Research Topics
| B M LesterSummaryAffiliation: Brown University Country: USA Publications
Research Grants
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Detail Information
Publications
The maternal lifestyle study: effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infantsBarry M Lester
Brown Medical School, Infant Development Center, Women and Infant s Hospital and Bradley Hospital, Providence, Rhode Island 02905 2499, USA
Pediatrics 110:1182-92. 2002..This was a prospective longitudinal multisite study of the effects of prenatal cocaine and/or opiate exposure on neurodevelopmental outcome in term and preterm infants at 1 month of age...- Comparison of motor self-regulatory and stress behaviors of preterm infants across body positionsIsabelle Roy Grenier
Advanced Masters Degree Program, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, Massachusetts, USA
Am J Occup Ther 57:289-97. 2003..These positions may benefit infants in the NICU by reducing the need for motor-based self-regulatory behaviors and potentially conserving energy for growth... - Low birth weight and preterm births: etiologic fraction attributable to prenatal drug exposureHenrietta S Bada
Department of Pediatrics, College of Medicine and College of Public Health, University of Kentucky, Lexington, KY 40536, USA
J Perinatol 25:631-7. 2005..20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). CONCLUSION: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine... 
Neurobehavioral disinhibition predicts initiation of substance use in children with prenatal cocaine exposureBarry M Lester
Brown Center for the Study of Children at Risk, Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI 02905, USA
Drug Alcohol Depend 126:80-6. 2012..Our hypothesis was that prenatal cocaine exposure predisposes the child to ND, which, in turn, is associated with initiation of substance use by age 16...- Services used by perinatal substance-users with child welfare involvement: a descriptive studyKenneth J McCann
Brown Center for the Study of Children at Risk, Women and Infants Hospital, Providence, RI, USA
Harm Reduct J 7:19. 2010..This paper describes services used by VIP-RI participants and child welfare outcomes... - The Neonatal Intensive Care Unit Network Neurobehavioral Scale proceduresBarry M Lester
Brown Medical School, Infant Development Center, Women and Infants Hospital and Bradley Hospital, Providence, Rhode Island 02903, USA
Pediatrics 113:641-67. 2004..Rating scales with scoring criteria are provided for each item. With training and certification, users of the manual will be able to reliably administer and score the Neonatal Intensive Care Unit Network Neurobehavioral Scale... - History and description of the Neonatal Intensive Care Unit Network Neurobehavioral ScaleBarry M Lester
Brown Medical School, Infant Development Center, Women and Infants Hospital, Providence, Rhode Island 02903, USA
Pediatrics 113:634-40. 2004..Finally we discuss the developmental model on which the NNNS is based and consider the implications of using the examination... 
Behavioral epigeneticsBarry M Lester
Department of Psychiatry, Warren Alpert Medical School, Brown University, Women and Infants Hospital, Providence, Rhode Island 02908, USA
Ann N Y Acad Sci 1226:14-33. 2011..This report provides an overview of the research presented by leading scientists and lively discussion about the future of investigation at the behavioral epigenetic level...- Prenatal cocaine exposure related to cortisol stress reactivity in 11-year-old childrenBarry M Lester
Department of Pediatrics, Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI 02905, USA
J Pediatr 157:288-295.e1. 2010..Determine the association between prenatal cocaine exposure and postnatal environmental adversity on salivary cortisol stress reactivity in school-aged children... - Third pathophysiology of prenatal cocaine exposureBarry M Lester
Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI 02905, USA
Dev Neurosci 31:23-35. 2009..This model is discussed in relation to follow-up studies of the effects of in utero cocaine exposure and maturational changes in brain development... - Treatment of substance abuse during pregnancyBarry M Lester
Warren Alpert Medical School of Brown University, Brown Center for the Study of Children at Risk, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA
Womens Health (Lond Engl) 4:67-77. 2008..We also discuss limitations of this research and issues that need to be addressed. The increasing understanding and acceptance of substance abuse as a treatable mental health disorder brings renewed optimism to this field... - The Maternal Lifestyle Study: drug use by meconium toxicology and maternal self-reportB M Lester
Brown Medical School, Women and Infants Hospital, Providence, Rhode Island 02905 2499, USA
Pediatrics 107:309-17. 2001..The objective of this study was to describe drug use by pregnant women participating in the 4-site Maternal Lifestyle Study of in utero cocaine and/or opiate exposure... - Summary statistics of neonatal intensive care unit network neurobehavioral scale scores from the maternal lifestyle study: a quasinormative sampleBarry M Lester
Brown Medical School, Infant Development Center, Women and Infants Hospital and Bradley Hospital, Providence, Rhode Island 02903, USA
Pediatrics 113:668-75. 2004..These tables can be used as quasinorms for comparison with other infants of this age... - Prenatal drug exposure and maternal and infant feeding behaviourL L LaGasse
Brown Medical School, Women and Infant s Hospital and Bradley Hospital, Providence, RI, USA University of Miami, Miami, FL, USA
Arch Dis Child Fetal Neonatal Ed 88:F391-9. 2003..To evaluate feeding difficulties and maternal behaviour during a feeding session with 1 month old infants prenatally exposed to cocaine and/or opiates... - Cocaine exposure is associated with subtle compromises of infants' and mothers' social-emotional behavior and dyadic features of their interaction in the face-to-face still-face paradigmE Z Tronick
Department of Psychiatry, Harvard Medical School and Child Development Unit, Children's Hospital, Boston, MA, USA
Dev Psychol 41:711-22. 2005.... - The NICU Network Neurobehavioral Scale. Clinical use with drug exposed infants and their mothersC F Boukydis
Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island, USA
Clin Perinatol 26:213-30. 1999..As we continue to develop assessment procedures based on understanding the capacities of the infant and understanding the parenting capacities of mothers, we will improve our ability to secure the welfare of drug-exposed infants... - Importance of stability of early living arrangements on behavior outcomes of children with and without prenatal drug exposureHenrietta S Bada
Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
J Dev Behav Pediatr 29:173-82. 2008..We evaluated whether living arrangements of children with or without prenatal drug exposure would be associated with their behavior outcomes and adaptive functioning... - Smoking during pregnancy and newborn neurobehaviorKaren L Law
Brown Medical School, Providence, Rhode Island, USA
Pediatrics 111:1318-23. 2003..Dose-response relationships could indicate neonatal withdrawal from nicotine. Research directed at understanding the effects of cigarette smoking during pregnancy on infants can lead to improved public health outcome... - The Maternal Lifestyle Study (MLS): effects of prenatal cocaine and/or opiate exposure on auditory brain response at one monthBarry M Lester
Brown Medical School, the Infant Development Center, Women and Infant's Hospital, and Bradley Hospital, Providence, Rhode Island 02905-2499, USA
J Pediatr 142:279-85. 2003..CONCLUSIONS: Prenatal cocaine and/or opiate exposure affects neural transmission. Detection of these effects requires a large sample with control for gestational age, other drugs, and level of cocaine use... - Demographic and psychosocial characteristics of mothers using methamphetamine during pregnancy: preliminary results of the infant development, environment, and lifestyle study (IDEAL)Chris Derauf
Department of Pediatrics, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96826, USA
Am J Drug Alcohol Abuse 33:281-9. 2007..These factors may impact the developmental outcomes of affected children... - Children of addicted womenBarry M Lester
Brown Center for the Study of Children at Risk, The Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI 02905, USA
J Addict Dis 29:259-76. 2010..The author discuss this "fetal origins" approach that involves fetal programming and the neuroendocrine system and the potential implications for adolescent brain and behavioral development... - The effect of parenting stress on child behavior problems in high-risk children with prenatal drug exposureDaniel M Bagner
Brown Center for the Study of Children at Risk, Women and Infants Hospital, The Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA
Child Psychiatry Hum Dev 40:73-84. 2009..To examine the relationship between early parenting stress and later child behavior in a high-risk sample and measure the effect of drug exposure on the relationship between parenting stress and child behavior... - Fetal effects of psychoactive drugsAmy L Salisbury
Department of Pediatrics, Brown Center for the Study of Children at Risk, Women and Infants Hospital of Rhode Island, 101 Dudley Street, Providence, RI 02905, USA
Clin Perinatol 36:595-619. 2009..We also discuss neurobehavioral techniques that may be useful in the early detection of the effects of in utero drug exposure... - Functional MRI and response inhibition in children exposed to cocaine in utero. Preliminary findingsStephen J Sheinkopf
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
Dev Neurosci 31:159-66. 2009..These preliminary findings suggest that prenatal cocaine may affect the development of brain systems involved in the regulation of attention and response inhibition... - Patterns of methamphetamine use during pregnancy: results from the Infant Development, Environment, and Lifestyle (IDEAL) StudySheri Della Grotta
Pediatrics Division, Brown Center for the Study of Children at Risk, Warren Alpert Medical School at Brown University and Women and Infant s Hospital, 101 Dudley Street, Providence, RI 02905, USA
Matern Child Health J 14:519-27. 2010..Future research will investigate the association of these patterns with neonatal outcomes... - Prenatal methamphetamine exposure and neonatal neurobehavioral outcome in the USA and New ZealandLinda L Lagasse
Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, RI, USA
Neurotoxicol Teratol 33:166-75. 2011..Methamphetamine (MA) use among pregnant women is a world-wide problem, but little is known of its impact on exposed infants... - Longitudinal study of maternal report of sleep problems in children with prenatal exposure to cocaine and other drugsKristen C Stone
Brown Center for the Study of Children at Risk, Women and Infants Hospital, 101 Dudley St, Providence, RI 02905, USA
Behav Sleep Med 7:196-207. 2009..01). Together, these preliminary findings suggest possible neurotoxic sleep effects that persist over time. Larger studies, however, need to be conducted that better control for potential postnatal confounding factors... - Infant neurobehavioral dysregulation: behavior problems in children with prenatal substance exposureBarry M Lester
Department of Pediatrics, Brown Center for the Study of Children at Risk, Women and Infants Hospital, Brown University, Providence, Rhode Island 02905, USA
Pediatrics 124:1355-62. 2009..The objective of this study was to test a developmental model of neurobehavioral dysregulation relating prenatal substance exposure to behavior problems at age 7... - Sleep problems in children with prenatal substance exposure: the Maternal Lifestyle studyKristen C Stone
Brown Center for the Study of Children at Risk, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA
Arch Pediatr Adolesc Med 164:452-6. 2010..To examine the associations between sleep problems and prenatal exposure to cocaine, opiates, marijuana, alcohol, and nicotine in children aged 1 month to 12 years... - Assessment of infant cry: acoustic cry analysis and parental perceptionLinda L Lagasse
Department of Pediatrics, Brown Medical School, Infant Development Center, Women and Infants Hospital, Providence, Rhode Island 02903, USA
Ment Retard Dev Disabil Res Rev 11:83-93. 2005..Deviations in the signal and/or misunderstanding the message can compromise infant care, parental effectiveness, and undermine the budding relationship. (c) 2005 Wiley-Liss, Inc. MRDD Research Reviews 2005;11:83-93... - Predictors of motor development in children prenatally exposed to cocaineCynthia Miller-Loncar
Brown Medical School, Women and Infants Hospital, Providence, RI 02903, United States
Neurotoxicol Teratol 27:213-20. 2005..Heavy cocaine use related to poorer motor performance as compared to no use, but there were no effects of level of cocaine use on change in motor skills... - Prenatal cocaine use and maternal depression: effects on infant neurobehaviorAmy L Salisbury
Brown Medical School, Providence, RI, USA
Neurotoxicol Teratol 29:331-40. 2007..The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study... - Normative neurobehavioral performance of healthy infants on the Neonatal Intensive Care Unit Network Neurobehavioral ScaleEdward Z Tronick
Child Development Unit, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 113:676-8. 2004..Descriptive statistics and percentiles are provided for the Neonatal Intensive Care Unit Network Neurobehavioral Scale summary scores. These tables can be used as quasinorms for comparison with other infants of this age... - Violence and delinquency, early onset drug use, and psychopathology in drug-exposed youth at 11 yearsLinda L Lagasse
Brown Medical School, Providence, Rhode Island, USA
Ann N Y Acad Sci 1094:313-8. 2006..This study provides new evidence for the impact of violence as well as resilience against disruptive forms of psychopathology and behavior... - Prenatal cocaine exposure: cardiorespiratory function and resilienceStephen J Sheinkopf
Brown Medical School, Providence, Rhode Island, USA
Ann N Y Acad Sci 1094:354-8. 2006..For high-risk children, low VT was related to higher ratings of adaptive behaviors. This finding suggests that regulatory functioning, as indexed by VT, may be a protective factor in prenatal CE... - Vagal tone as a resilience factor in children with prenatal cocaine exposureStephen J Sheinkopf
The Warren Alpert Medical School of Brown, Rhode Island, USA
Dev Psychopathol 19:649-73. 2007..This is consistent with theory linking reduced VT during tasks to adaptive regulation and indicates that such regulatory functioning may serve as a protective factor in prenatal CE... - Small for gestational age and higher birth weight predict childhood obesity in preterm infantsRonnesia B Gaskins
Center for Study of Children at Risk, Brown Alpert Medical School, Women and Infants Hospital of Rhode Island, Providence, Rhode Island 02905, USA
Am J Perinatol 27:721-30. 2010..Many (41%) of these high-risk preterm 11-year-olds were obese/overweight. Multiple growth-related processes may be involved in obesity risk for preterm children, including fetal programming as indicated by the SGA effect... - Interactions between maternal characteristics and neonatal behavior in the prediction of parenting stress and perception of infant temperamentStephen J Sheinkopf
Brown Medical School, Bradley Hospital, 1011 Veterans Memorial Parkway, East Providence, Rhode Island 02915, USA
J Pediatr Psychol 31:27-40. 2006..Prenatal cocaine exposure is a marker of developmental risk. Social environmental risk factors may include maternal stress and maternal perceptions of difficult infant temperament... - The effects of maternal depression on fetal heart rate response to vibroacoustic stimulationL Allister
Department of Pediatrics, Infant Development Center, Women and Infants Hospital of Rhode Island, Providence 02905, USA
Dev Neuropsychol 20:639-51. 2001..Delayed habituation of FHR in the fetuses of mothers with depression may be due to alterations in the internal hormonal environment and could have implications for postnatal information processing... - Variations of NICU sound by location and time of daySherry A Matook
NICU, Women and Infants Hospital, Providence, Rhode Island, USA
Neonatal Netw 29:87-95. 2010..The second aim was to determine whether there were differences in decibel levels across the five bays of the NICU, the four quadrants within each bay, and two 12-hour shifts... - Vulnerable infants program of Rhode Island: promoting permanency for substance-exposed infantsJean E Twomey
Brown Center for the Study of Children at Risk, Alpert Medical School, Women and Infants Hospital of Rhode Island, USA
Child Welfare 89:121-42. 2010.... - Impact of maternal substance use during pregnancy on childhood outcomeSeetha Shankaran
Wayne State University School of Medicine, Detroit, MI, USA
Semin Fetal Neonatal Med 12:143-50. 2007..Therefore, efforts should be made to prevent and treat behavioral problems as well as to limit the onset of drug use by adolescent children born to women who use drugs during pregnancy... - Clinical use of the Neonatal Intensive Care Unit Network Neurobehavioral ScaleC F Zachariah Boukydis
Merrill Palmer Institute, Wayne State University, Detroit, Michigan 48202, USA
Pediatrics 113:679-89. 2004..Finally, we present a case study with a clinical summary and a work sheet that clinicians may find useful for clinical consultation with caregivers and parents... - The maternal lifestyle study: cognitive, motor, and behavioral outcomes of cocaine-exposed and opiate-exposed infants through three years of ageDaniel S Messinger
Department of Psychology, University of Miami, Coral Gables, Florida, USA
Pediatrics 113:1677-85. 2004..To evaluate the direct effects of prenatal cocaine exposure and prenatal opiate exposure on infant mental, motor, and behavioral outcomes longitudinally between 1 and 3 years old... - The infant development, environment, and lifestyle study: effects of prenatal methamphetamine exposure, polydrug exposure, and poverty on intrauterine growthLynne M Smith
Department of Pediatrics, David Geffen School of Medicine at UCLA and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502
Pediatrics 118:1149-56. 2006..We examined the neonatal growth effects of prenatal methamphetamine exposure in the multicenter, longitudinal Infant Development, Environment and Lifestyle study... - Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndromeHendree E Jones
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Campus, Johns Hopkins University School of Medicine, D 3 East, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Drug Alcohol Depend 79:1-10. 2005..25). Results suggest that buprenorphine is not inferior to methadone on outcome measures assessing NAS and maternal and neonatal safety when administered starting in the second trimester of pregnancy... - Growth trajectories of preterm infants: birth to 12 yearsMary C Sullivan
University of Rhode Island, College of Nursing, Kingston, USA
J Pediatr Health Care 22:83-93. 2008..We investigated birth weight and neonatal morbidity in preterm infants' growth to age 12 years... - Prenatal methamphetamine use and neonatal neurobehavioral outcomeLynne M Smith
Los Angeles Biomedical Institute at Harbor UCLA Medical Center and David Geffen, School of Medicine at UCLA, Torrace, CA, USA
Neurotoxicol Teratol 30:20-8. 2008..Methamphetamine (MA) use among pregnant women is an increasing problem in the United States. How prenatal MA exposure affects neonatal neurobehavior is unknown...
Research Grants
- Prenatal Methamphetamine Exposure and School Aged OutcomeBarry M Lester; Fiscal Year: 2010..g. smoke). ..
- Prental Methamphetamine Exposure and Child DevelopmentBarry Lester; Fiscal Year: 2005....
- Maternal Opioid Treatment: Human Experimental ResearchBarry Lester; Fiscal Year: 2009..abstract_text> ..
- Prenatal Methamphetamine Exposure and School Aged OutcomeBarry Lester; Fiscal Year: 2007..g. smoke). ..
- Maternal Lifestyle Study Phase 5Barry Lester; Fiscal Year: 2007..A thorough understanding of the consequences of prenatal cocaine exposure and associated maternal lifestyles is necessary to the development of treatment and public policy initiatives. ..
- Resilience in ChildrenBarry Lester; Fiscal Year: 2006....