M M Levy

Summary

Affiliation: Brown University
Country: USA

Publications

  1. doi request reprint Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study
    Mitchell M Levy
    Division of Pulmonary and Critical Care Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
    Lancet Infect Dis 12:919-24. 2012
  2. pmc Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
  3. pmc Roundtable debate: Controversies in the management of the septic patient--desperately seeking consensus
    Aaron B Waxman
    Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Crit Care 9:E1. 2005
  4. pmc Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry
    Richard Beale
    Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
    Crit Care 14:R102. 2010
  5. pmc The challenge of sepsis
    Mitchell M Levy
    Brown University, Medical Intensive Care Unit, Rhode Island Hospital, Providence, RI, USA
    Crit Care 8:435-6. 2004
  6. pmc The electrocardiogram for sepsis: how close are we?
    Mitchell M Levy
    Rhode Island Hospital Brown University, 593 Eddy St, Providence, RI 02903, USA
    Crit Care 11:144. 2007
  7. doi request reprint The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
    Mitchell M Levy
    Division of Pulmonary, Sleep and Critical Care Medicine Care Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 38:367-74. 2010
  8. pmc The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
    Mitchell M Levy
    Division of Pulmonary, Sleep and Critical Care Medicine, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Intensive Care Med 36:222-31. 2010
  9. doi request reprint Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsis
    Mitchell Levy
    Rhode Island Hospital and Brown University Medical School, 593 Eddy St, Providence, RI 02903, USA
    Intensive Care Med 35:1196-203. 2009
  10. doi request reprint Facilitating knowledge transfer with single-center trials
    Mitchell M Levy
    Alpert Medical School at Brown University, Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 37:3120-3. 2009

Collaborators

Detail Information

Publications56

  1. doi request reprint Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study
    Mitchell M Levy
    Division of Pulmonary and Critical Care Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
    Lancet Infect Dis 12:919-24. 2012
    ..We aimed to use data from the Surviving Sepsis Campaign (SSC) to compare models of care and outcomes for patients with severe sepsis and septic shock in the USA and Europe...
  2. pmc Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
    ..We then look at the process of care and realize that, here, huge progress has been made. Lastly, we suggest how critical care medicine will continue to evolve for the better over the next 30 years...
  3. pmc Roundtable debate: Controversies in the management of the septic patient--desperately seeking consensus
    Aaron B Waxman
    Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Crit Care 9:E1. 2005
    ..This presentation is intended to show how experienced intensivists apply clinical science to their practice of critical care medicine...
  4. pmc Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry
    Richard Beale
    Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
    Crit Care 14:R102. 2010
    ....
  5. pmc The challenge of sepsis
    Mitchell M Levy
    Brown University, Medical Intensive Care Unit, Rhode Island Hospital, Providence, RI, USA
    Crit Care 8:435-6. 2004
  6. pmc The electrocardiogram for sepsis: how close are we?
    Mitchell M Levy
    Rhode Island Hospital Brown University, 593 Eddy St, Providence, RI 02903, USA
    Crit Care 11:144. 2007
    ..Efforts are now being directed toward evaluating the utility of biomarker profiles, containing multiple markers, for risk assessment and diagnosis in patients with suspected sepsis...
  7. doi request reprint The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
    Mitchell M Levy
    Division of Pulmonary, Sleep and Critical Care Medicine Care Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 38:367-74. 2010
    ..A performance improvement initiative targeted changing clinical behavior (process improvement) via bundles based on key SSC guideline recommendations...
  8. pmc The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
    Mitchell M Levy
    Division of Pulmonary, Sleep and Critical Care Medicine, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Intensive Care Med 36:222-31. 2010
    ..A performance improvement initiative targeted changing clinical behavior (process improvement) via bundles based on key SSC guideline recommendations on process improvement and patient outcomes...
  9. doi request reprint Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsis
    Mitchell Levy
    Rhode Island Hospital and Brown University Medical School, 593 Eddy St, Providence, RI 02903, USA
    Intensive Care Med 35:1196-203. 2009
    ..The safety of using heparin concomitantly with drotrecogin alfa (activated) {DrotAA} was explored in the XPRESS study. No heparin effect on mortality was observed. Safety results from that study are explored in more detail...
  10. doi request reprint Facilitating knowledge transfer with single-center trials
    Mitchell M Levy
    Alpert Medical School at Brown University, Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 37:3120-3. 2009
    ..To provide perspective for clinicians as they evaluate incorporating single-center trials and small randomized, controlled trials for use in daily practice by reviewing examples from the literature...
  11. ncbi request reprint A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation
    Mitchell M Levy
    Brown University School of Medicine, Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, 593 Eddy St, Main 7, Providence, RI, 02903, USA
    Chest 127:928-35. 2005
    ..To characterize and compare transfusion practices in a broad sample of patients receiving mechanical ventilation (MV) and not receiving MV in the ICU...
  12. ncbi request reprint 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  13. ncbi request reprint Early changes in organ function predict eventual survival in severe sepsis
    Mitchell M Levy
    Brown University School of Medicine, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 33:2194-201. 2005
    ..We hypothesized that a risk prediction model based on early (baseline to day 1 of study) response to standard care should be significantly related to 28-day survival...
  14. ncbi request reprint Pathophysiology of oxygen delivery in respiratory failure
    Mitchell M Levy
    Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital Brown University School of Medicine, 593 Eddy Street, Main 7, Providence, RI 02903, USA
    Chest 128:547S-553S. 2005
    ..This article provides an overview of oxygenation, hemoglobin, and Qt in patients with respiratory failure and highlights some of the current research that seeks safe and effective ways to improve DO(2) in these patients...
  15. ncbi request reprint Optimal peep in ARDS. Changing concepts and current controversies
    Mitchell M Levy
    Medical Intensive Care Unit, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
    Crit Care Clin 18:15-33, v-vi. 2002
    ..These points and others are delineated and discussed in this article...
  16. pmc Evaluating our end-of-life practice
    M M Levy
    Rhode Island Hospital, Providence, Rhode Island, USA
    Crit Care 5:182-3. 2001
    ..Intensivists in France make decisions despite a lack of formal guidelines in their country. This study should serve as a stimulus for educating the public and motivating more groups to monitor their end-of-life practices...
  17. pmc Association between critical care physician management and patient mortality in the intensive care unit
    Mitchell M Levy
    Brown University, Providence, Rhode Island, USA
    Ann Intern Med 148:801-9. 2008
    ..Critically ill patients admitted to intensive care units (ICUs) are thought to gain an added survival benefit from management by critical care physicians, but evidence of this benefit is scant...
  18. doi request reprint Reducing mortality in severe sepsis: the Surviving Sepsis Campaign
    Sean R Townsend
    Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, Brown University, 593 Eddy Street, APC 756, Providence, RI 02903, USA
    Clin Chest Med 29:721-33, x. 2008
    ..The literature that has characterized clinical experiences with interventions related to the campaign is reviewed and conclusions discussed...
  19. ncbi request reprint Finding out what we do in the ICU
    Mitchell M Levy
    Rhode Island Hospital, Intensive Care Unit, Providence, RI, USA
    Crit Care Med 34:227-8. 2006
  20. doi request reprint Perceptions of cost constraints, resource limitations, and rationing in United States intensive care units: results of a national survey
    Nicholas S Ward
    Division of Pulmonary Critical Care, Brown Medical School, Providence, RI, USA
    Crit Care Med 36:471-6. 2008
    ..To examine cost constraints, resource limitations, and rationing within U.S. intensive care units (ICUs) as perceived by ICU clinicians and the roles of ICU physician and nurse directors in resource allocation decisions...
  21. ncbi request reprint Comparison of a commercially available clinical information system with other methods of measuring critical care outcomes data
    Nicholas S Ward
    Medical Intensive Care Unit, Brown Medical School, Rhode Island Hospital, Providence, RI 02903, USA
    J Crit Care 19:10-5. 2004
    ..To compare the quality of data recorded by a commercially available clinical information system (CIS) to other commonly used methods for obtaining large amounts of patient data...
  22. doi request reprint Implementing a collaborative protocol in a sepsis intervention program: lessons learned
    Brian Casserly
    Memorial Hospital of Rhode Island, Brown University, 111 Brewster Street, Pawtucket, RI 02860, USA
    Lung 189:11-9. 2011
    ..However, despite a collaborative approach, the sepsis intervention program was underutilized with only 48% of the patients completing the sepsis intervention protocol...
  23. doi request reprint Biomarkers: diagnosis and risk assessment in sepsis
    Corey E Ventetuolo
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH 8, Room 101, 622 W 168th Street, New York City, NY 10032, USA
    Clin Chest Med 29:591-603, vii. 2008
    ..The most relevant markers are reviewed in this article, including interleukin-6, C-reactive protein, procalcitonin, triggering receptor expressed on myeloid cells-1, and biomarker panels...
  24. doi request reprint Hemodynamic monitoring in sepsis
    Brian Casserly
    Division of Pulmonary and Critical Care Medicine, The Memorial Hospital of Rhode Island, Pawtucket, RI, USA
    Crit Care Clin 25:803-23, ix. 2009
    ..This article examines emerging technologies as well as more established techniques used to monitor hemodynamics in sepsis and assesses their potential roles in optimization of sepsis-induced tissue hypoperfusion...
  25. ncbi request reprint Rationing and critical care medicine
    Nicholas S Ward
    Department of Pulmonary and Critical Care Medicine, Brown Medical School, Providence, Rhode Island, USA
    Crit Care Med 35:S102-5. 2007
    ..In addition, we review the pertinent literature on resource allocation and rationing in intensive care units...
  26. ncbi request reprint 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  27. ncbi request reprint End-of-life care in the intensive care unit: can we do better?
    M M Levy
    Brown University, Rhode Island Hospital, Providence, RI 02903, USA
    Crit Care Med 29:N56-61. 2001
    ..The quality of care our patients receive at the end of life will depend on our ability to answer these difficult questions...
  28. pmc Clinical review: fever in intensive care unit patients
    Michael Ryan
    Brown Medical School Rhode Island Hospital, Providence, Rhode Island, USA
    Crit Care 7:221-5. 2003
    ..The anti-inflammatory effects of HSPs, coupled with improved survival of animal models with fever and infection, call into question the routine practice of treating fever in critically ill patients...
  29. ncbi request reprint Successful determination of lower inflection point and maximal compliance in a population of patients with acute respiratory distress syndrome
    Nicholas S Ward
    Brown University School of Medicine, Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 30:963-8. 2002
    ....
  30. ncbi request reprint Blood transfusion practice today
    Nicholas S Ward
    Neurointensive Care Unit, Rhode Island Hospital, Brown Medical School, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Clin 20:179-86. 2004
    ....
  31. ncbi request reprint Clinical issues and research in respiratory failure from severe acute respiratory syndrome
    Mitchell M Levy
    Department of Medicine, Brown University Rhode Island Hospital, Providence, USA
    Am J Respir Crit Care Med 171:518-26. 2005
    ..The group recommended preparation for studies, including protocols, ethical considerations, Web-based registries, and data entry systems...
  32. ncbi request reprint A view from the other side
    Mitchell M Levy
    Brown Medical School and Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 35:603-4. 2007
    ..The environment in our intensive care units (ICUs) often serves the convenience of the staff who work in the ICU, rather than the critically ill patients and their loved ones who are, as a family unit, the objects of our care...
  33. ncbi request reprint Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome
    Mitchell M Levy
    Medical Intensive Care Unit Rhode Island Hospital Providence, RI, USA
    Crit Care Med 32:S595-7. 2004
  34. ncbi request reprint End-of-life care in the intensive care unit: state of the art in 2006
    Mitchell M Levy
    Brown University, Providence, Rhode Island, USA
    Crit Care Med 34:S306-8. 2006
    ..Quality indicators have been defined, and an audit tool can help assess levels of performance...
  35. ncbi request reprint Sepsis: a clinical update
    Corey E Ventetuolo
    Department of Medicine, Brown University, Providence, Rhode Island 02903, USA
    Clin J Am Soc Nephrol 3:571-7. 2008
  36. ncbi request reprint Visiting hours policies in New England intensive care units: strategies for improvement
    Melissa D Lee
    Brown Medical School and Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 35:497-501. 2007
    ....
  37. ncbi request reprint Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial
    Howard L Corwin
    Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    JAMA 288:2827-35. 2002
    ..Anemia is common in critically ill patients and results in a large number of red blood cell (RBC) transfusions. Recent data have raised the concern that RBC transfusions may be associated with worse clinical outcomes in some patients...
  38. ncbi request reprint Rationing critical care beds: a systematic review
    Tasnim Sinuff
    Crit Care Med 32:1588-97. 2004
    ..Rationing critical care beds occurs daily in the hospital setting. The objective of this systematic review was to examine the impact of rationing intensive care unit beds on the process and outcomes of care...
  39. ncbi request reprint Noninvasive positive pressure ventilation in critical and palliative care settings: understanding the goals of therapy
    J Randall Curtis
    Department of Medicine, University of Washington, Seattle, WA, USA
    Crit Care Med 35:932-9. 2007
    ..Therefore, the Society of Critical Care Medicine charged this Task Force with developing an approach for considering use of NPPV for patients who choose to forego endotracheal intubation...
  40. ncbi request reprint PEEP in ARDS--how much is enough?
    Mitchell M Levy
    N Engl J Med 351:389-91. 2004
  41. ncbi request reprint Mechanical ventilation in sepsis-induced acute lung injury/acute respiratory distress syndrome: an evidence-based review
    Jonathan E Sevransky
    Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 32:S548-53. 2004
    ....
  42. ncbi request reprint The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States
    Howard L Corwin
    Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Crit Care Med 32:39-52. 2004
    ..To quantify the incidence of anemia and red blood cell (RBC) transfusion practice in critically ill patients and to examine the relationship of anemia and RBC transfusion to clinical outcomes...
  43. doi request reprint Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain
    Ricard Ferrer
    Centro de Críticos, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Instituto Universitario Parc Tauli, Universidad Autonoma de Barcelona, Barcelona, Spain
    JAMA 299:2294-303. 2008
    ..Concern exists that current guidelines for care of patients with severe sepsis and septic shock are followed variably, possibly due to a lack of adequate education...
  44. ncbi request reprint DNR directives are established early in mechanically ventilated intensive care unit patients
    Tasnim Sinuff
    Department of Medicine, McMaster University Health Sciences Center, Room 2C11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
    Can J Anaesth 51:1034-41. 2004
    ..Our objective was to study the rate of establishing do-not-resuscitate (DNR) directives, determinants, and outcomes of those directives for mechanically ventilated patients...
  45. ncbi request reprint End-of-life care for the critically ill: A national intensive care unit survey
    Judith E Nelson
    Department of Medicine, Hertzberg Palliative Care Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Crit Care Med 34:2547-53. 2006
    ..We conducted this study to elicit the views and experiences of ICU directors regarding barriers to optimal end-of-life care and to identify the type, availability, and perceived benefit of specific strategies that may improve this care...
  46. ncbi request reprint Proposed quality measures for palliative care in the critically ill: a consensus from the Robert Wood Johnson Foundation Critical Care Workgroup
    Richard A Mularski
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon, USA
    Crit Care Med 34:S404-11. 2006
    ..The proposed measures are intended to stimulate further discussion, testing, and refinement for quality of care measurement and enhancement...
  47. ncbi request reprint Computers in the intensive care unit
    Mitchell M Levy
    J Crit Care 19:199-200. 2004
  48. ncbi request reprint Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  49. ncbi request reprint The world's major religions' points of view on end-of-life decisions in the intensive care unit
    Hans Henrik Bulow
    Department of Anaesthesiology and Intensive Care, Holbak Hospital, Smedelundsgade 60, 4300 Holbak, Denmark
    Intensive Care Med 34:423-30. 2008
    ..This review also discusses whether nutrition should be provided to patients in a permanent vegetative state, and the issues of brain death and organ donation...
  50. pmc Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
    Intensive Care Med 34:17-60. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004...
  51. ncbi request reprint Shared decision-making in the ICU: entering a new era
    Mitchell M Levy
    Crit Care Med 32:1966-8. 2004
  52. ncbi request reprint Rationing in the intensive care unit
    Robert D Truog
    Professor of Medical Ethics and Anesthesia Pediatrics, Harvard Medical School, Senior Associate in Critical Care Medicine, Children s Hospital, Boston, MA, USA
    Crit Care Med 34:958-63; quiz 971. 2006
    ..quot; Although some have maintained that rationing of health care is unethical, we argue that rationing is not only unavoidable but essential to ensuring the ethical distribution of medical goods and services...
  53. ncbi request reprint Dying in America
    Mitchell M Levy
    Crit Care Med 32:879-80. 2004
  54. ncbi request reprint Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Crit Care Med 32:858-73. 2004
    ....
  55. doi request reprint Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive
    Roman Jaeschke
    Department of Medicine, McMaster University, Hamilton, ON, Canada L8P 3B6
    BMJ 337:a744. 2008
  56. ncbi request reprint The ethical conduct of clinical research involving critically ill patients in the United States and Canada: principles and recommendations
    John M Luce
    Am J Respir Crit Care Med 170:1375-84. 2004