Daithi S Heffernan

Summary

Affiliation: Brown University
Country: USA

Publications

  1. doi request reprint Impact of socioethnic factors on outcomes following traumatic brain injury
    Daithi S Heffernan
    Division Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Trauma 70:527-34. 2011
  2. doi request reprint A divergent response of innate regulatory T-cells to sepsis in humans: Circulating invariant natural killer T-cells are preserved
    Daithi S Heffernan
    Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, United States Electronic address
    Hum Immunol 75:277-82. 2014
  3. doi request reprint Inflammatory mechanisms in sepsis: elevated invariant natural killer T-cell numbers in mouse and their modulatory effect on macrophage function
    Daithi S Heffernan
    Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA
    Shock 40:122-8. 2013
  4. pmc Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern
    Daithi S Heffernan
    Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, USA
    Crit Care 16:R12. 2012
  5. pmc Gender and acute respiratory distress syndrome in critically injured adults: a prospective study
    Daithi S Heffernan
    Division of Trauma and Surgical Critical Care, Department of Surgery, Warren Alpert Medical School, Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Trauma 71:878-83; discussion 883-5. 2011
  6. doi request reprint The development of a urinary tract infection is associated with increased mortality in trauma patients
    Sean F Monaghan
    Division of Trauma and Surgical Critical Care, Department of Surgery, Warren Alpert School of Medicine, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Trauma 71:1569-74. 2011
  7. doi request reprint Undiagnosed medical comorbidities in the uninsured: a significant predictor of mortality following trauma
    Vincent P Duron
    Division of Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Trauma Acute Care Surg 73:1093-8; discussion 1098-9. 2012
  8. doi request reprint Normal presenting vital signs are unreliable in geriatric blunt trauma victims
    Daithi S Heffernan
    Division of Trauma and Surgical Critical Care, Warren Alpert School of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    J Trauma 69:813-20. 2010
  9. doi request reprint Infections after trauma are associated with subsequent cardiac injury
    Sean F Monaghan
    Division of Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island, USA
    J Trauma Acute Care Surg 73:1079-84; discussion 1084-5. 2012
  10. doi request reprint Programmed death 1 expression as a marker for immune and physiological dysfunction in the critically ill surgical patient
    Sean F Monaghan
    Department of Surgery, Alpert School of Medicine at Brown, University and Rhode Island Hospital, Providence, Rhode Island, USA
    Shock 38:117-22. 2012

Collaborators

Detail Information

Publications17

  1. doi request reprint Impact of socioethnic factors on outcomes following traumatic brain injury
    Daithi S Heffernan
    Division Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Trauma 70:527-34. 2011
    ..We therefore sought to determine the independent effect on outcome after TBI from race, insurance status, intoxication on presentation, and median income...
  2. doi request reprint A divergent response of innate regulatory T-cells to sepsis in humans: Circulating invariant natural killer T-cells are preserved
    Daithi S Heffernan
    Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, United States Electronic address
    Hum Immunol 75:277-82. 2014
    ..Specifically, septic geriatric patients have marked mortality. How γδ-TCR(+) T-cells and iNKT-cells are altered in the settings of sepsis and advanced age, and how these changes correlate with mortality are unknown...
  3. doi request reprint Inflammatory mechanisms in sepsis: elevated invariant natural killer T-cell numbers in mouse and their modulatory effect on macrophage function
    Daithi S Heffernan
    Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI, USA
    Shock 40:122-8. 2013
    ..Invariant natural killer T cells offer therapeutic targets for modulating immune responses and detrimental effects of sepsis...
  4. pmc Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern
    Daithi S Heffernan
    Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, USA
    Crit Care 16:R12. 2012
    ..Although lymphocyte anergy and dysfunction following trauma is associated with increased risk for infection and sepsis, there is a paucity of data regarding the impact of a persistence of a low lymphocyte count in trauma patients...
  5. pmc Gender and acute respiratory distress syndrome in critically injured adults: a prospective study
    Daithi S Heffernan
    Division of Trauma and Surgical Critical Care, Department of Surgery, Warren Alpert Medical School, Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Trauma 71:878-83; discussion 883-5. 2011
    ..Human data are scant regarding the role of gender and sex hormones in developing ARDS. Our objective was to describe gender and hormonal differences in patients who develop ARDS in a large cohort of critically injured adults...
  6. doi request reprint The development of a urinary tract infection is associated with increased mortality in trauma patients
    Sean F Monaghan
    Division of Trauma and Surgical Critical Care, Department of Surgery, Warren Alpert School of Medicine, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Trauma 71:1569-74. 2011
    ..In October 2008, Medicare and Medicaid stopped paying for care associated with catheter-related urinary tract infections (UTIs). Although most clinicians agree UTIs are detrimental, there are little data to support this belief...
  7. doi request reprint Undiagnosed medical comorbidities in the uninsured: a significant predictor of mortality following trauma
    Vincent P Duron
    Division of Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Trauma Acute Care Surg 73:1093-8; discussion 1098-9. 2012
    ..The objective of this study was to determine whether rates of diagnosed or undiagnosed preexisting comorbidities significantly contribute to disparities in mortality rates observed between insured and uninsured trauma patients...
  8. doi request reprint Normal presenting vital signs are unreliable in geriatric blunt trauma victims
    Daithi S Heffernan
    Division of Trauma and Surgical Critical Care, Warren Alpert School of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    J Trauma 69:813-20. 2010
    ..Normal vital signs are typically associated with improved outcomes in trauma patients. Whether this association is true for geriatric patients is unclear...
  9. doi request reprint Infections after trauma are associated with subsequent cardiac injury
    Sean F Monaghan
    Division of Trauma and Surgical Critical Care, Department of Surgery, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island, USA
    J Trauma Acute Care Surg 73:1079-84; discussion 1084-5. 2012
    ..UTIs and VAPs induced inflammatory responses. We postulate that increased mortality seen in trauma patients with infections is caused by increased rates of cardiac injury...
  10. doi request reprint Programmed death 1 expression as a marker for immune and physiological dysfunction in the critically ill surgical patient
    Sean F Monaghan
    Department of Surgery, Alpert School of Medicine at Brown, University and Rhode Island Hospital, Providence, Rhode Island, USA
    Shock 38:117-22. 2012
    ....
  11. pmc Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1
    Sean F Monaghan
    Division of Surgical Research, Department of Surgery, Alpert School of Medicine at Brown University and Rhode Island Hospital, Providence, RI, USA
    Ann Surg 255:158-64. 2012
    ..To determine the contribution of programmed death receptor (PD)-1 in the morbidity and mortality associated with the development of indirect-acute lung injury...
  12. doi request reprint Empiric antibiotics pending bronchoalveolar lavage data in patients without pneumonia significantly alters the flora, but not the resistance profile, if a subsequent pneumonia develops
    Rajan K Thakkar
    Division of Trauma and Surgical Critical Care, Department of Surgery, Warren Alpert School of Medicine, Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Surg Res 181:323-8. 2013
    ..Empiric antibiotics are administered while awaiting BAL culture data. Little is known about the effects of these empiric antibiotics on patients with negative BAL microbiology if a subsequent VAP occurs during the same hospital course...
  13. pmc Local tissue expression of the cell death ligand, fas ligand, plays a central role in the development of extrapulmonary acute lung injury
    Rajan K Thakkar
    Shock Trauma Research Laboratories, Department of Surgery, Division of Surgical Research, Rhode Island Hospital The Alpert School of Medicine at Brown University, Providence, RI 02903, USA
    Shock 36:138-43. 2011
    ....
  14. ncbi request reprint B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients
    Nicholas J Shubin
    Department of Surgery at Rhode Island Hospital, Brown University Division of Surgical Research, 593 Eddy Street, Aldrich Building 2nd Floor, Providence, RI 02906, USA
    Crit Care 17:R276. 2013
    ....
  15. pmc BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction
    Nicholas J Shubin
    Division of Surgical Research, Department of Surgery at Rhode Island Hospital, Warren Alpert School of Medicine, Providence, RI, USA
    J Leukoc Biol 92:593-603. 2012
    ....
  16. ncbi request reprint The multiply injured trauma patient: resuscitation, rehabilitation, recovery
    Shea C Gregg
    Division of Trauma and Surgical Critical Care, The Warren Alpert Medical School, Brown University, USA
    Med Health R I 93:112, 115-6. 2010
    ..In addition to the doctors and nurses providing many aspects of the acute and chronic medical care, the rehabilitation component is delivered by several skilled specialists focused on maximizing functional outcomes...
  17. pmc Peritoneal free air due to evacuation of pneumobilia in blunt abdominal trauma
    Isaac Howley
    Department of Surgery, Rhode Island Hospital and the Warren Alpert School of Medicine, Brown University, Providence, RI 02903, USA
    J Emerg Trauma Shock 3:412-5. 2010
    ..Given that the subsequent laparotomy proved to be non-therapeutic, this report adds to the few cases of intra-peritoneal free air not helped by surgical intervention...