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Genomes and Genes | Carmen J MarsitSummaryAffiliation: Brown University Country: USA Publications
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Publications
Hypermethylation of E-cadherin is an independent predictor of improved survival in head and neck squamous cell carcinomaCarmen J Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
Cancer 113:1566-71. 2008....
Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributionsE Andres Houseman
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, 02115, USA
BMC Bioinformatics 9:365. 2008..Model-based cluster analysis is often used to identify DNA methylation subgroups in data, but it is unclear how to cluster DNA methylation data from arrays in a scalable and reliable manner...- DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancerCarmen J Marsit
Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
J Clin Oncol 29:1133-9. 2011..We sought to identify specific profiles of DNA methylation in peripheral blood that are associated with bladder cancer risk and therefore serve as an epigenetic marker of disease susceptibility... - A genotype-phenotype examination of cyclin D1 on risk and outcome of squamous cell carcinoma of the head and neckCarmen J Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
Clin Cancer Res 14:2371-7. 2008..We also examined how this genotype was associated with the risk of HNSCC and if this genotype-phenotype association was related to patient outcome... - In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placentaCharlotte S Wilhelm-Benartzi
Department of Epidemiology, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, USA
Environ Health Perspect 120:296-302. 2012..Environmental insults in utero may lead to changes in epigenetic mechanisms potentially affecting fetal development... - Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesotheliomaBrock C Christensen
Departments of Pathology and Laboratory Medicine, Community Health, Center for Environmental Health and Technology, and Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island 02903, USA
Cancer Res 70:5686-94. 2010..Our findings define a strong association between global genetic and global epigenetic dysregulation in mesothelioma, rather than a discrete, local coordination of gene inactivation... - Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinomaCarmen J Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
Carcinogenesis 30:416-22. 2009..We found that the etiologic heterogeneity of HNSCC is reflected in specific patterns of molecular epigenetic alterations within the tumors and that the DNA methylation profiles may hold clinical promise worthy of further study... - Identification of methylated genes associated with aggressive bladder cancerCarmen J Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
PLoS ONE 5:e12334. 2010..Methylation of these genes may be useful as clinical markers of the disease and may point to genes and pathways worthy of additional examination as novel targets for therapeutic treatment... - Copy number variation has little impact on bead-array-based measures of DNA methylationE Andres Houseman
Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
Bioinformatics 25:1999-2005. 2009..However, copy number variation may bias the measurement of DNA methylation. To investigate possible bias, we analyzed integrated data obtained from 19 head and neck squamous cell carcinoma (HNSCC) tumors and 23 mesothelioma tumors... - Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcomeBrock C Christensen
Department of Community Health, Center for Environmental Health and Technology, Brown University, 70 Ship Street, Providence, RI 02903, USA
Cancer Res 69:227-34. 2009..Importantly, these findings hold great promise for using epigenetic profiling in the diagnosis and prognosis of human cancers... - Downregulated microRNAs in the differential diagnosis of malignant pleural mesotheliomaGretchen V Gee
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
Int J Cancer 127:2859-69. 2010..This research points to novel approaches using miRNAs whose decreased expression is unique to mesothelioma as potentially suitable for rapid diagnosis and reveals prospective new targets for the treatment of this deadly disease... - Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association studyScott M Langevin
Department of Epidemiology, Brown University, Providence, RI, USA
Epigenetics 7:291-9. 2012..This profile demonstrates the potential of DNA methylation measured in blood for development of non-invasive applications for detection of head and neck cancer... - Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intakeBrock C Christensen
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
PLoS Genet 6:e1001043. 2010..0001) associated with methylation class membership. Breast cancer prognostic characteristics and risk-related exposures appear to be associated with gene-specific tumor methylation, as well as overall methylation patterns... - DNA methylation, isocitrate dehydrogenase mutation, and survival in gliomaBrock C Christensen
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
J Natl Cancer Inst 103:143-53. 2011.... - Biomarkers of HPV in head and neck squamous cell carcinomaCaihua Liang
Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA
Cancer Res 72:5004-13. 2012.... - Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancerGraham M Poage
Departments of Molecular Pharmacology and Physiology, Community Health Center for Environmental Health and Technology, and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA
Clin Cancer Res 17:3579-89. 2011..The degree to which these processes are coordinated is unclear so we investigated both in head and neck squamous cell carcinomas... - Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancerBrock C Christensen
Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA
Clin Cancer Res 16:3713-20. 2010..A polymorphism in the MIR196A2 locus has shown associations with lung, breast, esophageal, and gastric tumors but has not been examined in head and neck cancers, which share similar pathology and etiology to these diseases... - The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in bloodScott M Langevin
Department of Community Health, Brown University, Providence, RI, USA
Epigenetics 6:908-19. 2011.... - Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targetedGraham M Poage
Departments of Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island, United States of America
PLoS ONE 5:e9651. 2010.... - Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island contextBrock C Christensen
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
PLoS Genet 5:e1000602. 2009..Collectively we reveal key issues to consider both in the construction of reference and disease-related epigenomes and in the interpretation of potentially pathologically important alterations... - Gene-environment interactions of novel variants associated with head and neck cancerCaihua Liang
Department of Community Health, Brown University, Providence, Rhode Island, USA
Head Neck 34:1111-8. 2012..We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk... - Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancersDevin C Koestler
Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
Cancer Epidemiol Biomarkers Prev 21:1293-302. 2012.... - LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking ChineseHaley L Cash
Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
Int J Cancer 130:1151-9. 2012..006). Further research is needed to understand the relationships between methyl group availability and LINE-1 methylation in relation to bladder cancer risk... - Semi-supervised recursively partitioned mixture models for identifying cancer subtypesDevin C Koestler
Department of Community Health, Section for Biostatistics, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
Bioinformatics 26:2578-85. 2010..We propose a method called semi-supervised recursively partitioned mixture models (SS-RPMM) that utilizes array-based genetic and patient-level clinical data for finding cancer subtypes that are associated with patient survival... - Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility spermSara E Pacheco
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
PLoS ONE 6:e20280. 2011..We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function... - Bisphenol A exposure leads to specific microRNA alterations in placental cellsMichele Avissar-Whiting
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States
Reprod Toxicol 29:401-6. 2010..Overall, these results suggest that BPA can alter miRNA expression in placental cells, a potentially novel mode of BPA toxicity... - Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placentaMatthew A Maccani
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
Epigenetics 5:583-9. 2010..These results suggest that miR-146a is particularly responsive to exposures, and that smoking may elicit some of its downstream effects through alteration of miRNA expression... - MicroRNA expression ratio is predictive of head and neck squamous cell carcinomaMichele Avissar
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
Clin Cancer Res 15:2850-5. 2009..We sought to identify microRNAs altered in head and neck squamous cell carcinoma (HNSCC) and to determine whether microRNA expression is predictive of disease... - Association of secondhand smoke exposures with DNA methylation in bladder carcinomasCharlotte S Wilhelm-Benartzi
Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
Cancer Causes Control 22:1205-13. 2011..Epigenetic alterations in bladder tumors have been linked to primary cigarette smoking and could add to the biological plausibility of an association between SHS exposure and bladder cancer... - Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinomaMichele Avissar-Whiting
Department of Pathology, Brown University, Providence, RI, USA
Epigenetics 6:703-9. 2011..This work contributes to our understanding of how repressive marks on DNA and chromatin are dysregulated in carcinogenesis, knowledge that might aid the development of therapies or preventive strategies for human malignancies... - MicroRNA expression in head and neck cancer associates with alcohol consumption and survivalMichele Avissar
Department of Pathology and Laboratory Medicine, Brown University, Box G E5, Providence, RI 02912, USA
Carcinogenesis 30:2059-63. 2009..77) in a model controlled for patient age, gender and tumor stage. Together, these data suggest that alterations in miRNA expression are related to exposures causal in head and neck cancer and may be useful biomarkers of patient outcome... - Infant growth restriction is associated with distinct patterns of DNA methylation in human placentasCarolyn E Banister
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
Epigenetics 6:920-7. 2011.... - Allergies and risk of head and neck cancerDominique S Michaud
Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA
Cancer Causes Control 23:1317-22. 2012..Inverse associations have been reported among individuals with allergies and risk of brain and pancreatic cancers... - Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan IslandersHaley L Cash
Department of Pathology and Laboratory Medicine, International Health Institute, Public Health Program, Brown University, Providence, RI, USA
Epigenetics 6:1257-64. 2011.... - Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placentaAmanda C Filiberto
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
Epigenetics 6:566-72. 2011..Our work is one of the first to link infant growth as a measure of the intrauterine environment and epigenetic alterations to the GR and suggests that DNA methylation may be a critical determinant of placental function... - miR-16 and miR-21 expression in the placenta is associated with fetal growthMatthew A Maccani
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
PLoS ONE 6:e21210. 2011..We hypothesized that aberrant expression of miRNA in the placenta is associated with fetal growth, a measurable phenotype resulting from a number of intrauterine factors, and one which is significantly predictive of later life outcomes... - Endocrine disruptors, environmental oxygen, epigenetics and pregnancyJared C Robins
Division of Reproductive Endocrinology and Infertility, Women and Infants Hospital of Rhode Island, Providence, RI, USA
Front Biosci (Elite Ed) 3:690-700. 2011.... - Implications of LINE1 methylation for bladder cancer risk in womenCharlotte S Wilhelm
Department of Community Health Center for Environmental Health, Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
Clin Cancer Res 16:1682-9. 2010.... - Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profilesBrock C Christensen
Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA
Cancer Res 69:6315-21. 2009..Methylation profile-based differentiation of lung adenocarcinoma and mesothelioma is highly accurate, informs on the distinct etiologies of these diseases, and holds promise for clinical application... - A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancersBrock C Christensen
Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
Carcinogenesis 30:1003-7. 2009..7; 95% CI, 1.4-5.3). These data demonstrate that cases with the KRAS-LCS6 variant have significantly reduced survival time and suggest that this variant may alter the phenotype or therapeutic response of this disease... - Behavioral epigeneticsBarry M Lester
Department of Psychiatry, Warren Alpert Medical School, Brown University, Women and Infants Hospital, Providence, Rhode Island 02908, USA
Ann N Y Acad Sci 1226:14-33. 2011..This report provides an overview of the research presented by leading scientists and lively discussion about the future of investigation at the behavioral epigenetic level... 
Promoter hypermethylation is associated with current smoking, age, gender and survival in bladder cancerCarmen J Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
Carcinogenesis 28:1745-51. 2007....- Genetic and epigenetic tumor suppressor gene silencing are distinct molecular phenotypes driven by growth promoting mutations in nonsmall cell lung cancerCarmen J Marsit
Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
J Cancer Epidemiol 2008:215809. 2008..These data suggest that NSCLCs have distinct epigenetic or genetic alteration phenotypes acting upon tumor suppressor genes and that mutation of oncogenic growth promoting genes, such as KRAS, is associated with the epigenetic phenotype... - Epigenetics in the placentaMatthew A Maccani
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
Am J Reprod Immunol 62:78-89. 2009..Thus, epigenetic alterations may aid in disease diagnosis and prognosis as well as in targeting new treatment and prevention strategies... - Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinomaDebra Ting Hsiung
Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 16:108-14. 2007..This study aimed to determine whether global methylation in DNA derived from whole blood, a proxy tissue, is associated with HNSCC and to assess potential modification of this property by environmental or behavioral risk factors... - Carcinogen exposure and gene promoter hypermethylation in bladder cancerCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 27:112-6. 2006..These results, from human bladder tumors, add to the body of animal and in vitro evidence that suggests a role in epigenetic alterations for bladder carcinogens... - Line region hypomethylation is associated with lifestyle and differs by human papillomavirus status in head and neck squamous cell carcinomasC Sloane Furniss
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA
Cancer Epidemiol Biomarkers Prev 17:966-71. 2008.... - Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumorsCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Res 66:10621-9. 2006.... - Glutathione S-transferase polymorphisms and the synergy of alcohol and tobacco in oral, pharyngeal, and laryngeal carcinomaEdward S Peters
Division of Epidemiology, Louisiana State University Health Sciences School of Public Health, New Orleans, Louisiana, USA
Cancer Epidemiol Biomarkers Prev 15:2196-202. 2006..These data (showing that the GSTM1 deletion affects on the tobacco and alcohol synergy) suggest that the interaction of these carcinogens is, at least in part, driven by alcohol, enhancing the carcinogenic action of tobacco smoke... - Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesotheliomaBrock C Christensen
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 29:1555-9. 2008..These data suggest a novel tumorigenic mechanism of action of asbestos and may contribute to the understanding of precisely how asbestos exposure influences the etiology and clinical course of malignant mesothelioma... - Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancersDohun Pyeon
McArdle Laboratory for Cancer Research, University of Wisconsin Madison, Madison, WI 53706, USA
Cancer Res 67:4605-19. 2007.... - Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescenceCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Int J Cancer 114:219-23. 2005..1-2.3]. These results indicate that starting smoking under age 18 is an independent risk for RASSF1A hypermethylation, thus identifying a molecular alteration related to the epidemiologic effect of teenage smoking as a lung cancer risk... - Loss of heterozygosity of chromosome 3p21 is associated with mutant TP53 and better patient survival in non-small-cell lung cancerCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Res 64:8702-7. 2004.... - The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-AmericansCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 26:1446-9. 2005..This study points to the need for further examination of this gene and its variant in lung cancer and other diseases... - Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survivalCarmen J Marsit
Department of Cancer Cell Biology, Harvard School of Public Health, Boston, MA 02115, USA
Oncogene 23:1000-4. 2004..1 (95% CI 1.2-7.9). This study demonstrates that inactivation of the FANC-BRCA pathway is relatively common in solid tumors and may be related to tobacco and alcohol exposure and survival of these patients... - PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alterationCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Hum Pathol 36:768-76. 2005..PTEN loss may also be a favorable prognostic marker, although further studies are needed to confirm this finding... - Dairy products, leanness, and head and neck squamous cell carcinomaEdward S Peters
Epidemiology Program, Louisiana State University Health Sciences School of Public Health, New Orleans, Louisiana 70131, USA
Head Neck 30:1193-205. 2008.... - TP53 mutation, allelism and survival in non-small cell lung cancerHeather H Nelson
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 26:1770-3. 2005..Further, the combination of mutation with the codon 72 proline variant predicts poorer patient survival, particularly in a disease that has progressed outside the lung, a finding that warrants further investigation... - Carcinogen exposure and epigenetic silencing in bladder cancerCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Ann N Y Acad Sci 1076:810-21. 2006..01). These results from human bladder tumors, add to the body of animal and in vitro evidence that suggests bladder carcinogens play a crucial role in the induction of important epigenetic alterations... - Epigenetic silencing of the PRSS3 putative tumor suppressor gene in non-small cell lung cancerCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Mol Carcinog 44:146-50. 2005..On the other hand, the high prevalence of this alteration makes PRSS3 methylation an attractive biomarker for use in diagnostic or screening applications in NSCLC... - Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancerCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Res 65:7081-5. 2005..02) controlled for TP53 staining intensity and other survival-associated factors. Classifying tumors based on SFRP methylation status and TP53 protein staining intensity may be a clinically powerful predictor of invasive, deadly disease... - Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: association with smoking, TP53, and survivalCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Building I, Room 607, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Genet Cytogenet 162:115-21. 2005.... - Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinomaCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 119:1761-6. 2006....