Jon E Grant

..These findings require replication in larger groups, including non-psychiatric populations, to examine their generalizability...

..32; df = 58; P < .001; t = 7.32; df = 71; P < .001, respectively). These results suggest that patients with kleptomania and pathological gamblers have notably poor quality of life...

..This study examines the response to treatment in 17 patients with kleptomania who were treated with naltrexone as monotherapy for up to 3 years...

..Persons with kleptomania appear to have a high prevalence of personality disorders. Further studies are needed to understand the relationship of kleptomania to personality...

..The present findings indicate that many older pathological gamblers respond to "off-label" use of pharmacotherapy. The present findings are preliminary. Further studies with larger samples are needed to confirm these findings...

..The SCI-PG demonstrated excellent reliability and validity in diagnosing PG in subjects presenting with gambling problems. These findings require replication in other groups to examine their generalizability...

..There were no statistically significant differences by sex. Because kleptomania patients seeking treatment with medication may differ from others with kleptomania, further studies are needed...

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..Little is known about substance use disorders (SUDs) in individuals with body dysmorphic disorder (BDD). Although studies have examined SUD comorbidity in BDD, no previous studies have examined clinical correlates of SUD comorbidity...

..The authors examined the efficacy and tolerability of the opioid antagonist nalmefene in the treatment of adults with pathological gambling...

..To estimate the prevalence, sociodemographic correlates, comorbidity, and rates of mental health service utilization of fire-setters in the general population...

..Although prior studies have examined various clinical characteristics of pathological gambling (PG), limited data exist regarding the clinical correlates of PG based on preferred forms of gambling...

..Treatment approaches may need to be tailored for specific problems secondary to gambling and gender issues based on the history of having a problem gambling parent...

..Nicotine dependence frequently co-occurs with subsyndromal and pathological levels of gambling. The relationship of nicotine dependence, levels of gambling pathology, and other psychiatric disorders, however, is incompletely understood...

..Individuals with a juvenile-onset of OCD or comorbid BPD may be especially vulnerable to SUDs. Further research is needed to identify risk factors for SUDs and to better understand their impact on OCD course...

..Late-onset PG is relatively common and has distinct clinical characteristics suggesting that this population might benefit from unique prevention and treatment strategies...

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..Shoplifting is a relatively common behavior in young adults, but the demographic and neuropsychological correlates of shoplifting remain poorly characterized in this context...

..The goal of our study was to examine cognitive effects of alcohol in young adults at varied levels of alcohol usage using well-validated computerized cognitive measures...

..This study aimed to examine correlates of occupational disability in a large, clinical sample of individuals with a primary diagnosis of obsessive-compulsive disorder (OCD)...

..No studies have systematically examined predictors of medication treatment outcome in PG. Understanding clinical variables related to treatment outcome should help generate treatment algorithms for PG...

..The correlations between the G-SAS and the PG-YBOCS and Clinical Global Impression rating were excellent. Findings suggest that the G-SAS is reliable and valid in assessing changes in symptoms during a drug treatment study...

..However, these neurocognitive data suggest that lamotrigine may be valuable in a subset of patients who exhibit relatively impaired cognitive flexibility...

..N-acetyl cysteine (NAC), an amino acid, seems to restore extracellular glutamate concentration in the nucleus accumbens and therefore offers promise in reducing addictive behavior...

..Pathologic skin picking (PSP) is characterized by the repetitive and compulsive picking of skin which results in tissue damage...

..Quality of life was not associated with symptom severity. Larger studies should examine further the impact PSP and TTM have on quality of life as well as the role quality of life itself plays in the severity and duration of illness...

..An assessment of adolescent shopping behavior along a continuum of severity and its relationship to other behaviors and health issues is incompletely understood...

..These preliminary results suggest that there is a low prevalence of ICDs among individuals with OCD, although certain ICDs (skin picking) appear to be more common...

..Memantine, an N-methyl D-aspartate receptor antagonist, appears to reduce glutamate excitability and improve impulsive decision making, suggesting it may help individuals with PG...

..Whether or not putative pathological gambling subtypes differ in terms of their clinical and cognitive profiles has received little attention...

..The extent to which these disorders share a common cognitive phenotype, however, has yet to be examined. This study sought to compare inhibitory control processes in individuals with PSP or TTM...

..Trichotillomania is characterized by repetitive pulling causing noticeable hair loss. Pharmacological treatment data for trichotillomania are limited...

..This study sought to examine the clinical similarities between PSP and OCD...

..This study examined the efficacy and tolerability of the opioid antagonist naltrexone in adults with PG who have urges to gamble...

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..The objective of this study was to examine the prevalence and clinical correlates of pathological skin picking (PSP) in a large sample of individuals with body dysmorphic disorder (BDD)...

..04). Psychiatric comorbidity and impairment are high in gay and bisexual men with PG. Research is needed to optimize patient care for gay and bisexual men with PG...

..The results highlight the need for further research to identify common pathophysiological elements common to OCPD and associated disorders...

..Further research is needed to validate our findings and identify whether treatments should be specially tailored differently for men and women with grooming disorders...

..Although pathologic skin picking is a relatively common behavior, treatment data are limited. We hypothesized that lamotrigine would reduce the symptoms of pathologic skin picking...

..Women with borderline personality disorder-self-injurious behavior exhibit decreased white matter microstructural integrity in inferior frontal brain regions that may include components of orbito-frontal circuitry...

..This study examined the efficacy and tolerability of the opioid antagonist naltrexone in adults with kleptomania who have urges to steal...

..Kleptomania is associated with significant legal repercussions. The findings emphasize the need for rigorous treatment approaches to target kleptomania symptoms and prevent re-offending...

..This study sought to assess motor inhibitory control and aspects of cognitive flexibility in a sample of individuals with PSP...

..Certain ICDs are common among children and adolescents with OCD. Better identification of ICDs in children and adolescents with OCD is needed, as are empirically validated treatments for youth with co-occurring ICDs...

..This study sought to examine whether those benefits were maintained 6 months post-treatment...

..This study evaluated impulsivity and cognitive flexibility in a sample of pathological gamblers with differing smoking status...

..These findings suggest that medication dosing may be an important consideration in achieving symptom control...

..This study was carried out to test the hypothesis that the hepatic safety profile of prolonged high-dose oral naltrexone (150 mg/d) is acceptable if over-the-counter analgesic use is restricted...

..The present study was designed to test the short-term efficacy and safety of naltrexone in the treatment of kleptomania...

..Traditionally, mood and gambling symptoms have been known to overlap. In the present review we attempt to examine the diagnostic associations and implications for treatment...

..These preliminary results suggest that sexual obsessions are fairly common among individuals with OCD and may be associated with important clinical characteristics...

..This study was constructed to detail the demographic and phenomenological features of males with exhibitionism...

..We also discuss dosage strategies, the duration of treatment, issues surrounding medication compliance, and approaches to treatment-refractory pathological gambling, such as pharmacological and behavioral augmentation...

..Further exploration of these disorders and dimensions of personality may encourage a more inclusively global treatment approach...

..Larger, longer, placebo-controlled, double-blind studies are needed to evaluate further the safety and tolerability of escitalopram in the treatment of PG and co-occurring anxiety...

..Although the disorder is common, appropriate treatments for PSP are limited. Pharmacotherapeutic and certain cognitive-behavioral interventions have demonstrated promise in treating this disorder and need to be explored further...

..N-acetylcysteine, an amino acid, seems to restore the extracellular glutamate concentration in the nucleus accumbens and, therefore, offers promise in the reduction of compulsive behavior...

..Although prior studies have examined rates of bankruptcy in pathologic gambling (PG), there are only limited data regarding the clinical correlates of those with PG who declare bankruptcy because of gambling...

..We hypothesized that naltrexone would reduce the urges and behaviors associated with CSB...

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..We conclude that kleptomania is a distressing and disabling disorder associated with high rates of psychiatric comorbidity...

..This randomized, double-blind, placebo-controlled study investigated the efficacy and tolerability of paroxetine in the treatment of pathological gambling...

..Although PG is a disabling disorder that continues to represent a clinical challenge for the healthcare professional, our current knowledge of pharmacotherapy and psychosocial interventions offers potentially effective treatment options...

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..This study details the demographic and phenomenological features of individuals with DSM-IV lifetime pyromania...

..Paroxetine consistently demonstrated an advantage over placebo on the Clinical Global Impressions scale; however, a larger sample size may have registered significant differences...

..A brief clinical description of PGD is followed by a summary of published drug treatment outcomes and the basic principles of medication treatment in office practice...

..This study sought to detail the phenomenology and medical consequences of pathologic skin picking (PSP)...

..Naltrexone, or augmentation of naltrexone with an SSRI, appears to be most effective in relieving gambling symptoms...

..There appear to be some gender differences in the clinical features of PGD, and these differences may have treatment implications...

..These findings suggest that an understanding of early parenting behavior and a dimensional approach to the personality of kleptomaniacs may offer insight into this disorder and provide clues to treatment strategies...

..Body dysmorphic disorder (BDD) is a relatively common and often-disabling obsessive compulsive spectrum disorder that often goes unrecognized in clinical practice...

..Although research on body dysmorphic disorder (BDD) is increasing, no follow-up studies of this disorder's course of illness have been published...

..We hypothesized that body dysmorphic disorder would be underdiagnosed in patients with anorexia nervosa and that comorbidity with body dysmorphic disorder would result in greater overall dysfunction...

..Subtyping of individuals with kleptomania may be a useful way to better understand this behavior and decide on effective treatment interventions...

..The purpose of this investigation was to shed light on a possible link between dissociation and pathological gambling, a relatively common disorder whose phenomenology remains understudied...

..An improved understanding of the relationship would be helpful in treating individuals with co-occurring pathological gambling and nicotine dependence...

..056; df=1; P=.001). Persons with kleptomania appear to have a higher lifetime prevalence of impulse-control disorders and are more likely to have first-degree relatives with alcohol problems than are comparison subjects...

..To examine in a sex-sensitive manner the frequencies, clinical correlates, and patterns of co-occurrence of impulse-control disorders in adolescent psychiatric inpatients...

..Little is known about trichophagia in individuals with trichotillomania. Although studies have mentioned the behavior, no previous studies have examined clinical correlates of trichophagia...

..Predictors of treatment continuation may have clinical importance. Prospective longitudinal studies are needed to further elucidate the course of pathological gambling...

..Few empirical investigations have been performed in kleptomania, particularly with respect to gender-related influences...

..The construct of compulsivity as related to ICDs and OCD warrants additional investigation to identify the similarities and differences and to examine the implications for prevention and treatment strategies...

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..PG-YBOCS thus appears to be a reliable and valid measure of pathological gambling severity, and can be regarded as an important tool for clinicians and researchers treating pathological gamblers...

..The authors' goal was to examine the prevalence of impulse control disorders in psychiatric inpatients...

..Despite its relatively long history, kleptomania remains poorly understood to the general public, clinicians, and sufferers...

..We also examined the relationship between alcohol craving and the clinical characteristics of alcohol-dependent patients...

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..Although the article by Ledgerwood and colleagues provides additional insight into the relationship between pathological gambling and illegal behavior, many questions remain unanswered and warrant further investigation...

..We sought to examine the similarities and differences between these three groups from a clinical viewpoint...

..Little is known about the role of the endogenous opioid system in these differences. This study was conducted to compare adrenocortical, pain sensitivity, and blood pressure responses to opioid blockade using naltrexone in men and women...

..No significant differences were found for other measures assessed. Further research is necessary to determine the subpopulations in which these effects are of greatest magnitude and the long term safety implications of these effects...

..693, p=0.004). As a group, subjects with kleptomania did not demonstrate deficits on neuropsychological testing. Greater kleptomania symptom severity, however, was correlated with impairment in executive functioning...

..These preliminary findings suggest that neglectful parenting appears to be associated with pathological gambling disorder...