L D Fast

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Mirasol PRT treatment of donor white blood cells prevents the development of xenogeneic graft-versus-host disease in Rag2-/-gamma c-/- double knockout mice
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
    Transfusion 46:1553-60. 2006
  2. pmc Cellular immunotherapy for refractory hematological malignancies
    John L Reagan
    Division of Hematology Oncology, Rhode Island Hospital The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Transl Med 11:150. 2013
  3. doi request reprint Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irradiation in the prevention of transfusion-associated graft-versus-host disease?
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
    Transfusion 53:373-81. 2013
  4. doi request reprint Developments in the prevention of transfusion-associated graft-versus-host disease
    Loren D Fast
    Division of Hematology Oncology, Rhode Island Hospital and Alpert School of Medicine at Brown University, Providence, RI 02903, USA
    Br J Haematol 158:563-8. 2012
  5. ncbi request reprint Functional inactivation of white blood cells by Mirasol treatment
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence, 02903, USA
    Transfusion 46:642-8. 2006
  6. ncbi request reprint Control of immune responses induced by the transfer of allogeneic white blood cells during transfusion
    Loren D Fast
    Division of Hematology Oncology, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Transfusion 45:44S-50S. 2005
  7. ncbi request reprint Inhibition of xenogeneic GVHD by PEN110 treatment of donor human PBMNCs
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence 02903, USA
    Transfusion 44:282-5. 2004
  8. ncbi request reprint Genotypic regulation of alloantibody production in response to UVB-irradiated allogeneic donor cells
    Loren D Fast
    Department of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA
    Transfusion 43:1295-302. 2003
  9. ncbi request reprint The effect of exposing murine splenocytes to UVB light, psoralen plus UVA light, or gamma-irradiation on in vitro and in vivo immune responses
    Loren D Fast
    Division of Hematology Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Transfusion 43:576-83. 2003
  10. ncbi request reprint Inhibition of murine GVHD by PEN110 treatment
    Loren D Fast
    Department of Medicine, Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Transfusion 42:1326-32. 2002

Research Grants

  1. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Mirasol PRT treatment of donor white blood cells prevents the development of xenogeneic graft-versus-host disease in Rag2-/-gamma c-/- double knockout mice
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
    Transfusion 46:1553-60. 2006
    ..The ability of Mirasol PRT-treated mononuclear cells (MNCs) to generate xenogeneic graft-versus-host disease (GVHD) responses was used to model transfusion-associated GVHD (TAGVHD)...
  2. pmc Cellular immunotherapy for refractory hematological malignancies
    John L Reagan
    Division of Hematology Oncology, Rhode Island Hospital The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Transl Med 11:150. 2013
    ..The end goal of cellular therapy is not engraftment but instead is the purposeful rejection of donor cells so as to elicit a potent immune reaction that appears to break host tumor tolerance...
  3. doi request reprint Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irradiation in the prevention of transfusion-associated graft-versus-host disease?
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
    Transfusion 53:373-81. 2013
    ..To date, systems for pathogen and WBC inactivation of products containing red blood cells are less well established than those for platelets and plasma...
  4. doi request reprint Developments in the prevention of transfusion-associated graft-versus-host disease
    Loren D Fast
    Division of Hematology Oncology, Rhode Island Hospital and Alpert School of Medicine at Brown University, Providence, RI 02903, USA
    Br J Haematol 158:563-8. 2012
    ..Additional benefits of pathogen reduction protocols potentially include inhibition of antigen presentation, cytokine production and activation of lymphocytes...
  5. ncbi request reprint Functional inactivation of white blood cells by Mirasol treatment
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence, 02903, USA
    Transfusion 46:642-8. 2006
    ..Mirasol PRT treatment is a pathogen reduction protocol that is based on the inactivation of nucleic acid replication after exposure to riboflavin and light and was tested for its ability to inactivate nucleated WBC function...
  6. ncbi request reprint Control of immune responses induced by the transfer of allogeneic white blood cells during transfusion
    Loren D Fast
    Division of Hematology Oncology, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Transfusion 45:44S-50S. 2005
  7. ncbi request reprint Inhibition of xenogeneic GVHD by PEN110 treatment of donor human PBMNCs
    Loren D Fast
    Department of Medicine, Rhode Island Hospital Brown University, Providence 02903, USA
    Transfusion 44:282-5. 2004
    ..The limitation of these assays is that the in vivo GVHD response of treated human WBCs has not been tested directly...
  8. ncbi request reprint Genotypic regulation of alloantibody production in response to UVB-irradiated allogeneic donor cells
    Loren D Fast
    Department of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA
    Transfusion 43:1295-302. 2003
  9. ncbi request reprint The effect of exposing murine splenocytes to UVB light, psoralen plus UVA light, or gamma-irradiation on in vitro and in vivo immune responses
    Loren D Fast
    Division of Hematology Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Transfusion 43:576-83. 2003
    ....
  10. ncbi request reprint Inhibition of murine GVHD by PEN110 treatment
    Loren D Fast
    Department of Medicine, Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Transfusion 42:1326-32. 2002
    ....
  11. ncbi request reprint PEN110 treatment functionally inactivates the PBMNCs present in RBC units: comparison to the effects of exposure to gamma irradiation
    Loren D Fast
    Department of Medicine, Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Transfusion 42:1318-25. 2002
    ..PEN110 (Inactine, V. I. Technologies) is a chemical that inhibits the replication of infectious pathogens by modifying their nucleic acids. These experiments compared effects of PEN110 treatment or gamma irradiation on WBC function...
  12. ncbi request reprint Recipient elimination of allogeneic lymphoid cells: donor CD4(+) cells are effective alloantigen-presenting cells
    L D Fast
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Blood 96:1144-9. 2000
    ....
  13. ncbi request reprint CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2
    H C Su
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 160:5007-17. 1998
    ..By defining these critical steps in cellular and cytokine interactions for shaping endogenous immune responses, the studies advance understanding of the unique conditions regulating CD8+ T cell responses to viral challenges...
  14. ncbi request reprint IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice
    H C Su
    Division of Biology and Medicine, Brown University, Providence, RI 02912
    J Immunol 153:5674-81. 1994
    ..Because these responses can only be measured in the absence of CD8+ T lymphocytes, an exciting model of networking between T and NK cells in response to viruses is postulated...
  15. doi request reprint Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery
    Shaun P Murphy
    Department of Pediatrics, Women and Infants Hospital of Rhode Island Warren Alpert Medical School of Brown University, Providence, RI, USA
    Am J Obstet Gynecol 200:308.e1-9. 2009
    ..The purpose of this study was to determine in a mouse model whether uterine natural killer (uNK) cell cytotoxic activation induces infection/inflammation-associated preterm labor and delivery...
  16. ncbi request reprint Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null mice
    Shaun P Murphy
    Departments of Pediatrics and Pathology, Women and Infants Hospital, Rhode Island Hospital Brown University, Providence, RI 02905, USA
    J Immunol 175:4084-90. 2005
    ..Our results identify an immune mechanism of fetal demise involving IL-10 deficiency, NK cells, and inflammation. These results may provide insight into adverse pregnancy outcomes in humans...
  17. ncbi request reprint Microchimerism: a lasting legacy of transfusion?
    Loren D Fast
    Transfusion 46:1856-8. 2006

Research Grants4

  1. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
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