Research Topics
Species | L D FastSummaryAffiliation: Brown University Country: USA Publications
Research Grants
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Detail Information
Publications
Mirasol PRT treatment of donor white blood cells prevents the development of xenogeneic graft-versus-host disease in Rag2-/-gamma c-/- double knockout miceLoren D Fast
Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
Transfusion 46:1553-60. 2006..The ability of Mirasol PRT-treated mononuclear cells (MNCs) to generate xenogeneic graft-versus-host disease (GVHD) responses was used to model transfusion-associated GVHD (TAGVHD)...
Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irradiation in the prevention of transfusion-associated graft-versus-host disease?Loren D Fast
Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
Transfusion 53:373-81. 2013..To date, systems for pathogen and WBC inactivation of products containing red blood cells are less well established than those for platelets and plasma...- Developments in the prevention of transfusion-associated graft-versus-host diseaseLoren D Fast
Division of Hematology Oncology, Rhode Island Hospital and Alpert School of Medicine at Brown University, Providence, RI 02903, USA
Br J Haematol 158:563-8. 2012..Additional benefits of pathogen reduction protocols potentially include inhibition of antigen presentation, cytokine production and activation of lymphocytes... - Functional inactivation of white blood cells by Mirasol treatmentLoren D Fast
Department of Medicine, Rhode Island Hospital Brown University, Providence, 02903, USA
Transfusion 46:642-8. 2006..Mirasol PRT treatment is a pathogen reduction protocol that is based on the inactivation of nucleic acid replication after exposure to riboflavin and light and was tested for its ability to inactivate nucleated WBC function... - Control of immune responses induced by the transfer of allogeneic white blood cells during transfusionLoren D Fast
Division of Hematology/Oncology, Rhode Island Hospital, Providence, Rhode Island 02903, USA
Transfusion 45:44S-50S. 2005 - Inhibition of xenogeneic GVHD by PEN110 treatment of donor human PBMNCsLoren D Fast
Department of Medicine, Rhode Island Hospital Brown University, Providence 02903, USA
Transfusion 44:282-5. 2004..The limitation of these assays is that the in vivo GVHD response of treated human WBCs has not been tested directly... - Genotypic regulation of alloantibody production in response to UVB-irradiated allogeneic donor cellsLoren D Fast
Department of Medicine, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA
Transfusion 43:1295-302. 2003 - The effect of exposing murine splenocytes to UVB light, psoralen plus UVA light, or gamma-irradiation on in vitro and in vivo immune responsesLoren D Fast
Division of Hematology Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
Transfusion 43:576-83. 2003.... - Inhibition of murine GVHD by PEN110 treatmentLoren D Fast
Department of Medicine, Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
Transfusion 42:1326-32. 2002.... - PEN110 treatment functionally inactivates the PBMNCs present in RBC units: comparison to the effects of exposure to gamma irradiationLoren D Fast
Department of Medicine, Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
Transfusion 42:1318-25. 2002..PEN110 (Inactine, V. I. Technologies) is a chemical that inhibits the replication of infectious pathogens by modifying their nucleic acids. These experiments compared effects of PEN110 treatment or gamma irradiation on WBC function... - Recipient elimination of allogeneic lymphoid cells: donor CD4(+) cells are effective alloantigen-presenting cellsL D Fast
Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
Blood 96:1144-9. 2000.... - CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2H C Su
Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
J Immunol 160:5007-17. 1998..By defining these critical steps in cellular and cytokine interactions for shaping endogenous immune responses, the studies advance understanding of the unique conditions regulating CD8+ T cell responses to viral challenges... - IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient miceH C Su
Division of Biology and Medicine, Brown University, Providence, RI 02912
J Immunol 153:5674-81. 1994..Because these responses can only be measured in the absence of CD8+ T lymphocytes, an exciting model of networking between T and NK cells in response to viruses is postulated... - Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null miceShaun P Murphy
Departments of Pediatrics and Pathology, Women and Infants Hospital, Rhode Island Hospital Brown University, Providence, RI 02905, USA
J Immunol 175:4084-90. 2005..Our results identify an immune mechanism of fetal demise involving IL-10 deficiency, NK cells, and inflammation. These results may provide insight into adverse pregnancy outcomes in humans... - Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and deliveryShaun P Murphy
Department of Pediatrics, Women and Infants Hospital of Rhode Island Warren Alpert Medical School of Brown University, Providence, RI, USA
Am J Obstet Gynecol 200:308.e1-9. 2009..The purpose of this study was to determine in a mouse model whether uterine natural killer (uNK) cell cytotoxic activation induces infection/inflammation-associated preterm labor and delivery... - Microchimerism: a lasting legacy of transfusion?Loren D Fast
Transfusion 46:1856-8. 2006
Research Grants
- IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSIONLoren Fast; Fiscal Year: 2002..abstract_text> ..