Leslie B Gordon

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
    Brian C Capell
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, MSC 8004, Bethesda, MD 20892 8004, USA
    Proc Natl Acad Sci U S A 102:12879-84. 2005
  2. pmc Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody
    Dayle McClintock
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:2154-9. 2006
  3. pmc Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome
    Ingrid A Harten
    Hope Heart Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
    J Gerontol A Biol Sci Med Sci 66:1201-7. 2011
  4. pmc Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome
    Leslie B Gordon
    Department of Anesthesia, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:16666-71. 2012
  5. ncbi request reprint Highlights of the 2007 Progeria Research Foundation scientific workshop: progress in translational science
    Leslie B Gordon
    Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
    J Gerontol A Biol Sci Med Sci 63:777-87. 2008
  6. ncbi request reprint Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development
    Leslie B Gordon
    Department of Pediatrics, Rhode Island Hospital, Providence, Rhode Island, USA
    Pediatrics 120:824-33. 2007
  7. doi request reprint A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome
    Robert H Cleveland
    Pediatric Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Radiol 42:1089-98. 2012
  8. pmc Mechanisms of premature vascular aging in children with Hutchinson-Gilford progeria syndrome
    Marie Gerhard-Herman
    Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hypertension 59:92-7. 2012
  9. pmc Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment
    Nicole J Ullrich
    From the Departments of Neurology N J U, Y J C, Hematology Oncology M W K, Anesthesia L B G, M E K, Genetics D T M, and Radiology V M S, Boston Children s Hospital and Harvard Medical School, Boston, MA Department of Pediatrics L B G, Hasbro Children s Hospital and Warren Alpert Medical School of Brown University, Providence, RI and Department of Biostatistics and Computational Biology A G H, D N, Dana Farber Cancer Institute, Boston, MA
    Neurology 81:427-30. 2013
  10. doi request reprint Hutchinson-Gilford progeria is a skeletal dysplasia
    Catherine M Gordon
    Division of Adolescent Medicine and Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    J Bone Miner Res 26:1670-9. 2011

Collaborators

  • Ara Nazarian
  • Armin Schwartzman
  • Marie Gerhard-Herman
  • Robert H Cleveland
  • Susanna Y Huh
  • M W Kieran
  • Robert D Goldman
  • Antonei B Csoka
  • Alice Lichtenstein
  • Francis S Collins
  • Dayle McClintock
  • Joan M Lemire
  • Renee Varga
  • Nicole J Ullrich
  • Brian C Capell
  • Anita Giobbie-Hurder
  • David T Miller
  • Michael R Erdos
  • Donna Neuberg
  • Maria Eriksson
  • Ingrid A Harten
  • Catherine M Gordon
  • Bryan P Toole
  • Thomas N Wight
  • Melissa A Merideth
  • April Bingham
  • Elizabeth G Nabel
  • Karima Djabali
  • Monica E Kleinman
  • V Michelle Silvera
  • Yoon Jae Cho
  • Jason T Machan
  • Frank G Rothman
  • Robert J Doiron
  • Marsha A Moses
  • Monica Kleinman
  • Rima S Zahr
  • Nicolle Quinn
  • Adam S Curatolo
  • Brian D Snyder
  • Simeon Taylor
  • Emily Von Scheven
  • Nancy Sebring
  • Christopher T Parker
  • Brian P Brooks
  • Carmen C Brewer
  • Monique B Perry
  • Frederick T Murphy
  • Lynn H Gerber
  • Lawrence K Jung
  • Demetrio L Domingo
  • Gloria C Higgins
  • Thomas C Hart
  • Steven R Bauer
  • Carol A Wallace
  • Ann C M Smith
  • Donald P Goldsmith
  • Scott A Vogelgesang
  • Harry L Gewanter
  • Phillip Gorden
  • Alan N Baer
  • Danielle Mercatante Carrick
  • Frederick W Miller
  • Lisa G Rider
  • Rafael F Rivas-Chacon
  • John Miller
  • James C Reynolds
  • S Ray Mitchell
  • Donald A Person
  • Elizabeth Chalom Candell
  • Robert M Rennebohm
  • Laura James-Newton
  • C Michael Knee
  • E Arthur
  • Patience H White
  • Ildy M Katona
  • Balu H Athreya
  • Peter N Malleson
  • Karyl S Barron
  • Christopher Zalewski
  • H Jeffrey Kim
  • Jack A Yanovski
  • Ira N Targoff
  • Richard O Cannon
  • John F Bohnsack
  • Andrew H Eichenfield
  • Jerry C Jacobs
  • Stephen W George
  • Wendy J Introne
  • Andrea Gropman

Detail Information

Publications18

  1. pmc Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
    Brian C Capell
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, MSC 8004, Bethesda, MD 20892 8004, USA
    Proc Natl Acad Sci U S A 102:12879-84. 2005
    ..Last, treatment of both early- and late-passage human HGPS fibroblasts with FTIs resulted in significant reductions in nuclear blebbing. Our results suggest that treatment with FTIs represents a potential therapy for patients with HGPS...
  2. pmc Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody
    Dayle McClintock
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:2154-9. 2006
    ..This finding suggests that accumulation of progerin is directly involved in vascular disease in progeria...
  3. pmc Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome
    Ingrid A Harten
    Hope Heart Matrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
    J Gerontol A Biol Sci Med Sci 66:1201-7. 2011
    ..This metalloproteinase has the potential to serve as a biomarker of therapeutic efficacy when assessing treatments for HGPS...
  4. pmc Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome
    Leslie B Gordon
    Department of Anesthesia, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:16666-71. 2012
    ..Results from this clinical treatment trial for children with HGPS provide preliminary evidence that lonafarnib may improve vascular stiffness, bone structure, and audiological status...
  5. ncbi request reprint Highlights of the 2007 Progeria Research Foundation scientific workshop: progress in translational science
    Leslie B Gordon
    Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
    J Gerontol A Biol Sci Med Sci 63:777-87. 2008
  6. ncbi request reprint Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development
    Leslie B Gordon
    Department of Pediatrics, Rhode Island Hospital, Providence, Rhode Island, USA
    Pediatrics 120:824-33. 2007
    ..We sought to more clearly define the bone and weight abnormalities in patients with progeria as potential outcome parameters for prospective clinical trials...
  7. doi request reprint A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome
    Robert H Cleveland
    Pediatric Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Radiol 42:1089-98. 2012
    ..There has been no comprehensive prospective study describing the skeletal abnormalities associated with progeria...
  8. pmc Mechanisms of premature vascular aging in children with Hutchinson-Gilford progeria syndrome
    Marie Gerhard-Herman
    Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hypertension 59:92-7. 2012
    ....
  9. pmc Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment
    Nicole J Ullrich
    From the Departments of Neurology N J U, Y J C, Hematology Oncology M W K, Anesthesia L B G, M E K, Genetics D T M, and Radiology V M S, Boston Children s Hospital and Harvard Medical School, Boston, MA Department of Pediatrics L B G, Hasbro Children s Hospital and Warren Alpert Medical School of Brown University, Providence, RI and Department of Biostatistics and Computational Biology A G H, D N, Dana Farber Cancer Institute, Boston, MA
    Neurology 81:427-30. 2013
    ....
  10. doi request reprint Hutchinson-Gilford progeria is a skeletal dysplasia
    Catherine M Gordon
    Division of Adolescent Medicine and Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    J Bone Miner Res 26:1670-9. 2011
    ..Dietary intake was adequate, confirming that HGPS does not represent a model of malnutrition-induced bone loss. Taken together, these findings suggest that the phenotype of HGPS represents a unique skeletal dysplasia...
  11. ncbi request reprint Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
    Maria Eriksson
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Nature 423:293-8. 2003
    ..The discovery of the molecular basis of this disease may shed light on the general phenomenon of human ageing...
  12. pmc Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome
    Renee Varga
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:3250-5. 2006
    ..This mouse model should prove valuable for testing experimental therapies for this devastating disorder and for exploring cardiovascular disease in general...
  13. pmc Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
    Robert D Goldman
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:8963-8. 2004
    ....
  14. pmc The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin
    Dayle McClintock
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
    PLoS ONE 2:e1269. 2007
    ..Our findings demonstrate that progerin expression is a biomarker of normal cellular aging and may potentially be linked to terminal differentiation and senescence in elderly individuals...
  15. pmc Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity
    April Bingham
    From Office of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland 20892 1301, USA
    Medicine (Baltimore) 87:70-86. 2008
    ..Further study is warranted to investigate the pathogenesis of acquired LD in patients with DM...
  16. ncbi request reprint Aggrecan expression is substantially and abnormally upregulated in Hutchinson-Gilford Progeria Syndrome dermal fibroblasts
    Joan M Lemire
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA
    Mech Ageing Dev 127:660-9. 2006
    ..This demonstrates that elevated aggrecan expression and its secretion are aberrant features of HGPS. We conclude that HGPS cells can display massively altered transcript levels leading to the secretion of inappropriate protein species...
  17. ncbi request reprint Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome
    Leslie B Gordon
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Pediatr 146:336-41. 2005
    ..We determined whether children with HGPS demonstrate abnormalities in known biomarkers for cardiovascular disease (CVD) risk...
  18. pmc Phenotype and course of Hutchinson-Gilford progeria syndrome
    Melissa A Merideth
    National Human Genome Research Institute, Intramural Office of Rare Disease, National Institutes of Health, Bethesda, MD 20892 1851, USA
    N Engl J Med 358:592-604. 2008
    ....