Jan Klysik

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart
    Sheila A Haley
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    BMC Physiol 8:4. 2008
  2. ncbi request reprint Two new mouse chromosome 11 balancers
    Jan Klysik
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Genomics 83:303-10. 2004
  3. ncbi request reprint [Functional genomics and its impact on the future medicine]
    Jan Klysik
    Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
    Pol Merkur Lekarski 16:205-7. 2004
  4. ncbi request reprint Mice with the enhanced green fluorescent protein gene knocked in to chromosome 11 exhibit normal transmission ratios
    Jan Klysik
    Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biochem Genet 43:321-33. 2005
  5. pmc Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction
    Jan Klysik
    Department of Molecular Biology Cell Biology and Biochemistry, Brown University, Providence, RI 02912, United States
    Cell Signal 20:1-9. 2008
  6. ncbi request reprint Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury
    Jeffrey S Moffit
    Brown University, Department of Molecular Biology Cell Biology and Biochemistry, Division of Biology and Medicine, 70 Ship Street, Providence, RI 02912, USA
    J Androl 28:883-90. 2007
  7. ncbi request reprint Mice and humans: chromosome engineering and its application to functional genomics
    Jan Klysik
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    Acta Biochim Pol 49:553-69. 2002
  8. pmc GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling
    Barbara Giovannone
    Division of Endocrinology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
    Hum Mol Genet 18:4629-39. 2009
  9. ncbi request reprint Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality
    Mandy Pereira
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA
    Mech Ageing Dev 128:609-17. 2007
  10. pmc Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit
    Steven Theroux
    Department of Natural Science, Assumption College, Worcester, MA, United States
    Brain Res Bull 71:559-67. 2007

Collaborators

  • B Tudek
  • John M Sedivy
  • K Boekelheide
  • Vilhelm A Bohr
  • Mandy Pereira
  • Barbara Giovannone
  • Sheila A Haley
  • Jeffrey S Moffit
  • Steven Theroux
  • Stefano Goldwurm
  • William G Tsiaras
  • Galina Karashchuk
  • Corinne Lautier
  • Robert J Smith
  • Suzanne de la Monte
  • Lijun Zou
  • Lazaros K Kochilas
  • James F Padbury
  • Ting Zhao
  • Robert Jedrzejczak
  • Kimberly S Casten
  • Kam C Yeung
  • Ewa Bartnik
  • Penelope Mason
  • Lien Dybczynska
  • Erin Paul
  • Piotr P Stepien
  • Andrzej Wojcik
  • Roman J Szczesny
  • Leena Maddukuri
  • Rebecca D Burwell
  • Sylwia Dziwura

Detail Information

Publications10

  1. pmc Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart
    Sheila A Haley
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    BMC Physiol 8:4. 2008
    ..To investigate this hypothesis, we created a transgenic mouse (R26loxpTA-p57k/+) that expresses p57Kip2 specifically in cardiac tissue under the ventricular cardiomyocyte promoter Mlc2v...
  2. ncbi request reprint Two new mouse chromosome 11 balancers
    Jan Klysik
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Genomics 83:303-10. 2004
    ..With the addition of these balancers to the previously reported Trp53-Wnt3 balancer, most of mouse chromosome 11 is now available in balancer stocks...
  3. ncbi request reprint [Functional genomics and its impact on the future medicine]
    Jan Klysik
    Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
    Pol Merkur Lekarski 16:205-7. 2004
    ..Once gene analysis is completed, the face of medicine will change markedly. The greatest impact is expected on the front of individual diagnosis of disease genes and personalized treatments of patients...
  4. ncbi request reprint Mice with the enhanced green fluorescent protein gene knocked in to chromosome 11 exhibit normal transmission ratios
    Jan Klysik
    Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biochem Genet 43:321-33. 2005
    ....
  5. pmc Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction
    Jan Klysik
    Department of Molecular Biology Cell Biology and Biochemistry, Brown University, Providence, RI 02912, United States
    Cell Signal 20:1-9. 2008
    ..In this review, the role of RKIP-1 in cellular signaling, and especially its functions revealed using a mouse knockout model, are discussed...
  6. ncbi request reprint Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury
    Jeffrey S Moffit
    Brown University, Department of Molecular Biology Cell Biology and Biochemistry, Division of Biology and Medicine, 70 Ship Street, Providence, RI 02912, USA
    J Androl 28:883-90. 2007
    ..Overall, these studies indicate an important role for RKIP in reproduction as a modulator of capacitation but not in the regulation of testicular injury...
  7. ncbi request reprint Mice and humans: chromosome engineering and its application to functional genomics
    Jan Klysik
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    Acta Biochim Pol 49:553-69. 2002
    ..While these advances create new opportunities to address similar aberrations observed in human diseases, they also open new ways of scaling-up mutagenesis projects that try to catalogue and annotate cellular functions of mammalian genes...
  8. pmc GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling
    Barbara Giovannone
    Division of Endocrinology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
    Hum Mol Genet 18:4629-39. 2009
    ..These data provide further evidence for an important role of GIGYF2 in age-related neurodegeneration and IGF pathway signaling...
  9. ncbi request reprint Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality
    Mandy Pereira
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA
    Mech Ageing Dev 128:609-17. 2007
    ..These results indicate that the SUV3 protein is required in mammalian development and in somatic cells participates in genome maintenance through interaction with other genome fidelity housekeepers...
  10. pmc Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit
    Steven Theroux
    Department of Natural Science, Assumption College, Worcester, MA, United States
    Brain Res Bull 71:559-67. 2007
    ..In the brain, expression was ubiquitous in limbic formations, and homozygous mice developed olfaction deficits in the first year of life. We postulate that RKIP-1 may be a modulator of behavioral responses...