Martin B Keller

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Long-term treatment strategies in affective disorders
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:36-48. 2002
  2. ncbi request reprint Raising the expectations of long-term treatment strategies in anxiety disorders
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:166-74. 2002
  3. ncbi request reprint Depression treatment: a lifelong commitment?
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:133-41. 2002
  4. ncbi request reprint The naturalistic course of unipolar major depression in the absence of somatic therapy
    Michael A Posternak
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Providence, Rhode Island, USA
    J Nerv Ment Dis 194:324-9. 2006
  5. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 68:1246-56. 2007
  6. doi request reprint Recovery from multiple episodes of bipolar I depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Clin Psychiatry 74:e205-11. 2013
  7. pmc Predicting recovery from episodes of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02903 4970, United States
    J Affect Disord 107:285-91. 2008
  8. pmc Anxiety sensitivity as a predictor of the clinical course of panic disorder: a 1-year follow-up study
    Carlos Israel Pérez Benítez
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island 02912, USA
    Depress Anxiety 26:335-42. 2009
  9. ncbi request reprint Chronicity in posttraumatic stress disorder and predictors of the course of posttraumatic stress disorder among primary care patients
    Caron Zlotnick
    Butler Hospital, Providence, RI 02906, USA
    J Nerv Ment Dis 192:153-9. 2004
  10. pmc Impact of stressful life events on the course of panic disorder in adults
    Ethan Moitra
    Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02912, United States
    J Affect Disord 134:373-6. 2011

Detail Information

Publications77

  1. ncbi request reprint Long-term treatment strategies in affective disorders
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:36-48. 2002
    ..The significantly higher remission rates attained with venlafaxine treatment as compared with some SSRIs warrant further studies of SNRIs for the long-term treatment of depression...
  2. ncbi request reprint Raising the expectations of long-term treatment strategies in anxiety disorders
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:166-74. 2002
    ..Future studies should emphasize the role of preventive pharmacotherapy to improve the long-term course of anxiety and to reduce its associated suffering, suicide, and occupational and social impairment...
  3. ncbi request reprint Depression treatment: a lifelong commitment?
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 36:133-41. 2002
    ..Additional well-designed studies addressing these issues are urgently needed...
  4. ncbi request reprint The naturalistic course of unipolar major depression in the absence of somatic therapy
    Michael A Posternak
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Providence, Rhode Island, USA
    J Nerv Ment Dis 194:324-9. 2006
    ..Because treatment-seeking behavior is known to be associated with a worse prognosis, 23 weeks probably represents a lower-limit approximation of the median duration of an untreated depressive episode...
  5. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the 2-year and combined maintenance phases
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 68:1246-56. 2007
    ..To report second-year results from the 2-year maintenance phase of a long-term study to evaluate the efficacy and safety of venlafaxine extended release (ER) in preventing recurrence of depression...
  6. doi request reprint Recovery from multiple episodes of bipolar I depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Clin Psychiatry 74:e205-11. 2013
    ..To describe the duration of bipolar I major and minor depressive episodes and factors associated with time to recovery...
  7. pmc Predicting recovery from episodes of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02903 4970, United States
    J Affect Disord 107:285-91. 2008
    ..This study examined psychosocial functioning as a predictor of recovery from episodes of unipolar major depression...
  8. pmc Anxiety sensitivity as a predictor of the clinical course of panic disorder: a 1-year follow-up study
    Carlos Israel Pérez Benítez
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island 02912, USA
    Depress Anxiety 26:335-42. 2009
    ..The main purpose of this study was to examine whether NA and AS will also predict the clinical course of PD...
  9. ncbi request reprint Chronicity in posttraumatic stress disorder and predictors of the course of posttraumatic stress disorder among primary care patients
    Caron Zlotnick
    Butler Hospital, Providence, RI 02906, USA
    J Nerv Ment Dis 192:153-9. 2004
    ..e., full and partial PTSD). This study suggests that, in a primary care setting, PTSD is a persistent illness, and that many subjects who have recovered from PTSD continue to suffer from subthreshold symptoms of PTSD...
  10. pmc Impact of stressful life events on the course of panic disorder in adults
    Ethan Moitra
    Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02912, United States
    J Affect Disord 134:373-6. 2011
    ..However, limited attention has been paid to how SLEs might affect the severity of panic symptoms in individuals with PD/PDA. In this study, we examined the relationship between SLEs and panic symptom severity in adults with PD/PDA...
  11. ncbi request reprint Tachyphylaxis in unipolar major depressive disorder
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, 593 Eddy Street, Providence, RI 02903, USA
    J Clin Psychiatry 66:283-90. 2005
    ..This study describes recurrence of major depression despite maintenance pharmacotherapy, termed tachyphylaxis...
  12. ncbi request reprint Social anxiety disorder clinical course and outcome: review of Harvard/Brown Anxiety Research Project (HARP) findings
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02912, USA
    J Clin Psychiatry 67:14-9. 2006
    ..Whereas, the relapse rate, once recovery is achieved, is 34% during this 10-year follow-up. Treatment is underutilized in patients with SAD, and a long-term treatment approach may be needed to improve the likelihood of recovery from SAD...
  13. ncbi request reprint Distinguishing bipolar major depression from unipolar major depression with the screening assessment of depression-polarity (SAD-P)
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    J Clin Psychiatry 67:434-42. 2006
    ..The goal of this study was to develop and validate a brief instrument to screen for bipolar disorder in patients actively ill with major depression...
  14. pmc Mental health treatment received by primary care patients with posttraumatic stress disorder
    Benjamin F Rodriguez
    Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, R I, USA
    J Clin Psychiatry 64:1230-6. 2003
    ..Our purpose was to describe the characteristics of mental health treatment received by primary care patients diagnosed with PTSD...
  15. pmc A randomized, placebo-controlled trial of risperidone augmentation for patients with difficult-to-treat unipolar, non-psychotic major depression
    Gabor I Keitner
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, United States
    J Psychiatr Res 43:205-14. 2009
    ..This study evaluated risperidone as an augmenting agent for patients who failed or only partially responded to an adequate trial of an antidepressant medication...
  16. ncbi request reprint Is anyone really M.A.D.?: the occurrence and course of mixed anxiety-depressive disorder in a sample of primary care patients
    Risa B Weisberg
    Department of Psychiatry, Brown University, Providence, Rhode Island 02912, USA
    J Nerv Ment Dis 193:223-30. 2005
    ..Although this was not a prevalence study, results indicate a very low occurrence of MAD across 15 primary care settings. Further, they indicate that this diagnosis may not be stable across time and raise doubts about its utility...
  17. pmc Influence of psychiatric comorbidity on recovery and recurrence in generalized anxiety disorder, social phobia, and panic disorder: a 12-year prospective study
    Steven E Bruce
    Department of Psychiatry and Human Behavior, Brown University, RI 02906, USA
    Am J Psychiatry 162:1179-87. 2005
    ....
  18. doi request reprint Characteristics and predictors of social phobia course in a longitudinal study of primary-care patients
    Courtney Beard
    Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02912, USA
    Depress Anxiety 27:839-45. 2010
    ..To date, few researchers have examined the natural course of SP in primary care. We examined the natural course and predictors of recovery in a large sample of primary-care patients...
  19. ncbi request reprint Psychiatric treatment in primary care patients with anxiety disorders: a comparison of care received from primary care providers and psychiatrists
    Risa B Weisberg
    Department of Psychiatry, Brown University, Providence, RI 02096, USA
    Am J Psychiatry 164:276-82. 2007
    ..This study examined psychiatric treatment received by primary care patients with anxiety disorders and compared treatment received from primary care physicians and from psychiatrists...
  20. pmc Health-related Quality of Life across the anxiety disorders: findings from a sample of primary care patients
    Courtney Beard
    Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, RI 02912, USA
    J Anxiety Disord 24:559-64. 2010
    ..The current study extends previous research by showing that different anxiety disorders and comorbid conditions may be associated with impairment in specific domains of HR-QoL...
  21. pmc Psychometric properties of the Liebowitz Social Anxiety Scale (LSAS) in a longitudinal study of African Americans with anxiety disorders
    Courtney Beard
    Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, USA
    J Anxiety Disord 25:722-6. 2011
    ..Overall, the LSAS performed similarly in our African American sample as in previous European American samples. Exploratory factor analyses are warranted to determine whether a better factor structure exists for African Americans...
  22. ncbi request reprint Psychosocial impairment and recurrence of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Compr Psychiatry 45:423-30. 2004
    ..In patients who have recovered from an episode of major depression, the presence of psychosocial impairment may help identify who is at increased risk of recurrence...
  23. ncbi request reprint Prevalence and impact of comorbid anxiety and bipolar disorder
    Martin B Keller
    Department of Psychiatry and Human Behavior, Butler Hospital, Providence, RI 02906, USA
    J Clin Psychiatry 67:5-7. 2006
    ..Because the degree to which anxiety impacts patients with bipolar disorder is not fully known, more information is needed about the relationship between bipolar disorder and anxiety...
  24. ncbi request reprint Issues in treatment-resistant depression
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA
    J Clin Psychiatry 66:5-12. 2005
    ..Electroconvulsive therapy and psychotherapy offer additional treatment strategies. New nonpharmacologic therapies are under investigation. Remission is the goal of treatment...
  25. doi request reprint Use of benzodiazepines and selective serotonin reuptake inhibitors in middle-aged and older adults with anxiety disorders: a longitudinal and prospective study
    Carlos Israel Pérez Benítez
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA
    Am J Geriatr Psychiatry 16:5-13. 2008
    ....
  26. ncbi request reprint Are benzodiazepines still the medication of choice for patients with panic disorder with or without agoraphobia?
    Steven E Bruce
    Brown University, Providence, RI 02906, USA
    Am J Psychiatry 160:1432-8. 2003
    ..The authors examined how the use of psychotropic drugs has shifted over the course of 10 years to determine if prescribing patterns have changed to reflect these revised treatment guidelines...
  27. doi request reprint The relationship between sleep disturbance and the course of anxiety disorders in primary care patients
    Brook A Marcks
    Warren Alpert School of Medicine at Brown University, Department of Psychiatry and Human Behavior, Providence, RI 02912, USA
    Psychiatry Res 178:487-92. 2010
    ..The findings suggest that sleep disturbance in PTSD may have prognostic significance and may be important to address in clinical interventions...
  28. ncbi request reprint The long-term clinical course of generalized anxiety disorder
    Martin B Keller
    Department of Psychiatry, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 63:11-6. 2002
    ....
  29. pmc Factor structure and stability of the Anxiety Sensitivity Index in a longitudinal study of anxiety disorder patients
    Benjamin F Rodriguez
    Brown University Medical School, Department of Psychiatry and Human Behavior, Box G BH Duncan Building, Providence RI 02912, USA
    Behav Res Ther 42:79-91. 2004
    ..The theoretical implications of these findings for future evaluations of anxiety sensitivity are discussed...
  30. pmc Empirical typology of bipolar I mood episodes
    David A Solomon
    Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence, Rhode Island 02903 4970, USA
    Br J Psychiatry 195:525-30. 2009
    ..Much remains unknown about the phenomenology of bipolar I disorder...
  31. pmc Irritability and elation in a large bipolar youth sample: relative symptom severity and clinical outcomes over 4 years
    Jeffrey I Hunt
    Department of Psychiatry and Human Behavior, Emma Pendleton Bradley Hospital, Providence, RI, USA
    J Clin Psychiatry 74:e110-7. 2013
    ....
  32. pmc The clinical course of body dysmorphic disorder in the Harvard/Brown Anxiety Research Project (HARP)
    Andri S Bjornsson
    Rhode Island Hospital, Coro Center West, 1 Hoppin St, Providence, RI 02903, USA
    J Nerv Ment Dis 199:55-7. 2011
    ..14 over the 8 years. In conclusion, among individuals ascertained for anxiety disorders, the probability of recovering from BDD was relatively high and probability of BDD recurrence was low...
  33. doi request reprint Psychiatric treatment received by primary care patients with panic disorder with and without agoraphobia
    Brook A Marcks
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Box G BH, Duncan Bldg, Providence, RI 02912, USA
    Psychiatr Serv 60:823-30. 2009
    ....
  34. ncbi request reprint The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases
    Martin B Keller
    Brown University, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1371-9. 2007
    ..We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment...
  35. ncbi request reprint Social and health functioning in female primary care patients with post-traumatic stress disorder with and without comorbid substance abuse
    Caron Zlotnick
    Butler Hospital, Providence, RI, USA
    Compr Psychiatry 44:177-83. 2003
    ..These findings suggest that the presence of comorbid SUD may not explain the level of social and health difficulties associated with the dual diagnosis of PTSD and SUD...
  36. ncbi request reprint Relapse prevention with gepirone ER in outpatients with major depression
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychopharmacol 25:79-84. 2005
    ..In conclusion, gepirone ER at a dose range of 40 to 80 mg/d is effective for relapse prevention in patients with recurrent major depression. It is well tolerated during long-term treatment for up to approximately one year...
  37. ncbi request reprint Remission versus response: the new gold standard of antidepressant care
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    J Clin Psychiatry 65:53-9. 2004
    ..This dynamic is reinforced via the integration of current best therapeutic thinking in research settings, leading to clinical trials that more closely approximate an ideal, remission-focused treatment regimen...
  38. doi request reprint Key considerations in choosing an antidepressant
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02912, USA
    Postgrad Med 114:10-8. 2003
    ..Thus, it is critical to stay up to date with the best therapeutic approach, while remaining flexible as new therapies are developed...
  39. ncbi request reprint Rationale and options for the long-term treatment of depression
    Martin B Keller
    Brown University, Providence, Rhode Island 02906 4871, USA
    Hum Psychopharmacol 17:S43-6. 2002
    ..It is also well tolerated over prolonged periods. It should therefore prove suitable for use as maintenance treatment in depressed patients...
  40. ncbi request reprint Improving the course of illness and promoting continuation of treatment of bipolar disorder
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02906, USA
    J Clin Psychiatry 65:10-4. 2004
    ..Physicians can help improve adherence by selecting medications with simple dosage regimens and educating patients and families about the disorder and what to expect from medications...
  41. ncbi request reprint Nonpsychiatric illness among primary care patients with trauma histories and posttraumatic stress disorder
    Risa B Weisberg
    Department of Psychiatry and Human Behavior at Brown University in Providence, Rhode Island 02912, USA
    Psychiatr Serv 53:848-54. 2002
    ..The authors examined the relationship between posttraumatic stress disorder (PTSD), trauma, and self-reported nonpsychiatric medical conditions in a sample of 502 primary care patients with one or more anxiety disorders...
  42. ncbi request reprint Past, present, and future directions for defining optimal treatment outcome in depression: remission and beyond
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, RI 02906, USA
    JAMA 289:3152-60. 2003
    ..Until then, remission should continue to be based on the descriptive and experiential phenomena of symptoms and psychosocial functioning...
  43. ncbi request reprint Long-term treatment of patients with recurrent unipolar major depression: evidence to clinical practice
    Martin B Keller
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    CNS Spectr 11:4-5. 2006
  44. ncbi request reprint Short-term diagnostic stability of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders
    M Tracie Shea
    Department of Psychiatry and Human Behavior, Brown University Medical School, Duncan Building, 700 Butler Drive, Providence, RI 20906, USA
    Am J Psychiatry 159:2036-41. 2002
    ..This study prospectively examined the stability of four personality disorders (schizotypal, borderline, avoidant, and obsessive-compulsive) over a 1-year follow-up period...
  45. ncbi request reprint Do panic symptoms during periods of remission predict relapse of panic disorder?
    Risa B Weisberg
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, 02912, USA
    J Nerv Ment Dis 190:190-7. 2002
    ..Thus, although panic symptoms during remission may indicate an increased risk of subsequent relapse, the absence of symptoms during remission does not indicate that relapse is unlikely...
  46. ncbi request reprint The course of depression in elderly patients
    Timothy I Mueller
    Brown University Medical School, Department of Psychiatry and Human Behavior, c o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Am J Geriatr Psychiatry 12:22-9. 2004
    ..Studies on the course of major depressive disorder (MDD) among elderly persons are limited to short periods of follow-up, seldom provide comparisons with younger cohorts, and raise other methodological concerns...
  47. ncbi request reprint Paroxetine treatment of major depressive disorder
    Martin B Keller
    Department of Psychiatry, Brown University, Providence, RI 02906, USA
    Psychopharmacol Bull 37:42-52. 2003
    ....
  48. pmc Chronic forms of major depression are still undertreated in the 21st century: systematic assessment of 801 patients presenting for treatment
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    J Affect Disord 110:55-61. 2008
    ..These results and the consistency of similar results over time point to the dire need for patient and provider education regarding the signs and symptoms of depression and its treatment...
  49. pmc Substance use disorders among adolescents with bipolar spectrum disorders
    Benjamin I Goldstein
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 10:469-78. 2008
    ..We set out to examine the prevalence and correlates of substance use disorders (SUD) in a large sample of adolescents with bipolar disorder (BP)...
  50. ncbi request reprint Chronicity, relapse, and illness--course of panic disorder, social phobia, and generalized anxiety disorder: findings in men and women from 8 years of follow-up
    Kimberly A Yonkers
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06510, USA
    Depress Anxiety 17:173-9. 2003
    ..It may be that sex differences in the clinical course of anxiety disorders hold prognostic implications for patients with these illnesses...
  51. ncbi request reprint Chronic depression and comorbid personality disorders: response to sertraline versus imipramine
    James M Russell
    Department of Psychiatry and Behavioral Sciences, The University of Texas Medical Branch at Galveston, 77555, USA
    J Clin Psychiatry 64:554-61. 2003
    ..Few studies, though, have systematically examined the clinical correlates of Axis II personality disorder comorbidity or its effect on treatment response or time to response...
  52. ncbi request reprint A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness
    Andrew C Leon
    NIMH Collaborative Program on the Psychobiology of Depression, USA
    Am J Psychiatry 160:727-33. 2003
    ..This observational study examined the effectiveness of somatic antidepressant treatments as administered in the community...
  53. ncbi request reprint Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combination
    John Zajecka
    Department of Psychiatry, Rush Presbyterian St Luke s Medical Center, 1725 W Harrison Street, Suite 955, Chicago, IL 60612, USA
    J Clin Psychiatry 63:709-16. 2002
    ..This study compares the effects of antidepressant medication, psychotherapy, and combined treatment on sexual interest/satisfaction and function in patients with chronic major depression...
  54. ncbi request reprint A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Arch Gen Psychiatry 60:261-9. 2003
    ..This is the first prospective longitudinal study, to our knowledge, of the natural history of the weekly symptomatic status of bipolar II disorder (BP-II)...
  55. ncbi request reprint The comparative clinical phenotype and long term longitudinal episode course of bipolar I and II: a clinical spectrum or distinct disorders?
    Lewis L Judd
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, USA
    J Affect Disord 73:19-32. 2003
    ....
  56. ncbi request reprint Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213 2593, USA
    J Clin Psychiatry 63:493-500. 2002
    ..As nefazodone-mediated blockade of serotonin-2 receptors may directly relieve insomnia associated with depression, we examined the more specific effects of CBASP and nefazodone, singly and in combination, on sleep disturbances...
  57. ncbi request reprint The long-term natural history of the weekly symptomatic status of bipolar I disorder
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 59:530-7. 2002
    ..To our knowledge, this is the first prospective natural history study of weekly symptomatic status of patients with bipolar I disorder (BP-I) during long-term follow-up...
  58. ncbi request reprint Symptomatic and syndromal anxiety in chronic forms of major depression: effect of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination
    Philip T Ninan
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30329, USA
    J Clin Psychiatry 63:434-41. 2002
    ....
  59. ncbi request reprint Personality disorders and time to remission in generalized anxiety disorder, social phobia, and panic disorder
    Ann O Massion
    Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Arch Gen Psychiatry 59:434-40. 2002
    ..This investigation assessed the effect of personality disorders (PersDs) on time to remission in patients with generalized anxiety disorder, social phobia, or panic disorder...
  60. ncbi request reprint Clinical use of nefazodone in major depression: a 6-year perspective
    Alan F Schatzberg
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Calif 94305 5717, USA
    J Clin Psychiatry 63:18-31. 2002
  61. ncbi request reprint Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression
    Alan J Gelenberg
    Department of Psychiatry, Health Sciences Center, University of Arizona, PO Box 245002, Tucson, AZ 85724 5002, USA
    Biol Psychiatry 54:806-17. 2003
    ..This randomized, placebo-controlled study of the efficacy and safety of nefazodone in preventing recurrence was conducted for patients with chronic MDD...
  62. pmc Results of a naturalistic longitudinal study of benzodiazepine and SSRI use in the treatment of generalized anxiety disorder and social phobia
    Russell G Vasile
    Beth Israel Deaconess Medical Center, Boston, Massachusetts
    Depress Anxiety 22:59-67. 2005
    ..Difficulties in the implementation of treatment guidelines are discussed...
  63. pmc Long-term use of benzodiazepines in participants with comorbid anxiety and alcohol use disorders
    Timothy I Mueller
    Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Department of Psychiatry, Tucson, Arizona 85723, USA
    Alcohol Clin Exp Res 29:1411-8. 2005
    ..Earlier research showed that the use of benzodiazepines was not significantly associated with the presence or absence of a history of an AUD over the first year of follow-up. This report extends that investigation...
  64. ncbi request reprint Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 62:1322-30. 2005
    ..Evidence of psychosocial disability in bipolar disorder is based primarily on bipolar I disorder (BP-I) and does not relate disability to affective symptom severity and polarity or to bipolar II disorder (BP-II)...
  65. ncbi request reprint Self-reported depressive symptom measures: sensitivity to detecting change in a randomized, controlled trial of chronically depressed, nonpsychotic outpatients
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
    Neuropsychopharmacology 30:405-16. 2005
    ..Global patient ratings such as the PGI-I, as opposed to specific item-based ratings, provide less valid findings...
  66. ncbi request reprint Untangling depression and anxiety: clinical challenges
    Martin B Keller
    J Clin Psychiatry 66:1477-84. 2005
  67. ncbi request reprint Relationships among psychosocial functioning, diagnostic comorbidity, and the recurrence of generalized anxiety disorder, panic disorder, and major depression
    Benjamin F Rodriguez
    Department of Psychology, Southern Illinois University, Life Sciences II Room 222A, Carbondale, IL 62901 6502, USA
    J Anxiety Disord 19:752-66. 2005
    ..The Journal of Nervous and Mental Disease, 188, 805-812], and suggest that increased psychosocial impairment may be a risk factor for relapse...
  68. pmc Characteristics and predictors of full and partial recovery from generalized anxiety disorder in primary care patients
    Benjamin F Rodriguez
    Department of Psychology, Southern Illinois University at Carbondale, Carbondale, IL 62901 6502, USA
    J Nerv Ment Dis 194:91-7. 2006
    ..These results underscore that GAD is a chronic and persistent illness in primary care patients...
  69. ncbi request reprint The effectiveness of St. John's Wort in major depressive disorder: a naturalistic phase 2 follow-up in which nonresponders were provided alternate medication
    Alan J Gelenberg
    University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    J Clin Psychiatry 65:1114-9. 2004
    ..A continuation study of an extract of St. John's wort (Hypericum perforatum) for depression was performed in follow-up to an acute study that found no significant difference between St. John's wort extract and placebo...
  70. pmc Frequency and patterns of psychiatric comorbidity in a sample of primary care patients with anxiety disorders
    Benjamin F Rodriguez
    Department of Psychology, Southern Illinois University Carbondale, Life Science II, Room 281, Mailcode 6502, Carbondale, IL 62901, USA
    Compr Psychiatry 45:129-37. 2004
    ..2001). Implications of these results for both the mental health and primary care fields are also discussed...
  71. ncbi request reprint Placebo-controlled continuation treatment with mirtazapine: acute pattern of response predicts relapse
    Andrew A Nierenberg
    Havard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuropsychopharmacology 29:1012-8. 2004
    ..The low relapse rate for patients with an acute placebo pattern switched to placebo suggests specific drug effect played a smaller role in their initial improvement...
  72. ncbi request reprint Group comparisons of DSM-IV subtypes of chronic depression: validity of the distinctions, part 2
    James P McCullough
    Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284 2018, USA
    J Abnorm Psychol 112:614-22. 2003
    ..The authors suggest that chronic depression should be viewed as a single, broad condition that can assume a variety of clinical course configurations...
  73. ncbi request reprint Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States
    Charles B Nemeroff
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
    Arch Gen Psychiatry 64:466-72. 2007
    ....
  74. ncbi request reprint Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10012, USA
    J Clin Psychiatry 68:1014-23. 2007
    ..To test the long-term efficacy and safety of venlafaxine extended-release (ER) in preventing recurrence in patients with major depression...
  75. ncbi request reprint Therapeutic alliance in depression treatment: controlling for prior change and patient characteristics
    Daniel N Klein
    Department of Psychology and Psychiatry, State University of New York at Stony Brook, 11794 2500, USA
    J Consult Clin Psychol 71:997-1006. 2003
    ..Patients receiving combination treatment reported stronger alliances with their psychotherapists than patients receiving CBASP alone. However, the impact of the alliance on outcome was similar for both treatment conditions...
  76. pmc Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
    ..Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma...
  77. ncbi request reprint Predictors of treatment utilization among women with anorexia and bulimia nervosa
    Pamela K Keel
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 159:140-2. 2002
    ..The authors sought predictors of treatment utilization among women with eating disorders...