Agnes Kane

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Non-neoplastic and neoplastic pleural endpoints following fiber exposure
    V Courtney Broaddus
    University of California, San Francisco, San Francisco, California, USA
    J Toxicol Environ Health B Crit Rev 14:153-78. 2011
  2. pmc XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole
    Jodie R Pietruska
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Environ Health Perspect 118:1707-13. 2010
  3. pmc A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials
    Vanesa C Sanchez
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Part Fibre Toxicol 8:17. 2011
  4. doi request reprint Nanotoxicology: the asbestos analogy revisited
    Agnes B Kane
    Brown University, Providence, Rhode Island 02912, USA
    Nat Nanotechnol 3:378-9. 2008
  5. ncbi request reprint Animal models of malignant mesothelioma
    Agnes B Kane
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Inhal Toxicol 18:1001-4. 2006
  6. ncbi request reprint Accelerated progression of asbestos-induced mesotheliomas in heterozygous p53+/- mice
    Charles A Vaslet
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Toxicol Sci 68:331-8. 2002
  7. pmc SDF1/CXCL12 is involved in recruitment of stem-like progenitor cells to orthotopic murine malignant mesothelioma spheroids
    Bonnie W Lau
    Department of Pathology and Laboratory Medicine, Brown University, Box G 8235, Providence, RI 02912, USA
    Anticancer Res 30:2153-60. 2010
  8. doi request reprint Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma
    Nathan R Miselis
    Department of Pathology and Laboratory Medicine, Brown University, Box G E531, Providence, RI 02912, USA
    Mol Cancer Ther 7:788-99. 2008
  9. ncbi request reprint SV40 oncoproteins enhance asbestos-induced DNA double-strand breaks and abrogate senescence in murine mesothelial cells
    Jodie R Pietruska
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Cancer Res 67:3637-45. 2007
  10. pmc Adsorption of essential micronutrients by carbon nanotubes and the implications for nanotoxicity testing
    Lin Guo
    Division of Engineering Brown University, Providence, RI 02912, USA
    Small 4:721-7. 2008

Collaborators

  • Nathan R Miselis
  • Bonnie W Lau
  • Nico Van Rooijen
  • Andrea McClatchey
  • Brooke T Mossman
  • Maria E Ramos-Nino
  • Jodie R Pietruska
  • Vanesa C Sanchez
  • Deborah A Altomare
  • Robert H Hurt
  • V Courtney Broaddus
  • Charles A Vaslet
  • Aihui Yan
  • Lin Guo
  • Kristine L Skele
  • Suresh C Jhanwar
  • Assunta De Rienzo
  • Joseph R Testa
  • Zheng Long Yuan
  • Jeffrey I Everitt
  • Paula Weston
  • Brad Black
  • Anatoly Zhitkovich
  • Tatiana Johnston
  • Annette von dem Bussche
  • Michelle Buechner
  • Guang Hui Xiao
  • Huihong You
  • Karthik Devarajan
  • Wenyi Wei
  • Y Eugene Chin
  • Lijuan Wang
  • Ying jie Guan
  • Norma J Messier

Detail Information

Publications15

  1. pmc Non-neoplastic and neoplastic pleural endpoints following fiber exposure
    V Courtney Broaddus
    University of California, San Francisco, San Francisco, California, USA
    J Toxicol Environ Health B Crit Rev 14:153-78. 2011
    ..Gaps in our understanding have been outlined as guides for future research...
  2. pmc XRCC1 deficiency sensitizes human lung epithelial cells to genotoxicity by crocidolite asbestos and Libby amphibole
    Jodie R Pietruska
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Environ Health Perspect 118:1707-13. 2010
    ..Polymorphisms in XRCC1 have been associated with altered susceptibility to asbestos-related diseases. However, it is unclear whether oxidative DNA damage repaired by XRCC1 contributes to asbestos-induced chromosomal damage...
  3. pmc A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials
    Vanesa C Sanchez
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Part Fibre Toxicol 8:17. 2011
    ..We hypothesize that high aspect ratio nanomaterials will induce epithelioid granulomas in nonadherent macrophages in 3D cultures...
  4. doi request reprint Nanotoxicology: the asbestos analogy revisited
    Agnes B Kane
    Brown University, Providence, Rhode Island 02912, USA
    Nat Nanotechnol 3:378-9. 2008
  5. ncbi request reprint Animal models of malignant mesothelioma
    Agnes B Kane
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Inhal Toxicol 18:1001-4. 2006
    ..This murine model of asbestos carcinogenesis recapitulates the molecular and histopathological features of the human disease and has significant implications for preclinical testing of novel preventive or therapeutic modalities...
  6. ncbi request reprint Accelerated progression of asbestos-induced mesotheliomas in heterozygous p53+/- mice
    Charles A Vaslet
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Toxicol Sci 68:331-8. 2002
    ..As solid tumors develop, spontaneous loss of the wild-type allele accompanied by decreased apoptosis and genetic instability is associated with accelerated tumor growth, invasion, and lymphatic dissemination...
  7. pmc SDF1/CXCL12 is involved in recruitment of stem-like progenitor cells to orthotopic murine malignant mesothelioma spheroids
    Bonnie W Lau
    Department of Pathology and Laboratory Medicine, Brown University, Box G 8235, Providence, RI 02912, USA
    Anticancer Res 30:2153-60. 2010
    ..We found stem cells are recruited to malignant mesothelioma spheroids. We aimed to determine if stem cell recruitment depends on the chemokine SDF1, and if inhibition of the cognate receptor CXCR4 affects tumor growth...
  8. doi request reprint Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma
    Nathan R Miselis
    Department of Pathology and Laboratory Medicine, Brown University, Box G E531, Providence, RI 02912, USA
    Mol Cancer Ther 7:788-99. 2008
    ..p. injection. These reductions in tumor burden are statistically significant and identify TAMs as an important host-derived cell that contributes to growth, invasion, and metastasis in diffuse malignant peritoneal mesothelioma...
  9. ncbi request reprint SV40 oncoproteins enhance asbestos-induced DNA double-strand breaks and abrogate senescence in murine mesothelial cells
    Jodie R Pietruska
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Cancer Res 67:3637-45. 2007
    ..SV40 virus may contribute to mesothelioma progression by impairing stress-induced senescence, in part through p53 inactivation, thereby favoring survival and proliferation of mesothelial cells that have sustained DNA damage...
  10. pmc Adsorption of essential micronutrients by carbon nanotubes and the implications for nanotoxicity testing
    Lin Guo
    Division of Engineering Brown University, Providence, RI 02912, USA
    Small 4:721-7. 2008
  11. pmc Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?
    Vanesa C Sanchez
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:511-29. 2009
    ....
  12. pmc Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells
    Zheng Long Yuan
    Department of Surgery Science, Brown University School of Medicine Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Mol Cell Biol 24:9390-400. 2004
    ..These findings provide insight into Thr(p+1loop) residue in RTK autophosphorylation and constitutive activation of STAT3 in metastatic cancer cells...
  13. ncbi request reprint A mouse model recapitulating molecular features of human mesothelioma
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 65:8090-5. 2005
    ....
  14. ncbi request reprint Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Oncogene 24:6080-9. 2005
    ..These findings also suggest that mouse models of MM may be useful for future preclinical studies of pharmaceuticals targeting the PI3K/AKT pathway...
  15. ncbi request reprint Asbestos bodies: clues to the mechanism of asbestos toxicity?
    Agnes B Kane
    Hum Pathol 34:735-6. 2003

Research Grants27

  1. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2003
    ..Pharmacologic modulation of persistent inflammation triggered by biopersistent, carcinogenic fibers may provide a new strategy to prevent progression of malignant mesothelioma in exposed populations. ..
  2. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2004
    ..Pharmacologic modulation of persistent inflammation triggered by biopersistent, carcinogenic fibers may provide a new strategy to prevent progression of malignant mesothelioma in exposed populations. ..
  3. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2005
    ..Pharmacologic modulation of persistent inflammation triggered by biopersistent, carcinogenic fibers may provide a new strategy to prevent progression of malignant mesothelioma in exposed populations. ..
  4. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2006
    ..Pharmacologic modulation of persistent inflammation triggered by biopersistent, carcinogenic fibers may provide a new strategy to prevent progression of malignant mesothelioma in exposed populations. ..
  5. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2007
    ..Pharmacologic modulation of persistent inflammation triggered by biopersistent, carcinogenic fibers may provide a new strategy to prevent progression of malignant mesothelioma in exposed populations. ..
  6. TRAINING IN ENVIRONMENTAL PATHOLOGY
    Agnes Kane; Fiscal Year: 2007
    ..Dr. Agnes Kane MD/PhD has acted as Director of the program since its inception and the Co-Director is Dr...
  7. Chemical, Structural, and Superstructural Determinants of Nanocarbon Toxicity
    Agnes Kane; Fiscal Year: 2007
    ..Identification of specific chemical and physical properties of nanomaterials responsible for cellular toxicity will enable development of manufacturing methods and post processing steps to eliminate intrinsic toxicity. ..
  8. Chemical, Structural, and Superstructural Determinants of Nanocarbon Toxicity
    Agnes Kane; Fiscal Year: 2009
    ..Identification of specific chemical and physical properties of nanomaterials responsible for cellular toxicity will enable development of manufacturing methods and post processing steps to eliminate intrinsic toxicity. ..
  9. Chemical, Structural, and Superstructural Determinants of Nanocarbon Toxicity
    Agnes Kane; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This research will lead to rational material design strategies for manufacturing of carbon nanotubes with minimal adverse human health impact. ..
  10. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2001
    ....
  11. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 2000
    ....
  12. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 1992
    ..These experiments may lead to a rational approach to delay or interrupt the sequence of events leading to the development of mesotheliomas in individuals exposed to asbestos...
  13. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 1999
    ....
  14. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 1990
    ..These experiments may lead to a rational approach to delay or interrupt the sequence of events leading to the development of mesotheliomas in individuals exposed to asbestos...
  15. PATHOGENESIS OF MESENCHYMAL TUMORS INDUCED BY ASBESTOS
    Agnes Kane; Fiscal Year: 1991
    ..These experiments may lead to a rational approach to delay or interrupt the sequence of events leading to the development of mesotheliomas in individuals exposed to asbestos...
  16. Chemical, Structural, and Superstructural Determinants of Nanocarbon Toxicity
    Agnes B Kane; Fiscal Year: 2010
    ..Identification of specific chemical and physical properties of nanomaterials responsible for cellular toxicity will enable development of manufacturing methods and post processing steps to eliminate intrinsic toxicity. ..