Jennifer E Friedman

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Human schistosomiasis and anemia: the relationship and potential mechanisms
    Jennifer F Friedman
    Brown University, International Health Institute, Box G B495, Providence, RI 02912, USA
    Trends Parasitol 21:386-92. 2005
  2. ncbi request reprint Progression of stunting and its predictors among school-aged children in western Kenya
    J F Friedman
    US Department of State, Institute of International Education, Fulbright Fellowships, Washington, DC, USA
    Eur J Clin Nutr 59:914-22. 2005
  3. ncbi request reprint Relationship between Schistosoma japonicum and nutritional status among children and young adults in Leyte, the Philippines
    Jennifer F Friedman
    International Health Institute, Brown University, Providence, Rhode Island 02912, USA
    Am J Trop Med Hyg 72:527-33. 2005
  4. ncbi request reprint The dual burden of infectious and non-communicable diseases in the Asia-Pacific region: examples from the Philippines and the Samoan Islands
    Jennifer E Friedman
    Warren Alpert Medical School, Brown University, USA
    Med Health R I 90:346-50. 2007
  5. ncbi request reprint Malaria and nutritional status among pre-school children: results from cross-sectional surveys in western Kenya
    Jennifer F Friedman
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 73:698-704. 2005
  6. ncbi request reprint Child care center policies and practices for management of ill children
    Jennifer F Friedman
    Harvard Pediatric Health Services Research Fellowship Program, Children s Hospital Boston, Boston, MA, USA
    Ambul Pediatr 4:455-60. 2004
  7. ncbi request reprint Schistosomiasis and pregnancy
    Jennifer F Friedman
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
    Trends Parasitol 23:159-64. 2007
  8. ncbi request reprint Impact of permethrin-treated bed nets on growth, nutritional status, and body composition of primary school children in western Kenya
    Jennifer F Friedman
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:78-85. 2003
  9. ncbi request reprint Impact of permethrin-treated bed nets on malaria and all-cause morbidity in young children in an area of intense perennial malaria transmission in western Kenya: cross-sectional survey
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:100-7. 2003
  10. ncbi request reprint Impact of permethrin-treated bed nets on malaria, anemia, and growth in infants in an area of intense perennial malaria transmission in western Kenya
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:68-77. 2003

Research Grants

  1. S. japonicum morbidity and pro-inflammatory cytokines
    Jennifer Friedman; Fiscal Year: 2005
  2. Inflammation, Iron, and Cognition in S. japonicum
    Jennifer Friedman; Fiscal Year: 2005
  3. S.japonicum and pregnancy outcomes: an RCT
    Jennifer Friedman; Fiscal Year: 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Human schistosomiasis and anemia: the relationship and potential mechanisms
    Jennifer F Friedman
    Brown University, International Health Institute, Box G B495, Providence, RI 02912, USA
    Trends Parasitol 21:386-92. 2005
    ....
  2. ncbi request reprint Progression of stunting and its predictors among school-aged children in western Kenya
    J F Friedman
    US Department of State, Institute of International Education, Fulbright Fellowships, Washington, DC, USA
    Eur J Clin Nutr 59:914-22. 2005
    ....
  3. ncbi request reprint Relationship between Schistosoma japonicum and nutritional status among children and young adults in Leyte, the Philippines
    Jennifer F Friedman
    International Health Institute, Brown University, Providence, Rhode Island 02912, USA
    Am J Trop Med Hyg 72:527-33. 2005
    ..japonicum and both PEM and anemia. Exploration of the mechanisms of S. japonicum-associated anemia suggests that processes other than extracorporeal blood loss, such as anemia or inflammation, may be involved...
  4. ncbi request reprint The dual burden of infectious and non-communicable diseases in the Asia-Pacific region: examples from the Philippines and the Samoan Islands
    Jennifer E Friedman
    Warren Alpert Medical School, Brown University, USA
    Med Health R I 90:346-50. 2007
  5. ncbi request reprint Malaria and nutritional status among pre-school children: results from cross-sectional surveys in western Kenya
    Jennifer F Friedman
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 73:698-704. 2005
    ....
  6. ncbi request reprint Child care center policies and practices for management of ill children
    Jennifer F Friedman
    Harvard Pediatric Health Services Research Fellowship Program, Children s Hospital Boston, Boston, MA, USA
    Ambul Pediatr 4:455-60. 2004
    ....
  7. ncbi request reprint Schistosomiasis and pregnancy
    Jennifer F Friedman
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
    Trends Parasitol 23:159-64. 2007
    ....
  8. ncbi request reprint Impact of permethrin-treated bed nets on growth, nutritional status, and body composition of primary school children in western Kenya
    Jennifer F Friedman
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:78-85. 2003
    ..2%; P = 0.04). This may be consequent to reduced exposure to malaria with subsequent reduced elaboration of pro-inflammatory cytokines known to promote muscle wasting...
  9. ncbi request reprint Impact of permethrin-treated bed nets on malaria and all-cause morbidity in young children in an area of intense perennial malaria transmission in western Kenya: cross-sectional survey
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:100-7. 2003
    ..The ITNs substantially reduced malaria-associated morbidity and improved weight gain in young children in this area of intense perennial malaria transmission...
  10. ncbi request reprint Impact of permethrin-treated bed nets on malaria, anemia, and growth in infants in an area of intense perennial malaria transmission in western Kenya
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:68-77. 2003
    ..Reduced malaria exposure during infancy did not result, with continued ITN use, in increased malaria morbidity in one-year-old children...
  11. pmc Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4
    Mario Jiz
    Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02901, USA
    Infect Immun 77:2051-8. 2009
    ....
  12. ncbi request reprint Reduction of malaria during pregnancy by permethrin-treated bed nets in an area of intense perennial malaria transmission in western Kenya
    Feiko O Ter Kuile
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:50-60. 2003
    ..No beneficial impact was observed in gravidae five or higher. In areas of intense perennial malaria transmission, permethrin-treated bed nets reduce the adverse effect of malaria during the first four pregnancies...
  13. pmc Anemia of inflammation is related to cognitive impairment among children in Leyte, the Philippines
    Courtney L Olson
    Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, United States of America
    PLoS Negl Trop Dis 3:e533. 2009
    ..The objective of this study was to determine the effect of NIDA, due largely to AI in this context, on cognitive function after adjustment for potential confounders...
  14. ncbi request reprint Higher serum concentrations of DHEAS predict improved nutritional status in helminth-infected children, adolescents, and young adults in Leyte, the Philippines
    Hannah M Coutinho
    Center for International Health Research CIHR, Rhode Island Hospital, Brown University Medical School, Providence, RI 02903, USA
    J Nutr 137:433-9. 2007
    ..This novel regulatory mechanism of inflammation-related nutritional morbidity emphasizes the importance of treating prepubescent children for helminth infections...
  15. ncbi request reprint Pro-inflammatory cytokines and C-reactive protein are associated with undernutrition in the context of Schistosoma japonicum infection
    Hannah M Coutinho
    Center for International Health Research CIHR, Rhode Island Hospital, Brown University Medical School, Providence, RI 02903, USA
    Am J Trop Med Hyg 75:720-6. 2006
    ..005) and height-for-age Z-score (TNF-alpha only, P = 0.05). S. japonicum-associated undernutrition may, in part, result directly from inflammation...
  16. pmc Tissue inhibitor of matrix-metalloprotease-1 predicts risk of hepatic fibrosis in human Schistosoma japonicum infection
    Valeria Fabre
    Department of Medicine, Memorial Hospital of Rhode Island, Brown University Medical School, Providence, RI, USA
    J Infect Dis 203:707-14. 2011
    ..Little is known regarding the mechanisms of schistosome-associated hepatic fibrosis in humans, and few biomarkers for risk of fibrosis have been identified...
  17. pmc High prevalence of Schistosoma japonicum infection in water buffaloes in the Philippines assessed by real-time polymerase chain reaction
    Hai Wei Wu
    Department of Pathogen Biology, Nanjing Medical University, Nanjing, China
    Am J Trop Med Hyg 82:646-52. 2010
    ..japonicum infection in water buffaloes in the Philippines and warrant reexamination of the role of bovines in transmission of S. japonicum to humans in the Philippines...
  18. pmc Lessons learned from family-centred models of treatment for children living with HIV: current approaches and future directions
    Sarah C Leeper
    Brown University Medical School, Providence, Rhode Island, USA
    J Int AIDS Soc 13:S3. 2010
    ..A systematic review of family-centred HIV care programmes was conducted in order to describe both programme components and paediatric cohort characteristics...
  19. pmc Reduction in hookworm infection after praziquantel treatment among children and young adults in Leyte, the Philippines
    Julia G Shaw
    Department of Community Health, Brown University, Providence, RI, USA
    Am J Trop Med Hyg 83:416-21. 2010
    ..8%. Praziquantel treatment did not decrease the infection intensity of STHs. Control programs using praziquantel may have the added benefit of reducing hookworm infection and anemia in areas of coendemnicity...
  20. pmc Maternal Schistosomiasis japonica is associated with maternal, placental, and fetal inflammation
    Jonathan D Kurtis
    Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI 02903, USA
    Infect Immun 79:1254-61. 2011
    ..This potential mechanistic link between maternal schistosomiasis and poor birth outcomes will contribute to the debate regarding treatment of maternal schistosome infections...
  21. pmc Schistosoma japonicum reinfection after praziquantel treatment causes anemia associated with inflammation
    Tjalling Leenstra
    Center for International Health Research, Lifespan Hospitals, and Department of Pediatrics, Brown University Medical School, 55 Claverick Street, Suite 102, Providence, RI 02903, USA
    Infect Immun 74:6398-407. 2006
    ..Based on the proposed mechanism, anemia is unlikely to be ameliorated by iron therapy alone...
  22. ncbi request reprint Pubertal development predicts resistance to infection and reinfection with Schistosoma japonicum
    Jonathan D Kurtis
    Center for International Health Research, Rhode Island Hospital, Brown University School of Medicine, Providence, RI 02903, USA
    Clin Infect Dis 42:1692-8. 2006
    ..This epidemiologic pattern is consistent with either the slow development of resistance or the requirement of host developmental changes for the expression of resistance...
  23. ncbi request reprint Schistosomiasis japonica, anemia, and iron status in children, adolescents, and young adults in Leyte, Philippines 1
    Tjalling Leenstra
    International Health Institute, Brown University, Providence, RI 02903, USA
    Am J Clin Nutr 83:371-9. 2006
    ..Alternatively, anemia may result from cytokine-mediated dyserythropoiesis, as seen in anemia of inflammation...
  24. ncbi request reprint Acute care and antibiotic seeking for upper respiratory tract infections for children in day care: parental knowledge and day care center policies
    Jennifer F Friedman
    Harvard Pediatric Health Services Research Fellowship Program, The Children s Hospital, Boston, MA, USA
    Arch Pediatr Adolesc Med 157:369-74. 2003
    ..Studies suggest that physicians prescribe unnecessary antibiotics for upper respiratory tract infections (URIs) for children who attend day care on the basis of perceived pressure from parents and/or day care centers...
  25. ncbi request reprint Malaria is related to decreased nutritional status among male adolescents and adults in the setting of intense perennial transmission
    Jennifer F Friedman
    United States Department of State, Institute of International Education, Fulbright Fellowships, Washington, DC, USA
    J Infect Dis 188:449-57. 2003
    ..These effects of malaria may have pervasive health and socioeconomic consequences in areas where malaria is endemic...
  26. ncbi request reprint Schistosoma japonicum and occult blood loss in endemic villages in Leyte, the Philippines
    Hemal K Kanzaria
    International Health Institute, Brown University, Providence, Rhode Island 02912, USA
    Am J Trop Med Hyg 72:115-8. 2005
    ..0003; and OR = 1.6, P = 0.021, respectively). It is likely that occult blood loss plays a role only at heavier intensity S. japonicum infections and some other mechanism, such as anemia of inflammation, may be contributing to anemia...
  27. pmc Helminth infection and cognitive impairment among Filipino children
    Amara E Ezeamama
    International Health Institute, Brown University, Providence, Rhode Island 02912, USA
    Am J Trop Med Hyg 72:540-8. 2005
    ..04-30). Helminth infection was associated with lower performance in three of the four cognitive domains examined in this study. These relationships remained after rigorous control for other helminths and important confounding covariates...
  28. ncbi request reprint Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines
    Hannah M Coutinho
    International Health Institute, Brown University, Providence, RI 02912, USA
    J Infect Dis 192:528-36. 2005
    ..In addition, our data are consistent with the hypothesis that, by systemically increasing the levels of the proinflammatory cytokines IL-1 and IL-6, HF causes undernutrition and anemia...
  29. ncbi request reprint Functional significance of low-intensity polyparasite helminth infections in anemia
    Amara E Ezeamama
    International Health Institute, Brown University, Providence, RI 02912, USA
    J Infect Dis 192:2160-70. 2005
    ..We wanted to quantify the impact that polyparasite infections, including multiple concurrent low-intensity infections, have on anemia...
  30. ncbi request reprint Nutritional status improves after treatment of schistosoma japonicum-infected children and adolescents
    Hannah M Coutinho
    Center for International Health Research, Brown University Medical School, Providence, RI, USA
    J Nutr 136:183-8. 2006
    ..Based on the peak Hb improvement at 15 mo post-treatment, annual treatment intervals are recommended to reduce schistosomiasis-associated nutritional morbidity...
  31. pmc T-helper-2 cytokine responses to Sj97 predict resistance to reinfection with Schistosoma japonicum
    Tjalling Leenstra
    Center for International Health Research, Brown University Medical School, 55 Claverick St, Providence, RI 02903, USA
    Infect Immun 74:370-81. 2006
    ..These findings underscore Th2-type immune responses as central in human resistance to S. japonicum and support Sj97 as a leading vaccine candidate for this parasite...
  32. ncbi request reprint An update on anemia in less developed countries
    Karine Tolentino
    Center for International Health Research at Rhode Island Hospital and Department of Pediatrics, Brown University Medical School, Providence, Rhode Island, USA
    Am J Trop Med Hyg 77:44-51. 2007
    ..This review will focus on recent advances in our understanding of the burden of anemia in specific sub-groups, the causes and mechanisms of anemia, and consequences of anemia for the human host...
  33. doi request reprint The iron trap: iron, malaria and anemia at the mother-child interface
    Jennifer F Friedman
    Department of Pediatrics, Brown University, Providence, RI, USA
    Microbes Infect 11:460-6. 2009
    ..Improved iron status assays, and understanding of malaria protection mechanisms, are needed to manage these disorders...
  34. ncbi request reprint Illness transmission in the home: a possible role for alcohol-based hand gels
    Grace M Lee
    Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts 02215, USA
    Pediatrics 115:852-60. 2005
    ..We also sought to examine potential predictors of reduced illness transmission in the home in a secondary analysis...
  35. pmc Pilot-scale production and characterization of paramyosin, a vaccine candidate for schistosomiasis japonica
    Mario Jiz
    Center for International Health Research, Rhode Island Hospital, Providence, RI 02903, USA
    Infect Immun 76:3164-9. 2008
    ..japonicum-infected individuals contain anti-rSj97 IgE antibodies. Our method for pilot-scale production of recombinant full-length paramyosin will facilitate preclinical evaluation of paramyosin as a vaccine for schistosomiasis...
  36. ncbi request reprint Misconceptions about colds and predictors of health service utilization
    Grace M Lee
    Division of Infectious Diseases, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 111:231-6. 2003
    ..The objective of this study was to determine predictors of reported ED use and ambulatory care use for colds among families with young children...
  37. ncbi request reprint Prevalence and severity of malnutrition in pre-school children in a rural area of western Kenya
    Arthur M Kwena
    Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Am J Trop Med Hyg 68:94-9. 2003
    ..Malnutrition is likely to interact with infectious diseases, placing children 3-24 months of age at high risk of premature death in this area...

Research Grants5

  1. S. japonicum morbidity and pro-inflammatory cytokines
    Jennifer Friedman; Fiscal Year: 2005
    ..Her long term goals are to further our understanding of parasite associated morbidity in children and use this data to inform our efforts to promote the health of children in the developing world. ..
  2. Inflammation, Iron, and Cognition in S. japonicum
    Jennifer Friedman; Fiscal Year: 2005
    ..We hypothesize that host's pro-inflammatory immune responses to parasitic diseases decrease the bioavailability of iron through anemia of inflammation, which, in turn, negatively impacts cognitive function. ..
  3. S.japonicum and pregnancy outcomes: an RCT
    Jennifer Friedman; Fiscal Year: 2007
    ..A trophoblast apoptosis assay will also be used to assess the effect of maternal serum from 32 weeks gestation on trophoblast apoptosis. ..