Gregory D Jay

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint The effect of phospholipase digestion upon the boundary lubricating ability of synovial fluid
    G D Jay
    Department of Medicine, Brown University School of Medicine, Providence, Rhode Island, USA
    J Rheumatol 26:2454-7. 1999
  2. ncbi request reprint Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts
    G D Jay
    Department of Medicine, Brown University School of Medicine, Providence, RI, USA
    J Rheumatol 27:594-600. 2000
  3. pmc Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection
    Gregory D Jay
    Brown University, Providence, Rhode Island, USA
    Arthritis Rheum 64:1162-71. 2012
  4. pmc Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection
    Gregory D Jay
    Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    Arthritis Rheum 62:2382-91. 2010
  5. pmc Association between friction and wear in diarthrodial joints lacking lubricin
    Gregory D Jay
    Brown University, Department of Emergency Medicine, Providence, Rhode Island 02903, USA
    Arthritis Rheum 56:3662-9. 2007
  6. ncbi request reprint Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitis
    Gregory D Jay
    Department of Medicine, Brown University School of Medicine, Rhode Island 02903, USA
    J Rheumatol 31:557-64. 2004
  7. ncbi request reprint Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides
    G D Jay
    Department of Medicine, Section of Emergency Medicine, Brown University School of Medicine, Providence, RI 02903, USA
    Glycoconj J 18:807-15. 2001
  8. ncbi request reprint Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25
    G D Jay
    The Department of Medicine, Rhode Island Hospital, Providence 02903, USA
    J Orthop Res 19:677-87. 2001
  9. ncbi request reprint Analysis of physician ability in the measurement of pulsus paradoxus by sphygmomanometry
    G D Jay
    Department of Medicine, Brown University School of Medicine, Providence, RI 02903, USA
    Chest 118:348-52. 2000
  10. ncbi request reprint Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis
    Khaled A Elsaid
    Rhode Island Hospital, Providence, RI 02881, USA
    Arthritis Rheum 56:108-16. 2007

Collaborators

  • Khaled A Elsaid
  • Erin Teeple
  • B C Fleming
  • Ling Zhang
  • J J Crisco
  • Lei Wei
  • Leo Kobayashi
  • Selim Suner
  • Kyung Suk Kim
  • Junming Luo
  • Yow Pin Lim
  • John McMurdy
  • Marcel Jakob
  • Robert L Wears
  • Heikki J Helminen
  • Yao Qin Gong
  • Kimberly A Waller
  • Elizabeth I Drewniak
  • Bruno Zappone
  • Matthew L Warman
  • Jason T Machan
  • Matthew R Akelman
  • Rakan S Al-Rasheed
  • Jeffrey M Coles
  • Stefan Zauscher
  • Manabu Taguchi
  • Debby P Chang
  • Farshid Guilak
  • George W Greene
  • Jacob N Israelachvili
  • Kai Nan An
  • Chunfeng Zhao
  • Peter C Amadio
  • Scott J Woltman
  • Marijana Rucevic
  • James Rayner
  • Yulong Sun
  • David K Rhee
  • Dirk B Schaefer
  • John C Morey
  • Jennifer A Dunbar-Viveiros
  • Jeffrey Devine
  • Mark S Jones
  • Max Dannecker
  • Mark E Zobitz
  • Emin Oroudjev
  • Nehal I Abu-Lail
  • Chung Ja Cha
  • Jason J Blum
  • Yu Long Sun
  • Eric M Darling
  • Flor M Trespalcios
  • Gregory P Crawford
  • Loren D Fast
  • Andrew Sucov
  • Edward Siryaporn
  • Marina Ruths
  • Flor Trespalacios
  • Vijaya Potluri
  • George Brown
  • Evelyn J Berger
  • Linda M Quattrucci
  • Jason Machan
  • Matthew Stewart
  • Veronique Lefebvre
  • Hongwei Wang
  • MacArthur Baker
  • John D Carpten
  • Jose Marcelino
  • Patrick Smits
  • David Wendt
  • Michael Heberer
  • Matteo Moretti
  • Ivan Martin
  • Scott D Berns
  • Robert Simon
  • Kimberly A Dukes
  • Mary Salisbury

Detail Information

Publications42

  1. ncbi request reprint The effect of phospholipase digestion upon the boundary lubricating ability of synovial fluid
    G D Jay
    Department of Medicine, Brown University School of Medicine, Providence, Rhode Island, USA
    J Rheumatol 26:2454-7. 1999
    ..To identify the boundary lubricant in synovial fluid (SF). Is synovial lubrication mediated by surface active phospholipid as opposed to mucinous glycoprotein?..
  2. ncbi request reprint Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts
    G D Jay
    Department of Medicine, Brown University School of Medicine, Providence, RI, USA
    J Rheumatol 27:594-600. 2000
    ..The boundary lubricating ability of human synovial fluid has been attributed to lubricin, a mucinous glycoprotein. We investigated the primary structure of lubricin and its cellular origin...
  3. pmc Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection
    Gregory D Jay
    Brown University, Providence, Rhode Island, USA
    Arthritis Rheum 64:1162-71. 2012
    ....
  4. pmc Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection
    Gregory D Jay
    Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    Arthritis Rheum 62:2382-91. 2010
    ....
  5. pmc Association between friction and wear in diarthrodial joints lacking lubricin
    Gregory D Jay
    Brown University, Department of Emergency Medicine, Providence, Rhode Island 02903, USA
    Arthritis Rheum 56:3662-9. 2007
    ..In contrast to man-made bearings, mammalian diarthrodial joints must endogenously produce friction-reducing agents. This study was undertaken to investigate whether friction is associated with wear...
  6. ncbi request reprint Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitis
    Gregory D Jay
    Department of Medicine, Brown University School of Medicine, Rhode Island 02903, USA
    J Rheumatol 31:557-64. 2004
    ..Loss of synovial fluid's (SF) lubricating ability has been implicated in the pathogenesis of degenerative joint disease...
  7. ncbi request reprint Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides
    G D Jay
    Department of Medicine, Section of Emergency Medicine, Brown University School of Medicine, Providence, RI 02903, USA
    Glycoconj J 18:807-15. 2001
    ..4% of total beta(1-3)Gal-GalNAc sidechains following digestion with endo-alpha-N-acetyl-D-galactosaminidase. Biological boundary lubrication by synovial fluid in vitro is provided primarily by extensive O-linked beta(1-3)Gal-GalNAc...
  8. ncbi request reprint Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25
    G D Jay
    The Department of Medicine, Rhode Island Hospital, Providence 02903, USA
    J Orthop Res 19:677-87. 2001
    ..It is hypothesized that CAP, a large joint arthropathy, may be associated with ineffective boundary lubrication provided by synovial fluid...
  9. ncbi request reprint Analysis of physician ability in the measurement of pulsus paradoxus by sphygmomanometry
    G D Jay
    Department of Medicine, Brown University School of Medicine, Providence, RI 02903, USA
    Chest 118:348-52. 2000
    ..It is one of only a few measures that is not effort dependent and therefore important in the evaluation of patients with asthma...
  10. ncbi request reprint Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis
    Khaled A Elsaid
    Rhode Island Hospital, Providence, RI 02881, USA
    Arthritis Rheum 56:108-16. 2007
    ..To investigate the effect of arthritis development and progression on the integrity and function of lubricin and the relationship of lubricin to cartilage damage in a rat antigen-induced arthritis model...
  11. pmc Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis
    Kimberly A Waller
    Center for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 110:5852-7. 2013
    ....
  12. pmc Coefficients of friction, lubricin, and cartilage damage in the anterior cruciate ligament-deficient guinea pig knee
    Erin Teeple
    Bioengineering Laboratory, Department of Orthopaedics, Brown Medical School Rhode Island Hospital, CORO West, Suite 404, 1 Hoppin Street, Providence, Rhode Island 02903, USA
    J Orthop Res 26:231-7. 2008
    ..01). No significant differences in COF or lubricin concentration were found between the no OA and mild OA knees. Histology verified the extent of cartilage damage in each group...
  13. pmc Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee
    Erin Teeple
    Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, USA
    Am J Sports Med 39:164-72. 2011
    ..Because lubricin loss occurs after anterior cruciate ligament injury, intra-articular lubricin injections may reduce cartilage damage in the anterior cruciate ligament-deficient knee...
  14. pmc Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid and hylan G-F 20
    Kimberly A Waller
    Department of Orthopedics, and Department of Emergency Medicine, Warren Alpert Medical School of Brown University Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Rheumatol 39:1473-80. 2012
    ..We investigated the effectiveness of hylan G-F 20 to lower coefficient of friction (COF) and prevent chondrocyte apoptosis in vitro...
  15. pmc Animal models of osteoarthritis: challenges of model selection and analysis
    Erin Teeple
    Department of Emergency Medicine, Brown Medical School Rhode Island Hospital, 1 Hoppin Street Coro West, Suite 106, Providence, RI 02903, USA
    AAPS J 15:438-46. 2013
    ....
  16. pmc Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model
    Lei Wei
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Orthop Res 28:900-6. 2010
    ..This study indicates that the biomarkers and progression of OA may differ in the Hartley guinea pig models with and without posttraumatic OA...
  17. pmc Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse knees
    Elizabeth I Drewniak
    Alpert Medical School of Brown University, Rhode Island Hospital Providence, Rhode Island 02903, USA
    Arthritis Rheum 64:465-73. 2012
    ..To investigate the effects of lubricin gene dosage and cyclic loading on whole joint coefficient of friction and articular cartilage surface integrity in mouse knee joints...
  18. pmc Pendulum mass affects the measurement of articular friction coefficient
    Matthew R Akelman
    Bioengineering Laboratory, Department of Orthopaedics, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA
    J Biomech 46:615-8. 2013
    ..In conclusion, inter-study comparisons of articular pendulum μ values should not be made without recognizing the loads used, as μ values are mass dependent...
  19. pmc Comparison of two methods for calculating the frictional properties of articular cartilage using a simple pendulum and intact mouse knee joints
    Elizabeth I Drewniak
    Department of Orthopaedics, Bioengineering Laboratory, The Warren Alpert Medical School of Brown University RIH, Providence, RI, USA
    J Biomech 42:1996-9. 2009
    ..The Exp mu model provided a more accurate fit to the experimental data for predicting the frictional properties of intact joints in pendulum systems...
  20. pmc The role of lubricin in the mechanical behavior of synovial fluid
    G D Jay
    Division of Engineering and Department of Emergency Medicine, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 104:6194-9. 2007
    ..We conclude that lubricin provides synovial fluid with an ability to dissipate strain energy induced by mammalian locomotion, which is a chondroprotective feature that is distinct from boundary lubrication...
  21. ncbi request reprint Assuming exponential decay by incorporating viscous damping improves the prediction of the coefficient of friction in pendulum tests of whole articular joints
    J J Crisco
    Bioengineering Laboratory, Department of Orthopaedics, Brown Medicine School Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Proc Inst Mech Eng H 221:325-33. 2007
    ..The exponential decay function including both frictional and constant viscous damping presented herein dramatically increased the accuracy of measuring the COF in a pendulum test of modelled whole articular joints...
  22. ncbi request reprint Current thinking on viscosupplementation in osteoarthritis
    Gregory D Jay
    Brown Medical School, RI, USA
    Med Health R I 87:213-5. 2004
  23. ncbi request reprint Diffuse reflectance spectra of the palpebral conjunctiva and its utility as a noninvasive indicator of total hemoglobin
    John W McMurdy
    Brown University, Division of Engineering, Box D, Providence, Rhode Island 02906, USA
    J Biomed Opt 11:014019. 2006
    ....
  24. pmc Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury
    K A Elsaid
    Rhode Island Hospital, Providence, RI 02903, USA
    Arthritis Rheum 58:1707-15. 2008
    ..To study the effect of anterior cruciate ligament (ACL) injury on lubricin concentrations in synovial fluid (SF) and its correlation with time postinjury, inflammatory cytokines, lubricin-degrading enzymes, and SF proteoglycan content...
  25. pmc Frictional properties of Hartley guinea pig knees with and without proteolytic disruption of the articular surfaces
    E Teeple
    Bioengineering Laboratory, Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence, RI 02903, USA
    Osteoarthritis Cartilage 15:309-15. 2007
    ..To apply a pendulum technique to detect changes in the coefficient of friction of the articular cartilage of the intact guinea pig tibiofemoral joint after proteolytic disruption...
  26. pmc The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting tumor necrosis factor alpha on chondroprotection in an animal model
    K A Elsaid
    Brown University, Providence, Rhode Island, USA
    Arthritis Rheum 60:2997-3006. 2009
    ....
  27. ncbi request reprint Simulation intervention with manikin-based objective metrics improves CPR instructor chest compression performance skills without improvement in chest compression assessment skills
    Rakan S Al-Rasheed
    Department of Emergency Medicine, Brown University
    Simul Healthc 8:242-52. 2013
    ....
  28. ncbi request reprint Noninvasive optical, electrical, and acoustic methods of total hemoglobin determination
    John W McMurdy
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Clin Chem 54:264-72. 2008
    ..Currently there is no universally accepted, clinically applicable, noninvasive hemoglobin/hematocrit screening tool. The need for such a device has prompted an investigation into a breadth of techniques...
  29. ncbi request reprint Continuous noninvasive measurement of pulsus paradoxus complements medical decision making in assessment of acute asthma severity
    James Rayner
    Department of Emergency Medicine, Brown Medical School, Providence, RI, USA
    Chest 130:754-65. 2006
    ..The ability of PP to categorize acutely asthmatic patients in accordance with the earlier National Asthma Education and Prevention Program (NAEPP) expert panel report 1 guidelines was determined...
  30. ncbi request reprint Altered levels and molecular forms of granzyme k in plasma from septic patients
    Marijana Rucevic
    Division of Hematology Oncology, Department of Medicine, Rhode Island Hospital Brown Medical School, East Providence, Rhode Island 02903, USA02903
    Shock 27:488-93. 2007
    ....
  31. ncbi request reprint Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis
    K A Elsaid
    University of Rhode Island, Kingston, RI, USA
    Arthritis Rheum 52:1746-55. 2005
    ....
  32. ncbi request reprint Liquid-crystal materials find a new order in biomedical applications
    Scott J Woltman
    Department of Physics, Brown University, Providence, RI 02912, USA
    Nat Mater 6:929-38. 2007
    ..New areas of application in the realms of biology and medicine are stimulating innovation in basic and applied research into these materials...
  33. pmc The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005
    ..We conclude that lubricin has multiple functions in articulating joints and tendons that include the protection of surfaces and the control of synovial cell growth...
  34. pmc Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoprotein
    Bruno Zappone
    Materials Department and Materials Research Laboratory, University of California Santa Barbara, Santa Barbara, California, USA
    Biophys J 92:1693-708. 2007
    ..These results support recent suggestions that boundary lubrication and wear protection in articular joints are due to the presence of a biological polyelectrolyte on the cartilage surfaces...
  35. doi request reprint Lubricin surface modification improves extrasynovial tendon gliding in a canine model in vitro
    Manabu Taguchi
    Biomechanics Laboratory, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    J Bone Joint Surg Am 90:129-35. 2008
    ..The purpose of this study was to investigate the effects of exogenously applied lubricin on the gliding of extrasynovial tendons in a canine model in vitro...
  36. ncbi request reprint Molecular aspects of boundary lubrication by human lubricin: effect of disulfide bonds and enzymatic digestion
    Bruno Zappone
    Centro di Eccellenza LiCryL, University of Calabria, Rende CS, Italy
    Langmuir 24:1495-508. 2008
    ..Our results suggest that this "end-anchoring" has to be strong enough to impart the layer a sufficient resistance to shear, but without excessively restricting the conformational freedom of the adsorbed proteins...
  37. pmc In situ friction measurement on murine cartilage by atomic force microscopy
    Jeffrey M Coles
    Department of Mechanical Engineering and Materials Science, Duke University, 144 Hudson Hall, Box 90300, Durham, NC, USA
    J Biomech 41:541-8. 2008
    ..This measurement technique can be applied to future studies of cartilage friction and mechanical properties on genetically altered mice or other small animals...
  38. ncbi request reprint Point-of-care noninvasive hemoglobin determination using fiber optic reflectance spectroscopy
    Gregory D Jay
    Warren Alpert Medical School of Brown University, RI 02912, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:2932-5. 2007
    ....
  39. doi request reprint Conformational mechanics, adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces
    Debby P Chang
    Department of Mechanical Engineering and Materials Science, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC 27708, USA
    Langmuir 24:1183-93. 2008
    ....
  40. ncbi request reprint Expression and mapping of lubricin in canine flexor tendon
    Yulong Sun
    Orthopedic Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Orthop Res 24:1861-8. 2006
    ..Lubricin is ubiquitous in the FDP tendon, with variations in distribution and splicing that appear to correspond to discrete anatomic locations that differ by mechanical or nutritional environment...
  41. pmc Error reduction and performance improvement in the emergency department through formal teamwork training: evaluation results of the MedTeams project
    John C Morey
    Crew Performance Group, Dynamics Research Corporation, Andover, MA 01810, USA
    Health Serv Res 37:1553-81. 2002
    ..To evaluate the effectiveness of training and institutionalizing teamwork behaviors, drawn from aviation crew resource management (CRM) programs, on emergency department (ED) staff organized into caregiver teams...
  42. ncbi request reprint Lubricin reduces cartilage--cartilage integration
    Dirk B Schaefer
    Departments of Surgery and of Research, University Hospital Basel, Switzerland
    Biorheology 41:503-8. 2004
    ..Our findings suggest that the synovial milieu, by providing lubrication of cartilage surfaces, impairs cartilage--cartilage integration...