Research Topics
Genomes and Genes | Daithi S HeffernanSummaryAffiliation: Brown University Country: USA Publications
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Publications
Impact of socioethnic factors on outcomes following traumatic brain injuryDaithi S Heffernan
Division Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
J Trauma 70:527-34. 2011..We therefore sought to determine the independent effect on outcome after TBI from race, insurance status, intoxication on presentation, and median income...
Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis patternDaithi S Heffernan
Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, USA
Crit Care 16:R12. 2012..Although lymphocyte anergy and dysfunction following trauma is associated with increased risk for infection and sepsis, there is a paucity of data regarding the impact of a persistence of a low lymphocyte count in trauma patients...
Gender and acute respiratory distress syndrome in critically injured adults: a prospective studyDaithi S Heffernan
Division of Trauma and Surgical Critical Care, Department of Surgery, Warren Alpert Medical School, Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
J Trauma 71:878-83; discussion 883-5. 2011..Human data are scant regarding the role of gender and sex hormones in developing ARDS. Our objective was to describe gender and hormonal differences in patients who develop ARDS in a large cohort of critically injured adults...
The development of a urinary tract infection is associated with increased mortality in trauma patientsSean F Monaghan
Division of Trauma and Surgical Critical Care, Department of Surgery, Warren Alpert School of Medicine, Rhode Island Hospital, Providence, Rhode Island 02903, USA
J Trauma 71:1569-74. 2011..In October 2008, Medicare and Medicaid stopped paying for care associated with catheter-related urinary tract infections (UTIs). Although most clinicians agree UTIs are detrimental, there are little data to support this belief...
Undiagnosed medical comorbidities in the uninsured: a significant predictor of mortality following traumaVincent P Duron
Division of Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
J Trauma Acute Care Surg 73:1093-8; discussion 1098-9. 2012..The objective of this study was to determine whether rates of diagnosed or undiagnosed preexisting comorbidities significantly contribute to disparities in mortality rates observed between insured and uninsured trauma patients...
Normal presenting vital signs are unreliable in geriatric blunt trauma victimsDaithi S Heffernan
Division of Trauma and Surgical Critical Care, Warren Alpert School of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
J Trauma 69:813-20. 2010..Normal vital signs are typically associated with improved outcomes in trauma patients. Whether this association is true for geriatric patients is unclear...
Infections after trauma are associated with subsequent cardiac injurySean F Monaghan
Division of Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island, USA
J Trauma Acute Care Surg 73:1079-84; discussion 1084-5. 2012..UTIs and VAPs induced inflammatory responses. We postulate that increased mortality seen in trauma patients with infections is caused by increased rates of cardiac injury...
Programmed death 1 expression as a marker for immune and physiological dysfunction in the critically ill surgical patientSean F Monaghan
Department of Surgery, Alpert School of Medicine at Brown, University and Rhode Island Hospital, Providence, Rhode Island, USA
Shock 38:117-22. 2012....
Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1Sean F Monaghan
Division of Surgical Research, Department of Surgery, Alpert School of Medicine at Brown University and Rhode Island Hospital, Providence, RI, USA
Ann Surg 255:158-64. 2012..To determine the contribution of programmed death receptor (PD)-1 in the morbidity and mortality associated with the development of indirect-acute lung injury...
Local tissue expression of the cell death ligand, fas ligand, plays a central role in the development of extrapulmonary acute lung injuryRajan K Thakkar
Shock Trauma Research Laboratories, Department of Surgery, Division of Surgical Research, Rhode Island Hospital The Alpert School of Medicine at Brown University, Providence, RI 02903, USA
Shock 36:138-43. 2011....
BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunctionNicholas J Shubin
Division of Surgical Research, Department of Surgery at Rhode Island Hospital, Warren Alpert School of Medicine, Providence, RI, USA
J Leukoc Biol 92:593-603. 2012....
The multiply injured trauma patient: resuscitation, rehabilitation, recoveryShea C Gregg
Division of Trauma and Surgical Critical Care, The Warren Alpert Medical School, Brown University, USA
Med Health R I 93:112, 115-6. 2010..In addition to the doctors and nurses providing many aspects of the acute and chronic medical care, the rehabilitation component is delivered by several skilled specialists focused on maximizing functional outcomes...
Peritoneal free air due to evacuation of pneumobilia in blunt abdominal traumaIsaac Howley
Department of Surgery, Rhode Island Hospital and the Warren Alpert School of Medicine, Brown University, Providence, RI 02903, USA
J Emerg Trauma Shock 3:412-5. 2010..Given that the subsequent laparotomy proved to be non-therapeutic, this report adds to the few cases of intra-peritoneal free air not helped by surgical intervention...
