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Genomes and Genes | Suzanne M de la MonteSummaryAffiliation: Brown University Country: USA Publications
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Publications
Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's diseaseMing Tong
Department of Pathology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Alzheimers Dis 17:827-44. 2009..Improved detection and prevention of human exposures to nitrosamines will lead to earlier treatments and eventual quelling of these costly and devastating epidemics...
Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseasesS M de la Monte
Department of Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
Panminerva Med 54:171-8. 2012..The data suggest that a mal-signaling network mediated by toxic ceramides, ER stress, and insulin-resistance should be targeted to disrupt positive feedback loops that drive the AD neurodegeneration cascade...- Therapeutic targets of brain insulin resistance in sporadic Alzheimer's diseaseSuzanne M de la Monte
Department of Neurology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
Front Biosci (Elite Ed) 4:1582-605. 2012..Therefore, early and multi-modal preventive and treatment approaches should be regarded as essential... - Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's diseaseSuzanne M de la Monte
Departments of Medicine, Pathology, Neurology, and Neurosurgery, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
Curr Alzheimer Res 9:35-66. 2012.... 
Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's diseaseSuzanne M de la Monte
Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
Drugs 72:49-66. 2012..Altogether, the data strongly support the notion that we must shift toward the implementation of multimodal rather than unimodal diagnostic and therapeutic strategies for AD...- Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairmentSuzanne M de la Monte
Department of Pathology Neuropathology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 USA
Mol Neurodegener 4:54. 2009..We hypothesize that low-level exposure to nitrosamines that are widely present in processed foods, amplifies the deleterious effects of high fat intake in promoting T2DM, NASH, and neurodegeneration... - Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's diseaseSuzanne M de la Monte
Departments of Pathology and Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
J Alzheimers Dis 9:167-81. 2006..Adopting strategies to reduce the effects of NOS and NOX activities, and improve the actions of UCPs and PPARs may help in the treatment of AD... - Insulin resistance and Alzheimer's diseaseSuzanne M de la Monte
Department of Neurology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
BMB Rep 42:475-81. 2009..In essence, there are dual mechanisms of brain insulin resistance leading to AD-type neurodegeneration: one mediated by endogenous, CNS factors; and the other, peripheral insulin resistance with excess cytotoxic ceramide production... - Early limited nitrosamine exposures exacerbate high fat diet-mediated type 2 diabetes and neurodegenerationMing Tong
Department of Pathology Neuropathology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
BMC Endocr Disord 10:4. 2010..Intra-cerebral Streptozotocin, a nitrosamine-related compound, causes neurodegeneration, whereas peripheral treatment causes DM... - Insulin resistance in experimental alcohol-induced liver diseaseSuzanne M de la Monte
Departments of Medicine, Liver Research Center, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
J Gastroenterol Hepatol 23:e477-86. 2008..This study characterizes the mechanisms and consequences of ethanol-impaired insulin signaling in relation to oxidative injury and altered gene expression... - Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's diseaseSuzanne M de la Monte
Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
J Alzheimers Dis 10:89-109. 2006.... - Nitric oxide synthase 3-mediated neurodegeneration after intracerebral gene deliverySuzanne M de la Monte
Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA
J Neuropathol Exp Neurol 66:272-83. 2007..The coexisting increases in PPAR-delta and -gamma expression suggest that the adverse effects of NOS3 overexpression may be abated by PPAR agonist treatment... - Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitisSuzanne M de la Monte
Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
Curr Opin Investig Drugs 10:1049-60. 2009..Therapy that includes insulin-sensitizing agents may help prevent brain insulin resistance-mediated cognitive impairment... - Ethanol inhibits insulin expression and actions in the developing brainS M de la Monte
Department of Pathology and Medicine, Pierre Galletti Research Building, Rhode Island Hospital, Providence, USA
Cell Mol Life Sci 62:1131-45. 2005..The results demonstrate that ethanol inhibits insulin-mediated actions in the developing brain by reducing local insulin production and insulin RTK activation, leading to inhibition of glucose transport and ATP production... - Epidemilogical trends strongly suggest exposures as etiologic agents in the pathogenesis of sporadic Alzheimer's disease, diabetes mellitus, and non-alcoholic steatohepatitisSuzanne M de la Monte
Department of Pathology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Alzheimers Dis 17:519-29. 2009..Future research efforts should focus on refining our ability to detect and monitor human exposures to nitrosamines and assess early evidence of nitrosamine-mediated tissue injury and insulin resistance... - The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipidsSuzanne M de la Monte
Division of Neuropathology, Brown University, Providence, RI, USA
Int J Environ Res Public Health 6:2055-75. 2009.... - Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migrationSuzanne M de la Monte
Department of Medicine and Pathology, Rhode Island Hospital, Providence, 02903, USA
Alcohol 43:225-40. 2009..Because ethanol increases the activities of both GSK-3beta and Caspases, the inhibitory effect of ethanol on neuronal migration could be mediated by increased GSK-3beta phosphorylation and Caspase degradation of AAH protein... - Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegenerationSuzanne M de la Monte
Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
Lab Invest 83:287-98. 2003.... - si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorderSuzanne M de la Monte
Department of Pathology and Division of Neuropathology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
Mol Brain 4:13. 2011.... - Role of central nervous system insulin resistance in fetal alcohol spectrum disordersSuzanne M de la Monte
Department of Pathology, Rhode Island Hospital and the Warren Alpert School of Medicine at Brown University, Providence, RI, USA
J Popul Ther Clin Pharmacol 17:e390-404. 2010.... - Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signalingSuzanne M de la Monte
Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
J Alzheimers Dis 6:231-42. 2004.... - Ceramide-mediated insulin resistance and impairment of cognitive-motor functionsSuzanne M de la Monte
Department of Pathology Neuropathology, Rhode Island Hospital, Providence, RI 02903, USA
J Alzheimers Dis 21:967-84. 2010.... - Mechanisms of nitrosamine-mediated neurodegeneration: potential relevance to sporadic Alzheimer's diseaseSuzanne M de la Monte
Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA SuzanneDeLaMonte
J Alzheimers Dis 17:817-25. 2009..These results suggest that environmental exposures and food contaminants may play critical roles in the pathogenesis of sporadic AD... - Insulin and insulin-like growth factor resistance in alcoholic neurodegenerationSuzanne M de la Monte
Department of Medicine and Pathology, Rhode Island Hospital and Warren Alpert School of Medicine at Brown University, Providence, Rhode Island 02903, USA
Alcohol Clin Exp Res 32:1630-44. 2008.... - Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasivenessSuzanne M de la Monte
Departments of Medicine and Pathology, Brown Medical School, Liver Research Center, Rhode Island Hospital, 55 Claverick Street, 4th Floor, Providence, RI 02903, USA
J Hepatol 44:971-83. 2006..We measured aspartyl (asparaginyl)-beta-hydroxylase (AAH) gene expression in human hepatocelluar carcinoma and surrounding uninvolved liver at both the mRNA and protein level and examined the regulation and function of this enzyme... 
Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cellsStephanie A Lahousse
Departments of Medicine and Pathology, Rhode Island Hospital, Brown Medical School, and the Pathobiology Graduate Program, Brown University, Providence, RI, USA
BMC Cell Biol 7:41. 2006..This study examines the expression, regulation and function of AAH, and its related transcripts, Humbug and Junctin, which lack catalytic domains, using SH-Sy5y neuroblastoma cells...- Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-beta-hydroxylase expressionJade J Carter
Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
Acta Neuropathol 116:303-15. 2008..Therapeutic strategies to rectify CNS developmental abnormalities in FASD should target factors underlying the ethanol-associated increases in GSK-3beta and Caspase activation, e.g. IGF resistance and increased oxidative stress... - Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholineEnrique J Rivera
Department of Pathology, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
J Alzheimers Dis 8:247-68. 2005..Together, these data provide further evidence that AD represents a neuro-endocrine disorder that resembles a unique form of diabetes mellitus (? Type 3) and progresses with severity of neurodegeneration... - Ethanol-induced oxidative stress and mitochondrial dysfunction in rat placenta: relevance to pregnancy lossFusun Gundogan
Department of Pathology, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
Alcohol Clin Exp Res 34:415-23. 2010..Since ethanol also causes oxidative stress and DNA damage, we extended our investigations to assess the role of these pathological processes on placentation and placental gene expression... - PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repairMaoyin Pang
Liver Research Center and Department of Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
J Hepatol 50:1192-201. 2009..We investigated whether treatment with a PPARdelta agonist could restore hepatic insulin sensitivity, survival signaling, and regenerative responses vis-a-vis chronic ethanol feeding... - Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitisLascelles E Lyn-Cook
Department of Medicine, Division of Gastroenterology, and the Liver Research Center, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Alzheimers Dis 16:715-29. 2009..05-P<0.001) with development of NASH. In obesity, T2DM, or NASH, neurodegeneration with brain insulin resistance may be mediated by excess hepatic production of neurotoxic ceramides that readily cross the blood-brain barrier... - Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure modelAriel C Cohen
Department of Medicine, Rhode Island Hospital, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA
Alcohol Clin Exp Res 31:1558-73. 2007.... - Mechanisms of ceramide-mediated neurodegenerationMing Tong
Department of Medicine, Division of Gastroenterology, and the Liver Research Center, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Alzheimers Dis 16:705-14. 2009..CNS exposure to neurotoxic ceramides from exogenous sources, including liver, can cause neurodegeneration with impairments in insulin and IGF signaling mechanisms, similar to the findings in experimental models of obesity/T2DM, and NASH... - Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitusNatalie Moroz
Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Alzheimers Dis 15:29-44. 2008.... - Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanismsM Chiara Cantarini
Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
Hepatology 44:446-57. 2006..The functional role of AAH in relation to cell motility has been linked to increased activation of the Notch signaling pathway... - Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?Eric Steen
Department of Pathology, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
J Alzheimers Dis 7:63-80. 2005..Therefore, we propose the term, "Type 3 Diabetes" to reflect this newly identified pathogenic mechanism of neurodegeneration... - Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver diseaseLisa Longato
Division of Gastroenterology, Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
Oxid Med Cell Longev 2012:479348. 2012..Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic insulin resistance and may cause steatohepatitis to progress... - Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's diseaseNataniel Lester-Coll
Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
J Alzheimers Dis 9:13-33. 2006..e. Type 3 diabetes... - Prognostic value of aspartyl (asparaginyl)-beta-hydroxylase/humbug expression in non-small cell lung carcinomaMartin Luu
Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
Hum Pathol 40:639-44. 2009..Therefore, FB50 immunoreactivity may be useful in defining patient subsets that are likely to benefit from adjuvant therapy... - Impaired insulin/IGF signaling in experimental alcohol-related myopathyVan Anh Nguyen
Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
Nutrients 4:1058-75. 2012..Moreover, the increased oxidative stress, which could be mediated by mitochondrial dysfunction, may have led to inhibition of acetylcholinesterase, which itself is sufficient to cause myofiber atrophy and degeneration... - Role of aspartyl-(asparaginyl)-β-hydroxylase mediated notch signaling in cerebellar development and functionElizabeth Silbermann
Warren Alpert Medical School of Brown University, Providence, RI, USA
Behav Brain Funct 6:68. 2010..Ethanol impaired cerebellar neuron migration during development is associated with reduced expression of AAH... - Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicityMing Tong
Department of Pathology, Clinical Neuroscience, and Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Alzheimers Dis 16:585-99. 2009.... - Aspartyl-(asparaginyl) beta-hydroxylase, hypoxia-inducible factor-alpha and Notch cross-talk in regulating neuronal motilityMargot Lawton
Liver Research Center and Department of Medicine, Rhode Island Hospital, Providence, RI, USA
Oxid Med Cell Longev 3:347-56. 2010..These findings suggest that AAH and HIF-1α cross-talk within a hydroxylation-regulated signaling pathway that may be transiently driven by oxidative stress, and chronically regulated by insulin/IGF signaling... - Dysfunctional pro-ceramide, ER stress, and insulin/IGF signaling networks with progression of Alzheimer's diseaseSuzanne M de la Monte
Department of Pathology Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Suzanne DeLaMonte
J Alzheimers Dis 30:S217-29. 2012..Therefore, once established, this reverberating loop must be targeted using multi-pronged approaches to disrupt the AD neurodegeneration cascade... - siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growthFusun Gundogan
Department of Pathology, Women and Infants Hospital, Providence, RI, United States
Pathol Res Pract 207:545-53. 2011.... - Prognostic value of humbug gene overexpression in stage II colon cancerJiyi Wang
Department of Pathology, Liver Research Center, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
Hum Pathol 38:17-25. 2007..In addition, molecular studies demonstrated that the increased levels of FB50 detected were due to humbug, as opposed to AAH overexpression... - Role of aspartyl-(asparaginyl) beta-hydroxylase in placental implantation: Relevance to early pregnancy lossFusun Gundogan
Department of Pathology, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
Hum Pathol 38:50-9. 2007..The high levels of AAH in decidua and endometrial glands suggest a role for this molecule in "receptivity" of endometrium... - Peroxisome proliferator-activated receptor agonist treatment of alcohol-induced hepatic insulin resistanceSuzanne M de la Monte
Liver Research Center and Departments of Medicine and Pathology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Hepatol Res 41:386-98. 2011..Conclusion: PPAR agonists may help reduce the severity of chronic ethanol-induced liver injury and insulin/IGF resistance, even in the context of continued high-level ethanol consumption... - Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liverJong Eun Yeon
Liver Research Center, Department of Medicine, Brown Medical School, Providence, RI, USA
Hepatology 38:703-14. 2003..However, uncoupling of the signaling cascade downstream of PTEN that mediates apoptosis may account for the relatively modest degrees of ongoing cell loss observed in livers of chronic ethanol-fed rats... - Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitisMashiko Setshedi
Department of Medicine, Brown University, Providence, Rhode Island, USA
Alcohol Clin Exp Res 35:2139-51. 2011..As inflammation and oxidative stress can promote insulin resistance, effective treatment with antioxidants, for example, N-acetylcysteine (NAC), may restore ethanol-impaired insulin signaling in the liver... - Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotectionGuo-jun Chen
Department of Medicine and Pathology, Rhode Island Hospital, Brown University and Brown Medical School, Providence, RI, USA
J Alzheimers Dis 5:209-28. 2003.... - ATP luminescence-based motility-invasion assaySuzanne M de la Monte
Brown Medical School and Rhode Island Hospital, Providence, USA
Biotechniques 33:98-100, 102, 104 passim. 2002..In conclusion, the ALMI assay provides a reliable and flexible method to quantify cell motility and invasiveness using a luminescence microplate reader... - Insulin resistance, ceramide accumulation and endoplasmic reticulum stress in experimental chronic alcohol-induced steatohepatitisTeresa Ramirez
Liver Research Center, Divisions of Gastroenterology and Neuropathology, Departments of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Claverick Street, Providence, RI 02903, USA
Alcohol Alcohol 48:39-52. 2013..g. pro-inflammatory, pro-ceramide and endoplasmic reticulum (ER) stress cascades... - Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver diseaseZoltan Derdak
Division of Gastroenterology and Liver Research Center, Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA
J Hepatol 54:164-72. 2011..Furthermore, p53 not only activates programmed cell death pathways and suppresses hepatocellular survival signals, but also promotes gluconeogenesis to increase systemic insulin resistance due to a novel metabolic function... - Human aspartyl (asparaginyl) beta-hydroxylase monoclonal antibodies: potential biomarkers for pancreatic carcinomaKevin S Palumbo
Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
Pancreas 25:39-44. 2002.... - Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) beta-hydroxylase suppress migration of cholangiocarcinoma cellsTakashi Maeda
Departments of Medicine and Pathology, Liver Research Center, Rhode Island Hospital, Brown Medical School, 55 Claverick Street, 4th Floor, Providence, RI 02903, USA
J Hepatol 38:615-22. 2003..The consensus sequence for AAH beta-hydroxylation occurs in signaling molecules such as Notch and Notch homologs, which have roles in cell migration... - Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's diseaseSuzanne M de la Monte
Department of Pathology, Brown Medical School and Rhode Island Hospital, Providence, RI 02903, USA
J Alzheimers Dis 7:45-61. 2005..Strategies for intervention may depend entirely upon whether the CNS disease processes are mediated by peripheral, central, or both types of insulin resistance... - Clinicopathological correlates of aspartyl (asparaginyl) beta-hydroxylase over-expression in cholangiocarcinomaTakashi Maeda
Liver Research Center, Department of Medicine and Pathology, Rhode Island Hospital, Brown Medical School, 55 Claverick Street, 4th Floor Providence, RI 02903, USA
Cancer Detect Prev 28:313-8. 2004..05). CONCLUSIONS: These findings suggest that AAH has an important role in regulating invasive or metastatic tumor cell growth of human ICC, and that high levels of AAH expression correlate with poor prognosis... - Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistanceVan Anh Nguyen
Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
Nutrients 4:1042-57. 2012..Therefore, ALPN is likely mediated by molecular and signal transduction abnormalities similar to those identified in alcoholic liver and brain degeneration... - Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewedSuzanne M de la Monte
Department of Pathology Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA SuzanneDeLaMonte
J Alzheimers Dis 30:S231-49. 2012..Altogether, the data suggest that the triangulated mal-signaling network mediated by toxic ceramides, ER stress, and insulin resistance should be targeted to disrupt positive feedback loops that drive the AD neurodegeneration cascade... - Constitutive over-expression of the insulin receptor substrate-1 causes functional up-regulation of Fas receptorMarcus Wiedmann
Department of Medicine, Liver Research Center, Rhode Island Hospital, Brown University School of Medicine, 55 Claverick Street 4th floor, Providence, RI 02903, USA
J Hepatol 38:803-10. 2003..However, the livers eventually ceased to grow but remained approximately 25% larger than non-Tg livers. We hypothesized that this growth homeostasis was achieved by parallel activation of pro-apoptosis pathways... - Role of the aspartyl-asparaginyl-beta-hydroxylase gene in neuroblastoma cell motilityPaul S Sepe
Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA
Lab Invest 82:881-91. 2002..Because AAH expression is at a low level or undetectable in normal brain, the AAH gene may be a target for treating primitive neuroectodermal tumors... - Chronic alcohol-induced hepatic insulin resistance and endoplasmic reticulum stress ameliorated by peroxisome-proliferator activated receptor-δ agonist treatmentTeresa Ramirez
Liver Research Center and Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
J Gastroenterol Hepatol 28:179-87. 2013..Herein, we demonstrate that treatment with a PPAR-δ agonist enhances insulin signaling and reduces the severities of ER stress and ceramide accumulation in an experimental model of ethanol-induced steatohepatitis... - Glial vascular degeneration in CADASILThea Brennan-Krohn
Departments of Pathology Neuropathology, Neurology, Medicine, and Psychiatry and Human Behavior, Rhode Island Hospital, Butler Hospital, Veterans Affairs Medical Center, and Warren Alpert Medical School of Brown University, Providence, RI, USA
J Alzheimers Dis 21:1393-402. 2010..These preliminary findings suggest that CADASIL is mediated by both glial and vascular degeneration with reduced expression of IGF receptors and AAH, which regulate Notch expression and function... - High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolismLisa Longato
Departments of Medicine, Pathology and Neurology, Divisions of Gastroenterology and Neuropathology, and the Liver Research Center, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
Hepatol Res 42:412-27. 2012..Ceramide treatment impaired Huh7 cell viability, mitochondrial function, and insulin signaling. Conclusions: Increased hepatic ceramide generation and release may mediate both hepatic and peripheral insulin resistance in NAFLD... - Potential Role of Thymosin-alpha1 Adjuvant Therapy for GlioblastomaArno Sungarian
Departments of Medicine, Pathology, and Neurosurgery, Rhode Island Hospital and the Warren Alpert Medical School, Brown University, Providence, RI 02903, USA
J Oncol 2009:302084. 2009.... - Reduced expression of the cystic fibrosis transmembrane conductance regulator gene in the hypothalamus of patients with Alzheimer's diseaseStephanie A Lahousse
Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
J Alzheimers Dis 5:455-62. 2003..Since the hypothalamus is a late target of neurodegeneration in Alzheimer's disease (AD), we postulated that patients with end-stage AD and bodily wasting would have reduced levels of CFTR expression in the hypothalamus... - The AD7c-ntp neuronal thread protein biomarker for detecting Alzheimer's diseaseSuzanne M de la Monte
Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
Front Biosci 7:d989-96. 2002..The aggregate results from a number of studies suggest that AD7c-NTP is an excellent biomarker that could be helpful in the routine clinical evaluation of elderly patients at risk for AD... - Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neuronsJennifer Chu
Department of Pathology, Rhode Island Hospital, Pierre Galletti Research Building, Brown Medical School, Providence, RI 02903, USA
Acta Neuropathol 113:659-73. 2007..Together, the results suggest that mitochondrial dysfunction, oxidative stress, and DNA damage in FAS may be largely due to the toxic effects of ethanol rather than specific impairments in insulin or IGF signaling... - Weight loss amelioration of non-alcoholic steatohepatitis linked to shifts in hepatic ceramide expression and serum ceramide levelsKittichai Promrat
Division of Gastroenterology and Hepatology Liver Research Center, Rhode Island Hospital Department of Pathology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA
Hepatol Res 41:754-62. 2011..005). Conclusion: NASH is associated with increased insulin resistance and altered ceramide gene expression in liver. Weight loss-mediated reversal of NASH is associated with reduced pro-ceramide gene expression in liver... - Alcohol-induced disruption of endocrine signalingMartin J J Ronis
Arkansas Children s Nutrition Center, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
Alcohol Clin Exp Res 31:1269-85. 2007..Chronic gestational exposure to ethanol causes brain insulin and insulin-like growth factor resistance, by Suzanne M de la Monte; (4) Disruption of IGF-1 signaling in muscle: a mechanism underlying alcoholic myopathy, by Charles H...
Research Grants
- Effects of Ethanol on Insulin Signaling in the BrainSuzanne M de la Monte; Fiscal Year: 2010....
- Effects of Ethanol on Insulin Signaling in the BrainSuzanne de la Monte; Fiscal Year: 2009....
- Midcareer Investigator Award in Alcohol-Related Human Disease ResearchSuzanne de la Monte; Fiscal Year: 2007..The information included in this application demonstrates a productive career in human and translational research, and demonstrates Dr. De la Monte's commitment to continuing this type of work while mentoring scientists for the future. ..
- Effects of Ethanol on Insulin Signaling in the BrainSuzanne de la Monte; Fiscal Year: 2007..These investigations could lead to new approaches for rescuing neuronal cells from the adverse effects of chronic gestational exposure to ethanol. ..
- Effects of Ethanol on Insulin Signaling in the BrainSuzanne de la Monte; Fiscal Year: 2009....