Research Topics
| M M LevySummaryAffiliation: Brown University Country: USA Publications
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Publications
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort studyMitchell M Levy
Division of Pulmonary and Critical Care Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA Electronic address
Lancet Infect Dis 12:919-24. 2012..We aimed to use data from the Surviving Sepsis Campaign (SSC) to compare models of care and outcomes for patients with severe sepsis and septic shock in the USA and Europe...
Thirty years of critical care medicineJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
Crit Care 14:311. 2010..We then look at the process of care and realize that, here, huge progress has been made. Lastly, we suggest how critical care medicine will continue to evolve for the better over the next 30 years...
Roundtable debate: Controversies in the management of the septic patient--desperately seeking consensusAaron B Waxman
Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Crit Care 9:E1. 2005..This presentation is intended to show how experienced intensivists apply clinical science to their practice of critical care medicine...- Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registryRichard Beale
Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
Crit Care 14:R102. 2010.... - The challenge of sepsisMitchell M Levy
Brown University, Medical Intensive Care Unit, Rhode Island Hospital, Providence, RI, USA
Crit Care 8:435-6. 2004 - The electrocardiogram for sepsis: how close are we?Mitchell M Levy
Rhode Island Hospital Brown University, 593 Eddy St, Providence, RI 02903, USA
Crit Care 11:144. 2007..Efforts are now being directed toward evaluating the utility of biomarker profiles, containing multiple markers, for risk assessment and diagnosis in patients with suspected sepsis... - The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsisMitchell M Levy
Division of Pulmonary, Sleep and Critical Care Medicine Care Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
Crit Care Med 38:367-74. 2010..A performance improvement initiative targeted changing clinical behavior (process improvement) via bundles based on key SSC guideline recommendations... - The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsisMitchell M Levy
Division of Pulmonary, Sleep and Critical Care Medicine, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
Intensive Care Med 36:222-31. 2010..A performance improvement initiative targeted changing clinical behavior (process improvement) via bundles based on key SSC guideline recommendations on process improvement and patient outcomes... - Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsisMitchell Levy
Rhode Island Hospital and Brown University Medical School, 593 Eddy St, Providence, RI 02903, USA
Intensive Care Med 35:1196-203. 2009..The safety of using heparin concomitantly with drotrecogin alfa (activated) {DrotAA} was explored in the XPRESS study. No heparin effect on mortality was observed. Safety results from that study are explored in more detail... - Facilitating knowledge transfer with single-center trialsMitchell M Levy
Alpert Medical School at Brown University, Rhode Island Hospital, Providence, RI, USA
Crit Care Med 37:3120-3. 2009..To provide perspective for clinicians as they evaluate incorporating single-center trials and small randomized, controlled trials for use in daily practice by reviewing examples from the literature... 
A descriptive evaluation of transfusion practices in patients receiving mechanical ventilationMitchell M Levy
Brown University School of Medicine, Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, 593 Eddy St, Main 7, Providence, RI, 02903, USA
Chest 127:928-35. 2005..To characterize and compare transfusion practices in a broad sample of patients receiving mechanical ventilation (MV) and not receiving MV in the ICU...- 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceMitchell M Levy
Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
Intensive Care Med 29:530-8. 2003..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes... - Early changes in organ function predict eventual survival in severe sepsisMitchell M Levy
Brown University School of Medicine, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
Crit Care Med 33:2194-201. 2005..We hypothesized that a risk prediction model based on early (baseline to day 1 of study) response to standard care should be significantly related to 28-day survival... - Pathophysiology of oxygen delivery in respiratory failureMitchell M Levy
Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital Brown University School of Medicine, 593 Eddy Street, Main 7, Providence, RI 02903, USA
Chest 128:547S-553S. 2005..This article provides an overview of oxygenation, hemoglobin, and Qt in patients with respiratory failure and highlights some of the current research that seeks safe and effective ways to improve DO(2) in these patients... - Optimal peep in ARDS. Changing concepts and current controversiesMitchell M Levy
Medical Intensive Care Unit, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
Crit Care Clin 18:15-33, v-vi. 2002..These points and others are delineated and discussed in this article... - Evaluating our end-of-life practiceM M Levy
Rhode Island Hospital, Providence, Rhode Island, USA
Crit Care 5:182-3. 2001..Intensivists in France make decisions despite a lack of formal guidelines in their country. This study should serve as a stimulus for educating the public and motivating more groups to monitor their end-of-life practices... - Association between critical care physician management and patient mortality in the intensive care unitMitchell M Levy
Brown University, Providence, Rhode Island, USA
Ann Intern Med 148:801-9. 2008..Critically ill patients admitted to intensive care units (ICUs) are thought to gain an added survival benefit from management by critical care physicians, but evidence of this benefit is scant... - Reducing mortality in severe sepsis: the Surviving Sepsis CampaignSean R Townsend
Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, Brown University, 593 Eddy Street, APC 756, Providence, RI 02903, USA
Clin Chest Med 29:721-33, x. 2008..The literature that has characterized clinical experiences with interventions related to the campaign is reviewed and conclusions discussed... - Finding out what we do in the ICUMitchell M Levy
Rhode Island Hospital, Intensive Care Unit, Providence, RI, USA
Crit Care Med 34:227-8. 2006 - Perceptions of cost constraints, resource limitations, and rationing in United States intensive care units: results of a national surveyNicholas S Ward
Division of Pulmonary Critical Care, Brown Medical School, Providence, RI, USA
Crit Care Med 36:471-6. 2008..To examine cost constraints, resource limitations, and rationing within U.S. intensive care units (ICUs) as perceived by ICU clinicians and the roles of ICU physician and nurse directors in resource allocation decisions... - Comparison of a commercially available clinical information system with other methods of measuring critical care outcomes dataNicholas S Ward
Medical Intensive Care Unit, Brown Medical School, Rhode Island Hospital, Providence, RI 02903, USA
J Crit Care 19:10-5. 2004..To compare the quality of data recorded by a commercially available clinical information system (CIS) to other commonly used methods for obtaining large amounts of patient data... - Implementing a collaborative protocol in a sepsis intervention program: lessons learnedBrian Casserly
Memorial Hospital of Rhode Island, Brown University, 111 Brewster Street, Pawtucket, RI 02860, USA
Lung 189:11-9. 2011..However, despite a collaborative approach, the sepsis intervention program was underutilized with only 48% of the patients completing the sepsis intervention protocol... - Biomarkers: diagnosis and risk assessment in sepsisCorey E Ventetuolo
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH 8, Room 101, 622 W 168th Street, New York City, NY 10032, USA
Clin Chest Med 29:591-603, vii. 2008..The most relevant markers are reviewed in this article, including interleukin-6, C-reactive protein, procalcitonin, triggering receptor expressed on myeloid cells-1, and biomarker panels... - Hemodynamic monitoring in sepsisBrian Casserly
Division of Pulmonary and Critical Care Medicine, The Memorial Hospital of Rhode Island, Pawtucket, RI, USA
Crit Care Clin 25:803-23, ix. 2009..This article examines emerging technologies as well as more established techniques used to monitor hemodynamics in sepsis and assesses their potential roles in optimization of sepsis-induced tissue hypoperfusion... - Rationing and critical care medicineNicholas S Ward
Department of Pulmonary and Critical Care Medicine, Brown Medical School, Providence, Rhode Island, USA
Crit Care Med 35:S102-5. 2007..In addition, we review the pertinent literature on resource allocation and rationing in intensive care units... - 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceMitchell M Levy
Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
Crit Care Med 31:1250-6. 2003..This lack of evidence serves to underscore the challenge still present in diagnosing sepsis in 2003 for clinicians and researchers and also provides the basis for introducing PIRO as a hypothesis-generating model for future research... - End-of-life care in the intensive care unit: can we do better?M M Levy
Brown University, Rhode Island Hospital, Providence, RI 02903, USA
Crit Care Med 29:N56-61. 2001..The quality of care our patients receive at the end of life will depend on our ability to answer these difficult questions... - Clinical review: fever in intensive care unit patientsMichael Ryan
Brown Medical School/Rhode Island Hospital, Providence, Rhode Island, USA
Crit Care 7:221-5. 2003..The anti-inflammatory effects of HSPs, coupled with improved survival of animal models with fever and infection, call into question the routine practice of treating fever in critically ill patients... - Successful determination of lower inflection point and maximal compliance in a population of patients with acute respiratory distress syndromeNicholas S Ward
Brown University School of Medicine, Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, Providence, RI, USA
Crit Care Med 30:963-8. 2002..We conclude that determining optimal PEEP by maximal static compliance may be easier to measure and more frequently obtained at the bedside than by using a static pressure-volume curve... - Blood transfusion practice todayNicholas S Ward
Neurointensive Care Unit, Rhode Island Hospital, Brown Medical School, 593 Eddy Street, Providence, RI 02903, USA
Crit Care Clin 20:179-86. 2004.... - Clinical issues and research in respiratory failure from severe acute respiratory syndromeMitchell M Levy
Department of Medicine, Brown University/Rhode Island Hospital, Providence, USA
Am J Respir Crit Care Med 171:518-26. 2005..The group recommended preparation for studies, including protocols, ethical considerations, Web-based registries, and data entry systems... - A view from the other sideMitchell M Levy
Brown Medical School and Rhode Island Hospital, Providence, RI, USA
Crit Care Med 35:603-4. 2007..The environment in our intensive care units (ICUs) often serves the convenience of the staff who work in the ICU, rather than the critically ill patients and their loved ones who are, as a family unit, the objects of our care... - Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcomeMitchell M Levy
Medical Intensive Care Unit Rhode Island Hospital Providence, RI, USA
Crit Care Med 32:S595-7. 2004 - End-of-life care in the intensive care unit: state of the art in 2006Mitchell M Levy
Brown University, Providence, Rhode Island, USA
Crit Care Med 34:S306-8. 2006..Quality indicators have been defined, and an audit tool can help assess levels of performance... - Sepsis: a clinical updateCorey E Ventetuolo
Department of Medicine, Brown University, Providence, Rhode Island 02903, USA
Clin J Am Soc Nephrol 3:571-7. 2008 - Visiting hours policies in New England intensive care units: strategies for improvementMelissa D Lee
Brown Medical School and Rhode Island Hospital, Providence, RI, USA
Crit Care Med 35:497-501. 2007.... - Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trialHoward L Corwin
Critical Care Medicine, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
JAMA 288:2827-35. 2002..Anemia is common in critically ill patients and results in a large number of red blood cell (RBC) transfusions. Recent data have raised the concern that RBC transfusions may be associated with worse clinical outcomes in some patients... - Rationing critical care beds: a systematic reviewTasnim Sinuff
Crit Care Med 32:1588-97. 2004..Critical care bed rationing requires further investigation... - Noninvasive positive pressure ventilation in critical and palliative care settings: understanding the goals of therapyJ Randall Curtis
Department of Medicine, University of Washington, Seattle, WA, USA
Crit Care Med 35:932-9. 2007..Therefore, the Society of Critical Care Medicine charged this Task Force with developing an approach for considering use of NPPV for patients who choose to forego endotracheal intubation... - PEEP in ARDS--how much is enough?Mitchell M Levy
N Engl J Med 351:389-91. 2004 - Mechanical ventilation in sepsis-induced acute lung injury/acute respiratory distress syndrome: an evidence-based reviewJonathan E Sevransky
Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 32:S548-53. 2004..Weaning protocols should be in place that include spontaneous breathing trials and criteria for initiating such trials. The role of high-frequency oscillatory ventilation and airway pressure release ventilation in ARDS is uncertain... - The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United StatesHoward L Corwin
Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Crit Care Med 32:39-52. 2004..To quantify the incidence of anemia and red blood cell (RBC) transfusion practice in critically ill patients and to examine the relationship of anemia and RBC transfusion to clinical outcomes... - Improvement in process of care and outcome after a multicenter severe sepsis educational program in SpainRicard Ferrer
Centro de Críticos, Hospital de Sabadell, CIBER Enfermedades Respiratorias, Instituto Universitario Parc Tauli, Universidad Autonoma de Barcelona, Barcelona, Spain
JAMA 299:2294-303. 2008..Concern exists that current guidelines for care of patients with severe sepsis and septic shock are followed variably, possibly due to a lack of adequate education... - DNR directives are established early in mechanically ventilated intensive care unit patientsTasnim Sinuff
Department of Medicine, McMaster University Health Sciences Center, Room 2C11, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada
Can J Anaesth 51:1034-41. 2004..The strongest predictors of DNR directives were physician prediction of low probability of survival, physician perception of patient preference to limit life support, organ dysfunction, medical diagnosis and age... - End-of-life care for the critically ill: A national intensive care unit surveyJudith E Nelson
Department of Medicine, Hertzberg Palliative Care Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Crit Care Med 34:2547-53. 2006..We conducted this study to elicit the views and experiences of ICU directors regarding barriers to optimal end-of-life care and to identify the type, availability, and perceived benefit of specific strategies that may improve this care... - Proposed quality measures for palliative care in the critically ill: a consensus from the Robert Wood Johnson Foundation Critical Care WorkgroupRichard A Mularski
Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon, USA
Crit Care Med 34:S404-11. 2006..The proposed measures are intended to stimulate further discussion, testing, and refinement for quality of care measurement and enhancement... - Computers in the intensive care unitMitchell M Levy
J Crit Care 19:199-200. 2004 - Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008R Phillip Dellinger
Cooper University Hospital, Camden, NJ, USA
Crit Care Med 36:296-327. 2008..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004... - The world's major religions' points of view on end-of-life decisions in the intensive care unitHans Henrik Bulow
Department of Anaesthesiology and Intensive Care, Holbak Hospital, Smedelundsgade 60, 4300 Holbak, Denmark
Intensive Care Med 34:423-30. 2008..This review also discusses whether nutrition should be provided to patients in a permanent vegetative state, and the issues of brain death and organ donation... - Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008R Phillip Dellinger
Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
Intensive Care Med 34:17-60. 2008..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004... - Shared decision-making in the ICU: entering a new eraMitchell M Levy
Crit Care Med 32:1966-8. 2004 - Rationing in the intensive care unitRobert D Truog
Professor of Medical Ethics and Anesthesia (Pediatrics, Harvard Medical School, Senior Associate in Critical Care Medicine, Children's Hospital, Boston, MA, USA
Crit Care Med 34:958-63; quiz 971. 2006..Additional work is needed to elucidate how both empirical evidence and ethical analysis can further inform the rationing decisions that arise in the taxonomy described here... - Dying in AmericaMitchell M Levy
Crit Care Med 32:879-80. 2004 - Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shockR Phillip Dellinger
Crit Care Med 32:858-73. 2004..The impact of these guidelines will be formally tested and guidelines updated annually and even more rapidly as some important new knowledge becomes as available... - Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusiveRoman Jaeschke
Department of Medicine, McMaster University, Hamilton, ON, Canada L8P 3B6
BMJ 337:a744. 2008 - The ethical conduct of clinical research involving critically ill patients in the United States and Canada: principles and recommendationsJohn M Luce
Am J Respir Crit Care Med 170:1375-84. 2004