E Mathiowitz

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Effect of lecithin and MgCO3 as additives on the enzymatic activity of carbonic anhydrase encapsulated in poly(lactide-co-glycolide) (PLGA) microspheres
    Maryellen Sandor
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Biochim Biophys Acta 1570:63-74. 2002
  2. ncbi request reprint Biologically erodable microspheres as potential oral drug delivery systems
    E Mathiowitz
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Nature 386:410-4. 1997
  3. doi request reprint Drug delivery systems
    Edith Mathiowitz
    Artificial Organs Laboratory, Brown University, Providence, RI 02912, USA
    Toxicol Pathol 36:16-20. 2008
  4. ncbi request reprint Effect of protein molecular weight on release from micron-sized PLGA microspheres
    M Sandor
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    J Control Release 76:297-311. 2001
  5. ncbi request reprint Degradation of multi-phase microspheres fabricated via solvent removal
    J Godbee
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    J Microencapsul 21:331-52. 2004
  6. ncbi request reprint Role of solvent/non-solvent ratio on microsphere formation using the solvent removal method
    J Godbee
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    J Microencapsul 21:151-60. 2004
  7. ncbi request reprint Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride
    C G Thanos
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Pharm Res 20:1093-100. 2003
  8. ncbi request reprint Effect of manufacturing conditions on the formation of double-walled polymer microspheres
    K Leach
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    J Microencapsul 16:153-67. 1999
  9. ncbi request reprint Regenerative medicine for limb trauma
    Roy K Aaron
    Brown Medical School, Providence, RI 02906, USA
    Med Health R I 90:6-9. 2007
  10. ncbi request reprint Transfection of HEK cells via DNA-loaded PLGA and P(FASA) nanospheres
    M Sandor
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown Medical School, Brown University, Providence, RI 02912, USA
    J Drug Target 10:497-506. 2002

Research Grants

  1. BIOADHESIVE MICROSPHERES
    Edith Mathiowitz; Fiscal Year: 2002

Collaborators

  • C G Thanos
  • D F Emerich
  • L Escobar
  • S Chen
  • P Chaturvedi
  • Z Liu
  • H Qian
  • Roy K Aaron
  • K Vijayaraghavan
  • J Godbee
  • A Peter Morello
  • M Sandor
  • Nejat K Egilmez
  • Ana Jaklenec
  • Bryan Laulicht
  • P Weston
  • N A Rahman
  • Atima Sharma
  • E Scott
  • P Pattamunuch
  • Maryellen Sandor
  • Peter Cheifetz
  • Eugene Wan
  • Maria E Murray
  • K Leach
  • Anubhav Tripathi
  • Natalie Forbes
  • Roxanne Burrill
  • Carl M Harper
  • Laura Hammer
  • Raji E Nair
  • Yong S Jong
  • Richard B Bankert
  • J Harris
  • Alex Riechel
  • Ian Kaplan
  • S Mehta
  • J Marshall
  • D Enscore
  • K Noh

Detail Information

Publications20

  1. ncbi request reprint Effect of lecithin and MgCO3 as additives on the enzymatic activity of carbonic anhydrase encapsulated in poly(lactide-co-glycolide) (PLGA) microspheres
    Maryellen Sandor
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Biochim Biophys Acta 1570:63-74. 2002
    ..Addition of MgCO3 further increased the amount of monomer in both the extracted and released protein by decreasing the amount of acid-induced cleavage and noncovalent aggregation, but still greatly decreased the activity of the enzyme...
  2. ncbi request reprint Biologically erodable microspheres as potential oral drug delivery systems
    E Mathiowitz
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Nature 386:410-4. 1997
    ..We show that these microspheres increase the absorption of three model substances of widely different molecular size: dicumarol, insulin and plasmid DNA...
  3. doi request reprint Drug delivery systems
    Edith Mathiowitz
    Artificial Organs Laboratory, Brown University, Providence, RI 02912, USA
    Toxicol Pathol 36:16-20. 2008
  4. ncbi request reprint Effect of protein molecular weight on release from micron-sized PLGA microspheres
    M Sandor
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    J Control Release 76:297-311. 2001
    ..Interestingly, microspheres encapsulating large proteins maintained sustained release rates for 56 days...
  5. ncbi request reprint Degradation of multi-phase microspheres fabricated via solvent removal
    J Godbee
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    J Microencapsul 21:331-52. 2004
    ..The in vitro study showed a rapid mass loss initially (first 3 days), followed by a fairly constant mass through 16 weeks, while the in vivo study showed a mass gain due to tissue influx...
  6. ncbi request reprint Role of solvent/non-solvent ratio on microsphere formation using the solvent removal method
    J Godbee
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    J Microencapsul 21:151-60. 2004
    ....
  7. ncbi request reprint Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride
    C G Thanos
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Pharm Res 20:1093-100. 2003
    ..This study was carried out to show the effect of particle size reduction and bioadhesion on the dissolution and relative bioavailability of dicumarol...
  8. ncbi request reprint Effect of manufacturing conditions on the formation of double-walled polymer microspheres
    K Leach
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    J Microencapsul 16:153-67. 1999
    ..The efficiency of the process to produce DW microspheres increased and the process time decreased with increasing air flow across the surface of the encapsulation vessel...
  9. ncbi request reprint Regenerative medicine for limb trauma
    Roy K Aaron
    Brown Medical School, Providence, RI 02906, USA
    Med Health R I 90:6-9. 2007
  10. ncbi request reprint Transfection of HEK cells via DNA-loaded PLGA and P(FASA) nanospheres
    M Sandor
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown Medical School, Brown University, Providence, RI 02912, USA
    J Drug Target 10:497-506. 2002
    ..Additionally, the effective dose delivered to cells via nanospheres was approximately 25% that of lipofectamine, indicating that transfection via PLGA and P(FASA) nanospheres might actually be more efficient...
  11. ncbi request reprint Localization of bovine serum albumin in double-walled microspheres
    N A Rahman
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Box G, Providence, RI 02912, USA
    J Control Release 94:163-75. 2004
    ..Hence microspheres with a double-walled morphology have the potential for therapeutic use where a high burst might be detrimental...
  12. ncbi request reprint Formulating the alginate-polyornithine biocapsule for prolonged stability: evaluation of composition and manufacturing technique
    C G Thanos
    LCT BioPharma, Incorporated, Providence, Rhode Island 02906, USA
    J Biomed Mater Res A 83:216-24. 2007
    ....
  13. ncbi request reprint The effects of infiltration on protein release from multi-phase microspheres fabricated via solvent removal
    J Godbee
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    J Microencapsul 19:783-96. 2002
    ....
  14. ncbi request reprint Novel scaffolds fabricated from protein-loaded microspheres for tissue engineering
    Ana Jaklenec
    Center for Biomedical Engineering, Brown University, Providence, RI 02912, USA
    Biomaterials 29:185-92. 2008
    ....
  15. ncbi request reprint Preparation and characterization of poly(methyl methacrylate) - iron (III) oxide microparticles using a modified solvent evaporation method
    A Peter Morello
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    J Microencapsul 24:476-91. 2007
    ..The use of solvent mixtures did not improve the encapsulation efficiency of alpha-Fe(2)O(3) but the use of ethyl acetate helped to induce the clustering of alpha-Fe(2)O(3) along the peripheries of the microparticles...
  16. ncbi request reprint Investigating the effects of surfactants on the size and hydrolytic stability of poly(adipic anhydride) particles
    A Peter Morello
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    J Microencapsul 24:40-56. 2007
    ..44 and 0.04, respectively). In addition, quantitative DSC and FT-IR analysis confirmed that altering the particle size could also influence the hydrolytic stability of pAA...
  17. ncbi request reprint Enhancing the oral bioavailability of the poorly soluble drug dicumarol with a bioadhesive polymer
    Chris G Thanos
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    J Pharm Sci 92:1677-89. 2003
    ..A nonadhesive formulation, fabricated with poly(lactic acid) (PLA), showed 91% relative bioavailability. Both particle size and polymer composition play a role in oral absorption of dicumarol...
  18. doi request reprint Evaluation of continuous flow nanosphere formation by controlled microfluidic transport
    Bryan Laulicht
    Department of Molecular Pharmacology, and Division of Engineering and Medical Science, Brown University, Providence, Rhode Island 02912, USA
    Langmuir 24:9717-26. 2008
    ....
  19. ncbi request reprint Characterization of cytokine-encapsulated controlled-release microsphere adjuvants
    Atima Sharma
    TherapyX, Inc, Buffalo, NY, USA
    Cancer Biother Radiopharm 19:764-9. 2004
    ..These studies demonstrate that biochemical properties of microsphere formulations vary depending on the cytokine, and rigorous characterization of formulations is a prerequisite to in vivo testing...
  20. ncbi request reprint Tumor vaccination with cytokine-encapsulated microspheres
    Nejat K Egilmez
    Department of Microbiology, State University of New York, Buffalo, NY, USA
    Methods Mol Med 75:687-96. 2003

Research Grants8

  1. BIOADHESIVE MICROSPHERES
    Edith Mathiowitz; Fiscal Year: 2002
    ..The end goal is to move these novel drug delivery systems from research to clinical applications for treatment of diseases. ..