PHILIP GRUPPUSO

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)
    ROSA H JIMENEZ
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e9084. 2010
  2. pmc Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines
    ROSA H JIMENEZ
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA
    PLoS ONE 4:e7373. 2009
  3. pmc Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1)
    Gokhan Demirkan
    Department of Pediatrics, Brown University and Rhode Island Hospital, Providence, Rhode Island, United States of America
    PLoS ONE 6:e21729. 2011
  4. pmc Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)
    Dudley W Lamming
    3Division of Pediatric Endocrinology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    FASEB J 28:300-15. 2014
  5. pmc Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    BMC Physiol 12:1. 2012
  6. ncbi request reprint Medical education at Brown Medical School
    Philip A Gruppuso
    Brown Medical School, Box G A218, Providence, RI 02912, USA
    Med Health R I 89:298. 2006
  7. ncbi request reprint The Brown Medical School Class of 2006
    Philip A Gruppuso
    Brown Medical School, Providence, RI 02912, USA
    Med Health R I 89:299-303. 2006
  8. pmc Hepatic translation control in the late-gestation fetal rat
    Philip A Gruppuso
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Regul Integr Comp Physiol 295:R558-67. 2008
  9. ncbi request reprint The Warren Alpert Medical School of Brown University: class of 2008
    Philip A Gruppuso
    The Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
    Med Health R I 91:242-6. 2008
  10. ncbi request reprint Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK
    P A Gruppuso
    Department of Pediatrics, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI, USA
    FEBS Lett 466:200-4. 2000

Research Grants

  1. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2003
  2. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2003
  3. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2004
  4. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2004
  5. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2004
  6. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2005
  7. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2005
  8. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2005
  9. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2006
  10. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2006

Collaborators

Detail Information

Publications42

  1. pmc Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)
    ROSA H JIMENEZ
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 5:e9084. 2010
    ..The latter are resistant to the growth inhibitory effects of rapamycin, thus providing us with an opportunity to study the gene expression effects of rapamycin without confounding effects on cell proliferation...
  2. pmc Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines
    ROSA H JIMENEZ
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA
    PLoS ONE 4:e7373. 2009
    ..However, resistance to its growth inhibitory effects is common. We hypothesized that hepatic cell lines with varying rapamycin responsiveness would show common characteristics accounting for resistance to the drug...
  3. pmc Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of rapamycin complex 1 (mTORC1)
    Gokhan Demirkan
    Department of Pediatrics, Brown University and Rhode Island Hospital, Providence, Rhode Island, United States of America
    PLoS ONE 6:e21729. 2011
    ..Though studied extensively, the mechanisms involved in many mTORC1 biological functions remain poorly understood...
  4. pmc Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)
    Dudley W Lamming
    3Division of Pediatric Endocrinology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    FASEB J 28:300-15. 2014
    ..We conclude that hepatic mTORC2 exerts a broad spectrum of biological effects under physiological conditions. Our findings provide a context for the development of targeted therapies to modulate mTORC2 signaling...
  5. pmc Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    BMC Physiol 12:1. 2012
    ..In order to investigate the functional role of c-Myc in adult liver, we have developed a hepatocyte-specific c-myc knockout mouse, c-mycfl/fl;Alb-Cre...
  6. ncbi request reprint Medical education at Brown Medical School
    Philip A Gruppuso
    Brown Medical School, Box G A218, Providence, RI 02912, USA
    Med Health R I 89:298. 2006
  7. ncbi request reprint The Brown Medical School Class of 2006
    Philip A Gruppuso
    Brown Medical School, Providence, RI 02912, USA
    Med Health R I 89:299-303. 2006
  8. pmc Hepatic translation control in the late-gestation fetal rat
    Philip A Gruppuso
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Regul Integr Comp Physiol 295:R558-67. 2008
    ..These differences may confer differential sensitivity to the growth inhibitory effects of rapamycin...
  9. ncbi request reprint The Warren Alpert Medical School of Brown University: class of 2008
    Philip A Gruppuso
    The Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
    Med Health R I 91:242-6. 2008
  10. ncbi request reprint Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK
    P A Gruppuso
    Department of Pediatrics, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI, USA
    FEBS Lett 466:200-4. 2000
    ..Our results indicate that hepatic, EGF-sensitive MEK kinase activity may reside with a previously unidentified and physiologically relevant form of Raf and/or MEKK...
  11. ncbi request reprint Effects of maternal starvation on hepatocyte proliferation in the late gestation fetal rat
    Philip A Gruppuso
    Department of Pediatrics, Rhode Island Hospital and Brown University, 593 Eddy St, Providence, RI 02903, USA
    Pediatr Res 57:185-91. 2005
    ..Our results are consistent with the hypothesis that restricted nutrient availability signals to the hepatocyte cell cycle in fetuses of fasted mothers, thereby accounting for decreased hepatocyte proliferation and liver mass...
  12. pmc The physiology and pathophysiology of rapamycin resistance: implications for cancer
    Philip A Gruppuso
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI USA
    Cell Cycle 10:1050-8. 2011
    ....
  13. ncbi request reprint Identification of candidate growth-regulating genes that are overexpressed in late gestation fetal liver in the rat
    P A Gruppuso
    Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Biochim Biophys Acta 1494:242-7. 2000
    ..Based on our identification of these genes and previous work characterizing their role in growth regulation, we conclude that they may contribute to the mitogenic signaling phenotype of fetal rat hepatocytes...
  14. ncbi request reprint The Warren Alpert Medical School of Brown University: Class of 2007
    Philip A Gruppuso
    The Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
    Med Health R I 90:266-71. 2007
  15. pmc Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling
    Mimi S Kim
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Endocrinol Metab 296:E1374-82. 2009
    ..Thus nutrient restriction appears to directly modulate bone growth through unidentified mTOR-independent mechanisms in addition to the well-characterized mTOR nutrient-sensing pathway...
  16. pmc Rapamycin inhibits liver growth during refeeding in rats via control of ribosomal protein translation but not cap-dependent translation initiation
    Padmanabhan Anand
    Department of Pediatrics, Brown University and Rhode Island Hospital, Providence, RI 02903, USA
    J Nutr 136:27-33. 2006
    ..We conclude that accretion of liver protein during refeeding is dependent on mTOR-mediated activation of the translation of ribosomal proteins but not dependent on mTOR-mediated activation of cap-dependent translation initiation...
  17. ncbi request reprint Insulin signaling during perinatal liver development in the rat
    Padmanabhan Anand
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    Am J Physiol Endocrinol Metab 283:E844-52. 2002
    ..Our results indicate that protein synthesis during late-gestation liver development may be mTOR and insulin independent. Reexamination of the role of insulin in fetal liver physiology may be warranted...
  18. ncbi request reprint Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development
    Leila Khamzina
    Liver Research Center, Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island, USA
    Gastroenterology 125:572-85. 2003
    ..The purpose of this study was to determine the roles of the insulin receptor substrate (IRS-1 and IRS-2)-mediated growth cascades in rapidly growing fetal rat liver...
  19. ncbi request reprint Nucleolar localization of hepatic c-Myc: a potential mechanism for c-Myc regulation
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Biochim Biophys Acta 1743:141-50. 2005
    ..We speculate that the nucleolus may act to sequester c-Myc in quiescent hepatocytes while providing a pool of c-Myc that is readily available to reach its targets in the nucleus...
  20. pmc The mechanism of ascorbic acid-induced differentiation of ATDC5 chondrogenic cells
    Tecla M Temu
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Am J Physiol Endocrinol Metab 299:E325-34. 2010
    ....
  21. ncbi request reprint Commentary: the unsustainable cost of undergraduate medical education: an overlooked element of U.S. health care reform
    Eli Y Adashi
    Warren Alpert Medical School of Brown University, Providence, Rhode Island 02912, USA
    Acad Med 85:763-5. 2010
    ..All of these measures could and should be addressed as integral components of health care reform if we are to address the shortage of primary care physicians and other workforce needs...
  22. ncbi request reprint Insulin receptor substrate-1 is present in hepatocyte nuclei from intact rats
    Joan M Boylan
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    Endocrinology 143:4178-83. 2002
    ..Our results indicate that insulin signaling, which terminates in an array of nuclear events, may originate at the immediate postreceptor level with IRS-1 activation within the nucleus of normal hepatocytes...
  23. doi request reprint Encouraging scholarship: medical school programs to promote student inquiry beyond the traditional medical curriculum
    Emily P Green
    Scholarly Concentrations Program, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02912, USA
    Acad Med 85:409-18. 2010
    ....
  24. ncbi request reprint Redesigning the clinical curriculum at the Warren Alpert Medical School of Brown University
    Jeffrey Borkan
    Department of Family Medicine, The Warren Alpert Medical School of Brown University, USA
    Med Health R I 92:300-2. 2009
    ..The redesign should produce an educational process which not only more adequately prepares students for the future, but helps produce leaders in multiple fields of medicine and re-establishes Brown as an innovator in medical education...
  25. ncbi request reprint Insulin-like growth factor-I signaling is modified during chondrocyte differentiation
    Chanika Phornphutkul
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Endocrinol 183:477-86. 2004
    ..We conclude that IGF-I promotes both proliferation and differentiation of chondrocytes and that the differentiation effects of IGF-I may require uncoupling of signaling to the ERK pathway...
  26. pmc The effect of rapamycin on bone growth in rabbits
    Chanika Phornphutkul
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Orthop Res 27:1157-61. 2009
    ..and suggest that the possible inhibitory effects of rapamycin on skeletal growth warrant further attention before its use in children...
  27. ncbi request reprint Coordinated regulation of c-Myc and Max in rat liver development
    Jennifer A Sanders
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 290:G145-55. 2006
    ....
  28. ncbi request reprint The regulation of hepatic protein synthesis during fasting in the rat
    Padmanabhan Anand
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02903, USA
    J Biol Chem 280:16427-36. 2005
    ..However, the translation of rpS8, an mRNA with a 5'-oligopyrimidine tract, did not coincide with rpS6 phosphorylation, thus dissociating rpS6 phosphorylation from the translational control of this subset of mRNAs...
  29. pmc The effect of rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats
    Jennifer A Sanders
    Dept of Pediatrics, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 295:C406-13. 2008
    ..Furthermore, the well-characterized effects of rapamycin in tissue culture systems are not recapitulated in the asynchronous cell proliferation that accompanies normal growth and tissue remodeling...
  30. ncbi request reprint The role of insulin in chondrogenesis
    Chanika Phornphutkul
    Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Mol Cell Endocrinol 249:107-15. 2006
    ..These results support assignment of a physiological role for this hormone in linear bone growth...
  31. ncbi request reprint The role of nuclear factor kappaB in late-gestation liver development in the rat
    Michelle Embree-Ku
    Department of Pediatrics, Rhode Island Hospital, MPS 215, 593 Eddy Street, Providence, RI 02903, USA
    Hepatology 42:326-34. 2005
    ..Given this finding and the high level of proliferation in late-gestation fetal liver, we predict that alternative antiapoptotic mechanisms are active during this period of rapid hepatic growth...
  32. ncbi request reprint D-type cyclins and G1 progression during liver development in the rat
    Joan M Boylan
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Biochem Biophys Res Commun 330:722-30. 2005
    ..We speculate that the switch in D-type cyclins may be associated with the dependence on mitogenic signaling that develops as hepatocytes mature...
  33. pmc Disorders of the growth plate
    Chanika Phornphutkul
    Department of Pediatrics, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Curr Opin Endocrinol Diabetes Obes 16:430-4. 2009
    ..To summarize the recent advances in our understanding of the majors genes involved in chondrogenesis and their molecular mechanisms...
  34. ncbi request reprint Educating the next generation of leaders in medicine: The Scholarly Concentrations Program at the Warren Alpert Medical School of Brown University
    Emily Rickards
    Scholarly Concentrations Program, Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
    Med Health R I 90:275-6, 280-2. 2007
    ..We anticipate that the SC Program will raise the profile of the Alpert Medical School of Brown University nationally, and ultimately carve a distinctive place for the school among the top medical education programs in the country...
  35. pmc mTOR signaling contributes to chondrocyte differentiation
    Chanika Phornphutkul
    Department of Pediatrics, Division of Pediatric Endocrinology and Metabolism, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    Dev Dyn 237:702-12. 2008
    ..Our findings support the hypothesis that nutrients, acting through mTOR, directly influence chondrocyte differentiation and long bone growth...
  36. pmc The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells
    Sunny J S Yoo
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    J Cell Biochem 105:290-300. 2008
    ..Our results indicate that the yeast Tap42/TOR paradigm is not conserved in hepatic cells...
  37. ncbi request reprint Redesigning the medical science curriculum at the Warren Alpert Medical School of Brown University
    Sonia Garg
    Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
    Med Health R I 90:272-4. 2007
  38. ncbi request reprint Mechanical stretch induces fetal type II cell differentiation via an epidermal growth factor receptor-extracellular-regulated protein kinase signaling pathway
    Juan Sanchez-Esteban
    Department of Pediatrics, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA
    Am J Respir Cell Mol Biol 30:76-83. 2004
    ..These results suggest that EGFR may be a mechanosensor during fetal lung development. These findings may have significant implications for the design of strategies to accelerate lung maturation...
  39. ncbi request reprint Regulation of adolescent rat intestinal epithelial inducible nitric oxide synthase expression in endotoxin tolerance: modulation of signal transduction
    Caroline S Cerezo
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    Shock 21:476-83. 2004
    ..Endotoxin tolerance can be demonstrated in intestinal epithelial cells using an in vivo model. Modulation of NF-kappaB signaling may be key in the down-regulation of LPS effect seen in tolerance...
  40. pmc Subunit composition and developmental regulation of hepatic protein phosphatase 2A (PP2A)
    Sunny J S Yoo
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Arch Biochem Biophys 461:186-93. 2007
    ..In addition, a significant proportion of PP2A was in inactive forms that may involve novel regulatory subunits. Our results indicate that methylation of PP2A-C appears to be a primary determinant for the biogenesis of PP2A heterotrimers...
  41. ncbi request reprint Targeted hepatic overexpression of human IRS-1: postnatal effects in the developing mouse
    Peter J Giannone
    Division of Neonatology, Women and Infants Hospital of Rhode Island and Brown University, Providence, RI 02903, USA
    Biochim Biophys Acta 1672:112-9. 2004
    ..Our findings indicate that hepatic IRS-1-mediated signaling may be limited in neonatal mice at two levels, post-transcriptional down-regulation of IRS-1 content and attenuated signaling beyond the level of PI3K activation...
  42. ncbi request reprint Glycemic control with metformin or insulin therapy in adolescents with type 2 diabetes mellitus
    Penny M Kadmon
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Pediatr Endocrinol Metab 17:1185-93. 2004
    ..Only metformin and insulin are approved by the FDA for adolescents...

Research Grants35

  1. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2003
    ..We anticipate that these studies will provide novel insights into the regulation of hepatocyte proliferation during normal development and in the mature rat. ..
  2. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2003
    ..We anticipate that our results will provide insight into mechanisms that control the proliferation of hepatocytes under both physiological and pathophysiological conditions. ..
  3. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2004
    ..Furthermore, we anticipate that our findings will relate to diverse areas of liver biology, including the hepatic response to liver injury, hepatic carcinogenesis, and liver stem cell biology. ..
  4. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2004
    ..We anticipate that these studies will provide novel insights into the regulation of hepatocyte proliferation during normal development and in the mature rat. ..
  5. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2004
    ..We anticipate that our results will provide insight into mechanisms that control the proliferation of hepatocytes under both physiological and pathophysiological conditions. ..
  6. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2005
    ..Furthermore, we anticipate that our findings will relate to diverse areas of liver biology, including the hepatic response to liver injury, hepatic carcinogenesis, and liver stem cell biology. ..
  7. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2005
    ..We anticipate that our results will provide insight into mechanisms that control the proliferation of hepatocytes under both physiological and pathophysiological conditions. ..
  8. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2005
    ..We anticipate that these studies will provide novel insights into the regulation of hepatocyte proliferation during normal development and in the mature rat. ..
  9. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2006
    ..Furthermore, we anticipate that our findings will relate to diverse areas of liver biology, including the hepatic response to liver injury, hepatic carcinogenesis, and liver stem cell biology. ..
  10. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2006
    ..We anticipate that these studies will provide novel insights into the regulation of hepatocyte proliferation during normal development and in the mature rat. ..
  11. Nutritional Regulation of Fetal Liver Development
    PHILIP GRUPPUSO; Fiscal Year: 2007
    ..Furthermore, we anticipate that our findings will relate to diverse areas of liver biology, including the hepatic response to liver injury, hepatic carcinogenesis, and liver stem cell biology. ..
  12. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2007
    ....
  13. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2009
    ....
  14. INSULIN RESISTANCE IN THE GROWTH RETARDED FETAL RAT
    PHILIP GRUPPUSO; Fiscal Year: 2002
    ..The investigator plans to use the maternal dietary restriction IUGR rat model to study the changes in the insulin/IGF signaling which occur in these animals in pre- and postnatal periods in order to understand the underlying mechanism. ..
  15. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2002
    ..We anticipate that our results will provide insight into mechanisms that control the proliferation of hepatocytes under both physiological and pathophysiological conditions. ..
  16. Hepatocyte Proliferation During Development: Role of p38
    PHILIP GRUPPUSO; Fiscal Year: 2002
    ..We anticipate that these studies will provide novel insights into the regulation of hepatocyte proliferation during normal development and in the mature rat. ..
  17. INSULIN RESISTANCE IN THE GROWTH RETARDED FETAL RAT
    PHILIP GRUPPUSO; Fiscal Year: 1999
    ..The investigator plans to use the maternal dietary restriction IUGR rat model to study the changes in the insulin/IGF signaling which occur in these animals in pre- and postnatal periods in order to understand the underlying mechanism. ..
  18. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 1999
    ..We anticipate that our results will have implications for the physiology and pathophysiology of perinatal hepatocyte growth and hepatic development. ..
  19. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 1993
    ..It is anticipated that the results of these studies will shed light on basic mechanisms regulating hepatic growth in the fetus and the nature of perturbations in these mechanisms which accompany IUGR...
  20. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 1990
    ..It is anticipated that the changes which occur in IUGR will provide insight into the regulation of fetal hepatic growth...
  21. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 1991
    ..It is anticipated that the changes which occur in IUGR will provide insight into the regulation of fetal hepatic growth...
  22. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 1992
    ..It is anticipated that the changes which occur in IUGR will provide insight into the regulation of fetal hepatic growth...
  23. INSULIN RESISTANCE IN THE GROWTH RETARDED FETAL RAT
    PHILIP GRUPPUSO; Fiscal Year: 2000
    ..The investigator plans to use the maternal dietary restriction IUGR rat model to study the changes in the insulin/IGF signaling which occur in these animals in pre- and postnatal periods in order to understand the underlying mechanism. ..
  24. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2000
    ..We anticipate that our results will have implications for the physiology and pathophysiology of perinatal hepatocyte growth and hepatic development. ..
  25. INSULIN RESISTANCE IN THE GROWTH RETARDED FETAL RAT
    PHILIP GRUPPUSO; Fiscal Year: 2001
    ..The investigator plans to use the maternal dietary restriction IUGR rat model to study the changes in the insulin/IGF signaling which occur in these animals in pre- and postnatal periods in order to understand the underlying mechanism. ..
  26. REGULATION OF FETAL HEPATIC GROWTH
    PHILIP GRUPPUSO; Fiscal Year: 2001
    ..We anticipate that our results will provide insight into mechanisms that control the proliferation of hepatocytes under both physiological and pathophysiological conditions. ..
  27. REGULATION OF FETAL HEPATIC GROWTH
    Philip A Gruppuso; Fiscal Year: 2010
    ....