Chi Ming Hai

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Systems biology of HBOC-induced vasoconstriction
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Curr Drug Discov Technol 9:204-11. 2012
  2. ncbi request reprint Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Austrian Academy of Sciences, Salzburg, Austria
    Exp Cell Res 280:64-74. 2002
  3. ncbi request reprint Maternal dexamethasone treatment alters myosin isoform expression and contractile dynamics in fetal arteries
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, School of Medicine, Brown University, Box G B3, Providence, RI 02912, USA
    Am J Physiol Heart Circ Physiol 283:H1743-9. 2002
  4. ncbi request reprint Mechanistic systems biology of inflammatory gene expression in airway smooth muscle as tool for asthma drug development
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Box G B3, 171 Meeting Street, Providence, Rhode Island 02912, USA
    Curr Drug Discov Technol 5:279-88. 2008
  5. ncbi request reprint Caldesmon as a therapeutic target for proliferative vascular diseases
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Mini Rev Med Chem 8:1209-13. 2008
  6. ncbi request reprint Airway smooth muscle cell as therapeutic target of inflammation
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, 171 Meeting Street, Providence, RI 02912, USA
    Curr Med Chem 14:67-76. 2007
  7. ncbi request reprint An expanded latch-bridge model of protein kinase C-mediated smooth muscle contraction
    Chi Ming Hai
    Brown University, Box G B3, Providence, RI 02912, USA
    J Appl Physiol 98:1356-65. 2005
  8. ncbi request reprint Caldesmon phosphorylation in actin cytoskeletal remodeling
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Box G B3, Providence, RI 02912, USA
    Eur J Cell Biol 85:305-9. 2006
  9. ncbi request reprint Cholinergic receptor-mediated differential cytoskeletal recruitment of actin- and integrin-binding proteins in intact airway smooth muscle
    Hak Rim Kim
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Am J Physiol Cell Physiol 287:C1375-83. 2004
  10. pmc Cholinergic receptor and cyclic stretch-mediated inflammatory gene expression in intact ASM
    Jeannette Kanefsky
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Box G B3, Providence, RI 02912, USA
    Am J Respir Cell Mol Biol 34:417-25. 2006

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Systems biology of HBOC-induced vasoconstriction
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Curr Drug Discov Technol 9:204-11. 2012
    ....
  2. ncbi request reprint Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Austrian Academy of Sciences, Salzburg, Austria
    Exp Cell Res 280:64-74. 2002
    ..The podosome columns could represent molecular scaffolds where PKC-alpha phosphorylates regulatory proteins necessary for Ca(2+) sensitization in smooth muscle cells...
  3. ncbi request reprint Maternal dexamethasone treatment alters myosin isoform expression and contractile dynamics in fetal arteries
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, School of Medicine, Brown University, Box G B3, Providence, RI 02912, USA
    Am J Physiol Heart Circ Physiol 283:H1743-9. 2002
    ..We speculate that dexamethasone-induced increases in fetal myosin LC17(a) isoform expression represent accelerated differentiation of a subpopulation of vascular smooth muscle cells from the fetal to adult phenotype...
  4. ncbi request reprint Mechanistic systems biology of inflammatory gene expression in airway smooth muscle as tool for asthma drug development
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Box G B3, 171 Meeting Street, Providence, Rhode Island 02912, USA
    Curr Drug Discov Technol 5:279-88. 2008
    ....
  5. ncbi request reprint Caldesmon as a therapeutic target for proliferative vascular diseases
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Mini Rev Med Chem 8:1209-13. 2008
    ..Recently, overexpression of caldesmon has been shown to inhibit neointimal formation after experimental angioplasty, suggesting that caldesmon may be a potential therapeutic target for proliferative vascular diseases...
  6. ncbi request reprint Airway smooth muscle cell as therapeutic target of inflammation
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, 171 Meeting Street, Providence, RI 02912, USA
    Curr Med Chem 14:67-76. 2007
    ..Detailed understanding of the cellular components and interactions in the inflammatory network of the airway system may lead to rational targeting of multiple cells and mediators in the treatment of airway inflammation...
  7. ncbi request reprint An expanded latch-bridge model of protein kinase C-mediated smooth muscle contraction
    Chi Ming Hai
    Brown University, Box G B3, Providence, RI 02912, USA
    J Appl Physiol 98:1356-65. 2005
    ....
  8. ncbi request reprint Caldesmon phosphorylation in actin cytoskeletal remodeling
    Chi Ming Hai
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Box G B3, Providence, RI 02912, USA
    Eur J Cell Biol 85:305-9. 2006
    ....
  9. ncbi request reprint Cholinergic receptor-mediated differential cytoskeletal recruitment of actin- and integrin-binding proteins in intact airway smooth muscle
    Hak Rim Kim
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Am J Physiol Cell Physiol 287:C1375-83. 2004
    ..alpha-Actinin, talin, and metavinculin appear to be key cytoskeletal proteins involved in the recruitment process...
  10. pmc Cholinergic receptor and cyclic stretch-mediated inflammatory gene expression in intact ASM
    Jeannette Kanefsky
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Box G B3, Providence, RI 02912, USA
    Am J Respir Cell Mol Biol 34:417-25. 2006
    ..These findings suggest that cyclic stretch regulates inflammatory gene expression in intact airway smooth muscle in an amplitude- and frequency-dependent manner by modulating the activity of L-type voltage-gated calcium channels...
  11. ncbi request reprint Sinusoidal length oscillation- and receptor-mediated mRNA expression of myosin isoforms and alpha-SM actin in airway smooth muscle
    Melissa Wahl
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Box G B3, Providence, RI 02912, USA
    Am J Physiol Cell Physiol 287:C1697-708. 2004
    ..A potential implication of these findings is that periodic stretching of airways during respiratory cycles may modulate mRNA expression by receptor agonists in airway smooth muscle cells in vivo...
  12. ncbi request reprint Dynamics of length-force relations in airway smooth muscle
    Jeanette Silberstein
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, P O Box G B3, Providence, RI 02912, USA
    Respir Physiol Neurobiol 132:205-21. 2002
    ..The observed complex dynamics of length-force relations could explain the complex lung mechanics in vivo...
  13. pmc Length-dependent modulation of cytoskeletal remodeling and mechanical energetics in airway smooth muscle
    Hak Rim Kim
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    Am J Respir Cell Mol Biol 44:888-97. 2011
    ..This postulate predicts that targeting the signaling molecules involved in cytoskeletal recruitment may provide a novel approach to dilating collapsed airways in obstructive airway disease...
  14. ncbi request reprint Mechanisms of mechanical strain memory in airway smooth muscle
    Hak Rim Kim
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA
    Can J Physiol Pharmacol 83:811-5. 2005
    ....
  15. pmc Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells
    Zhizhan Gu
    Department of Molecular Pharmacology, Physiology and Biotechnology, Box G B3, Brown University, Providence, RI 02912, USA
    Exp Cell Res 313:849-66. 2007
    ..These results suggest that Erk1/2 and caldesmon differentially modulate PKC-mediated formation and/or dynamics of podosomes in A7r5 vascular smooth muscle cells...
  16. ncbi request reprint Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation
    Qing Lu
    Pulmonary Vascular Biology Laboratory, Providence VA Medical Center, Providence, R 02908, USA
    Circ Res 94:306-15. 2004
    ..Therefore, carboxyl methylation of RhoA may modulate endothelial barrier function...
  17. pmc Differential sensitivities of pulmonary and coronary arteries to hemoglobin-based oxygen carriers and nitrovasodilators: study in a bovine ex vivo model of vascular strips
    Vera Fonseca
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, USA
    Vascul Pharmacol 52:215-23. 2010
    ..Among the three nitrovasodilators investigated, nitroglycerin appears to be the most promising candidate for attenuating HBOC-induced pulmonary hypertension in older HBOCs...
  18. doi request reprint Relative roles of heme-irons and globin-thiols in the genesis of acellular hemoglobin mediated vasoconstriction
    Hae won Kim
    Department of Molecular Pharmacology, Physiology and Biotechnology Brown University, 171 Meeting Street, Providence, RI 02912, USA
    Artif Cells Blood Substit Immobil Biotechnol 38:5-12. 2010
    ..These results indicate that reactive globin-thiols do not appear to play a prominent role relative to heme-irons in Hb-mediated vasoconstriction...
  19. ncbi request reprint On the terminology for describing the length-force relationship and its changes in airway smooth muscle
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    J Appl Physiol 97:2029-34. 2004
    ..We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously...

Research Grants9

  1. MECHANOSENSITIVE MODULATION OF AIRWAY CONTRACTION
    Chi Ming Hai; Fiscal Year: 1999
    ..The hope is that understanding this biological feedback mechanism may offer a new way of controlling airway smooth muscle activation and therefore airway resistance. ..