Research Topics
Species | Lorenzo LeggioSummaryAffiliation: Brown University Country: USA Publications
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Publications
Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and cravingLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Addict Biol 17:452-64. 2012..This investigation suggests that ghrelin is potentially able to affect alcohol-seeking behaviors, such as alcohol drinking and craving, representing a new potential neuropharmacological target for AD...- Baclofen promotes alcohol abstinence in alcohol dependent cirrhotic patients with hepatitis C virus (HCV) infectionL Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
Addict Behav 37:561-4. 2012..e. albumin, INR) in alcohol-dependent HCV-infected cirrhotic patients. Baclofen may represent a clinically relevant alcohol pharmacotherapy for these patients... 
New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medicationsLorenzo Leggio
Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02912, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:1106-17. 2008..The promising results in terms of both safety and efficacy are reported. However, we also note the need of more methodologically controlled studies on a greater number of patients, involving more complicated forms of AWS...- Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseasesL Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Drug News Perspect 23:157-66. 2010..e., GHS-R1a antagonists and/or inverse agonists) might affect alcohol-seeking behavior, thus having therapeutic potential in alcohol use disorders. Future laboratory and clinical studies testing this hypothesis are warranted... - Effectiveness and safety of baclofen in the treatment of alcohol dependent patientsLorenzo Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
CNS Neurol Disord Drug Targets 9:33-44. 2010..g., baclofen's biobehavioral mechanisms, different baclofen doses, differences in severity and in alcoholic subtypes, different formulations of baclofen, possible combination of baclofen with other medications)... - Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependenceLorenzo Leggio
Center for Alcohol and Addiction Studies, Brown University Medical School, Providence, RI 02912, USA
Curr Pharm Des 16:2159-18. 2010.... 
Blood glucose level, alcohol heavy drinking, and alcohol craving during treatment for alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) StudyLorenzo Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA
Alcohol Clin Exp Res 33:1539-44. 2009..Heavy drinking may increase blood glucose levels. Moreover, in alcohol-dependent subjects, glucose may play a putative role in alcohol preference...- Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelinLorenzo Leggio
Center for Alcohol and Addiction Studies, Brown University Medical School, Providence, Rhode Island, USA
Alcohol Clin Exp Res 35:194-202. 2011..Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications... - Renin and aldosterone but not the natriuretic peptide correlate with obsessive craving in medium-term abstinent alcohol-dependent patients: a longitudinal studyLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol 42:375-81. 2008..In conclusion, the renin-aldosterone axis could play a role in craving in medium-term abstinent patients and thereby leading to the hypothesis that alcohol craving could be influenced by the fluid volume intake... - Relationship between the hypothalamic-pituitary-thyroid axis and alcohol craving in alcohol-dependent patients: a longitudinal studyLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol Clin Exp Res 32:2047-53. 2008..Investigating this association in alcohol-dependent (AD) patients was the aim of this preliminary and exploratory study... - Preliminary findings on the use of metadoxine for the treatment of alcohol dependence and alcoholic liver diseaseLorenzo Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
Hum Psychopharmacol 26:554-9. 2011..Metadoxine is approved in Europe for alcohol intoxication and is also indicated for alcoholic liver disease (ALD). This study aims to investigate the use of metadoxine as a potential pharmacotherapy for alcohol dependence (AD)... - Typologies of alcohol dependence. From Jellinek to genetics and beyondLorenzo Leggio
Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Box G S 121 4, Providence, RI 02912, USA
Neuropsychol Rev 19:115-29. 2009..Greater emphasis, however, must be made to more clearly delineate this field of research, while moving toward more standardized typologies... - Is cortisol involved in the alcohol-related fat mass impairment? A longitudinal clinical studyLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol Alcohol 44:211-5. 2009..The goal of this study was to investigate if there is any relationship between HP-hormones and metabolic and nutritional parameters in alcoholic subjects... - Role of trait anxiety in persistent radicular pain after surgery for lumbar disc herniation: a 1-year longitudinal studyCristina D'Angelo
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Neurosurgery 67:265-71. 2010..To evaluate anxiety and depression as prognostic factors for radicular and back pain after surgery in patients with lumbar disc herniation in a 1-year follow-up study... - Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled studyGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Lancet 370:1915-22. 2007..We aimed to investigate the effectiveness and safety of baclofen in achieving and maintaining alcohol abstinence in patients with liver cirrhosis... - Analysis of the T1288R mutation of the Wilson disease ATP7B gene in four generations of a family: possible genotype-phenotype correlation with hepatic onsetLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, L go Gemelli 8, 00168, Rome, Italy
Dig Dis Sci 52:2570-5. 2007..Consequently, a genotype-phenotype correlation could be hypothesized, although further studies are necessary to clarify this topic... - The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humansGeorge A Kenna
Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA
Neuropsychol Rev 22:211-28. 2012..Pharmacotherapies that take advantage of our new understanding of hormones, their receptors, or their potential relationship to craving may shed light on the treatment of this disorder... - Affective and psychiatric disorders in celiac diseaseGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Dig Dis 26:140-8. 2008..The available data suggest that screening for CD in patients with affective and/or psychiatric symptoms may be useful since these disorders could be the expression of an organic disease rather than primary psychiatric illnesses... - Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patientsGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
Alcohol Clin Exp Res 30:1933-7. 2006..Alcohol-craving and food-seeking behavior could share common neural circuits. Ghrelin is related to nutritional status, but few data are available in alcoholic patients on the relationship between ghrelin and nutritional disorders... - Insulin but not insulin growth factor-1 correlates with craving in currently drinking alcohol-dependent patientsLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol Clin Exp Res 32:450-8. 2008..The aim of this clinical study was to evaluate the relationships between insulin and IGF-1 plasma concentrations and alcohol craving... - Increased serum high-density lipoprotein-cholesterol concentration in celiac disease after gluten-free diet treatment correlates with body fat storesEsmeralda Capristo
Department of Internal Medicine, Catholic University, Rome, Italy
J Clin Gastroenterol 43:946-9. 2009..We evaluated blood lipids and body composition in 26 CD patients with low HDL-C level (<1.0 mmol/L) at diagnosis and after GFD... - Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trialGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, I 00168 Rome, Italy
Alcohol Alcohol 46:312-7. 2011..To explore the effect of baclofen in a dose of 20 mg three times per day, compared with the already studied dose of 10 mg three times per day, in the treatment of alcohol dependence... - Acute alcohol intoxicationLuisa Vonghia
Institute of Internal Medicine, Catholic University of Rome, Italy
Eur J Intern Med 19:561-7. 2008..In patients presenting an acute alcohol intoxication, alcohol-related disorders should be detected so that the patient can be directed to an alcohol treatment unit, where a personalized, specific treatment can be established... - Suppression of alcohol delirium tremens by baclofen administration: a case reportGiovanni Addolorato
Institute of Internal Medicine, Catholic University of the Sacred Heart, Gemelli Hospital, Largo A Gemelli 8, 00168 Rome, Italy
Clin Neuropharmacol 26:258-62. 2003..Here, we report a case of DT successfully treated with baclofen. This result indicates that the efficacy of baclofen in the treatment of DT should be examined in future clinical trials... - Social phobia in coeliac diseaseGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Scand J Gastroenterol 43:410-5. 2008..Although social phobia is included among the anxiety disorders, its presence in CD has never been investigated. The aim of the present study was to evaluate social phobia in CD patients... - Coeliac disease and hearing loss: preliminary data on a new possible associationLorenzo Leggio
Institutes of Internal Medicine, Catholic University of Rome, Rome, Italy
Scand J Gastroenterol 42:1209-13. 2007..At present, no data are available on the presence of hearing loss disorder in coeliac patients. The aim of the present study was to investigate the prevalence of hearing loss in coeliac patients compared with that in healthy controls... - Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepamGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Am J Med 119:276.e13-8. 2006..Accordingly, the present study was designed to compare efficacy, tolerability and safety of baclofen versus diazepam in the treatment of AWS... - State and trait anxiety and depression in patients with primary brain tumors before and after surgery: 1-year longitudinal studyCristina D'Angelo
Institute of Internal Medicine, Catholic University of Rome, and Department of Cardiac Surgery, St Andrea Hospital, Rome, Italy
J Neurosurg 108:281-6. 2008..The relationships between these affective disorders and the patient's sex, tumor histology, and laterality of the tumor were also evaluated... - Metabolic and nutritional features in adult celiac patientsNoemi Malandrino
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Dig Dis 26:128-33. 2008..Thus, an early and accurate evaluation of nutritional status and energy metabolism represents a fundamental tool in the management of CD patients... - Review of topiramate: an antiepileptic for the treatment of alcohol dependenceGeorge A Kenna
Department of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02908, USA
Curr Drug Abuse Rev 2:135-42. 2009..While the manufacturer will not pursue approval of an indication for the treatment of alcohol dependence, the drug will soon be available generically, making it more affordable for a greater proportion of the public... - A within-group design of nontreatment seeking 5-HTTLPR genotyped alcohol-dependent subjects receiving ondansetron and sertralineGeorge A Kenna
Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02908, USA
Alcohol Clin Exp Res 33:315-23. 2009..The aim of this study was to match and mismatch L/L, S/S, or S/L genotypes with administration of ondansetron and sertraline... - Psychosocial findings in alcohol-dependent patients before and after three months of total alcohol abstinenceAnna Ferrulli
Institute of Internal Medicine, Catholic University of Rome Rome, Italy
Front Psychiatry 1:17. 2010..Larger controlled studies are needed to confirm these findings... - Role of the GABA(B) receptor system in alcoholism and stress: focus on clinical studies and treatment perspectivesGiovanni Addolorato
Institute of Internal Medicine, Agostino Gemelli Hospital, Catholic University of Rome, Rome, Italy
Alcohol 43:559-63. 2009..e., cirrhosis). Future studies should investigate which alcoholic subtype may better benefit of the administration of baclofen in the treatment of alcohol dependence... - Effects of short-term moderate alcohol administration on oxidative stress and nutritional status in healthy malesGiovanni Addolorato
Institutes of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168, Rome, Italy
Appetite 50:50-6. 2008..Finally, short-term moderate ethanol intake appeared to influence the FM, although it was not able to significantly affect nutritional or body composition... - Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium reportGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Largo A Gemelli 8, Rome, Italy
Drug Alcohol Rev 28:160-5. 2009..Accordingly, research on this topic could lead to possible development of new therapeutic approaches in the treatment of patients with alcohol problems... - A human laboratory pilot study with baclofen in alcoholic individualsLorenzo Leggio
Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA
Pharmacol Biochem Behav 103:784-91. 2013..In conclusion, baclofen's ability to reduce alcohol drinking may be related to its effects on the biphasic effects of alcohol, but larger studies are needed to confirm these preliminary findings... - How many cravings? Pharmacological aspects of craving treatment in alcohol addiction: a reviewGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Neuropsychobiology 51:59-66. 2005..In this review, the main drugs currently used in the treatment of patients with alcohol problems are described. A hypothesis of pharmacological treatment of the different types of craving is also discussed... - Fecal calprotectin concentrations in alcoholic patients: a longitudinal studyMassimo Montalto
Institute of Internal Medicine, Catholic University of Rome, Italy
Eur J Gastroenterol Hepatol 23:76-80. 2011..Moreover, FCCs in the alcoholics were compared with the FCCs in healthy controls... - Neurobiochemical and clinical aspects of craving in alcohol addiction: a reviewGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Gemelli Hospital, Largo A. Gemelli 8, 00168 Rome, Italy
Addict Behav 30:1209-24. 2005.... - Intestinal malabsorption and skin diseasesLudovico Abenavoli
Institutes of Internal Medicine, Catholic University, Rome, Italy
Dig Dis 26:167-74. 2008..The growing evidence of the association between skin disorders and intestinal diseases suggests that the skin could be considered the 'mirror of the gut'... - Superior vena cava thrombosis treated by angioplasty and stenting in a cirrhotic patient with peritoneovenous shuntLorenzo Leggio
Institutes of Internal Medicine, Catholic University of Rome, Rome, Italy
Ann Thorac Cardiovasc Surg 14:60-2. 2008..The patient died in June 2006 due to severe liver function impairment and hepato-renal syndrome. The present case shows that percutaneous transluminal angioplasty represents a good choice for primary intervention... - The therapeutic potential of gamma-hydroxybutyric acid for alcohol dependence: balancing the risks and benefits. A focus on clinical dataGiovanni Addolorato
Catholic University of Rome, Institute of Internal Medicine, L o A Gemelli 8, I 00168 Rome, Italy
Expert Opin Investig Drugs 18:675-86. 2009..Finally, GHB and naltrexone combined together represent a possible approach deserving future investigations... - Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findingsLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, L go A Gemelli 8, I 00168 Rome, Italy
Alcohol Alcohol 44:341-52. 2009..These possible interactions could lead to future intriguing research aimed at understanding and treating alcohol craving and dependence... - Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapyGeorge A Kenna
Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence
Pharmgenomics Pers Med 5:19-35. 2012..Studies assessing 5-HTTLPR as the solitary genetic factor contributing to the etiology of psychiatric disorders continue to face the challenges of statistically small effect sizes and limited replication... - Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulationGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Neuropsychopharmacology 37:163-77. 2012..Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism... - A new mutation of Wilson's disease P-type ATPase gene in a patient with cirrhosis and coombs-positive hemolytic anemiaLorenzo Leggio
Institutes of Internal Medicine, Catholic University of Rome, Rome
Dig Dis Sci 51:34-8. 2006 - Primary renal angiosarcoma: a rare malignancy. A case report and review of the literatureLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Urol Oncol 24:307-12. 2006..A case of primary renal angiosarcoma presenting as a large kidney mass and flank pain occurring after traumatism is reported. The present case represents further evidence of a rare malignancy... - Current and promising pharmacotherapies, and novel research target areas in the treatment of alcohol dependence: a reviewSteven Edwards
Center for Alcohol and Addiction Studies Brown University Medical School, Providence, RI 02912, USA
Curr Pharm Des 17:1323-32. 2011..e. cannabinoid receptors, CRF, NPY, ghrelin). Finally, the present review also discusses the attempts to personalize medication for AD treatment by alcohol typology and pharmacogenetics... - HIV testing in hazardous drinking: a survey analysisMiriam Fenton
Department of Community Health, Brown University Medical School, Providence, Rhode Island 02912, USA
Subst Use Misuse 45:204-12. 2010..89) the odds of ever having had an HIV test compared to nonhazardous drinkers. Therefore public health interventions targeted at hazardous drinkers to increase the rate of HIV testing are suggested. The study's limitations are noted... - Role of the tumor necrosis factor antagonists in the treatment of inflammatory bowel disease: an updateVeruscka Leso
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Eur J Gastroenterol Hepatol 22:779-86. 2010..The goal of this review is to provide an update and analyze the pros and cons of using anti-TNF therapies in the treatment of IBD... - A safety and tolerability laboratory study of the combination of aripiprazole and topiramate in volunteers who drink alcoholGeorge A Kenna
Department of Psychiatry and the Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, USA
Hum Psychopharmacol 24:465-72. 2009..The ultimate aim for this research is to determine whether this combination is safe and is superior to either drug taken alone in reducing alcohol use in alcohol dependent patients... - Complementary therapies for treating alcoholism First Annual meeting by Complementary Medicine Research Group of the Italian Society for Alcohol Studies-May 5, 2006, Florence, ItalyLudovico Abenavoli
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Fitoterapia 79:142-7. 2008 - Understanding and treating patients with alcoholic cirrhosis: an updateGiovanni Addolorato
Institute of Internal Medicine, Catholic University of Rome GA, LL, Rome, Italy
Alcohol Clin Exp Res 33:1136-44. 2009..All together the information available suggests the need of a multimodal approach in the clinical management of these patients... - Serotonin transporter (SERT) brain density and neurobiological Cloninger subtypes model: a lesson by human autoradiography studiesLorenzo Leggio
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
Alcohol Alcohol 43:148-50. 2008..New developments in the neurobiological understanding of subtypes of alcoholic patients, could led to get the basis for a more personalized pharmacological therapy... - The treatment of alcohol and opioid dependence in pregnant womenAnnemarie Heberlein
Department of Psychiatry, Social Psychiatry and Psychotherapy, Center for Addiction Research CARe, Hannover Medical School, Hannover, Germany
Curr Opin Psychiatry 25:559-64. 2012..This article addresses the question of 'best treatment options', which clinicians face when treating pregnant women with alcohol and opioid dependence... - Rapid regression of psoriasis in a coeliac patient after gluten-free diet. A case report and review of the literatureGiovanni Addolorato
Institute of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
Digestion 68:9-12. 2003..However, at present the relationship between CD and psoriasis remains controversial since there are few and contrasting data on this topic... - Coenzyme Q 10 and cardiovascular risk factors in idiopathic sudden sensorineural hearing loss patientsGabriella Cadoni
Institute of Otorhinolaryngology, Catholic University of the Sacred Heart, Rome, Italy
Otol Neurotol 28:878-83. 2007..We investigated the association of idiopathic sudden sensorineural hearing loss (ISSNHL) with coenzyme Q (CoQ) and cardiovascular risk factors... - Tolerance to baclofen's sedative effect in alcohol-addicted patients: no dissipation after a period of abstinenceGiovanni Addolorato
Psychopharmacology (Berl) 178:351-2. 2005 - Baclofen for outpatient treatment of alcohol withdrawal syndromeGiovanni Addolorato
J Fam Pract 54:24. 2005 - Baclofen use in the treatment of alcohol delirium tremensLorenzo Leggio
Arch Intern Med 165:586; author reply 587. 2005 - Psychological support counseling: a new strategy to increase gluten-free diet compliance in celiac patientsLorenzo Leggio
Am J Gastroenterol 100:1424-5. 2005 - Complementary medicine for alcohol dependence in Italian services: a mail questionnaireGabriele Bardazzi
Centro Diurno Alcologico, UFM C, Azienda Sanitaria Fiorentina, Villa Basilewsky, Via Lorenzo il Magnifico, 104, 50127 Firenze, Italy
Complement Ther Clin Pract 12:216-21. 2006..CM plays an integrated role with traditional forms of alcohol treatment in Italian alcohol services and this utilization could be useful to reduce drop-outs and improve alcohol treatment compliance...