Affiliation: Brown University
Lipscombe D, López Soto E. Alternative splicing of neuronal genes: new mechanisms and new therapies. Curr Opin Neurobiol. 2019;57:26-31 pubmed publisher
..Recent publications demonstrate the value of delineating basic mechanisms that dictate exon choice to inform the development of new therapeutic strategies that correct or compensate for damaging deficits in alternative splicing. ..
Lipscombe D, Allen S, Toro C. Control of neuronal voltage-gated calcium ion channels from RNA to protein. Trends Neurosci. 2013;36:598-609 pubmed publisher
Yanagi K, Wu Z, Amaya J, Chapkis N, Duffy A, Hajdarovic K, et al
. Meta-analysis of Genetic Modifiers Reveals Candidate Dysregulated Pathways in Amyotrophic Lateral Sclerosis. Neuroscience. 2019;396:A3-A20 pubmed publisher
..Understanding genes that modify ALS-associated defects will help to elucidate the molecular pathways that underlie ALS and provide additional targets for therapeutic intervention. ..
Lipscombe D, Pan J. Tripping the HCN breaker. Neuron. 2009;62:747-50 pubmed publisher
..In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a bidirectional spin. ..
Jiang Y, Andrade A, Lipscombe D. Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA. Mol Pain. 2013;9:67 pubmed publisher
..Our findings show that the analgesic action of morphine, but not ziconotide or gabapentin, to thermal stimuli is linked to which Cacna1b exon, e37a or e37b, is selected during alternative pre-mRNA splicing. ..
Lipscombe D, Andrade A. Calcium Channel CaVÎ±â‚ Splice Isoforms - Tissue Specificity and Drug Action. Curr Mol Pharmacol. 2015;8:22-31 pubmed
Lipscombe D, López Soto E. Protected by a Fox. Neuron. 2018;98:3-5 pubmed publisher
..In this issue of Neuron, Vuong et al. (2018) reveal an unlikely role for a broadly expressed RNA binding protein, Rbfox1, in protecting inhibitory transmission in the hippocampus. ..