Research Topics
| E Andres HousemanSummaryAffiliation: Brown University Country: USA Publications
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Detail Information
Publications
Copy number variation has little impact on bead-array-based measures of DNA methylationE Andres Houseman
Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
Bioinformatics 25:1999-2005. 2009..However, copy number variation may bias the measurement of DNA methylation. To investigate possible bias, we analyzed integrated data obtained from 19 head and neck squamous cell carcinoma (HNSCC) tumors and 23 mesothelioma tumors...- Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinomaCarmen J Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
Carcinogenesis 30:416-22. 2009..We found that the etiologic heterogeneity of HNSCC is reflected in specific patterns of molecular epigenetic alterations within the tumors and that the DNA methylation profiles may hold clinical promise worthy of further study... - Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesotheliomaBrock C Christensen
Departments of Pathology and Laboratory Medicine, Community Health, Center for Environmental Health and Technology, and Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island 02903, USA
Cancer Res 70:5686-94. 2010..Our findings define a strong association between global genetic and global epigenetic dysregulation in mesothelioma, rather than a discrete, local coordination of gene inactivation... - In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placentaCharlotte S Wilhelm-Benartzi
Department of Epidemiology, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, USA
Environ Health Perspect 120:296-302. 2012..Environmental insults in utero may lead to changes in epigenetic mechanisms potentially affecting fetal development... - Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association studyScott M Langevin
Department of Epidemiology, Brown University, Providence, RI, USA
Epigenetics 7:291-9. 2012..This profile demonstrates the potential of DNA methylation measured in blood for development of non-invasive applications for detection of head and neck cancer... - DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancerCarmen J Marsit
Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
J Clin Oncol 29:1133-9. 2011..We sought to identify specific profiles of DNA methylation in peripheral blood that are associated with bladder cancer risk and therefore serve as an epigenetic marker of disease susceptibility... - Downregulated microRNAs in the differential diagnosis of malignant pleural mesotheliomaGretchen V Gee
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
Int J Cancer 127:2859-69. 2010..This research points to novel approaches using miRNAs whose decreased expression is unique to mesothelioma as potentially suitable for rapid diagnosis and reveals prospective new targets for the treatment of this deadly disease... - Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intakeBrock C Christensen
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
PLoS Genet 6:e1001043. 2010..0001) associated with methylation class membership. Breast cancer prognostic characteristics and risk-related exposures appear to be associated with gene-specific tumor methylation, as well as overall methylation patterns... - Identification of methylated genes associated with aggressive bladder cancerCarmen J Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
PLoS ONE 5:e12334. 2010..Methylation of these genes may be useful as clinical markers of the disease and may point to genes and pathways worthy of additional examination as novel targets for therapeutic treatment... - DNA methylation, isocitrate dehydrogenase mutation, and survival in gliomaBrock C Christensen
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
J Natl Cancer Inst 103:143-53. 2011.... - Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island contextBrock C Christensen
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
PLoS Genet 5:e1000602. 2009..Collectively we reveal key issues to consider both in the construction of reference and disease-related epigenomes and in the interpretation of potentially pathologically important alterations... - Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility spermSara E Pacheco
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
PLoS ONE 6:e20280. 2011..We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function... - The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in bloodScott M Langevin
Department of Community Health, Brown University, Providence, RI, USA
Epigenetics 6:908-19. 2011.... - Biomarkers of HPV in head and neck squamous cell carcinomaCaihua Liang
Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA
Cancer Res 72:5004-13. 2012.... - Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targetedGraham M Poage
Departments of Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island, United States of America
PLoS ONE 5:e9651. 2010.... - Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancersDevin C Koestler
Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
Cancer Epidemiol Biomarkers Prev 21:1293-302. 2012.... - LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking ChineseHaley L Cash
Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
Int J Cancer 130:1151-9. 2012..006). Further research is needed to understand the relationships between methyl group availability and LINE-1 methylation in relation to bladder cancer risk... - Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancerGraham M Poage
Departments of Molecular Pharmacology and Physiology, Community Health Center for Environmental Health and Technology, and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA
Clin Cancer Res 17:3579-89. 2011..The degree to which these processes are coordinated is unclear so we investigated both in head and neck squamous cell carcinomas... - Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposureSarah N Campion
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA
Reprod Toxicol 33:382-9. 2012..These findings provide candidate genes for further investigation of the testicular response to damage... - Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinomaMichele Avissar-Whiting
Department of Pathology, Brown University, Providence, RI, USA
Epigenetics 6:703-9. 2011..This work contributes to our understanding of how repressive marks on DNA and chromatin are dysregulated in carcinogenesis, knowledge that might aid the development of therapies or preventive strategies for human malignancies... - Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profilesBrock C Christensen
Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA
Cancer Res 69:6315-21. 2009..Methylation profile-based differentiation of lung adenocarcinoma and mesothelioma is highly accurate, informs on the distinct etiologies of these diseases, and holds promise for clinical application... - Semi-supervised recursively partitioned mixture models for identifying cancer subtypesDevin C Koestler
Department of Community Health, Section for Biostatistics, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
Bioinformatics 26:2578-85. 2010..We propose a method called semi-supervised recursively partitioned mixture models (SS-RPMM) that utilizes array-based genetic and patient-level clinical data for finding cancer subtypes that are associated with patient survival... 
Gene-environment interactions of novel variants associated with head and neck cancerCaihua Liang
Department of Community Health, Brown University, Providence, Rhode Island, USA
Head Neck 34:1111-8. 2012..We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk...- Decreased NK cells in patients with head and neck cancer determined in archival DNAWilliam P Accomando
Department of Pathology and Laboratory Medicine, Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA
Clin Cancer Res 18:6147-54. 2012..To examine NK cell levels in archived bloods from a study of human head and neck squamous cell carcinoma (HNSCC), a new DNA-based quantification method was developed... - Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan IslandersHaley L Cash
Department of Pathology and Laboratory Medicine, International Health Institute, Public Health Program, Brown University, Providence, RI, USA
Epigenetics 6:1257-64. 2011.... - Infant growth restriction is associated with distinct patterns of DNA methylation in human placentasCarolyn E Banister
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
Epigenetics 6:920-7. 2011.... - Genetic and epigenetic tumor suppressor gene silencing are distinct molecular phenotypes driven by growth promoting mutations in nonsmall cell lung cancerCarmen J Marsit
Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
J Cancer Epidemiol 2008:215809. 2008..These data suggest that NSCLCs have distinct epigenetic or genetic alteration phenotypes acting upon tumor suppressor genes and that mutation of oncogenic growth promoting genes, such as KRAS, is associated with the epigenetic phenotype... 
Promoter hypermethylation is associated with current smoking, age, gender and survival in bladder cancerCarmen J Marsit
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
Carcinogenesis 28:1745-51. 2007....- Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathwaysSarah N Campion
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
Toxicol Sci 117:457-65. 2010....