Lorenzo Leggio

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medications
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02912, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1106-17. 2008
  2. pmc Psychosocial findings in alcohol-dependent patients before and after three months of total alcohol abstinence
    Anna Ferrulli
    Institute of Internal Medicine, Catholic University of Rome Rome, Italy
    Front Psychiatry 1:17. 2010
  3. doi request reprint Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Addict Biol 17:452-64. 2012
  4. doi request reprint Baclofen promotes alcohol abstinence in alcohol dependent cirrhotic patients with hepatitis C virus (HCV) infection
    L Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Addict Behav 37:561-4. 2012
  5. doi request reprint Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Hum Psychopharmacol 26:554-9. 2011
  6. doi request reprint Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 32:2047-53. 2008
  7. doi request reprint Typologies of alcohol dependence. From Jellinek to genetics and beyond
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Box G S 121 4, Providence, RI 02912, USA
    Neuropsychol Rev 19:115-29. 2009
  8. doi request reprint Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases
    L Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Drug News Perspect 23:157-66. 2010
  9. doi request reprint Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University Medical School, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 35:194-202. 2011
  10. pmc Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Alcohol Clin Exp Res 33:1539-44. 2009

Collaborators

Detail Information

Publications69

  1. ncbi request reprint New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medications
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02912, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1106-17. 2008
    ..The promising results in terms of both safety and efficacy are reported. However, we also note the need of more methodologically controlled studies on a greater number of patients, involving more complicated forms of AWS...
  2. pmc Psychosocial findings in alcohol-dependent patients before and after three months of total alcohol abstinence
    Anna Ferrulli
    Institute of Internal Medicine, Catholic University of Rome Rome, Italy
    Front Psychiatry 1:17. 2010
    ..Larger controlled studies are needed to confirm these findings...
  3. doi request reprint Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Addict Biol 17:452-64. 2012
    ..This investigation suggests that ghrelin is potentially able to affect alcohol-seeking behaviors, such as alcohol drinking and craving, representing a new potential neuropharmacological target for AD...
  4. doi request reprint Baclofen promotes alcohol abstinence in alcohol dependent cirrhotic patients with hepatitis C virus (HCV) infection
    L Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Addict Behav 37:561-4. 2012
    ..e. albumin, INR) in alcohol-dependent HCV-infected cirrhotic patients. Baclofen may represent a clinically relevant alcohol pharmacotherapy for these patients...
  5. doi request reprint Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver disease
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Hum Psychopharmacol 26:554-9. 2011
    ..Metadoxine is approved in Europe for alcohol intoxication and is also indicated for alcoholic liver disease (ALD). This study aims to investigate the use of metadoxine as a potential pharmacotherapy for alcohol dependence (AD)...
  6. doi request reprint Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 32:2047-53. 2008
    ..Investigating this association in alcohol-dependent (AD) patients was the aim of this preliminary and exploratory study...
  7. doi request reprint Typologies of alcohol dependence. From Jellinek to genetics and beyond
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Box G S 121 4, Providence, RI 02912, USA
    Neuropsychol Rev 19:115-29. 2009
    ..Greater emphasis, however, must be made to more clearly delineate this field of research, while moving toward more standardized typologies...
  8. doi request reprint Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases
    L Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Drug News Perspect 23:157-66. 2010
    ..e., GHS-R1a antagonists and/or inverse agonists) might affect alcohol-seeking behavior, thus having therapeutic potential in alcohol use disorders. Future laboratory and clinical studies testing this hypothesis are warranted...
  9. doi request reprint Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University Medical School, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 35:194-202. 2011
    ..Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications...
  10. pmc Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
    Alcohol Clin Exp Res 33:1539-44. 2009
    ..Heavy drinking may increase blood glucose levels. Moreover, in alcohol-dependent subjects, glucose may play a putative role in alcohol preference...
  11. ncbi request reprint Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependence
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University Medical School, Providence, RI 02912, USA
    Curr Pharm Des 16:2159-18. 2010
    ....
  12. ncbi request reprint Effectiveness and safety of baclofen in the treatment of alcohol dependent patients
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    CNS Neurol Disord Drug Targets 9:33-44. 2010
    ..g., baclofen's biobehavioral mechanisms, different baclofen doses, differences in severity and in alcoholic subtypes, different formulations of baclofen, possible combination of baclofen with other medications)...
  13. doi request reprint Renin and aldosterone but not the natriuretic peptide correlate with obsessive craving in medium-term abstinent alcohol-dependent patients: a longitudinal study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol 42:375-81. 2008
    ..In conclusion, the renin-aldosterone axis could play a role in craving in medium-term abstinent patients and thereby leading to the hypothesis that alcohol craving could be influenced by the fluid volume intake...
  14. ncbi request reprint Is cortisol involved in the alcohol-related fat mass impairment? A longitudinal clinical study
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Alcohol 44:211-5. 2009
    ..The goal of this study was to investigate if there is any relationship between HP-hormones and metabolic and nutritional parameters in alcoholic subjects...
  15. ncbi request reprint Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Lancet 370:1915-22. 2007
    ..We aimed to investigate the effectiveness and safety of baclofen in achieving and maintaining alcohol abstinence in patients with liver cirrhosis...
  16. ncbi request reprint Role of trait anxiety in persistent radicular pain after surgery for lumbar disc herniation: a 1-year longitudinal study
    Cristina D'Angelo
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Neurosurgery 67:265-71. 2010
    ..To evaluate anxiety and depression as prognostic factors for radicular and back pain after surgery in patients with lumbar disc herniation in a 1-year follow-up study...
  17. ncbi request reprint Analysis of the T1288R mutation of the Wilson disease ATP7B gene in four generations of a family: possible genotype-phenotype correlation with hepatic onset
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, L go Gemelli 8, 00168, Rome, Italy
    Dig Dis Sci 52:2570-5. 2007
    ..Consequently, a genotype-phenotype correlation could be hypothesized, although further studies are necessary to clarify this topic...
  18. pmc The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humans
    George A Kenna
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA
    Neuropsychol Rev 22:211-28. 2012
    ..Pharmacotherapies that take advantage of our new understanding of hormones, their receptors, or their potential relationship to craving may shed light on the treatment of this disorder...
  19. ncbi request reprint Affective and psychiatric disorders in celiac disease
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Dig Dis 26:140-8. 2008
    ..The available data suggest that screening for CD in patients with affective and/or psychiatric symptoms may be useful since these disorders could be the expression of an organic disease rather than primary psychiatric illnesses...
  20. ncbi request reprint Increased serum high-density lipoprotein-cholesterol concentration in celiac disease after gluten-free diet treatment correlates with body fat stores
    Esmeralda Capristo
    Department of Internal Medicine, Catholic University, Rome, Italy
    J Clin Gastroenterol 43:946-9. 2009
    ..We evaluated blood lipids and body composition in 26 CD patients with low HDL-C level (<1.0 mmol/L) at diagnosis and after GFD...
  21. ncbi request reprint Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
    Alcohol Clin Exp Res 30:1933-7. 2006
    ..Alcohol-craving and food-seeking behavior could share common neural circuits. Ghrelin is related to nutritional status, but few data are available in alcoholic patients on the relationship between ghrelin and nutritional disorders...
  22. ncbi request reprint Insulin but not insulin growth factor-1 correlates with craving in currently drinking alcohol-dependent patients
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 32:450-8. 2008
    ..The aim of this clinical study was to evaluate the relationships between insulin and IGF-1 plasma concentrations and alcohol craving...
  23. doi request reprint A human laboratory pilot study with baclofen in alcoholic individuals
    Lorenzo Leggio
    Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
    Pharmacol Biochem Behav 103:784-91. 2013
    ..In conclusion, baclofen's ability to reduce alcohol drinking may be related to its effects on the biphasic effects of alcohol, but larger studies are needed to confirm these preliminary findings...
  24. doi request reprint Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
    Alcohol Alcohol 46:312-7. 2011
    ..To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence...
  25. ncbi request reprint Acute alcohol intoxication
    Luisa Vonghia
    Institute of Internal Medicine, Catholic University of Rome, Italy
    Eur J Intern Med 19:561-7. 2008
    ..In patients presenting an acute alcohol intoxication, alcohol-related disorders should be detected so that the patient can be directed to an alcohol treatment unit, where a personalized, specific treatment can be established...
  26. ncbi request reprint Management of alcohol dependence in patients with liver disease
    Giovanni Addolorato
    Department of Internal Medicine, Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, Largo Gemelli 8, 00168 Rome, Italy
    CNS Drugs 27:287-99. 2013
    ..To date, baclofen represents the only anti-craving medication formally tested in a randomized clinical trial in alcoholic patients affected by liver cirrhosis, although additional confirmatory studies are warranted...
  27. doi request reprint Social phobia in coeliac disease
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Scand J Gastroenterol 43:410-5. 2008
    ..Although social phobia is included among the anxiety disorders, its presence in CD has never been investigated. The aim of the present study was to evaluate social phobia in CD patients...
  28. ncbi request reprint Coeliac disease and hearing loss: preliminary data on a new possible association
    Lorenzo Leggio
    Institutes of Internal Medicine, Catholic University of Rome, Rome, Italy
    Scand J Gastroenterol 42:1209-13. 2007
    ..At present, no data are available on the presence of hearing loss disorder in coeliac patients. The aim of the present study was to investigate the prevalence of hearing loss in coeliac patients compared with that in healthy controls...
  29. doi request reprint State and trait anxiety and depression in patients with primary brain tumors before and after surgery: 1-year longitudinal study
    Cristina D'Angelo
    Institute of Internal Medicine, Catholic University of Rome, and Department of Cardiac Surgery, St Andrea Hospital, Rome, Italy
    J Neurosurg 108:281-6. 2008
    ..The relationships between these affective disorders and the patient's sex, tumor histology, and laterality of the tumor were also evaluated...
  30. ncbi request reprint Suppression of alcohol delirium tremens by baclofen administration: a case report
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of the Sacred Heart, Gemelli Hospital, Largo A Gemelli 8, 00168 Rome, Italy
    Clin Neuropharmacol 26:258-62. 2003
    ..Here, we report a case of DT successfully treated with baclofen. This result indicates that the efficacy of baclofen in the treatment of DT should be examined in future clinical trials...
  31. ncbi request reprint Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepam
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Am J Med 119:276.e13-8. 2006
    ..Accordingly, the present study was designed to compare efficacy, tolerability and safety of baclofen versus diazepam in the treatment of AWS...
  32. ncbi request reprint Liver transplantation in alcoholic patients: impact of an alcohol addiction unit within a liver transplant center
    Giovanni Addolorato
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy Alcohol Addiction Unit, Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Clin Exp Res 37:1601-8. 2013
    ..We evaluated retrospectively the impact of the AAU on alcohol recidivism after transplantation. The relationship between alcohol recidivism and the duration of alcohol abstinence before transplant was evaluated as well...
  33. doi request reprint A within-group design of nontreatment seeking 5-HTTLPR genotyped alcohol-dependent subjects receiving ondansetron and sertraline
    George A Kenna
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02908, USA
    Alcohol Clin Exp Res 33:315-23. 2009
    ..The aim of this study was to match and mismatch L/L, S/S, or S/L genotypes with administration of ondansetron and sertraline...
  34. ncbi request reprint Metabolic and nutritional features in adult celiac patients
    Noemi Malandrino
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Dig Dis 26:128-33. 2008
    ..Thus, an early and accurate evaluation of nutritional status and energy metabolism represents a fundamental tool in the management of CD patients...
  35. ncbi request reprint Review of topiramate: an antiepileptic for the treatment of alcohol dependence
    George A Kenna
    Department of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02908, USA
    Curr Drug Abuse Rev 2:135-42. 2009
    ..While the manufacturer will not pursue approval of an indication for the treatment of alcohol dependence, the drug will soon be available generically, making it more affordable for a greater proportion of the public...
  36. doi request reprint Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium report
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, Rome, Italy
    Drug Alcohol Rev 28:160-5. 2009
    ..Accordingly, research on this topic could lead to possible development of new therapeutic approaches in the treatment of patients with alcohol problems...
  37. doi request reprint Role of the GABA(B) receptor system in alcoholism and stress: focus on clinical studies and treatment perspectives
    Giovanni Addolorato
    Institute of Internal Medicine, Agostino Gemelli Hospital, Catholic University of Rome, Rome, Italy
    Alcohol 43:559-63. 2009
    ..e., cirrhosis). Future studies should investigate which alcoholic subtype may better benefit of the administration of baclofen in the treatment of alcohol dependence...
  38. ncbi request reprint Effects of short-term moderate alcohol administration on oxidative stress and nutritional status in healthy males
    Giovanni Addolorato
    Institutes of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168, Rome, Italy
    Appetite 50:50-6. 2008
    ..Finally, short-term moderate ethanol intake appeared to influence the FM, although it was not able to significantly affect nutritional or body composition...
  39. doi request reprint Fecal calprotectin concentrations in alcoholic patients: a longitudinal study
    Massimo Montalto
    Institute of Internal Medicine, Catholic University of Rome, Italy
    Eur J Gastroenterol Hepatol 23:76-80. 2011
    ..Moreover, FCCs in the alcoholics were compared with the FCCs in healthy controls...
  40. ncbi request reprint How many cravings? Pharmacological aspects of craving treatment in alcohol addiction: a review
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Neuropsychobiology 51:59-66. 2005
    ..In this review, the main drugs currently used in the treatment of patients with alcohol problems are described. A hypothesis of pharmacological treatment of the different types of craving is also discussed...
  41. ncbi request reprint Neurobiochemical and clinical aspects of craving in alcohol addiction: a review
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, Largo A Gemelli 8, 00168 Rome, Italy
    Addict Behav 30:1209-24. 2005
    ....
  42. ncbi request reprint Intestinal malabsorption and skin diseases
    Ludovico Abenavoli
    Institutes of Internal Medicine, Catholic University, Rome, Italy
    Dig Dis 26:167-74. 2008
    ..The growing evidence of the association between skin disorders and intestinal diseases suggests that the skin could be considered the 'mirror of the gut'...
  43. ncbi request reprint Primary renal angiosarcoma: a rare malignancy. A case report and review of the literature
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Urol Oncol 24:307-12. 2006
    ..A case of primary renal angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported. The present case represents further evidence of a rare malignancy...
  44. ncbi request reprint Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findings
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168 Rome, Italy
    Alcohol Alcohol 44:341-52. 2009
    ..These possible interactions could lead to future intriguing research aimed at understanding and treating alcohol craving and dependence...
  45. ncbi request reprint Superior vena cava thrombosis treated by angioplasty and stenting in a cirrhotic patient with peritoneovenous shunt
    Lorenzo Leggio
    Institutes of Internal Medicine, Catholic University of Rome, Rome, Italy
    Ann Thorac Cardiovasc Surg 14:60-2. 2008
    ..The patient died in June 2006 due to severe liver function impairment and hepato-renal syndrome. The present case shows that percutaneous transluminal angioplasty represents a good choice for primary intervention...
  46. ncbi request reprint The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical data
    Giovanni Addolorato
    Catholic University of Rome, Institute of Internal Medicine, L o A Gemelli 8, I 00168 Rome, Italy
    Expert Opin Investig Drugs 18:675-86. 2009
    ..Finally, GHB and naltrexone combined together represent a possible approach deserving future investigations...
  47. ncbi request reprint Pharmacotherapy for alcoholic patients with alcoholic liver disease
    Cynthia L Vuittonet
    Cynthia L Vuittonet, M D, is Resident Physician, Department of Internal Medicine, Warren Alpert Medical School, Brown University, Providence, RI Michael Halse, Pharm D, is Resident Pharmacist, South County Hospital, Wakefield, RI Lorenzo Leggio, M D, Ph D, M Sc, is Section Chief, Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, and Section Chief, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, and Adjunct Associate Professor, Center for Alcohol and Addiction Studies, Brown University Samuel B Fricchione, B A, is Research Assistant Michael Brickley, B A, is Research Assistant Carolina L Haass Koffler, Pharm D, is Post Doctoral Fellow and Tonya Tavares, M A, is Senior Research Assistant
    Am J Health Syst Pharm 71:1265-76. 2014
    ..An update on pharmacotherapy for achieving and maintaining abstinence and mitigating hepatic damage in patients with alcoholic liver disease (ALD) is presented...
  48. pmc Ondansetron reduces naturalistic drinking in nontreatment-seeking alcohol-dependent individuals with the LL 5'-HTTLPR genotype: a laboratory study
    George A Kenna
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island
    Alcohol Clin Exp Res 38:1567-74. 2014
    ....
  49. pmc Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy
    George A Kenna
    Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence
    Pharmgenomics Pers Med 5:19-35. 2012
    ..Studies assessing 5-HTTLPR as the solitary genetic factor contributing to the etiology of psychiatric disorders continue to face the challenges of statistically small effect sizes and limited replication...
  50. pmc Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Neuropsychopharmacology 37:163-77. 2012
    ..Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism...
  51. doi request reprint HIV testing in hazardous drinking: a survey analysis
    Miriam Fenton
    Department of Community Health, Brown University Medical School, Providence, Rhode Island 02912, USA
    Subst Use Misuse 45:204-12. 2010
    ..89) the odds of ever having had an HIV test compared to nonhazardous drinkers. Therefore public health interventions targeted at hazardous drinkers to increase the rate of HIV testing are suggested. The study's limitations are noted...
  52. ncbi request reprint Current and promising pharmacotherapies, and novel research target areas in the treatment of alcohol dependence: a review
    Steven Edwards
    Center for Alcohol and Addiction Studies Brown University Medical School, Providence, RI 02912, USA
    Curr Pharm Des 17:1323-32. 2011
    ..e. cannabinoid receptors, CRF, NPY, ghrelin). Finally, the present review also discusses the attempts to personalize medication for AD treatment by alcohol typology and pharmacogenetics...
  53. doi request reprint A safety and tolerability laboratory study of the combination of aripiprazole and topiramate in volunteers who drink alcohol
    George A Kenna
    Department of Psychiatry and the Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
    Hum Psychopharmacol 24:465-72. 2009
    ..The ultimate aim for this research is to determine whether this combination is safe and is superior to either drug taken alone in reducing alcohol use in alcohol dependent patients...
  54. ncbi request reprint Role of the tumor necrosis factor antagonists in the treatment of inflammatory bowel disease: an update
    Veruscka Leso
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Eur J Gastroenterol Hepatol 22:779-86. 2010
    ..The goal of this review is to provide an update and analyze the pros and cons of using anti-TNF therapies in the treatment of IBD...
  55. ncbi request reprint A new mutation of Wilson's disease P-type ATPase gene in a patient with cirrhosis and coombs-positive hemolytic anemia
    Lorenzo Leggio
    Institutes of Internal Medicine, Catholic University of Rome, Rome
    Dig Dis Sci 51:34-8. 2006
  56. pmc Fasting-induced increase in plasma ghrelin is blunted by intravenous alcohol administration: a within-subject placebo-controlled study
    Lorenzo Leggio
    Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA Electronic address
    Psychoneuroendocrinology 38:3085-91. 2013
    ..These findings lead us to hypothesize that alcohol might affect ghrelin signaling not only via a local effect on the stomach mucosa, but also via a systemic effect...
  57. doi request reprint Complementary therapies for treating alcoholism First Annual meeting by Complementary Medicine Research Group of the Italian Society for Alcohol Studies-May 5, 2006, Florence, Italy
    Ludovico Abenavoli
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Fitoterapia 79:142-7. 2008
  58. doi request reprint Serotonin transporter (SERT) brain density and neurobiological Cloninger subtypes model: a lesson by human autoradiography studies
    Lorenzo Leggio
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Alcohol Alcohol 43:148-50. 2008
    ..New developments in the neurobiological understanding of subtypes of alcoholic patients, could led to get the basis for a more personalized pharmacological therapy...
  59. ncbi request reprint Understanding and treating patients with alcoholic cirrhosis: an update
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome GA, LL, Rome, Italy
    Alcohol Clin Exp Res 33:1136-44. 2009
    ..All together the information available suggests the need of a multimodal approach in the clinical management of these patients...
  60. pmc Pharmacological approaches to reducing craving in patients with alcohol use disorders
    Carolina L Haass-Koffler
    Center for Alcohol and Addiction Studies, Brown University, Box G S121 5, Providence, RI, 02812, USA
    CNS Drugs 28:343-60. 2014
    ....
  61. doi request reprint The treatment of alcohol and opioid dependence in pregnant women
    Annemarie Heberlein
    Department of Psychiatry, Social Psychiatry and Psychotherapy, Center for Addiction Research CARe, Hannover Medical School, Hannover, Germany
    Curr Opin Psychiatry 25:559-64. 2012
    ..This article addresses the question of 'best treatment options', which clinicians face when treating pregnant women with alcohol and opioid dependence...
  62. ncbi request reprint Coenzyme Q 10 and cardiovascular risk factors in idiopathic sudden sensorineural hearing loss patients
    Gabriella Cadoni
    Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy
    Otol Neurotol 28:878-83. 2007
    ..We investigated the association of idiopathic sudden sensorineural hearing loss (ISSNHL) with coenzyme Q (CoQ) and cardiovascular risk factors...
  63. ncbi request reprint Rapid regression of psoriasis in a coeliac patient after gluten-free diet. A case report and review of the literature
    Giovanni Addolorato
    Institute of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
    Digestion 68:9-12. 2003
    ..However, at present the relationship between CD and psoriasis remains controversial since there are few and contrasting data on this topic...
  64. ncbi request reprint Psychological support counseling: a new strategy to increase gluten-free diet compliance in celiac patients
    Lorenzo Leggio
    Am J Gastroenterol 100:1424-5. 2005
  65. ncbi request reprint Baclofen use in the treatment of alcohol delirium tremens
    Lorenzo Leggio
    Arch Intern Med 165:586; author reply 587. 2005
  66. ncbi request reprint Tolerance to baclofen's sedative effect in alcohol-addicted patients: no dissipation after a period of abstinence
    Giovanni Addolorato
    Psychopharmacology (Berl) 178:351-2. 2005
  67. ncbi request reprint Baclofen for outpatient treatment of alcohol withdrawal syndrome
    Giovanni Addolorato
    J Fam Pract 54:24. 2005
  68. ncbi request reprint Complementary medicine for alcohol dependence in Italian services: a mail questionnaire
    Gabriele Bardazzi
    Centro Diurno Alcologico, UFM C, Azienda Sanitaria Fiorentina, Villa Basilewsky, Via Lorenzo il Magnifico, 104, 50127 Firenze, Italy
    Complement Ther Clin Pract 12:216-21. 2006
    ..CM plays an integrated role with traditional forms of alcohol treatment in Italian alcohol services and this utilization could be useful to reduce drop-outs and improve alcohol treatment compliance...