Thomas Flatt

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Counting calories in Drosophila diet restriction
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Exp Gerontol 42:247-51. 2007
  2. ncbi Pleiotropic effects of methoprene-tolerant (Met), a gene involved in juvenile hormone metabolism, on life history traits in Drosophila melanogaster
    Thomas Flatt
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Genetica 122:141-60. 2004
  3. ncbi Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
  4. ncbi The evolutionary genetics of canalization
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, Rhode Island 02912, USA
    Q Rev Biol 80:287-316. 2005
  5. ncbi Physiology. Still pondering an age-old question
    Thomas Flatt
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 318:1255-6. 2007
  6. ncbi Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster
    Thomas Flatt
    Department of Biology, Section of Ecology and Evolution, University of Fribourg, Fribourg, Switzerland
    Evolution 61:1980-91. 2007
  7. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008
  8. pmc Drosophila germ-line modulation of insulin signaling and lifespan
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 105:6368-73. 2008
  9. pmc dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster
    Johannes H Bauer
    Department of Molecular Biology, Brown University Providence, RI 02912, USA
    Aging (Albany NY) 1:38-48. 2009
  10. ncbi Stabilizing factors interact in promoting host-parasite coexistence
    Thomas Flatt
    Department of Biology, Unit of Ecology and Evolution, University of Fribourg, Chemin du Musee 10, CH 1700 Fribourg, Switzerland
    J Theor Biol 228:241-9. 2004

Detail Information

Publications14

  1. pmc Counting calories in Drosophila diet restriction
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Exp Gerontol 42:247-51. 2007
    ..Since caloric intake correlates with yeast concentration and thus with the intake of every metabolite in this dietary component, it is premature to conclude for Drosophila that calories do not explain extension of life span...
  2. ncbi Pleiotropic effects of methoprene-tolerant (Met), a gene involved in juvenile hormone metabolism, on life history traits in Drosophila melanogaster
    Thomas Flatt
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Genetica 122:141-60. 2004
    ..The allelic effects of Met support genetic models where pleiotropy at genes associated with hormone regulation can contribute to the evolution of life history traits...
  3. ncbi Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
  4. ncbi The evolutionary genetics of canalization
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, Rhode Island 02912, USA
    Q Rev Biol 80:287-316. 2005
    ..Although there are several methods to detect canalization, there are still serious problems with unambiguously demonstrating canalization, particularly its adaptive value...
  5. ncbi Physiology. Still pondering an age-old question
    Thomas Flatt
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 318:1255-6. 2007
  6. ncbi Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster
    Thomas Flatt
    Department of Biology, Section of Ecology and Evolution, University of Fribourg, Fribourg, Switzerland
    Evolution 61:1980-91. 2007
    ..This supports the hypothesis that JH may mediate evolution of longer life span, but--contrary to our expectation-this apparently does not need to trade--off with fecundity...
  7. pmc Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    J Exp Biol 211:2712-24. 2008
    ..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge...
  8. pmc Drosophila germ-line modulation of insulin signaling and lifespan
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 105:6368-73. 2008
    ..These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved...
  9. pmc dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster
    Johannes H Bauer
    Department of Molecular Biology, Brown University Providence, RI 02912, USA
    Aging (Albany NY) 1:38-48. 2009
    ..Taken together, our data demonstrate that Dmp53 is a down stream target of dSir2 enzymatic activity and mediates some aspects of the life span extending effects of CR...
  10. ncbi Stabilizing factors interact in promoting host-parasite coexistence
    Thomas Flatt
    Department of Biology, Unit of Ecology and Evolution, University of Fribourg, Chemin du Musee 10, CH 1700 Fribourg, Switzerland
    J Theor Biol 228:241-9. 2004
    ....
  11. ncbi A role for genetic accommodation in evolution?
    Christian Braendle
    Institut Jacques Monod, CNRS, Universit├ęs Paris 6 and 7, Paris, France
    Bioessays 28:868-73. 2006
    ..We argue that genetic accommodation, including assimilation, is a plausible mechanism in evolution; however, more work is required to test how this mechanism acts and how often it is involved in evolutionary change...
  12. ncbi Assessing natural variation in genes affecting Drosophila lifespan
    Thomas Flatt
    Mech Ageing Dev 125:155-9. 2004
  13. ncbi Size and shape: the developmental regulation of static allometry in insects
    Alexander W Shingleton
    Department of Zoology, Michigan State University, 203 Natural Science, East Lansing, MI 48910, USA
    Bioessays 29:536-48. 2007
    ..This model serves as the foundation for a research program that will result in a deeper understanding of the relationship between growth and form, a question that has fascinated biologists for centuries...
  14. pmc Evolution in group-structured populations can resolve the tragedy of the commons
    Timothy Killingback
    College of William and Mary, Department of Mathematics, Williamsburg, VA 23187, USA
    Proc Biol Sci 273:1477-81. 2006
    ..Since this mechanism depends only on population dynamics and requires no cognitive abilities on the part of the agents concerned, it potentially applies to organisms at all levels of complexity...