Martin Keller

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi Raising the expectations of long-term treatment strategies in anxiety disorders
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:166-74. 2002
  2. ncbi Social and health functioning in female primary care patients with post-traumatic stress disorder with and without comorbid substance abuse
    Caron Zlotnick
    Butler Hospital, Providence, RI, USA
    Compr Psychiatry 44:177-83. 2003
  3. ncbi Paroxetine treatment of major depressive disorder
    Martin B Keller
    Department of Psychiatry, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 37:42-52. 2003
  4. ncbi The course of depression in elderly patients
    Timothy I Mueller
    Brown University Medical School, Department of Psychiatry and Human Behavior, c o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Am J Geriatr Psychiatry 12:22-9. 2004
  5. ncbi Remission versus response: the new gold standard of antidepressant care
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 65:53-9. 2004
  6. ncbi Impact of parental history of substance use disorders on the clinical course of anxiety disorders
    Maria E Pagano
    Department of Psychiatry, Division of Child Psychiatry, Case Western Reserve University, Euclid Avenue, Cleveland, OH, USA
    Subst Abuse Treat Prev Policy 2:13. 2007
  7. ncbi Past, present, and future directions for defining optimal treatment outcome in depression: remission and beyond
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02906, USA
    JAMA 289:3152-60. 2003
  8. ncbi The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 68:1246-56. 2007
  9. ncbi The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases
    Martin B Keller
    Brown University, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1371-9. 2007
  10. ncbi Key considerations in choosing an antidepressant
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02912, USA
    Postgrad Med 114:10-8. 2003

Research Grants

  1. COLLABORATIVE DEPRESSION STUDY
    Martin Keller; Fiscal Year: 2004
  2. REVAMP Follow-Up Study
    Martin Keller; Fiscal Year: 2007
  3. COLLABORATIVE DEPRESSION STUDY
    Martin Keller; Fiscal Year: 2007
  4. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    Martin Keller; Fiscal Year: 2006
  5. Course and Outcome for Bipolar Disorder in Youth (COBY)
    Martin Keller; Fiscal Year: 2007
  6. Harvard/Brown Anxiety Program (HARP)
    Martin B Keller; Fiscal Year: 2010
  7. Course and Outcome for Bipolar Disorder in Youth (COBY)
    Martin Keller; Fiscal Year: 2009
  8. Harvard/Brown Anxiety Program (HARP)
    Martin Keller; Fiscal Year: 2009
  9. Harvard/Brown Anxiety Research Project (HARP)
    Martin Keller; Fiscal Year: 2007
  10. HARVARD BROWN ANXIETY RESEARCH PROJECT
    Martin Keller; Fiscal Year: 2002

Detail Information

Publications95

  1. ncbi Raising the expectations of long-term treatment strategies in anxiety disorders
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:166-74. 2002
    ..Future studies should emphasize the role of preventive pharmacotherapy to improve the long-term course of anxiety and to reduce its associated suffering, suicide, and occupational and social impairment...
  2. ncbi Social and health functioning in female primary care patients with post-traumatic stress disorder with and without comorbid substance abuse
    Caron Zlotnick
    Butler Hospital, Providence, RI, USA
    Compr Psychiatry 44:177-83. 2003
    ..These findings suggest that the presence of comorbid SUD may not explain the level of social and health difficulties associated with the dual diagnosis of PTSD and SUD...
  3. ncbi Paroxetine treatment of major depressive disorder
    Martin B Keller
    Department of Psychiatry, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 37:42-52. 2003
    ....
  4. ncbi The course of depression in elderly patients
    Timothy I Mueller
    Brown University Medical School, Department of Psychiatry and Human Behavior, c o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Am J Geriatr Psychiatry 12:22-9. 2004
    ..Studies on the course of major depressive disorder (MDD) among elderly persons are limited to short periods of follow-up, seldom provide comparisons with younger cohorts, and raise other methodological concerns...
  5. ncbi Remission versus response: the new gold standard of antidepressant care
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 65:53-9. 2004
    ..This dynamic is reinforced via the integration of current best therapeutic thinking in research settings, leading to clinical trials that more closely approximate an ideal, remission-focused treatment regimen...
  6. ncbi Impact of parental history of substance use disorders on the clinical course of anxiety disorders
    Maria E Pagano
    Department of Psychiatry, Division of Child Psychiatry, Case Western Reserve University, Euclid Avenue, Cleveland, OH, USA
    Subst Abuse Treat Prev Policy 2:13. 2007
    ..The purpose of this study was to examine prospectively the relationship between parental substance use disorders and the course of anxiety disorders in adulthood over the course of 12 years...
  7. ncbi Past, present, and future directions for defining optimal treatment outcome in depression: remission and beyond
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02906, USA
    JAMA 289:3152-60. 2003
    ..Until then, remission should continue to be based on the descriptive and experiential phenomena of symptoms and psychosocial functioning...
  8. ncbi The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 68:1246-56. 2007
    ..To report second-year results from the 2-year maintenance phase of a long-term study to evaluate the efficacy and safety of venlafaxine extended release (ER) in preventing recurrence of depression...
  9. ncbi The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases
    Martin B Keller
    Brown University, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1371-9. 2007
    ..We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment...
  10. ncbi Key considerations in choosing an antidepressant
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02912, USA
    Postgrad Med 114:10-8. 2003
    ..Thus, it is critical to stay up to date with the best therapeutic approach, while remaining flexible as new therapies are developed...
  11. ncbi Improving the course of illness and promoting continuation of treatment of bipolar disorder
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02906, USA
    J Clin Psychiatry 65:10-4. 2004
    ..Physicians can help improve adherence by selecting medications with simple dosage regimens and educating patients and families about the disorder and what to expect from medications...
  12. ncbi Relapse prevention with gepirone ER in outpatients with major depression
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychopharmacol 25:79-84. 2005
    ..In conclusion, gepirone ER at a dose range of 40 to 80 mg/d is effective for relapse prevention in patients with recurrent major depression. It is well tolerated during long-term treatment for up to approximately one year...
  13. ncbi Issues in treatment-resistant depression
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA
    J Clin Psychiatry 66:5-12. 2005
    ..Electroconvulsive therapy and psychotherapy offer additional treatment strategies. New nonpharmacologic therapies are under investigation. Remission is the goal of treatment...
  14. ncbi Social anxiety disorder clinical course and outcome: review of Harvard/Brown Anxiety Research Project (HARP) findings
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02912, USA
    J Clin Psychiatry 67:14-9. 2006
    ..Whereas, the relapse rate, once recovery is achieved, is 34% during this 10-year follow-up. Treatment is underutilized in patients with SAD, and a long-term treatment approach may be needed to improve the likelihood of recovery from SAD...
  15. ncbi Long-term treatment of patients with recurrent unipolar major depression: evidence to clinical practice
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    CNS Spectr 11:4-5. 2006
  16. ncbi Phenomenology of children and adolescents with bipolar spectrum disorders
    David Axelson
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Gen Psychiatry 63:1139-48. 2006
    ..Children and adolescents who present with manic symptoms frequently do not meet the full DSM-IV criteria for bipolar I disorder (BP-I)...
  17. ncbi Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response
    Joan Rosenbaum Asarnow
    Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    J Am Acad Child Adolesc Psychiatry 48:330-9. 2009
    ..This study examines predictors and moderators of treatment response, with the goal of informing efforts to match youths to optimal treatment strategies...
  18. ncbi Childhood-onset bipolar disorder: Evidence for increased familial loading of psychiatric illness
    Richard Rende
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    J Am Acad Child Adolesc Psychiatry 46:197-204. 2007
    ..To determine whether childhood-onset bipolar disorder (BP) is associated with an increased psychiatric family history compared with adolescent-onset BP...
  19. ncbi Suicide attempts and nonsuicidal self-injury in the treatment of resistant depression in adolescents: findings from the TORDIA study
    Joan Rosenbaum Asarnow
    University of California Los Angeles UCLA, Department of Psychiatry, Los Angeles, CA 90095 6968, USA
    J Am Acad Child Adolesc Psychiatry 50:772-81. 2011
    ..To evaluate the clinical and prognostic significance of suicide attempts (SAs) and nonsuicidal self-injury (NSSI) in adolescents with treatment-resistant depression...
  20. ncbi Irritability without elation in a large bipolar youth sample: frequency and clinical description
    Jeffrey Hunt
    Warren Alpert Medical School, Brown University, USA
    J Am Acad Child Adolesc Psychiatry 48:730-9. 2009
    ....
  21. ncbi Comparison of manic and depressive symptoms between children and adolescents with bipolar spectrum disorders
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Bipolar Disord 11:52-62. 2009
    ..To compare the most severe lifetime (current or past) mood symptoms, duration of illness, and rates of lifetime comorbid disorders among youth with bipolar spectrum disorders [BP (bipolar-I, bipolar-II and bipolar-not otherwise specified)]...
  22. ncbi Concordance between clinician and patient ratings as predictors of response, remission, and recurrence in major depressive disorder
    Boadie W Dunlop
    Department of Psychiatry, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
    J Psychiatr Res 45:96-103. 2011
    ..Poor agreement between patient- and clinician-ratings of depression severity is primarily a state phenomenon, although it is trait-like for some patients...
  23. ncbi Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness
    Richard Rende
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    J Affect Disord 96:127-31. 2006
    ..Few studies have examined the specificity and non-specificity in patterns of familial loading for presentation of psychotic symptoms in pediatric bipolar disorder (BP)...
  24. ncbi Mental health treatment received by primary care patients with posttraumatic stress disorder
    Benjamin F Rodriguez
    Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, R I, USA
    J Clin Psychiatry 64:1230-6. 2003
    ..Our purpose was to describe the characteristics of mental health treatment received by primary care patients diagnosed with PTSD...
  25. ncbi Child comorbidity, maternal mood disorder, and perceptions of family functioning among bipolar youth
    Christianne Esposito-Smythers
    Department of Psychiatry, Brown Medical School, Providence, RI 02912, USA
    J Am Acad Child Adolesc Psychiatry 45:955-64. 2006
    ..To examine the association between youth comorbid psychiatric disorders, maternal mood disorder, and perceptions of family cohesion and conflict among youth diagnosed with pediatric bipolar disorder (PBD)...
  26. ncbi The naturalistic course of unipolar major depression in the absence of somatic therapy
    Michael A Posternak
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Providence, Rhode Island, USA
    J Nerv Ment Dis 194:324-9. 2006
    ..Because treatment-seeking behavior is known to be associated with a worse prognosis, 23 weeks probably represents a lower-limit approximation of the median duration of an untreated depressive episode...
  27. ncbi Correlation between patient and clinician assessments of depression severity in the PREVENT study
    Boadie W Dunlop
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
    Psychiatry Res 177:177-83. 2010
    ..This study analyzed agreement between commonly used depression rating scales in the Prevention of Recurrent Episodes of Depression with Venlafaxine Extended Release (ER) for Two Years (PREVENT) trial...
  28. ncbi Factors associated with mental health service utilization among bipolar youth
    Christie J Rizzo
    Department of Psychiatry and Human Behavior, Brown Medical School, CAAS, Box G BH, Providence, RI 02912, USA
    Bipolar Disord 9:839-50. 2007
    ..Demographic variables, youth bipolar characteristics, youth comorbid conditions, and parental psychopathology were examined as predictors of treatment utilization across different levels of care...
  29. ncbi Tachyphylaxis in unipolar major depressive disorder
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, 593 Eddy Street, Providence, RI 02903, USA
    J Clin Psychiatry 66:283-90. 2005
    ..This study describes recurrence of major depression despite maintenance pharmacotherapy, termed tachyphylaxis...
  30. ncbi Is anyone really M.A.D.?: the occurrence and course of mixed anxiety-depressive disorder in a sample of primary care patients
    Risa B Weisberg
    Department of Psychiatry, Brown University, Providence, Rhode Island 02912, USA
    J Nerv Ment Dis 193:223-30. 2005
    ..Although this was not a prevalence study, results indicate a very low occurrence of MAD across 15 primary care settings. Further, they indicate that this diagnosis may not be stable across time and raise doubts about its utility...
  31. ncbi A randomized, placebo-controlled trial of risperidone augmentation for patients with difficult-to-treat unipolar, non-psychotic major depression
    Gabor I Keitner
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, United States
    J Psychiatr Res 43:205-14. 2009
    ..This study evaluated risperidone as an augmenting agent for patients who failed or only partially responded to an adequate trial of an antidepressant medication...
  32. ncbi Prevalence and impact of comorbid anxiety and bipolar disorder
    Martin B Keller
    Department of Psychiatry and Human Behavior, Butler Hospital, Providence, RI 02906, USA
    J Clin Psychiatry 67:5-7. 2006
    ..Because the degree to which anxiety impacts patients with bipolar disorder is not fully known, more information is needed about the relationship between bipolar disorder and anxiety...
  33. ncbi Predicting recovery from episodes of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02903 4970, United States
    J Affect Disord 107:285-91. 2008
    ..This study examined psychosocial functioning as a predictor of recovery from episodes of unipolar major depression...
  34. ncbi The long-term natural history of the weekly symptomatic status of bipolar I disorder
    Lewis L Judd
    Department of Psychiatry, University of California-San Diego, La Jolla, CA 92093-0603, USA
    Arch Gen Psychiatry 59:530-7. 2002
    ..Symptom severity levels fluctuate, often within the same patient over time. Bipolar I disorder is expressed as a dimensional illness featuring the full range (spectrum) of affective symptom severity and polarity...
  35. ncbi Symptomatic and syndromal anxiety in chronic forms of major depression: effect of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination
    Philip T Ninan
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30329, USA
    J Clin Psychiatry 63:434-41. 2002
    ..Among patients with a concurrent anxiety disorder, nefazodone. either alone or in combination with CBASP, improves anxiety symptoms faster than CBASP alone, independent of depressive symptom reduction...
  36. ncbi Chronic forms of major depression are still undertreated in the 21st century: systematic assessment of 801 patients presenting for treatment
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    J Affect Disord 110:55-61. 2008
    ..These results and the consistency of similar results over time point to the dire need for patient and provider education regarding the signs and symptoms of depression and its treatment...
  37. ncbi Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression
    Alan J Gelenberg
    Department of Psychiatry, Health Sciences Center, University of Arizona, PO Box 245002, Tucson, AZ 85724-5002, USA
    Biol Psychiatry 54:806-17. 2003
    ..8%). Somnolence was significantly greater among the patients taking active medication (15.4%), compared with placebo (4.6%). CONCLUSIONS: Nefazodone is well-tolerated and is an effective maintenance therapy for chronic forms of MDD...
  38. ncbi Chronicity, relapse, and illness--course of panic disorder, social phobia, and generalized anxiety disorder: findings in men and women from 8 years of follow-up
    Kimberly A Yonkers
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06510, USA
    Depress Anxiety 17:173-9. 2003
    ..It may be that sex differences in the clinical course of anxiety disorders hold prognostic implications for patients with these illnesses...
  39. ncbi Chronicity in posttraumatic stress disorder and predictors of the course of posttraumatic stress disorder among primary care patients
    Caron Zlotnick
    Butler Hospital, Providence, RI 02906, USA
    J Nerv Ment Dis 192:153-9. 2004
    ..e., full and partial PTSD). This study suggests that, in a primary care setting, PTSD is a persistent illness, and that many subjects who have recovered from PTSD continue to suffer from subthreshold symptoms of PTSD...
  40. ncbi A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, La Jolla 92093-0603, USA
    Arch Gen Psychiatry 60:261-9. 2003
    ..Longitudinally, BP-II is expressed as a dimensional illness involving the full severity range of depressive and hypomanic symptoms. Hypomania of long or short duration in BP-II seems to be part of the same disease process...
  41. ncbi Do panic symptoms during periods of remission predict relapse of panic disorder?
    Risa B Weisberg
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, 02912, USA
    J Nerv Ment Dis 190:190-7. 2002
    ..Thus, although panic symptoms during remission may indicate an increased risk of subsequent relapse, the absence of symptoms during remission does not indicate that relapse is unlikely...
  42. ncbi Personality disorders and time to remission in generalized anxiety disorder, social phobia, and panic disorder
    Ann O Massion
    Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Arch Gen Psychiatry 59:434-40. 2002
    ..This investigation assessed the effect of personality disorders (PersDs) on time to remission in patients with generalized anxiety disorder, social phobia, or panic disorder...
  43. ncbi Substance use disorders among adolescents with bipolar spectrum disorders
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 10:469-78. 2008
    ..We set out to examine the prevalence and correlates of substance use disorders (SUD) in a large sample of adolescents with bipolar disorder (BP)...
  44. ncbi Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
    J Clin Psychiatry 68:1014-23. 2007
    ..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
  45. ncbi Clinical course of children and adolescents with bipolar spectrum disorders
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Arch Gen Psychiatry 63:175-83. 2006
    ..Despite the high morbidity associated with bipolar disorder (BP), few studies have prospectively studied the course of this illness in youth...
  46. ncbi Sources of site differences in the efficacy of a multisite clinical trial: the Treatment of SSRI-Resistant Depression in Adolescents
    Anthony Spirito
    Clinical Psychology Training Consortium, Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, USA
    J Consult Clin Psychol 77:439-50. 2009
    ..Study findings are discussed with respect to the overall study outcomes in TORDIA as well as MRCTs in general...
  47. ncbi Long-term use of benzodiazepines in participants with comorbid anxiety and alcohol use disorders
    Timothy I Mueller
    Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Department of Psychiatry, Tucson, Arizona 85723, USA
    Alcohol Clin Exp Res 29:1411-8. 2005
    ..Earlier research showed that the use of benzodiazepines was not significantly associated with the presence or absence of a history of an AUD over the first year of follow-up. This report extends that investigation...
  48. ncbi Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 62:1322-30. 2005
    ..Evidence of psychosocial disability in bipolar disorder is based primarily on bipolar I disorder (BP-I) and does not relate disability to affective symptom severity and polarity or to bipolar II disorder (BP-II)...
  49. ncbi Predictors of treatment utilization among women with anorexia and bulimia nervosa
    Pamela K Keel
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 159:140-2. 2002
    ..CONCLUSIONS: Women with more severe pathology have higher treatment utilization rates. This pattern may explain the seeming lack of treatment efficacy for eating disorders outside of randomized controlled studies...
  50. ncbi Distinguishing bipolar major depression from unipolar major depression with the screening assessment of depression-polarity (SAD-P)
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    J Clin Psychiatry 67:434-42. 2006
    ..The goal of this study was to develop and validate a brief instrument to screen for bipolar disorder in patients actively ill with major depression...
  51. ncbi Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combination
    John Zajecka
    Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, 1725 W. Harrison Street, Suite 955, Chicago, IL 60612, USA
    J Clin Psychiatry 63:709-16. 2002
    ..Treatment with nefazodone, CBASP, and combined treatment improved sexual interest/satisfaction, with greatest improvement observed with combined treatment...
  52. ncbi Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Arch Gen Psychiatry 66:1178-88. 2009
    ..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone...
  53. ncbi Use of benzodiazepines and selective serotonin reuptake inhibitors in middle-aged and older adults with anxiety disorders: a longitudinal and prospective study
    Carlos Israel Pérez Benítez
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA
    Am J Geriatr Psychiatry 16:5-13. 2008
    ....
  54. ncbi The relationship between sleep disturbance and the course of anxiety disorders in primary care patients
    Brook A Marcks
    Warren Alpert School of Medicine at Brown University, Department of Psychiatry and Human Behavior, Providence, RI 02912, USA
    Psychiatry Res 178:487-92. 2010
    ..The findings suggest that sleep disturbance in PTSD may have prognostic significance and may be important to address in clinical interventions...
  55. ncbi Anxiety sensitivity as a predictor of the clinical course of panic disorder: a 1-year follow-up study
    Carlos Israel Pérez Benítez
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island 02912, USA
    Depress Anxiety 26:335-42. 2009
    ..The main purpose of this study was to examine whether NA and AS will also predict the clinical course of PD...
  56. ncbi Characteristics and predictors of social phobia course in a longitudinal study of primary-care patients
    Courtney Beard
    Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02912, USA
    Depress Anxiety 27:839-45. 2010
    ..To date, few researchers have examined the natural course of SP in primary care. We examined the natural course and predictors of recovery in a large sample of primary-care patients...
  57. ncbi Psychiatric treatment in primary care patients with anxiety disorders: a comparison of care received from primary care providers and psychiatrists
    Risa B Weisberg
    Department of Psychiatry, Brown University, Providence, RI 02096, USA
    Am J Psychiatry 164:276-82. 2007
    ..This study examined psychiatric treatment received by primary care patients with anxiety disorders and compared treatment received from primary care physicians and from psychiatrists...
  58. ncbi Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States
    Charles B Nemeroff
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
    Arch Gen Psychiatry 64:466-72. 2007
    ....
  59. ncbi Health-related Quality of Life across the anxiety disorders: findings from a sample of primary care patients
    Courtney Beard
    Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, RI 02912, USA
    J Anxiety Disord 24:559-64. 2010
    ..The current study extends previous research by showing that different anxiety disorders and comorbid conditions may be associated with impairment in specific domains of HR-QoL...
  60. ncbi Psychosocial impairment and recurrence of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Compr Psychiatry 45:423-30. 2004
    ..In patients who have recovered from an episode of major depression, the presence of psychosocial impairment may help identify who is at increased risk of recurrence...
  61. ncbi Factor structure and stability of the Anxiety Sensitivity Index in a longitudinal study of anxiety disorder patients
    Benjamin F Rodriguez
    Brown University Medical School, Department of Psychiatry and Human Behavior, Box G BH Duncan Building, Providence RI 02912, USA
    Behav Res Ther 42:79-91. 2004
    ..The theoretical implications of these findings for future evaluations of anxiety sensitivity are discussed...
  62. ncbi Long-term treatment strategies in affective disorders
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:36-48. 2002
    ..The significantly higher remission rates attained with venlafaxine treatment as compared with some SSRIs warrant further studies of SNRIs for the long-term treatment of depression...
  63. ncbi Depression treatment: a lifelong commitment?
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:133-41. 2002
    ..Additional well-designed studies addressing these issues are urgently needed...
  64. ncbi Self-reported depressive symptom measures: sensitivity to detecting change in a randomized, controlled trial of chronically depressed, nonpsychotic outpatients
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Neuropsychopharmacology 30:405-16. 2005
    ..Global patient ratings such as the PGI-I, as opposed to specific item-based ratings, provide less valid findings...
  65. ncbi Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study
    Steven E Bruce
    Department of Psychiatry and Human Behavior, Brown University, RI 02906, USA
    Am J Psychiatry 162:1179-87. 2005
    ....
  66. ncbi Are benzodiazepines still the medication of choice for patients with panic disorder with or without agoraphobia?
    Steven E Bruce
    Brown University, Providence, RI 02906, USA
    Am J Psychiatry 160:1432-8. 2003
    ..The authors examined how the use of psychotropic drugs has shifted over the course of 10 years to determine if prescribing patterns have changed to reflect these revised treatment guidelines...
  67. ncbi Nonpsychiatric illness among primary care patients with trauma histories and posttraumatic stress disorder
    Risa B Weisberg
    Department of Psychiatry and Human Behavior at Brown University in Providence, Rhode Island 02912, USA
    Psychiatr Serv 53:848-54. 2002
    ..The authors examined the relationship between posttraumatic stress disorder (PTSD), trauma, and self-reported nonpsychiatric medical conditions in a sample of 502 primary care patients with one or more anxiety disorders...
  68. ncbi Psychiatric treatment received by primary care patients with panic disorder with and without agoraphobia
    Brook A Marcks
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G BH, Duncan Bldg, Providence, RI 02912, USA
    Psychiatr Serv 60:823-30. 2009
    ....
  69. ncbi The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9086, USA
    Biol Psychiatry 54:573-83. 2003
    ..The QIDS-SR(16) has highly acceptable psychometric properties, which supports the usefulness of this brief rating of depressive symptom severity in both clinical and research settings...
  70. ncbi Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 63:493-500. 2002
    ..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances...
  71. ncbi The long-term clinical course of generalized anxiety disorder
    Martin B Keller
    Department of Psychiatry, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 63:11-6. 2002
    ....
  72. ncbi The clinical course of body dysmorphic disorder in the Harvard/Brown Anxiety Research Project (HARP)
    Andri S Bjornsson
    Rhode Island Hospital, Coro Center West, 1 Hoppin St, Providence, RI 02903, USA
    J Nerv Ment Dis 199:55-7. 2011
    ..14 over the 8 years. In conclusion, among individuals ascertained for anxiety disorders, the probability of recovering from BDD was relatively high and probability of BDD recurrence was low...
  73. ncbi Predictors of prospectively examined suicide attempts among youth with bipolar disorder
    Tina R Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Arch Gen Psychiatry 69:1113-22. 2012
    ..Individuals with early onset of bipolar disorder are at high risk for suicide. Yet, no study to date has examined factors associated with prospective risk for suicide attempts among youth with bipolar disorder...
  74. ncbi Sertraline treatment of co-occurring alcohol dependence and major depression
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 26:13-20. 2006
    ..This multicenter, double-blind, placebo-controlled trial of sertraline was designed to address many of the potential methodological shortcomings of studies of co-occurring disorders...
  75. ncbi Effective components of TORDIA cognitive-behavioral therapy for adolescent depression: preliminary findings
    Betsy D Kennard
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8589, USA
    J Consult Clin Psychol 77:1033-41. 2009
    ..Finally, social skills and problem solving may be active elements in CBT for adolescent depression and should be considered in treatment by those working with seriously depressed youths...
  76. ncbi Rationale and options for the long-term treatment of depression
    Martin B Keller
    Brown University, Providence, Rhode Island 02906-4871, USA
    Hum Psychopharmacol 17:S43-6. 2002
    ..It is also well tolerated over prolonged periods. It should therefore prove suitable for use as maintenance treatment in depressed patients...
  77. ncbi Preliminary findings regarding overweight and obesity in pediatric bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychiatry 69:1953-9. 2008
    ..Overweight/obesity is highly prevalent among adults with bipolar disorder and has been associated with illness severity. Little is known regarding overweight/obesity among youth with bipolar disorder...
  78. ncbi Significance of cigarette smoking among youths with bipolar disorder
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Addict 17:364-71. 2008
    ..Daily heavy smokers had greater prevalence of SUD and suicide attempts, and worse depression versus daily light smokers. Smoking among youths with BP is independently associated with suicide attempts and SUD...
  79. ncbi Effects of risperidone augmentation in patients with treatment-resistant depression: Results of open-label treatment followed by double-blind continuation
    Mark Hyman Rapaport
    Department of Psychiatry, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Neuropsychopharmacology 31:2505-13. 2006
    ..1 and 64.1%, respectively (p < or = 0.05). Open-label risperidone augmentation substantially enhanced response in treatment-resistant patients, but the longer-term benefits of augmentation were not demonstrated in this study...
  80. ncbi Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder
    Martin Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    Biol Psychiatry 59:216-23. 2006
    ..The concept of neurokinin(1) receptor antagonism as an antidepressant mechanism was not supported...
  81. ncbi The prospectively observed course of illness among depressed patients who commit suicide
    William Coryell
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Acta Psychiatr Scand 105:218-23. 2002
    ..These analyses were conducted to describe the course of illness among patients with major affective disorders who commit suicide...
  82. ncbi Chronic depression and comorbid personality disorders: response to sertraline versus imipramine
    James M Russell
    Department of Psychiatry and Behavioral Sciences, The University of Texas Medical Branch at Galveston, 77555, USA
    J Clin Psychiatry 64:554-61. 2003
    ..Few studies, though, have systematically examined the clinical correlates of Axis II personality disorder comorbidity or its effect on treatment response or time to response...
  83. ncbi Clinical use of nefazodone in major depression: a 6-year perspective
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Calif 94305-5717, USA
    J Clin Psychiatry 63:18-31. 2002
  84. ncbi The effectiveness of St. John's Wort in major depressive disorder: a naturalistic phase 2 follow-up in which nonresponders were provided alternate medication
    Alan J Gelenberg
    University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    J Clin Psychiatry 65:1114-9. 2004
    ..A continuation study of an extract of St. John's wort (Hypericum perforatum) for depression was performed in follow-up to an acute study that found no significant difference between St. John's wort extract and placebo...
  85. ncbi Characteristics and predictors of full and partial recovery from generalized anxiety disorder in primary care patients
    Benjamin F Rodriguez
    Department of Psychology, Southern Illinois University at Carbondale, Carbondale, IL 62901-6502, USA
    J Nerv Ment Dis 194:91-7. 2006
    ..These results underscore that GAD is a chronic and persistent illness in primary care patients...
  86. ncbi Untangling depression and anxiety: clinical challenges
    Martin B Keller
    J Clin Psychiatry 66:1477-84. 2005
  87. ncbi Results of a naturalistic longitudinal study of benzodiazepine and SSRI use in the treatment of generalized anxiety disorder and social phobia
    Russell G Vasile
    Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Depress Anxiety 22:59-67. 2005
    ..Difficulties in the implementation of treatment guidelines are discussed...
  88. ncbi Relationships among psychosocial functioning, diagnostic comorbidity, and the recurrence of generalized anxiety disorder, panic disorder, and major depression
    Benjamin F Rodriguez
    Department of Psychology, Southern Illinois University, Life Sciences II Room 222A, Carbondale, IL 62901 6502, USA
    J Anxiety Disord 19:752-66. 2005
    ..The Journal of Nervous and Mental Disease, 188, 805-812], and suggest that increased psychosocial impairment may be a risk factor for relapse...
  89. ncbi Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
    ..Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma...
  90. ncbi Placebo-controlled continuation treatment with mirtazapine: acute pattern of response predicts relapse
    Andrew A Nierenberg
    Havard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropsychopharmacology 29:1012-8. 2004
    ..The low relapse rate for patients with an acute placebo pattern switched to placebo suggests specific drug effect played a smaller role in their initial improvement...
  91. ncbi Group comparisons of DSM-IV subtypes of chronic depression: validity of the distinctions, part 2
    James P McCullough
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    J Abnorm Psychol 112:614-22. 2003
    ..The authors suggest that chronic depression should be viewed as a single, broad condition that can assume a variety of clinical course configurations...
  92. ncbi Therapeutic alliance in depression treatment: controlling for prior change and patient characteristics
    Daniel N Klein
    Department of Psychology and Psychiatry, State University of New York at Stony Brook, 11794 2500, USA
    J Consult Clin Psychol 71:997-1006. 2003
    ..Patients receiving combination treatment reported stronger alliances with their psychotherapists than patients receiving CBASP alone. However, the impact of the alliance on outcome was similar for both treatment conditions...
  93. ncbi The comparative clinical phenotype and long term longitudinal episode course of bipolar I and II: a clinical spectrum or distinct disorders?
    Lewis L Judd
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, USA
    J Affect Disord 73:19-32. 2003
    ....
  94. ncbi A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness
    Andrew C Leon
    NIMH Collaborative Program on the Psychobiology of Depression, USA
    Am J Psychiatry 160:727-33. 2003
    ..This observational study examined the effectiveness of somatic antidepressant treatments as administered in the community...
  95. ncbi Frequency and patterns of psychiatric comorbidity in a sample of primary care patients with anxiety disorders
    Benjamin F Rodriguez
    Department of Psychology, Southern Illinois University-Carbondale, Life Science II, Room 281, Mailcode 6502, Carbondale, IL 62901, USA
    Compr Psychiatry 45:129-37. 2004
    ..2001). Implications of these results for both the mental health and primary care fields are also discussed...

Research Grants40

  1. COLLABORATIVE DEPRESSION STUDY
    Martin Keller; Fiscal Year: 2004
    ....
  2. REVAMP Follow-Up Study
    Martin Keller; Fiscal Year: 2007
    ....
  3. COLLABORATIVE DEPRESSION STUDY
    Martin Keller; Fiscal Year: 2007
    ..abstract_text> ..
  4. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    Martin Keller; Fiscal Year: 2006
    ..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study ..
  5. Course and Outcome for Bipolar Disorder in Youth (COBY)
    Martin Keller; Fiscal Year: 2007
    ....
  6. Harvard/Brown Anxiety Program (HARP)
    Martin B Keller; Fiscal Year: 2010
    ....
  7. Course and Outcome for Bipolar Disorder in Youth (COBY)
    Martin Keller; Fiscal Year: 2009
    ....
  8. Harvard/Brown Anxiety Program (HARP)
    Martin Keller; Fiscal Year: 2009
    ....
  9. Harvard/Brown Anxiety Research Project (HARP)
    Martin Keller; Fiscal Year: 2007
    ..abstract_text> ..
  10. HARVARD BROWN ANXIETY RESEARCH PROJECT
    Martin Keller; Fiscal Year: 2002
    ..abstract_text> ..
  11. Course and Outcome for Bipolar Disorder in Youth (COBY)
    Martin B Keller; Fiscal Year: 2010
    ....