EDWARD FILARDO

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University Medical School, 593 Eddy Street, Aldrich Building Room 708, Providence, Rhode Island 02903, USA
    Endocrinology 153:2953-62. 2012
  2. ncbi Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    E J Filardo
    Department of Medicine and Surgery, Rhode Island Hospital and Brown University, Providence 02903, USA
    Mol Endocrinol 14:1649-60. 2000
  3. ncbi Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    Edward J Filardo
    Department of Surgery, Rhode Island Hospital, and Brown University, Providence, Rhode Island 02903, USA
    Mol Endocrinol 16:70-84. 2002
  4. ncbi GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Trends Endocrinol Metab 16:362-7. 2005
  5. ncbi Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital, and Department of Pathology, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Clin Cancer Res 12:6359-66. 2006
  6. ncbi Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane
    E Filardo
    Department of Medicine, Brown University, and Rhode Island Hospital, 593 Eddy Street, Aldrich Building, Room 718, Providence, Rhode Island 02903, USA
    Endocrinology 148:3236-45. 2007
  7. doi Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Steroids 73:870-3. 2008
  8. ncbi Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
    Edward J Filardo
    Department of Medicine, Division of Clinical Pharmacology, Rhode Island Hospital and Brown University, Aldrich Bldg Rm 718, 593 Eddy Street, Providence, RI 02903, USA
    J Steroid Biochem Mol Biol 80:231-8. 2002
  9. ncbi Integrins beta1, alpha6, and alpha3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms
    Juan Sanchez-Esteban
    Dept of Pediatrics, Women and Infants Hospital of Rhode Island, 101 Dudley St, and Department of Medicine, Brown Medical School, Providence, RI 02905, USA
    Am J Physiol Lung Cell Mol Physiol 290:L343-50. 2006

Detail Information

Publications9

  1. pmc Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University Medical School, 593 Eddy Street, Aldrich Building Room 708, Providence, Rhode Island 02903, USA
    Endocrinology 153:2953-62. 2012
    ..However, they do exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth. Here, we discuss the role of GPER-1 in female reproductive cancers as well as renal and vascular physiology...
  2. ncbi Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
    E J Filardo
    Department of Medicine and Surgery, Rhode Island Hospital and Brown University, Providence 02903, USA
    Mol Endocrinol 14:1649-60. 2000
    ..Our data imply that ER-negative breast tumors that continue to express GPR30 may use estrogen to drive growth factor-dependent cellular responses...
  3. ncbi Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    Edward J Filardo
    Department of Surgery, Rhode Island Hospital, and Brown University, Providence, Rhode Island 02903, USA
    Mol Endocrinol 16:70-84. 2002
    ....
  4. ncbi GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Trends Endocrinol Metab 16:362-7. 2005
    ..Thus, estrogen can signal by the same mechanism as various other hormones, through a specific 7TM receptor...
  5. ncbi Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital, and Department of Pathology, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Clin Cancer Res 12:6359-66. 2006
    ..Here, the significance of GPR30 in human breast cancer was evaluated by comparing its relationship to steroid hormone receptor expression and tumor progression variables...
  6. ncbi Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane
    E Filardo
    Department of Medicine, Brown University, and Rhode Island Hospital, 593 Eddy Street, Aldrich Building, Room 718, Providence, Rhode Island 02903, USA
    Endocrinology 148:3236-45. 2007
    ..These results suggest that GPR30, like other 7TMRs, functions as a plasma membrane receptor...
  7. doi Association of the membrane estrogen receptor, GPR30, with breast tumor metastasis and transactivation of the epidermal growth factor receptor
    Edward J Filardo
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    Steroids 73:870-3. 2008
    ....
  8. ncbi Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
    Edward J Filardo
    Department of Medicine, Division of Clinical Pharmacology, Rhode Island Hospital and Brown University, Aldrich Bldg Rm 718, 593 Eddy Street, Providence, RI 02903, USA
    J Steroid Biochem Mol Biol 80:231-8. 2002
    ..This novel mechanism by which estrogen activates growth factor-dependent signaling and its implications for breast cancer biology are discussed further in this review...
  9. ncbi Integrins beta1, alpha6, and alpha3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms
    Juan Sanchez-Esteban
    Dept of Pediatrics, Women and Infants Hospital of Rhode Island, 101 Dudley St, and Department of Medicine, Brown Medical School, Providence, RI 02905, USA
    Am J Physiol Lung Cell Mol Physiol 290:L343-50. 2006
    ..However, they may act via distinct mechanisms, including some that are independent of their cell anchoring role...

Research Grants4