    Steven F Moss
    Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Helicobacter 12:23-30. 2007
    ..Finally, Helicobacter hepaticus infection has been linked to both intestinal and breast tumorigenesis in susceptible strains of female mice - a provocative and novel finding warranting further investigation...
  5. ncbi request reprint Mechanisms of disease: Inflammation and the origins of cancer
    Steven F Moss
    Rhode Island Hospital and Department of Medicine, Brown University, Providence, Rhode Island 02903, USA
    Nat Clin Pract Oncol 2:90-7; quiz 1 p following 113. 2005
    ..Thus, therapeutic opportunities exist to target the causative microbe, the consequent inflammatory mediator, or epithelial cell responses. Such measures could be of value to reduce cancer risk in inflammation-associated malignancies...
  6. pmc HelicoVax: epitope-based therapeutic Helicobacter pylori vaccination in a mouse model
    Steven F Moss
    Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA steven
    Vaccine 29:2085-91. 2011
    ..These results suggest that further development of an epitope-based mucosal vaccine may be beneficial in eradicating H. pylori and reducing the burden of the associated gastric diseases in humans...
  7. pmc Helicobacter pylori virulence factors in gastric carcinogenesis
    Sicheng Wen
    Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Cancer Lett 282:1-8. 2009
    ..Improved understanding of the pathogenesis of H. pylori-associated gastric cancer may improve risk stratification for prevention and therapy...
  8. ncbi request reprint p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice
    Noriyoshi Kuzushita
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
    Gastroenterology 129:1544-56. 2005
    ..We therefore evaluated p27-deficient mice as a model for H pylori-associated gastric cancer...
  9. ncbi request reprint Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis
    Hangxiu Xu
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 64:8521-5. 2004
    ..These results identify a pathway for oxidative stress-induced epithelial cell apoptosis and DNA damage due to SMO(PAOh1) activation by H. pylori that may contribute to the pathogenesis of the infection and development of gastric cancer...
  10. ncbi request reprint Helicobacter pylori increases proteasome-mediated degradation of p27(kip1) in gastric epithelial cells
    Hidetoshi Eguchi
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Cancer Res 63:4739-46. 2003
    ..Increased degradation of p27 by H. pylori through a proteasome-dependent, ubiquitin-independent pathway may contribute to the increased risk of gastric cancer associated with chronic H. pylori infection...
  11. ncbi request reprint Altered expression of Skp2, c-Myc and p27 proteins but not mRNA after H. pylori eradication in chronic gastritis
    Sung S Kim
    Department of Medicine, Rhode Island Hospital Brown University, Providence, RI 02903, USA
    Mod Pathol 19:49-58. 2006
    ..H. pylori may influence cell cycle progression and carcinogenesis through post-translational effects on specific gene expression...
  12. ncbi request reprint Targeting Helicobacter pylori in gastric carcinogenesis
    Dong Soo Lee
    Rhode Island Hospital Brown University, Department Medicine, 593 Eddy St, Providence, RI 02903, USA
    Expert Opin Ther Targets 11:757-69. 2007
    ..Targeting H. pylori to prevent gastric cancer may be best achieved through vaccination, better understanding of the molecular pathogenesis of H. pylori-associated carcinogenesis and additional chemopreventive strategies...
  13. ncbi request reprint Helicobacter pylori
    Steven F Moss
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital, 593 Eddy Street, APC 4, Providence, RI 02903, USA
    Curr Opin Infect Dis 16:445-51. 2003
    ..H. pylori is therefore of great interest to clinicians and researchers of many, often disparate, disciplines. We highlight recent advances in this fast changing field from many different areas...
  14. ncbi request reprint Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation
    Murray B Resnick
    Department of Pathology, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Hum Pathol 36:886-92. 2005
    ..The up-regulation of claudin expression during gastric carcinogenesis suggests their potential utility as diagnostic biomarkers and possible targets for therapeutic intervention...
  15. ncbi request reprint GERD 2003 -- a consensus on the way ahead
    Steven F Moss
    Brown University, Providence, R I, USA
    Digestion 67:111-7. 2003
    ..Intestinal metaplasia in the lower esophagus is probably very common. Whether and how to, first, screen for, and then, perform surveillance in Barrett's esophagus remains highly problematic and contentious...
  16. pmc Expression analysis of Barrett's esophagus-associated high-grade dysplasia in laser capture microdissected archival tissue
    Edmond Sabo
    Department of Pathology and Medicine, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Clin Cancer Res 14:6440-8. 2008
    ..The aim of this study was to determine the differential transcriptome of HGD compared with NDBE through gene microarray analysis of epithelial cells microdissected from archival tissue specimens...
  17. ncbi request reprint p16Ink4a is overexpressed in H. pylori-associated gastritis and is correlated with increased epithelial apoptosis
    Haim Shirin
    Department of Gastroenterology, The E Wolfson Medical Center, Sackler Faculty of Medicine, TelAviv University, Israel
    Helicobacter 8:66-71. 2003
    ..The aim of the current study was to examine whether H. pylori infection also affects the expression of p16 in the gastric mucosa of H. pylori-infected patients...
  18. ncbi request reprint p27kip1 expression is inversely related to the grade of gastric MALT lymphoma
    Haim Shirin
    Department of Gastroenterology, The E Wolfson Medical Center, Holon and Tel Aviv University, Israel
    Int J Gastrointest Cancer 35:25-32. 2005
    ..Decreased or lost expression of the cyclin-dependent kinase inhibitor p27kip1 protein has been found to be a poor prognostic factor in many cancers, including gastric cancer...
  19. ncbi request reprint Helicobacter pylori infection and the development of gastric cancer
    Ramy Eid
    N Engl J Med 346:65-7. 2002
  20. ncbi request reprint COX-2 inhibition and the prevention of gastric cancer
    Dong Soo Lee
    Digestion 74:184-6. 2006
  21. ncbi request reprint Positive serology for Helicobacter pylori and vomiting in the pregnancy
    Haim Shirin
    Department of Gastroenterology, E Wolfson Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Holon, Israel
    Arch Gynecol Obstet 270:10-4. 2004
    ..The purpose of this study was to evaluate whether seropositivity for IgG antibodies to H. pylori may also be related to nausea, vomiting, heartburn and epigastric pain in pregnancy...
  22. ncbi request reprint Non-steroidal anti-inflammatory drugs have bacteriostatic and bactericidal activity against Helicobacter pylori
    Haim Shirin
    Department of Gastroenterology, E Wolfson Medical Center, Tel Aviv University, Tel Aviv, Israel
    J Gastroenterol Hepatol 21:1388-93. 2006
    ..Therefore, the purpose of the present paper was to examine whether specific NSAIDs inhibit the growth of Helicobacter pylori in vitro...
  23. ncbi request reprint Helicobacter pylori and apoptosis
    Emilia Mia Sordillo
    Department of Pathology and Laboratory Medicine, College of Physicians and Surgeons of Columbia University, St Luke s Roosevelt Hospital Center, New York, New York 10025, USA
    Methods Enzymol 358:319-34. 2002
  24. ncbi request reprint Whistler summary: "the slow rate of rapid progress"
    Richard H Hunt
    J Clin Gastroenterol 41:539-45. 2007

Research Grants9

  1. H pylori mediated gastric carcinogenesis
    Steven Moss; Fiscal Year: 2002
    ..pylori. 2. Evaluate in clinical specimens novel candidate gastric cancer genes identified from the differential global genome expression profiles of parental AGS gastric cells and their apoptosis-resistant derivatives. ..
  2. p27 & apoptosis resistance in gastric cancer
    Steven Moss; Fiscal Year: 2006
    ..Our overall long-term goal is to contribute to the development of new clinical strategies for the prevention, diagnosis and treatment of gastric cancer. ..
  3. p27 & apoptosis resistance in gastric cancer
    Steven Moss; Fiscal Year: 2007
    ..Our overall long-term goal is to contribute to the development of new clinical strategies for the prevention, diagnosis and treatment of gastric cancer. ..
  4. p27 & apoptosis resistance in gastric cancer
    Steven Moss; Fiscal Year: 2009
    ..Our overall long-term goal is to contribute to the development of new clinical strategies for the prevention, diagnosis and treatment of gastric cancer. ..
  5. p27 & apoptosis resistance in gastric cancer
    Steven F Moss; Fiscal Year: 2010
    ..Our overall long-term goal is to contribute to the development of new clinical strategies for the prevention, diagnosis and treatment of gastric cancer. ..
  6. p27 & apoptosis resistance in gastric cancer
    Steven Moss; Fiscal Year: 2009
    ..Our overall long-term goal is to contribute to the development of new clinical strategies for the prevention, diagnosis and treatment of gastric cancer. ..