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Affiliation: Brown University
Jiang Y, Andrade A, Lipscombe D. Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA. Mol Pain. 2013;9:67 pubmed publisher
..Our findings show that the analgesic action of morphine, but not ziconotide or gabapentin, to thermal stimuli is linked to which Cacna1b exon, e37a or e37b, is selected during alternative pre-mRNA splicing. ..
Lipscombe D, Andrade A. Calcium Channel CaVÎ±â‚ Splice Isoforms - Tissue Specificity and Drug Action. Curr Mol Pharmacol. 2015;8:22-31 pubmed