JULIE KAUER

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Addictive drugs and stress trigger a common change at VTA synapses
    Julie A Kauer
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuron 37:549-50. 2003
  2. pmc LTP of GABAergic synapses in the ventral tegmental area and beyond
    Fereshteh S Nugent
    Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, RI 02912, USA
    J Physiol 586:1487-93. 2008
  3. doi request reprint Hot flash: TRPV channels in the brain
    Julie A Kauer
    Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, RI 02912, USA
    Trends Neurosci 32:215-24. 2009
  4. ncbi request reprint Learning mechanisms in addiction: synaptic plasticity in the ventral tegmental area as a result of exposure to drugs of abuse
    Julie A Kauer
    Department of Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Physiol 66:447-75. 2004
  5. ncbi request reprint Opioids block long-term potentiation of inhibitory synapses
    Fereshteh S Nugent
    Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, Rhode Island 02912, USA
    Nature 446:1086-90. 2007
  6. ncbi request reprint Novel protein kinase A-dependent long-term depression of excitatory synapses
    Johanna L Gutlerner
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuron 36:921-31. 2002
  7. pmc Plasticity of addiction: a mesolimbic dopamine short-circuit?
    Jason L Niehaus
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Am J Addict 18:259-71. 2009
  8. ncbi request reprint Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection
    Lavina J Faleiro
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuropsychopharmacology 29:2115-25. 2004
  9. ncbi request reprint Repeated exposure to amphetamine disrupts dopaminergic modulation of excitatory synaptic plasticity and neurotransmission in nucleus accumbens
    Yong Li
    Department of Molecular Pharmacology, Physiology and Biotechnology MPPB, Brown University, Providence, Rhode Island 02912, USA
    Synapse 51:1-10. 2004
  10. ncbi request reprint Amphetamine depresses excitatory synaptic transmission at prefrontal cortical layer V synapses
    Robert D Mair
    Department of Molecular Pharmacology, Physiology and Biotechnology, Box G B4, Brown University, Providence, RI 02912, USA
    Neuropharmacology 52:193-9. 2007

Research Grants

Collaborators

  • Robert Malenka
  • Susan Jones
  • Michael Ehlers
  • Fereshteh S Nugent
  • Jason L Niehaus
  • Helen E Gibson
  • Robert D Mair
  • Jeffrey G Edwards
  • Esther C Penick
  • Yong Li
  • Lavina J Faleiro
  • Mikyoung Park
  • Johanna L Gutlerner
  • NELSON D CRUZ-BERMUDEZ
  • Rachel S Page
  • Alison R Hwong
  • Matthew J Van Hook
  • Yoko Udaka
  • Esther Chapin Penick
  • Eric M Snyder

Detail Information

Publications17

  1. ncbi request reprint Addictive drugs and stress trigger a common change at VTA synapses
    Julie A Kauer
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuron 37:549-50. 2003
    ..This common response may represent a starting point for dissecting early changes that underlie addiction...
  2. pmc LTP of GABAergic synapses in the ventral tegmental area and beyond
    Fereshteh S Nugent
    Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, RI 02912, USA
    J Physiol 586:1487-93. 2008
    ..Here we put this work into the context of other examples of synaptic plasticity at GABAergic synapses...
  3. doi request reprint Hot flash: TRPV channels in the brain
    Julie A Kauer
    Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, RI 02912, USA
    Trends Neurosci 32:215-24. 2009
    ..Here, we review evidence that TRPV channels in the central nervous system might contribute to many basic neuronal functions including resting membrane potential, neurotransmitter release and synaptic plasticity...
  4. ncbi request reprint Learning mechanisms in addiction: synaptic plasticity in the ventral tegmental area as a result of exposure to drugs of abuse
    Julie A Kauer
    Department of Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Physiol 66:447-75. 2004
    ..This review focuses on alterations in cellular and synaptic physiology in the ventral tegmental area (VTA) in response to addictive drugs...
  5. ncbi request reprint Opioids block long-term potentiation of inhibitory synapses
    Fereshteh S Nugent
    Brown University, Department of Molecular Pharmacology, Physiology and Biotechnology, Providence, Rhode Island 02912, USA
    Nature 446:1086-90. 2007
    ..These neuroadaptations to opioid drugs might contribute to early stages of addiction, and may potentially be exploited therapeutically using drugs targeting GABA(A) receptors...
  6. ncbi request reprint Novel protein kinase A-dependent long-term depression of excitatory synapses
    Johanna L Gutlerner
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuron 36:921-31. 2002
    ..However, unlike the case for any previously described form of LTD, activation of cyclic AMP-dependent protein kinase (PKA) is necessary and sufficient to trigger LTD at synapses on VTA dopamine neurons...
  7. pmc Plasticity of addiction: a mesolimbic dopamine short-circuit?
    Jason L Niehaus
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Am J Addict 18:259-71. 2009
    ..Innovative treatments directly targeting these drug-induced changes in brain reward components and circuits may be efficacious in reducing drug use and relapse...
  8. ncbi request reprint Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection
    Lavina J Faleiro
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuropsychopharmacology 29:2115-25. 2004
    ..We conclude that amphetamine induces rapid changes in synaptic AMPAR/NMDAR ratios, suggesting that potentiation of glutamatergic synapses is a relatively early event in the series of neuroadaptations in response to drugs of abuse...
  9. ncbi request reprint Repeated exposure to amphetamine disrupts dopaminergic modulation of excitatory synaptic plasticity and neurotransmission in nucleus accumbens
    Yong Li
    Department of Molecular Pharmacology, Physiology and Biotechnology MPPB, Brown University, Providence, Rhode Island 02912, USA
    Synapse 51:1-10. 2004
    ..Our results support the notion that after psychostimulant exposure, excitatory synapses on NAc neurons alter their response to further psychostimulant for long periods of time...
  10. ncbi request reprint Amphetamine depresses excitatory synaptic transmission at prefrontal cortical layer V synapses
    Robert D Mair
    Department of Molecular Pharmacology, Physiology and Biotechnology, Box G B4, Brown University, Providence, RI 02912, USA
    Neuropharmacology 52:193-9. 2007
    ..Dysregulation of this mechanism could contribute to the impairment in cognitive performance associated with abnormal PFC dopamine receptor activation...
  11. ncbi request reprint Synaptic plasticity and addiction
    Julie A Kauer
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Nat Rev Neurosci 8:844-58. 2007
    ..Reversing or preventing these drug-induced synaptic modifications may prove beneficial in the treatment of one of society's most intractable health problems...
  12. ncbi request reprint High-frequency afferent stimulation induces long-term potentiation of field potentials in the ventral tegmental area
    Fereshteh S Nugent
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuropsychopharmacology 33:1704-12. 2008
    ..Field potential recordings may provide a convenient approach to explore the basic electrophysiological properties of VTA neurons and the development of addiction-related processes in this brain region...
  13. pmc TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons
    Helen E Gibson
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuron 57:746-59. 2008
    ..Like other forms of hippocampal synaptic plasticity, TRPV1-mediated LTD may have a role in long-term changes in physiological and pathological circuit behavior during learning and epileptic activity...
  14. pmc PKG and PKA signaling in LTP at GABAergic synapses
    Fereshteh S Nugent
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Neuropsychopharmacology 34:1829-42. 2009
    ..Taken together, our data suggest a synapse-specific role for NO-cGMP-PKG signaling pathway in opioid-induced plasticity of VTA GABA(A) synapses...
  15. ncbi request reprint Recycling endosomes supply AMPA receptors for LTP
    Mikyoung Park
    Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
    Science 305:1972-5. 2004
    ..Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification...
  16. ncbi request reprint Inhibitory synapses turn exciting
    Julie A Kauer
    Nat Neurosci 8:257-8. 2005
  17. ncbi request reprint Neuroscience: a home for the nicotine habit
    Julie A Kauer
    Nature 436:31-2. 2005

Research Grants18

  1. Inhibitory Synaptic Transmission and Drugs of Abuse
    Julie A Kauer; Fiscal Year: 2010
    ..I expect our work to elucidate the cellular mechanisms by which opioid compounds alter the normal function of this brain area essential for normal reward processing. ..
  2. Glutamatergic Synapses on Hippocampal Interneurons
    JULIE KAUER; Fiscal Year: 2007
    ..This work will provide insight into the proteins and signaling molecules required for regulation of normal synaptic transmission and plasticity at CNS excitatory synapses. ..
  3. Inhibitory Synaptic Transmission and Drugs of Abuse
    JULIE KAUER; Fiscal Year: 2007
    ..I expect our work to elucidate the cellular mechanisms by which opioid compounds alter the normal function of this brain area essential for normal reward processing. ..
  4. Synaptic plasticity in the VTA studied in vivo
    JULIE KAUER; Fiscal Year: 2004
    ..We expect that the proposed studies will confirm our in vitro work, and provide important new leads to use in that work. ..
  5. GLUTAMATE SYNAPSES IN SENSITIZATION TO DRUGS OF ABUSE
    JULIE KAUER; Fiscal Year: 2004
    ..We will continue using electrophysiological methods to examine the effects of amphetamine on neurons in the VTA slice preparation. ..
  6. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010
    ..Here we will explore the novel hypothesis that TRPV1 contributes to hippocampal excitability, and could represent a novel therapeutic target for epileptic seizures. ..