E Andres Houseman

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Copy number variation has little impact on bead-array-based measures of DNA methylation
    E Andres Houseman
    Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
    Bioinformatics 25:1999-2005. 2009
  2. pmc In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta
    Charlotte S Wilhelm-Benartzi
    Department of Epidemiology, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, USA
    Environ Health Perspect 120:296-302. 2012
  3. pmc Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Carcinogenesis 30:416-22. 2009
  4. pmc Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma
    Brock C Christensen
    Departments of Pathology and Laboratory Medicine, Community Health, Center for Environmental Health and Technology, and Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island 02903, USA
    Cancer Res 70:5686-94. 2010
  5. pmc Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study
    Scott M Langevin
    Department of Epidemiology, Brown University, Providence, RI, USA
    Epigenetics 7:291-9. 2012
  6. pmc Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS Genet 6:e1001043. 2010
  7. pmc Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma
    Gretchen V Gee
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Int J Cancer 127:2859-69. 2010
  8. pmc DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer
    Carmen J Marsit
    Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    J Clin Oncol 29:1133-9. 2011
  9. pmc Decreased NK cells in patients with head and neck cancer determined in archival DNA
    William P Accomando
    Department of Pathology and Laboratory Medicine, Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA
    Clin Cancer Res 18:6147-54. 2012
  10. pmc Identification of methylated genes associated with aggressive bladder cancer
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e12334. 2010

Collaborators

Detail Information

Publications30

  1. pmc Copy number variation has little impact on bead-array-based measures of DNA methylation
    E Andres Houseman
    Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
    Bioinformatics 25:1999-2005. 2009
    ..However, copy number variation may bias the measurement of DNA methylation. To investigate possible bias, we analyzed integrated data obtained from 19 head and neck squamous cell carcinoma (HNSCC) tumors and 23 mesothelioma tumors...
  2. pmc In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta
    Charlotte S Wilhelm-Benartzi
    Department of Epidemiology, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island, USA
    Environ Health Perspect 120:296-302. 2012
    ..Environmental insults in utero may lead to changes in epigenetic mechanisms potentially affecting fetal development...
  3. pmc Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Carcinogenesis 30:416-22. 2009
    ..We found that the etiologic heterogeneity of HNSCC is reflected in specific patterns of molecular epigenetic alterations within the tumors and that the DNA methylation profiles may hold clinical promise worthy of further study...
  4. pmc Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma
    Brock C Christensen
    Departments of Pathology and Laboratory Medicine, Community Health, Center for Environmental Health and Technology, and Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island 02903, USA
    Cancer Res 70:5686-94. 2010
    ..Our findings define a strong association between global genetic and global epigenetic dysregulation in mesothelioma, rather than a discrete, local coordination of gene inactivation...
  5. pmc Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study
    Scott M Langevin
    Department of Epidemiology, Brown University, Providence, RI, USA
    Epigenetics 7:291-9. 2012
    ..This profile demonstrates the potential of DNA methylation measured in blood for development of non-invasive applications for detection of head and neck cancer...
  6. pmc Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS Genet 6:e1001043. 2010
    ..0001) associated with methylation class membership. Breast cancer prognostic characteristics and risk-related exposures appear to be associated with gene-specific tumor methylation, as well as overall methylation patterns...
  7. pmc Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma
    Gretchen V Gee
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Int J Cancer 127:2859-69. 2010
    ..This research points to novel approaches using miRNAs whose decreased expression is unique to mesothelioma as potentially suitable for rapid diagnosis and reveals prospective new targets for the treatment of this deadly disease...
  8. pmc DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer
    Carmen J Marsit
    Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    J Clin Oncol 29:1133-9. 2011
    ..We sought to identify specific profiles of DNA methylation in peripheral blood that are associated with bladder cancer risk and therefore serve as an epigenetic marker of disease susceptibility...
  9. pmc Decreased NK cells in patients with head and neck cancer determined in archival DNA
    William P Accomando
    Department of Pathology and Laboratory Medicine, Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA
    Clin Cancer Res 18:6147-54. 2012
    ..To examine NK cell levels in archived bloods from a study of human head and neck squamous cell carcinoma (HNSCC), a new DNA-based quantification method was developed...
  10. pmc Identification of methylated genes associated with aggressive bladder cancer
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e12334. 2010
    ..Methylation of these genes may be useful as clinical markers of the disease and may point to genes and pathways worthy of additional examination as novel targets for therapeutic treatment...
  11. pmc DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    J Natl Cancer Inst 103:143-53. 2011
    ....
  12. pmc Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    PLoS Genet 5:e1000602. 2009
    ..Collectively we reveal key issues to consider both in the construction of reference and disease-related epigenomes and in the interpretation of potentially pathologically important alterations...
  13. pmc Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm
    Sara E Pacheco
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 6:e20280. 2011
    ..We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function...
  14. pmc The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood
    Scott M Langevin
    Department of Community Health, Brown University, Providence, RI, USA
    Epigenetics 6:908-19. 2011
    ....
  15. pmc Biomarkers of HPV in head and neck squamous cell carcinoma
    Caihua Liang
    Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA
    Cancer Res 72:5004-13. 2012
    ....
  16. pmc Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted
    Graham M Poage
    Departments of Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e9651. 2010
    ....
  17. pmc Association of secondhand smoke exposures with DNA methylation in bladder carcinomas
    Charlotte S Wilhelm-Benartzi
    Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
    Cancer Causes Control 22:1205-13. 2011
    ..Epigenetic alterations in bladder tumors have been linked to primary cigarette smoking and could add to the biological plausibility of an association between SHS exposure and bladder cancer...
  18. pmc Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers
    Devin C Koestler
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Cancer Epidemiol Biomarkers Prev 21:1293-302. 2012
    ....
  19. pmc LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese
    Haley L Cash
    Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
    Int J Cancer 130:1151-9. 2012
    ..006). Further research is needed to understand the relationships between methyl group availability and LINE-1 methylation in relation to bladder cancer risk...
  20. pmc Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer
    Graham M Poage
    Departments of Molecular Pharmacology and Physiology, Community Health Center for Environmental Health and Technology, and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA
    Clin Cancer Res 17:3579-89. 2011
    ..The degree to which these processes are coordinated is unclear so we investigated both in head and neck squamous cell carcinomas...
  21. pmc Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure
    Sarah N Campion
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA
    Reprod Toxicol 33:382-9. 2012
    ..These findings provide candidate genes for further investigation of the testicular response to damage...
  22. pmc Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma
    Michele Avissar-Whiting
    Department of Pathology, Brown University, Providence, RI, USA
    Epigenetics 6:703-9. 2011
    ..This work contributes to our understanding of how repressive marks on DNA and chromatin are dysregulated in carcinogenesis, knowledge that might aid the development of therapies or preventive strategies for human malignancies...
  23. pmc Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles
    Brock C Christensen
    Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA
    Cancer Res 69:6315-21. 2009
    ..Methylation profile-based differentiation of lung adenocarcinoma and mesothelioma is highly accurate, informs on the distinct etiologies of these diseases, and holds promise for clinical application...
  24. pmc Semi-supervised recursively partitioned mixture models for identifying cancer subtypes
    Devin C Koestler
    Department of Community Health, Section for Biostatistics, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
    Bioinformatics 26:2578-85. 2010
    ..We propose a method called semi-supervised recursively partitioned mixture models (SS-RPMM) that utilizes array-based genetic and patient-level clinical data for finding cancer subtypes that are associated with patient survival...
  25. pmc Gene-environment interactions of novel variants associated with head and neck cancer
    Caihua Liang
    Department of Community Health, Brown University, Providence, Rhode Island, USA
    Head Neck 34:1111-8. 2012
    ..We used these SNPs to investigate the potential gene-gene and gene-environment interactions in head and neck squamous cell carcinoma (HNSCC) risk...
  26. pmc Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders
    Haley L Cash
    Department of Pathology and Laboratory Medicine, International Health Institute, Public Health Program, Brown University, Providence, RI, USA
    Epigenetics 6:1257-64. 2011
    ....
  27. pmc Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas
    Carolyn E Banister
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Epigenetics 6:920-7. 2011
    ....
  28. pmc Genetic and epigenetic tumor suppressor gene silencing are distinct molecular phenotypes driven by growth promoting mutations in nonsmall cell lung cancer
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA
    J Cancer Epidemiol 2008:215809. 2008
    ..These data suggest that NSCLCs have distinct epigenetic or genetic alteration phenotypes acting upon tumor suppressor genes and that mutation of oncogenic growth promoting genes, such as KRAS, is associated with the epigenetic phenotype...
  29. ncbi request reprint Promoter hypermethylation is associated with current smoking, age, gender and survival in bladder cancer
    Carmen J Marsit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Carcinogenesis 28:1745-51. 2007
    ....
  30. pmc Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways
    Sarah N Campion
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Toxicol Sci 117:457-65. 2010
    ....