Genomes and Genes
Affiliation: Brown University
- Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heartSheila A Haley
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
BMC Physiol 8:4. 2008..To investigate this hypothesis, we created a transgenic mouse (R26loxpTA-p57k/+) that expresses p57Kip2 specifically in cardiac tissue under the ventricular cardiomyocyte promoter Mlc2v...
- Two new mouse chromosome 11 balancersJan Klysik
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Genomics 83:303-10. 2004..With the addition of these balancers to the previously reported Trp53-Wnt3 balancer, most of mouse chromosome 11 is now available in balancer stocks...
- [Functional genomics and its impact on the future medicine]Jan Klysik
Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
Pol Merkur Lekarski 16:205-7. 2004..Once gene analysis is completed, the face of medicine will change markedly. The greatest impact is expected on the front of individual diagnosis of disease genes and personalized treatments of patients...
- Mice with the enhanced green fluorescent protein gene knocked in to chromosome 11 exhibit normal transmission ratiosJan Klysik
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
Biochem Genet 43:321-33. 2005....
- Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproductionJan Klysik
Department of Molecular Biology Cell Biology and Biochemistry, Brown University, Providence, RI 02912, United States
Cell Signal 20:1-9. 2008..In this review, the role of RKIP-1 in cellular signaling, and especially its functions revealed using a mouse knockout model, are discussed...
- Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injuryJeffrey S Moffit
Brown University, Department of Molecular Biology Cell Biology and Biochemistry, Division of Biology and Medicine, 70 Ship Street, Providence, RI 02912, USA
J Androl 28:883-90. 2007..Overall, these studies indicate an important role for RKIP in reproduction as a modulator of capacitation but not in the regulation of testicular injury...
- Mice and humans: chromosome engineering and its application to functional genomicsJan Klysik
Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
Acta Biochim Pol 49:553-69. 2002..While these advances create new opportunities to address similar aberrations observed in human diseases, they also open new ways of scaling-up mutagenesis projects that try to catalogue and annotate cellular functions of mammalian genes...
- GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signalingBarbara Giovannone
Division of Endocrinology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
Hum Mol Genet 18:4629-39. 2009..These data provide further evidence for an important role of GIGYF2 in age-related neurodegeneration and IGF pathway signaling...
- Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethalityMandy Pereira
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA
Mech Ageing Dev 128:609-17. 2007..These results indicate that the SUV3 protein is required in mammalian development and in somatic cells participates in genome maintenance through interaction with other genome fidelity housekeepers...
- Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficitSteven Theroux
Department of Natural Science, Assumption College, Worcester, MA, United States
Brain Res Bull 71:559-67. 2007..In the brain, expression was ubiquitous in limbic formations, and homozygous mice developed olfaction deficits in the first year of life. We postulate that RKIP-1 may be a modulator of behavioral responses...