Gregory D Jay
Affiliation: Brown University
- The effect of phospholipase digestion upon the boundary lubricating ability of synovial fluidG D Jay
Department of Medicine, Brown University School of Medicine, Providence, Rhode Island, USA
J Rheumatol 26:2454-7. 1999..To identify the boundary lubricant in synovial fluid (SF). Is synovial lubrication mediated by surface active phospholipid as opposed to mucinous glycoprotein?..
- Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblastsG D Jay
Department of Medicine, Brown University School of Medicine, Providence, RI, USA
J Rheumatol 27:594-600. 2000..The boundary lubricating ability of human synovial fluid has been attributed to lubricin, a mucinous glycoprotein. We investigated the primary structure of lubricin and its cellular origin...
- Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transectionGregory D Jay
Brown University, Providence, Rhode Island, USA
Arthritis Rheum 64:1162-71. 2012....
- Association between friction and wear in diarthrodial joints lacking lubricinGregory D Jay
Brown University, Department of Emergency Medicine, Providence, Rhode Island 02903, USA
Arthritis Rheum 56:3662-9. 2007..In contrast to man-made bearings, mammalian diarthrodial joints must endogenously produce friction-reducing agents. This study was undertaken to investigate whether friction is associated with wear...
- Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transectionGregory D Jay
Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
Arthritis Rheum 62:2382-91. 2010....
- Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitisGregory D Jay
Department of Medicine, Brown University School of Medicine, Rhode Island 02903, USA
J Rheumatol 31:557-64. 2004..Loss of synovial fluid's (SF) lubricating ability has been implicated in the pathogenesis of degenerative joint disease...
- Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharidesG D Jay
Department of Medicine, Section of Emergency Medicine, Brown University School of Medicine, Providence, RI 02903, USA
Glycoconj J 18:807-15. 2001..4% of total beta(1-3)Gal-GalNAc sidechains following digestion with endo-alpha-N-acetyl-D-galactosaminidase. Biological boundary lubrication by synovial fluid in vitro is provided primarily by extensive O-linked beta(1-3)Gal-GalNAc...
- Analysis of physician ability in the measurement of pulsus paradoxus by sphygmomanometryG D Jay
Department of Medicine, Brown University School of Medicine, Providence, RI 02903, USA
Chest 118:348-52. 2000..It is one of only a few measures that is not effort dependent and therefore important in the evaluation of patients with asthma...
- Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25G D Jay
The Department of Medicine, Rhode Island Hospital, Providence 02903, USA
J Orthop Res 19:677-87. 2001..It is hypothesized that CAP, a large joint arthropathy, may be associated with ineffective boundary lubrication provided by synovial fluid...
- Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritisKhaled A Elsaid
Rhode Island Hospital, Providence, RI 02881, USA
Arthritis Rheum 56:108-16. 2007..To investigate the effect of arthritis development and progression on the integrity and function of lubricin and the relationship of lubricin to cartilage damage in a rat antigen-induced arthritis model...
- Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosisKimberly A Waller
Center for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912, USA
Proc Natl Acad Sci U S A 110:5852-7. 2013....
- Coefficients of friction, lubricin, and cartilage damage in the anterior cruciate ligament-deficient guinea pig kneeErin Teeple
Bioengineering Laboratory, Department of Orthopaedics, Brown Medical School Rhode Island Hospital, CORO West, Suite 404, 1 Hoppin Street, Providence, Rhode Island 02903, USA
J Orthop Res 26:231-7. 2008..01). No significant differences in COF or lubricin concentration were found between the no OA and mild OA knees. Histology verified the extent of cartilage damage in each group...
- Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat kneeErin Teeple
Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, USA
Am J Sports Med 39:164-72. 2011..Because lubricin loss occurs after anterior cruciate ligament injury, intra-articular lubricin injections may reduce cartilage damage in the anterior cruciate ligament-deficient knee...
- Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid and hylan G-F 20Kimberly A Waller
Department of Orthopedics, and Department of Emergency Medicine, Warren Alpert Medical School of Brown University Rhode Island Hospital, Providence, Rhode Island 02903, USA
J Rheumatol 39:1473-80. 2012..We investigated the effectiveness of hylan G-F 20 to lower coefficient of friction (COF) and prevent chondrocyte apoptosis in vitro...
- Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig modelLei Wei
Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
J Orthop Res 28:900-6. 2010..This study indicates that the biomarkers and progression of OA may differ in the Hartley guinea pig models with and without posttraumatic OA...
- Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse kneesElizabeth I Drewniak
Alpert Medical School of Brown University, Rhode Island Hospital Providence, Rhode Island 02903, USA
Arthritis Rheum 64:465-73. 2012..To investigate the effects of lubricin gene dosage and cyclic loading on whole joint coefficient of friction and articular cartilage surface integrity in mouse knee joints...
- Pendulum mass affects the measurement of articular friction coefficientMatthew R Akelman
Bioengineering Laboratory, Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA
J Biomech 46:615-8. 2013..In conclusion, inter-study comparisons of articular pendulum μ values should not be made without recognizing the loads used, as μ values are mass dependent...
- Comparison of two methods for calculating the frictional properties of articular cartilage using a simple pendulum and intact mouse knee jointsElizabeth I Drewniak
Department of Orthopaedics, Bioengineering Laboratory, The Warren Alpert Medical School of Brown University RIH, Providence, RI, USA
J Biomech 42:1996-9. 2009..The Exp mu model provided a more accurate fit to the experimental data for predicting the frictional properties of intact joints in pendulum systems...
- The role of lubricin in the mechanical behavior of synovial fluidG D Jay
Division of Engineering and Department of Emergency Medicine, Brown University, Providence, RI 02912, USA
Proc Natl Acad Sci U S A 104:6194-9. 2007..We conclude that lubricin provides synovial fluid with an ability to dissipate strain energy induced by mammalian locomotion, which is a chondroprotective feature that is distinct from boundary lubrication...
- Assuming exponential decay by incorporating viscous damping improves the prediction of the coefficient of friction in pendulum tests of whole articular jointsJ J Crisco
Bioengineering Laboratory, Department of Orthopaedics, Brown Medicine School Rhode Island Hospital, Providence, Rhode Island 02903, USA
Proc Inst Mech Eng H 221:325-33. 2007..The exponential decay function including both frictional and constant viscous damping presented herein dramatically increased the accuracy of measuring the COF in a pendulum test of modelled whole articular joints...
- Animal models of osteoarthritis: challenges of model selection and analysisErin Teeple
Department of Emergency Medicine, Brown Medical School Rhode Island Hospital, 1 Hoppin Street Coro West, Suite 106, Providence, Rhode Island, 02903, USA
AAPS J 15:438-46. 2013....
- Current thinking on viscosupplementation in osteoarthritisGregory D Jay
Brown Medical School, RI, USA
Med Health R I 87:213-5. 2004
- Diffuse reflectance spectra of the palpebral conjunctiva and its utility as a noninvasive indicator of total hemoglobinJohn W McMurdy
Brown University, Division of Engineering, Box D, Providence, Rhode Island 02906, USA
J Biomed Opt 11:014019. 2006....
- The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal modelK A Elsaid
Brown University, Providence, Rhode Island, USA
Arthritis Rheum 60:2997-3006. 2009....
- Frictional properties of Hartley guinea pig knees with and without proteolytic disruption of the articular surfacesE Teeple
Bioengineering Laboratory, Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, RI 02903, USA
Osteoarthritis Cartilage 15:309-15. 2007..To apply a pendulum technique to detect changes in the coefficient of friction of the articular cartilage of the intact guinea pig tibiofemoral joint after proteolytic disruption...
- Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injuryK A Elsaid
Rhode Island Hospital, Providence, RI 02903, USA
Arthritis Rheum 58:1707-15. 2008..To study the effect of anterior cruciate ligament (ACL) injury on lubricin concentrations in synovial fluid (SF) and its correlation with time postinjury, inflammatory cytokines, lubricin-degrading enzymes, and SF proteoglycan content...
- Altered levels and molecular forms of granzyme k in plasma from septic patientsMarijana Rucevic
Division of Hematology Oncology, Department of Medicine, Rhode Island Hospital Brown Medical School, East Providence, Rhode Island 02903, USA02903
Shock 27:488-93. 2007....
- Noninvasive optical, electrical, and acoustic methods of total hemoglobin determinationJohn W McMurdy
Division of Engineering, Brown University, Providence, RI 02912, USA
Clin Chem 54:264-72. 2008..Currently there is no universally accepted, clinically applicable, noninvasive hemoglobin/hematocrit screening tool. The need for such a device has prompted an investigation into a breadth of techniques...
- Continuous noninvasive measurement of pulsus paradoxus complements medical decision making in assessment of acute asthma severityJames Rayner
Department of Emergency Medicine, Brown Medical School, Providence, RI, USA
Chest 130:754-65. 2006..The ability of PP to categorize acutely asthmatic patients in accordance with the earlier National Asthma Education and Prevention Program (NAEPP) expert panel report 1 guidelines was determined...
- Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritisK A Elsaid
University of Rhode Island, Kingston, RI, USA
Arthritis Rheum 52:1746-55. 2005....
- Liquid-crystal materials find a new order in biomedical applicationsScott J Woltman
Department of Physics, Brown University, Providence, RI 02912, USA
Nat Mater 6:929-38. 2007..New areas of application in the realms of biology and medicine are stimulating innovation in basic and applied research into these materials...
- Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoproteinBruno Zappone
Materials Department and Materials Research Laboratory, University of California Santa Barbara, Santa Barbara, California, USA
Biophys J 92:1693-708. 2007..These results support recent suggestions that boundary lubrication and wear protection in articular joints are due to the presence of a biological polyelectrolyte on the cartilage surfaces...
- Lubricin surface modification improves extrasynovial tendon gliding in a canine model in vitroManabu Taguchi
Biomechanics Laboratory, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
J Bone Joint Surg Am 90:129-35. 2008..The purpose of this study was to investigate the effects of exogenously applied lubricin on the gliding of extrasynovial tendons in a canine model in vitro...
- Molecular aspects of boundary lubrication by human lubricin: effect of disulfide bonds and enzymatic digestionBruno Zappone
Centro di Eccellenza LiCryL, University of Calabria, Rende CS, Italy
Langmuir 24:1495-508. 2008..Our results suggest that this "end-anchoring" has to be strong enough to impart the layer a sufficient resistance to shear, but without excessively restricting the conformational freedom of the adsorbed proteins...
- In situ friction measurement on murine cartilage by atomic force microscopyJeffrey M Coles
Department of Mechanical Engineering and Materials Science, Duke University, 144 Hudson Hall, Box 90300, Durham, NC, USA
J Biomech 41:541-8. 2008..This measurement technique can be applied to future studies of cartilage friction and mechanical properties on genetically altered mice or other small animals...
- The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowthDavid K Rhee
Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Clin Invest 115:622-31. 2005..We conclude that lubricin has multiple functions in articulating joints and tendons that include the protection of surfaces and the control of synovial cell growth...
- Error reduction and performance improvement in the emergency department through formal teamwork training: evaluation results of the MedTeams projectJohn C Morey
Crew Performance Group, Dynamics Research Corporation, Andover, MA 01810, USA
Health Serv Res 37:1553-81. 2002..To evaluate the effectiveness of training and institutionalizing teamwork behaviors, drawn from aviation crew resource management (CRM) programs, on emergency department (ED) staff organized into caregiver teams...
- Expression and mapping of lubricin in canine flexor tendonYulong Sun
Orthopedic Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, Minnesota 55905, USA
J Orthop Res 24:1861-8. 2006..Lubricin is ubiquitous in the FDP tendon, with variations in distribution and splicing that appear to correspond to discrete anatomic locations that differ by mechanical or nutritional environment...
- Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfacesDebby P Chang
Department of Mechanical Engineering and Materials Science, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC 27708, USA
Langmuir 24:1183-93. 2008....
- Point-of-care noninvasive hemoglobin determination using fiber optic reflectance spectroscopyGregory D Jay
Warren Alpert Medical School of Brown University, RI 02912, USA
Conf Proc IEEE Eng Med Biol Soc 2007:2932-5. 2007....
- Lubricin reduces cartilage--cartilage integrationDirk B Schaefer
Departments of Surgery and of Research, University Hospital Basel, Switzerland
Biorheology 41:503-8. 2004..Our findings suggest that the synovial milieu, by providing lubrication of cartilage surfaces, impairs cartilage--cartilage integration...