Research Topics
| Jennifer E FriedmanSummaryAffiliation: Brown University Country: USA Publications
Research Grants
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Detail Information
Publications
Human schistosomiasis and anemia: the relationship and potential mechanismsJennifer F Friedman
Brown University, International Health Institute, Box G B495, Providence, RI 02912, USA
Trends Parasitol 21:386-92. 2005....- Progression of stunting and its predictors among school-aged children in western KenyaJ F Friedman
US Department of State, Institute of International Education, Fulbright Fellowships, Washington, DC, USA
Eur J Clin Nutr 59:914-22. 2005.... - Relationship between Schistosoma japonicum and nutritional status among children and young adults in Leyte, the PhilippinesJennifer F Friedman
International Health Institute, Brown University, Providence, Rhode Island 02912, USA
Am J Trop Med Hyg 72:527-33. 2005..japonicum and both PEM and anemia. Exploration of the mechanisms of S. japonicum-associated anemia suggests that processes other than extracorporeal blood loss, such as anemia or inflammation, may be involved... - The dual burden of infectious and non-communicable diseases in the Asia-Pacific region: examples from the Philippines and the Samoan IslandsJennifer E Friedman
Warren Alpert Medical School, Brown University, USA
Med Health R I 90:346-50. 2007 - Malaria and nutritional status among pre-school children: results from cross-sectional surveys in western KenyaJennifer F Friedman
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Am J Trop Med Hyg 73:698-704. 2005.... - Child care center policies and practices for management of ill childrenJennifer F Friedman
Harvard Pediatric Health Services Research Fellowship Program, Children s Hospital Boston, Boston, MA, USA
Ambul Pediatr 4:455-60. 2004.... - Schistosomiasis and pregnancyJennifer F Friedman
Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
Trends Parasitol 23:159-64. 2007.... - Impact of permethrin-treated bed nets on growth, nutritional status, and body composition of primary school children in western KenyaJennifer F Friedman
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Am J Trop Med Hyg 68:78-85. 2003..2%; P = 0.04). This may be consequent to reduced exposure to malaria with subsequent reduced elaboration of pro-inflammatory cytokines known to promote muscle wasting... - Impact of permethrin-treated bed nets on malaria and all-cause morbidity in young children in an area of intense perennial malaria transmission in western Kenya: cross-sectional surveyFeiko O Ter Kuile
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Am J Trop Med Hyg 68:100-7. 2003..The ITNs substantially reduced malaria-associated morbidity and improved weight gain in young children in this area of intense perennial malaria transmission... - Impact of permethrin-treated bed nets on malaria, anemia, and growth in infants in an area of intense perennial malaria transmission in western KenyaFeiko O Ter Kuile
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Am J Trop Med Hyg 68:68-77. 2003..Reduced malaria exposure during infancy did not result, with continued ITN use, in increased malaria morbidity in one-year-old children... - Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4Mario Jiz
Center for International Health Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02901, USA
Infect Immun 77:2051-8. 2009.... - Reduction of malaria during pregnancy by permethrin-treated bed nets in an area of intense perennial malaria transmission in western KenyaFeiko O Ter Kuile
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Am J Trop Med Hyg 68:50-60. 2003..No beneficial impact was observed in gravidae five or higher. In areas of intense perennial malaria transmission, permethrin-treated bed nets reduce the adverse effect of malaria during the first four pregnancies... - Anemia of inflammation is related to cognitive impairment among children in Leyte, the PhilippinesCourtney L Olson
Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, United States of America
PLoS Negl Trop Dis 3:e533. 2009..The objective of this study was to determine the effect of NIDA, due largely to AI in this context, on cognitive function after adjustment for potential confounders... - Higher serum concentrations of DHEAS predict improved nutritional status in helminth-infected children, adolescents, and young adults in Leyte, the PhilippinesHannah M Coutinho
Center for International Health Research CIHR, Rhode Island Hospital, Brown University Medical School, Providence, RI 02903, USA
J Nutr 137:433-9. 2007..This novel regulatory mechanism of inflammation-related nutritional morbidity emphasizes the importance of treating prepubescent children for helminth infections... - Pro-inflammatory cytokines and C-reactive protein are associated with undernutrition in the context of Schistosoma japonicum infectionHannah M Coutinho
Center for International Health Research CIHR, Rhode Island Hospital, Brown University Medical School, Providence, RI 02903, USA
Am J Trop Med Hyg 75:720-6. 2006..005) and height-for-age Z-score (TNF-alpha only, P = 0.05). S. japonicum-associated undernutrition may, in part, result directly from inflammation... - Tissue inhibitor of matrix-metalloprotease-1 predicts risk of hepatic fibrosis in human Schistosoma japonicum infectionValeria Fabre
Department of Medicine, Memorial Hospital of Rhode Island, Brown University Medical School, Providence, RI, USA
J Infect Dis 203:707-14. 2011..Little is known regarding the mechanisms of schistosome-associated hepatic fibrosis in humans, and few biomarkers for risk of fibrosis have been identified... - High prevalence of Schistosoma japonicum infection in water buffaloes in the Philippines assessed by real-time polymerase chain reactionHai Wei Wu
Department of Pathogen Biology, Nanjing Medical University, Nanjing, China
Am J Trop Med Hyg 82:646-52. 2010..japonicum infection in water buffaloes in the Philippines and warrant reexamination of the role of bovines in transmission of S. japonicum to humans in the Philippines... - Lessons learned from family-centred models of treatment for children living with HIV: current approaches and future directionsSarah C Leeper
Brown University Medical School, Providence, Rhode Island, USA
J Int AIDS Soc 13:S3. 2010..A systematic review of family-centred HIV care programmes was conducted in order to describe both programme components and paediatric cohort characteristics... - Reduction in hookworm infection after praziquantel treatment among children and young adults in Leyte, the PhilippinesJulia G Shaw
Department of Community Health, Brown University, Providence, RI, USA
Am J Trop Med Hyg 83:416-21. 2010..8%. Praziquantel treatment did not decrease the infection intensity of STHs. Control programs using praziquantel may have the added benefit of reducing hookworm infection and anemia in areas of coendemnicity... - Maternal Schistosomiasis japonica is associated with maternal, placental, and fetal inflammationJonathan D Kurtis
Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI 02903, USA
Infect Immun 79:1254-61. 2011..This potential mechanistic link between maternal schistosomiasis and poor birth outcomes will contribute to the debate regarding treatment of maternal schistosome infections... - Schistosoma japonicum reinfection after praziquantel treatment causes anemia associated with inflammationTjalling Leenstra
Center for International Health Research, Lifespan Hospitals, and Department of Pediatrics, Brown University Medical School, 55 Claverick Street, Suite 102, Providence, RI 02903, USA
Infect Immun 74:6398-407. 2006..Based on the proposed mechanism, anemia is unlikely to be ameliorated by iron therapy alone... - Pubertal development predicts resistance to infection and reinfection with Schistosoma japonicumJonathan D Kurtis
Center for International Health Research, Rhode Island Hospital, Brown University School of Medicine, Providence, RI 02903, USA
Clin Infect Dis 42:1692-8. 2006..This epidemiologic pattern is consistent with either the slow development of resistance or the requirement of host developmental changes for the expression of resistance... - Schistosomiasis japonica, anemia, and iron status in children, adolescents, and young adults in Leyte, Philippines 1Tjalling Leenstra
International Health Institute, Brown University, Providence, RI 02903, USA
Am J Clin Nutr 83:371-9. 2006..Alternatively, anemia may result from cytokine-mediated dyserythropoiesis, as seen in anemia of inflammation... - Acute care and antibiotic seeking for upper respiratory tract infections for children in day care: parental knowledge and day care center policiesJennifer F Friedman
Harvard Pediatric Health Services Research Fellowship Program, The Children's Hospital, Boston, MA, USA
Arch Pediatr Adolesc Med 157:369-74. 2003.... - Malaria is related to decreased nutritional status among male adolescents and adults in the setting of intense perennial transmissionJennifer F Friedman
United States Department of State, Institute of International Education, Fulbright Fellowships, Washington, DC, USA
J Infect Dis 188:449-57. 2003..These effects of malaria may have pervasive health and socioeconomic consequences in areas where malaria is endemic... - Schistosoma japonicum and occult blood loss in endemic villages in Leyte, the PhilippinesHemal K Kanzaria
International Health Institute, Brown University, Providence, Rhode Island 02912, USA
Am J Trop Med Hyg 72:115-8. 2005..0003; and OR = 1.6, P = 0.021, respectively). It is likely that occult blood loss plays a role only at heavier intensity S. japonicum infections and some other mechanism, such as anemia of inflammation, may be contributing to anemia... - Helminth infection and cognitive impairment among Filipino childrenAmara E Ezeamama
International Health Institute, Brown University, Providence, Rhode Island 02912, USA
Am J Trop Med Hyg 72:540-8. 2005..04-30). Helminth infection was associated with lower performance in three of the four cognitive domains examined in this study. These relationships remained after rigorous control for other helminths and important confounding covariates... - Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, PhilippinesHannah M Coutinho
International Health Institute, Brown University, Providence, RI 02912, USA
J Infect Dis 192:528-36. 2005..In addition, our data are consistent with the hypothesis that, by systemically increasing the levels of the proinflammatory cytokines IL-1 and IL-6, HF causes undernutrition and anemia... - Functional significance of low-intensity polyparasite helminth infections in anemiaAmara E Ezeamama
International Health Institute, Brown University, Providence, RI 02912, USA
J Infect Dis 192:2160-70. 2005..We wanted to quantify the impact that polyparasite infections, including multiple concurrent low-intensity infections, have on anemia... - Nutritional status improves after treatment of schistosoma japonicum-infected children and adolescentsHannah M Coutinho
Center for International Health Research, Brown University Medical School, Providence, RI, USA
J Nutr 136:183-8. 2006..Based on the peak Hb improvement at 15 mo post-treatment, annual treatment intervals are recommended to reduce schistosomiasis-associated nutritional morbidity... - T-helper-2 cytokine responses to Sj97 predict resistance to reinfection with Schistosoma japonicumTjalling Leenstra
Center for International Health Research, Brown University Medical School, 55 Claverick St, Providence, RI 02903, USA
Infect Immun 74:370-81. 2006..These findings underscore Th2-type immune responses as central in human resistance to S. japonicum and support Sj97 as a leading vaccine candidate for this parasite... - An update on anemia in less developed countriesKarine Tolentino
Center for International Health Research at Rhode Island Hospital and Department of Pediatrics, Brown University Medical School, Providence, Rhode Island, USA
Am J Trop Med Hyg 77:44-51. 2007..This review will focus on recent advances in our understanding of the burden of anemia in specific sub-groups, the causes and mechanisms of anemia, and consequences of anemia for the human host... - The iron trap: iron, malaria and anemia at the mother-child interfaceJennifer F Friedman
Department of Pediatrics, Brown University, Providence, RI, USA
Microbes Infect 11:460-6. 2009..Improved iron status assays, and understanding of malaria protection mechanisms, are needed to manage these disorders... - Illness transmission in the home: a possible role for alcohol-based hand gelsGrace M Lee
Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts 02215, USA
Pediatrics 115:852-60. 2005..We also sought to examine potential predictors of reduced illness transmission in the home in a secondary analysis... - Pilot-scale production and characterization of paramyosin, a vaccine candidate for schistosomiasis japonicaMario Jiz
Center for International Health Research, Rhode Island Hospital, Providence, RI 02903, USA
Infect Immun 76:3164-9. 2008..japonicum-infected individuals contain anti-rSj97 IgE antibodies. Our method for pilot-scale production of recombinant full-length paramyosin will facilitate preclinical evaluation of paramyosin as a vaccine for schistosomiasis... - Misconceptions about colds and predictors of health service utilizationGrace M Lee
Division of Infectious Diseases, Children s Hospital, Boston, Massachusetts 02115, USA
Pediatrics 111:231-6. 2003..The objective of this study was to determine predictors of reported ED use and ambulatory care use for colds among families with young children... - Prevalence and severity of malnutrition in pre-school children in a rural area of western KenyaArthur M Kwena
Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
Am J Trop Med Hyg 68:94-9. 2003..Malnutrition is likely to interact with infectious diseases, placing children 3-24 months of age at high risk of premature death in this area...
Research Grants
- S. japonicum morbidity and pro-inflammatory cytokinesJennifer Friedman; Fiscal Year: 2005..Her long term goals are to further our understanding of parasite associated morbidity in children and use this data to inform our efforts to promote the health of children in the developing world. ..
- Inflammation, Iron, and Cognition in S. japonicumJennifer Friedman; Fiscal Year: 2005..We hypothesize that host's pro-inflammatory immune responses to parasitic diseases decrease the bioavailability of iron through anemia of inflammation, which, in turn, negatively impacts cognitive function. ..
- S.japonicum and pregnancy outcomes: an RCTJennifer Friedman; Fiscal Year: 2007..A trophoblast apoptosis assay will also be used to assess the effect of maternal serum from 32 weeks gestation on trophoblast apoptosis. ..