Suzanne M de la Monte

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease
    Ming Tong
    Department of Pathology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 17:827-44. 2009
  2. ncbi request reprint Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseases
    S M de la Monte
    Department of Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
    Panminerva Med 54:171-8. 2012
  3. pmc Potential Role of Thymosin-alpha1 Adjuvant Therapy for Glioblastoma
    Arno Sungarian
    Departments of Medicine, Pathology, and Neurosurgery, Rhode Island Hospital and the Warren Alpert Medical School, Brown University, Providence, RI 02903, USA
    J Oncol 2009:302084. 2009
  4. pmc Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease
    Lisa Longato
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Oxid Med Cell Longev 2012:479348. 2012
  5. ncbi request reprint Brain metabolic dysfunction at the core of Alzheimer's disease
    Suzanne M de la Monte
    Departments of Pathology Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Neurology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Neurosurgery, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Electronic address
    Biochem Pharmacol 88:548-59. 2014
  6. pmc Aspartyl-(asparaginyl) beta-hydroxylase, hypoxia-inducible factor-alpha and Notch cross-talk in regulating neuronal motility
    Margot Lawton
    Liver Research Center and Department of Medicine, Rhode Island Hospital, Providence, RI, USA
    Oxid Med Cell Longev 3:347-56. 2010
  7. pmc Acetaldehyde adducts in alcoholic liver disease
    Mashiko Setshedi
    Department of Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA
    Oxid Med Cell Longev 3:178-85. 2010
  8. doi request reprint Relationships between diabetes and cognitive impairment
    Suzanne M de la Monte
    Department of Pathology Neuropathology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA Department of Neurology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA Department of Neurosurgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA Electronic address
    Endocrinol Metab Clin North Am 43:245-67. 2014
  9. doi request reprint Human alcohol-related neuropathology
    Suzanne M de la Monte
    Departments of Pathology Neuropathology, Neurology, and Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Room 419, Providence, RI, 02903, USA
    Acta Neuropathol 127:71-90. 2014
  10. ncbi request reprint Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art
    Suzanne M de la Monte
    Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Departments of Pathology Neuropathology, Neurology, and Neurosurgery, Pierre Galletti Research Building, Claverick Street, Room 419, Providence, RI 02903, USA 1 401 444 7364 1 401 444 2939
    Expert Opin Drug Deliv 10:1699-709. 2013

Research Grants

  1. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2003
  2. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2009
  3. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2007
  4. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2005
  5. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2004
  6. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2009
  7. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne M de la Monte; Fiscal Year: 2010
  8. Midcareer Investigator Award in Alcohol-Related Human Disease Research
    Suzanne de la Monte; Fiscal Year: 2007
  9. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2006

Collaborators

Detail Information

Publications80

  1. pmc Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease
    Ming Tong
    Department of Pathology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 17:827-44. 2009
    ..Improved detection and prevention of human exposures to nitrosamines will lead to earlier treatments and eventual quelling of these costly and devastating epidemics...
  2. ncbi request reprint Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseases
    S M de la Monte
    Department of Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
    Panminerva Med 54:171-8. 2012
    ..The data suggest that a mal-signaling network mediated by toxic ceramides, ER stress, and insulin-resistance should be targeted to disrupt positive feedback loops that drive the AD neurodegeneration cascade...
  3. pmc Potential Role of Thymosin-alpha1 Adjuvant Therapy for Glioblastoma
    Arno Sungarian
    Departments of Medicine, Pathology, and Neurosurgery, Rhode Island Hospital and the Warren Alpert Medical School, Brown University, Providence, RI 02903, USA
    J Oncol 2009:302084. 2009
    ....
  4. pmc Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease
    Lisa Longato
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Oxid Med Cell Longev 2012:479348. 2012
    ..Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic insulin resistance and may cause steatohepatitis to progress...
  5. ncbi request reprint Brain metabolic dysfunction at the core of Alzheimer's disease
    Suzanne M de la Monte
    Departments of Pathology Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Neurology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Neurosurgery, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Electronic address
    Biochem Pharmacol 88:548-59. 2014
    ..These concepts offer opportunities to discover and implement new treatments and devise preventive measures to conquer the AD and other insulin resistance disease epidemics. ..
  6. pmc Aspartyl-(asparaginyl) beta-hydroxylase, hypoxia-inducible factor-alpha and Notch cross-talk in regulating neuronal motility
    Margot Lawton
    Liver Research Center and Department of Medicine, Rhode Island Hospital, Providence, RI, USA
    Oxid Med Cell Longev 3:347-56. 2010
    ..These findings suggest that AAH and HIF-1α cross-talk within a hydroxylation-regulated signaling pathway that may be transiently driven by oxidative stress, and chronically regulated by insulin/IGF signaling...
  7. pmc Acetaldehyde adducts in alcoholic liver disease
    Mashiko Setshedi
    Department of Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA
    Oxid Med Cell Longev 3:178-85. 2010
    ..Herein, we review the role of acetaldehyde adducts in the pathogenesis of chronic ALD and HCC...
  8. doi request reprint Relationships between diabetes and cognitive impairment
    Suzanne M de la Monte
    Department of Pathology Neuropathology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA Department of Neurology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA Department of Neurosurgery, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA Electronic address
    Endocrinol Metab Clin North Am 43:245-67. 2014
    ..A future role of endocrinologists and diabetologists could be to provide integrative diagnostic and treatment approaches for this collection of diseases that seem to share pathophysiological and pathogenetic bases. ..
  9. doi request reprint Human alcohol-related neuropathology
    Suzanne M de la Monte
    Departments of Pathology Neuropathology, Neurology, and Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Room 419, Providence, RI, 02903, USA
    Acta Neuropathol 127:71-90. 2014
    ..Further progress is needed to better understand the pathophysiology of this exposure-related constellation of nervous system diseases and better correlate the underlying pathology with in vivo imaging and biochemical lesions. ..
  10. ncbi request reprint Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art
    Suzanne M de la Monte
    Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Departments of Pathology Neuropathology, Neurology, and Neurosurgery, Pierre Galletti Research Building, Claverick Street, Room 419, Providence, RI 02903, USA 1 401 444 7364 1 401 444 2939
    Expert Opin Drug Deliv 10:1699-709. 2013
    ..Therapeutic challenges faced include the ability to provide effective treatments that do not require repeated injections and also the ability to minimize the potentially hazardous off-target effects...
  11. ncbi request reprint Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease
    Suzanne M de la Monte
    Department of Neurology, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
    Front Biosci (Elite Ed) 4:1582-605. 2012
    ..Therefore, early and multi-modal preventive and treatment approaches should be regarded as essential...
  12. pmc Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease
    Suzanne M de la Monte
    Departments of Medicine, Pathology, Neurology, and Neurosurgery, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Curr Alzheimer Res 9:35-66. 2012
    ....
  13. doi request reprint Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease
    Suzanne M de la Monte
    Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Drugs 72:49-66. 2012
    ..Altogether, the data strongly support the notion that we must shift toward the implementation of multimodal rather than unimodal diagnostic and therapeutic strategies for AD...
  14. pmc Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment
    Suzanne M de la Monte
    Department of Pathology Neuropathology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903 USA
    Mol Neurodegener 4:54. 2009
    ..We hypothesize that low-level exposure to nitrosamines that are widely present in processed foods, amplifies the deleterious effects of high fat intake in promoting T2DM, NASH, and neurodegeneration...
  15. pmc Ceramide-mediated insulin resistance and impairment of cognitive-motor functions
    Suzanne M de la Monte
    Department of Pathology Neuropathology, Rhode Island Hospital, Providence, RI 02903, USA
    J Alzheimers Dis 21:967-84. 2010
    ....
  16. pmc si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder
    Suzanne M de la Monte
    Department of Pathology and Division of Neuropathology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Mol Brain 4:13. 2011
    ....
  17. doi request reprint Epidemilogical trends strongly suggest exposures as etiologic agents in the pathogenesis of sporadic Alzheimer's disease, diabetes mellitus, and non-alcoholic steatohepatitis
    Suzanne M de la Monte
    Department of Pathology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 17:519-29. 2009
    ..Future research efforts should focus on refining our ability to detect and monitor human exposures to nitrosamines and assess early evidence of nitrosamine-mediated tissue injury and insulin resistance...
  18. pmc Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration
    Suzanne M de la Monte
    Department of Medicine and Pathology, Rhode Island Hospital, Providence, 02903, USA
    Alcohol 43:225-40. 2009
    ..Because ethanol increases the activities of both GSK-3beta and Caspases, the inhibitory effect of ethanol on neuronal migration could be mediated by increased GSK-3beta phosphorylation and Caspase degradation of AAH protein...
  19. ncbi request reprint Insulin resistance and Alzheimer's disease
    Suzanne M de la Monte
    Department of Neurology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
    BMB Rep 42:475-81. 2009
    ..In essence, there are dual mechanisms of brain insulin resistance leading to AD-type neurodegeneration: one mediated by endogenous, CNS factors; and the other, peripheral insulin resistance with excess cytotoxic ceramide production...
  20. pmc The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids
    Suzanne M de la Monte
    Division of Neuropathology, Brown University, Providence, RI, USA
    Int J Environ Res Public Health 6:2055-75. 2009
    ....
  21. ncbi request reprint Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis
    Suzanne M de la Monte
    Warren Alpert Medical School of Brown University, Providence, RI 02912, USA
    Curr Opin Investig Drugs 10:1049-60. 2009
    ..Therapy that includes insulin-sensitizing agents may help prevent brain insulin resistance-mediated cognitive impairment...
  22. pmc Role of central nervous system insulin resistance in fetal alcohol spectrum disorders
    Suzanne M de la Monte
    Department of Pathology, Rhode Island Hospital and the Warren Alpert School of Medicine at Brown University, Providence, RI, USA
    J Popul Ther Clin Pharmacol 17:e390-404. 2010
    ....
  23. pmc Early limited nitrosamine exposures exacerbate high fat diet-mediated type 2 diabetes and neurodegeneration
    Ming Tong
    Department of Pathology Neuropathology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    BMC Endocr Disord 10:4. 2010
    ..Intra-cerebral Streptozotocin, a nitrosamine-related compound, causes neurodegeneration, whereas peripheral treatment causes DM...
  24. doi request reprint Insulin resistance in experimental alcohol-induced liver disease
    Suzanne M de la Monte
    Departments of Medicine, Liver Research Center, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Gastroenterol Hepatol 23:e477-86. 2008
    ..This study characterizes the mechanisms and consequences of ethanol-impaired insulin signaling in relation to oxidative injury and altered gene expression...
  25. ncbi request reprint Nitric oxide synthase 3-mediated neurodegeneration after intracerebral gene delivery
    Suzanne M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA
    J Neuropathol Exp Neurol 66:272-83. 2007
    ..The coexisting increases in PPAR-delta and -gamma expression suggest that the adverse effects of NOS3 overexpression may be abated by PPAR agonist treatment...
  26. ncbi request reprint Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease
    Suzanne M de la Monte
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 10:89-109. 2006
    ....
  27. ncbi request reprint Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease
    Suzanne M de la Monte
    Departments of Pathology and Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 9:167-81. 2006
    ..Adopting strategies to reduce the effects of NOS and NOX activities, and improve the actions of UCPs and PPARs may help in the treatment of AD...
  28. ncbi request reprint Ethanol inhibits insulin expression and actions in the developing brain
    S M de la Monte
    Department of Pathology and Medicine, Pierre Galletti Research Building, Rhode Island Hospital, Providence, USA
    Cell Mol Life Sci 62:1131-45. 2005
    ..The results demonstrate that ethanol inhibits insulin-mediated actions in the developing brain by reducing local insulin production and insulin RTK activation, leading to inhibition of glucose transport and ATP production...
  29. ncbi request reprint Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signaling
    Suzanne M de la Monte
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 6:231-42. 2004
    ....
  30. ncbi request reprint Nitric oxide synthase-3 overexpression causes apoptosis and impairs neuronal mitochondrial function: relevance to Alzheimer's-type neurodegeneration
    Suzanne M de la Monte
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    Lab Invest 83:287-98. 2003
    ....
  31. ncbi request reprint Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness
    Suzanne M de la Monte
    Departments of Medicine and Pathology, Brown Medical School, Liver Research Center, Rhode Island Hospital, 55 Claverick Street, 4th Floor, Providence, RI 02903, USA
    J Hepatol 44:971-83. 2006
    ..We measured aspartyl (asparaginyl)-beta-hydroxylase (AAH) gene expression in human hepatocelluar carcinoma and surrounding uninvolved liver at both the mRNA and protein level and examined the regulation and function of this enzyme...
  32. doi request reprint Mechanisms of nitrosamine-mediated neurodegeneration: potential relevance to sporadic Alzheimer's disease
    Suzanne M de la Monte
    Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA SuzanneDeLaMonte
    J Alzheimers Dis 17:817-25. 2009
    ..These results suggest that environmental exposures and food contaminants may play critical roles in the pathogenesis of sporadic AD...
  33. pmc Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration
    Suzanne M de la Monte
    Department of Medicine and Pathology, Rhode Island Hospital and Warren Alpert School of Medicine at Brown University, Providence, Rhode Island 02903, USA
    Alcohol Clin Exp Res 32:1630-44. 2008
    ....
  34. pmc Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells
    Stephanie A Lahousse
    Departments of Medicine and Pathology, Rhode Island Hospital, Brown Medical School, and the Pathobiology Graduate Program, Brown University, Providence, RI, USA
    BMC Cell Biol 7:41. 2006
    ..This study examines the expression, regulation and function of AAH, and its related transcripts, Humbug and Junctin, which lack catalytic domains, using SH-Sy5y neuroblastoma cells...
  35. doi request reprint Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-beta-hydroxylase expression
    Jade J Carter
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Acta Neuropathol 116:303-15. 2008
    ..Therapeutic strategies to rectify CNS developmental abnormalities in FASD should target factors underlying the ethanol-associated increases in GSK-3beta and Caspase activation, e.g. IGF resistance and increased oxidative stress...
  36. pmc PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair
    Maoyin Pang
    Liver Research Center and Department of Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
    J Hepatol 50:1192-201. 2009
    ..We investigated whether treatment with a PPARdelta agonist could restore hepatic insulin sensitivity, survival signaling, and regenerative responses vis-a-vis chronic ethanol feeding...
  37. ncbi request reprint Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine
    Enrique J Rivera
    Department of Pathology, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 8:247-68. 2005
    ..Together, these data provide further evidence that AD represents a neuro-endocrine disorder that resembles a unique form of diabetes mellitus (? Type 3) and progresses with severity of neurodegeneration...
  38. pmc Ethanol-induced oxidative stress and mitochondrial dysfunction in rat placenta: relevance to pregnancy loss
    Fusun Gundogan
    Department of Pathology, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Alcohol Clin Exp Res 34:415-23. 2010
    ..Since ethanol also causes oxidative stress and DNA damage, we extended our investigations to assess the role of these pathological processes on placentation and placental gene expression...
  39. pmc Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis
    Lascelles E Lyn-Cook
    Department of Medicine, Division of Gastroenterology, and the Liver Research Center, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 16:715-29. 2009
    ..05-P<0.001) with development of NASH. In obesity, T2DM, or NASH, neurodegeneration with brain insulin resistance may be mediated by excess hepatic production of neurotoxic ceramides that readily cross the blood-brain barrier...
  40. ncbi request reprint Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model
    Ariel C Cohen
    Department of Medicine, Rhode Island Hospital, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 31:1558-73. 2007
    ....
  41. doi request reprint Mechanisms of ceramide-mediated neurodegeneration
    Ming Tong
    Department of Medicine, Division of Gastroenterology, and the Liver Research Center, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 16:705-14. 2009
    ..CNS exposure to neurotoxic ceramides from exogenous sources, including liver, can cause neurodegeneration with impairments in insulin and IGF signaling mechanisms, similar to the findings in experimental models of obesity/T2DM, and NASH...
  42. ncbi request reprint Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus
    Natalie Moroz
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 15:29-44. 2008
    ....
  43. ncbi request reprint Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms
    M Chiara Cantarini
    Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
    Hepatology 44:446-57. 2006
    ..The functional role of AAH in relation to cell motility has been linked to increased activation of the Notch signaling pathway...
  44. doi request reprint Therapeutic reversal of chronic alcohol-related steatohepatitis with the ceramide inhibitor myriocin
    Ming Tong
    Liver Research Center, Division of Gastroenterology, Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
    Int J Exp Pathol 95:49-63. 2014
    ..However, additional measures are needed to protect the liver from alcohol-induced necroinflammatory responses vis-à-vis continued alcohol abuse. ..
  45. pmc Impaired insulin/IGF signaling in experimental alcohol-related myopathy
    Van Anh Nguyen
    Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
    Nutrients 4:1058-75. 2012
    ..Moreover, the increased oxidative stress, which could be mediated by mitochondrial dysfunction, may have led to inhibition of acetylcholinesterase, which itself is sufficient to cause myofiber atrophy and degeneration...
  46. ncbi request reprint Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
    Eric Steen
    Department of Pathology, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 7:63-80. 2005
    ..Therefore, we propose the term, "Type 3 Diabetes" to reflect this newly identified pathogenic mechanism of neurodegeneration...
  47. ncbi request reprint Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease
    Nataniel Lester-Coll
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 9:13-33. 2006
    ..e. Type 3 diabetes...
  48. pmc Prognostic value of aspartyl (asparaginyl)-beta-hydroxylase/humbug expression in non-small cell lung carcinoma
    Martin Luu
    Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Hum Pathol 40:639-44. 2009
    ..Therefore, FB50 immunoreactivity may be useful in defining patient subsets that are likely to benefit from adjuvant therapy...
  49. doi request reprint Ceramide inhibitor myriocin restores insulin/insulin growth factor signaling for liver remodeling in experimental alcohol-related steatohepatitis
    Diana Lizarazo
    Liver Research Center, Division of Gastroenterology, Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Gastroenterol Hepatol 28:1660-8. 2013
    ..AAH mediates its effects by activating Notch, and in ALD, insulin/IGF signaling, AAH, and Notch are inhibited...
  50. pmc Insulin resistance, ceramide accumulation and endoplasmic reticulum stress in experimental chronic alcohol-induced steatohepatitis
    Teresa Ramirez
    Liver Research Center, Divisions of Gastroenterology and Neuropathology, Departments of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Claverick Street, Providence, RI 02903, USA
    Alcohol Alcohol 48:39-52. 2013
    ..g. pro-inflammatory, pro-ceramide and endoplasmic reticulum (ER) stress cascades...
  51. pmc Role of aspartyl-(asparaginyl)-β-hydroxylase mediated notch signaling in cerebellar development and function
    Elizabeth Silbermann
    Warren Alpert Medical School of Brown University, Providence, RI, USA
    Behav Brain Funct 6:68. 2010
    ..Ethanol impaired cerebellar neuron migration during development is associated with reduced expression of AAH...
  52. pmc Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity
    Ming Tong
    Department of Pathology, Clinical Neuroscience, and Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 16:585-99. 2009
    ....
  53. ncbi request reprint Prognostic value of humbug gene overexpression in stage II colon cancer
    Jiyi Wang
    Department of Pathology, Liver Research Center, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA
    Hum Pathol 38:17-25. 2007
    ..In addition, molecular studies demonstrated that the increased levels of FB50 detected were due to humbug, as opposed to AAH overexpression...
  54. ncbi request reprint Role of aspartyl-(asparaginyl) beta-hydroxylase in placental implantation: Relevance to early pregnancy loss
    Fusun Gundogan
    Department of Pathology, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Hum Pathol 38:50-9. 2007
    ..The high levels of AAH in decidua and endometrial glands suggest a role for this molecule in "receptivity" of endometrium...
  55. doi request reprint Chronic alcohol-induced hepatic insulin resistance and endoplasmic reticulum stress ameliorated by peroxisome-proliferator activated receptor-δ agonist treatment
    Teresa Ramirez
    Liver Research Center and Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Gastroenterol Hepatol 28:179-87. 2013
    ..Herein, we demonstrate that treatment with a PPAR-δ agonist enhances insulin signaling and reduces the severities of ER stress and ceramide accumulation in an experimental model of ethanol-induced steatohepatitis...
  56. doi request reprint Dysfunctional pro-ceramide, ER stress, and insulin/IGF signaling networks with progression of Alzheimer's disease
    Suzanne M de la Monte
    Department of Pathology Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA Suzanne DeLaMonte
    J Alzheimers Dis 30:S217-29. 2012
    ..Therefore, once established, this reverberating loop must be targeted using multi-pronged approaches to disrupt the AD neurodegeneration cascade...
  57. pmc siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth
    Fusun Gundogan
    Department of Pathology, Women and Infants Hospital, Providence, RI, United States
    Pathol Res Pract 207:545-53. 2011
    ....
  58. ncbi request reprint Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver
    Jong Eun Yeon
    Liver Research Center, Department of Medicine, Brown Medical School, Providence, RI, USA
    Hepatology 38:703-14. 2003
    ..However, uncoupling of the signaling cascade downstream of PTEN that mediates apoptosis may account for the relatively modest degrees of ongoing cell loss observed in livers of chronic ethanol-fed rats...
  59. pmc Peroxisome proliferator-activated receptor agonist treatment of alcohol-induced hepatic insulin resistance
    Suzanne M de la Monte
    Liver Research Center and Departments of Medicine and Pathology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Hepatol Res 41:386-98. 2011
    ..Conclusion:  PPAR agonists may help reduce the severity of chronic ethanol-induced liver injury and insulin/IGF resistance, even in the context of continued high-level ethanol consumption...
  60. doi request reprint Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis
    Mashiko Setshedi
    Department of Medicine, Brown University, Providence, Rhode Island, USA
    Alcohol Clin Exp Res 35:2139-51. 2011
    ..As inflammation and oxidative stress can promote insulin resistance, effective treatment with antioxidants, for example, N-acetylcysteine (NAC), may restore ethanol-impaired insulin signaling in the liver...
  61. ncbi request reprint Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection
    Guo Jun Chen
    Department of Medicine and Pathology, Rhode Island Hospital, Brown University and Brown Medical School, Providence, RI, USA
    J Alzheimers Dis 5:209-28. 2003
    ....
  62. ncbi request reprint ATP luminescence-based motility-invasion assay
    Suzanne M de la Monte
    Brown Medical School and Rhode Island Hospital, Providence, USA
    Biotechniques 33:98-100, 102, 104 passim. 2002
    ..In conclusion, the ALMI assay provides a reliable and flexible method to quantify cell motility and invasiveness using a luminescence microplate reader...
  63. pmc Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance
    Van Anh Nguyen
    Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI 02903, USA
    Nutrients 4:1042-57. 2012
    ..Therefore, ALPN is likely mediated by molecular and signal transduction abnormalities similar to those identified in alcoholic liver and brain degeneration...
  64. ncbi request reprint Human aspartyl (asparaginyl) beta-hydroxylase monoclonal antibodies: potential biomarkers for pancreatic carcinoma
    Kevin S Palumbo
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Pancreas 25:39-44. 2002
    ..Pancreatic adenocarcinoma is among the top 10 leading causes of death due to cancer in the United States. The lack of reliable and sensitive biomarkers for this disease makes it difficult to render an early diagnosis...
  65. ncbi request reprint Antisense oligodeoxynucleotides directed against aspartyl (asparaginyl) beta-hydroxylase suppress migration of cholangiocarcinoma cells
    Takashi Maeda
    Departments of Medicine and Pathology, Liver Research Center, Rhode Island Hospital, Brown Medical School, 55 Claverick Street, 4th Floor, Providence, RI 02903, USA
    J Hepatol 38:615-22. 2003
    ..The consensus sequence for AAH beta-hydroxylation occurs in signaling molecules such as Notch and Notch homologs, which have roles in cell migration...
  66. ncbi request reprint Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease
    Suzanne M de la Monte
    Department of Pathology, Brown Medical School and Rhode Island Hospital, Providence, RI 02903, USA
    J Alzheimers Dis 7:45-61. 2005
    ..Strategies for intervention may depend entirely upon whether the CNS disease processes are mediated by peripheral, central, or both types of insulin resistance...
  67. pmc Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease
    Zoltan Derdak
    Division of Gastroenterology and Liver Research Center, Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI 02903, USA
    J Hepatol 54:164-72. 2011
    ..Furthermore, p53 not only activates programmed cell death pathways and suppresses hepatocellular survival signals, but also promotes gluconeogenesis to increase systemic insulin resistance due to a novel metabolic function...
  68. ncbi request reprint Clinicopathological correlates of aspartyl (asparaginyl) beta-hydroxylase over-expression in cholangiocarcinoma
    Takashi Maeda
    Liver Research Center, Department of Medicine and Pathology, Rhode Island Hospital, Brown Medical School, 55 Claverick Street, 4th Floor Providence, RI 02903, USA
    Cancer Detect Prev 28:313-8. 2004
    ..AAH may have a role in regulating invasive or metastatic tumor cell growth of human intrahepatic cholangiocarcinoma...
  69. doi request reprint Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed
    Suzanne M de la Monte
    Department of Pathology Neuropathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA SuzanneDeLaMonte
    J Alzheimers Dis 30:S231-49. 2012
    ..Altogether, the data suggest that the triangulated mal-signaling network mediated by toxic ceramides, ER stress, and insulin resistance should be targeted to disrupt positive feedback loops that drive the AD neurodegeneration cascade...
  70. ncbi request reprint Role of the aspartyl-asparaginyl-beta-hydroxylase gene in neuroblastoma cell motility
    Paul S Sepe
    Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA
    Lab Invest 82:881-91. 2002
    ..Because AAH expression is at a low level or undetectable in normal brain, the AAH gene may be a target for treating primitive neuroectodermal tumors...
  71. ncbi request reprint Constitutive over-expression of the insulin receptor substrate-1 causes functional up-regulation of Fas receptor
    Marcus Wiedmann
    Department of Medicine, Liver Research Center, Rhode Island Hospital, Brown University School of Medicine, 55 Claverick Street 4th floor, Providence, RI 02903, USA
    J Hepatol 38:803-10. 2003
    ..However, the livers eventually ceased to grow but remained approximately 25% larger than non-Tg livers. We hypothesized that this growth homeostasis was achieved by parallel activation of pro-apoptosis pathways...
  72. ncbi request reprint Glial vascular degeneration in CADASIL
    Thea Brennan-Krohn
    Departments of Pathology Neuropathology, Neurology, Medicine, and Psychiatry and Human Behavior, Rhode Island Hospital, Butler Hospital, Veterans Affairs Medical Center, and Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Alzheimers Dis 21:1393-402. 2010
    ..These preliminary findings suggest that CADASIL is mediated by both glial and vascular degeneration with reduced expression of IGF receptors and AAH, which regulate Notch expression and function...
  73. doi request reprint High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism
    Lisa Longato
    Departments of Medicine, Pathology and Neurology, Divisions of Gastroenterology and Neuropathology, and the Liver Research Center, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA
    Hepatol Res 42:412-27. 2012
    ..Ceramide treatment impaired Huh7 cell viability, mitochondrial function, and insulin signaling. Conclusions:  Increased hepatic ceramide generation and release may mediate both hepatic and peripheral insulin resistance in NAFLD...
  74. ncbi request reprint Reduced expression of the cystic fibrosis transmembrane conductance regulator gene in the hypothalamus of patients with Alzheimer's disease
    Stephanie A Lahousse
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    J Alzheimers Dis 5:455-62. 2003
    ..Since the hypothalamus is a late target of neurodegeneration in Alzheimer's disease (AD), we postulated that patients with end-stage AD and bodily wasting would have reduced levels of CFTR expression in the hypothalamus...
  75. ncbi request reprint Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons
    Jennifer Chu
    Department of Pathology, Rhode Island Hospital, Pierre Galletti Research Building, Brown Medical School, Providence, RI 02903, USA
    Acta Neuropathol 113:659-73. 2007
    ..Together, the results suggest that mitochondrial dysfunction, oxidative stress, and DNA damage in FAS may be largely due to the toxic effects of ethanol rather than specific impairments in insulin or IGF signaling...
  76. doi request reprint Weight loss amelioration of non-alcoholic steatohepatitis linked to shifts in hepatic ceramide expression and serum ceramide levels
    Kittichai Promrat
    Division of Gastroenterology and Hepatology Liver Research Center, Rhode Island Hospital Department of Pathology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA
    Hepatol Res 41:754-62. 2011
    ..005). Conclusion:  NASH is associated with increased insulin resistance and altered ceramide gene expression in liver. Weight loss-mediated reversal of NASH is associated with reduced pro-ceramide gene expression in liver...
  77. ncbi request reprint The AD7c-ntp neuronal thread protein biomarker for detecting Alzheimer's disease
    Suzanne M de la Monte
    Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
    Front Biosci 7:d989-96. 2002
    ..The aggregate results from a number of studies suggest that AD7c-NTP is an excellent biomarker that could be helpful in the routine clinical evaluation of elderly patients at risk for AD...
  78. ncbi request reprint Alcohol-induced disruption of endocrine signaling
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 31:1269-85. 2007
    ..Chronic gestational exposure to ethanol causes brain insulin and insulin-like growth factor resistance, by Suzanne M de la Monte; (4) Disruption of IGF-1 signaling in muscle: a mechanism underlying alcoholic myopathy, by Charles H...

Research Grants11

  1. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2003
    ..These investigations could lead to new approaches for rescuing neuronal cells from the adverse effects of chronic gestational exposure to ethanol. ..
  2. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2009
    ....
  3. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2007
    ..These investigations could lead to new approaches for rescuing neuronal cells from the adverse effects of chronic gestational exposure to ethanol. ..
  4. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2005
    ..These investigations could lead to new approaches for rescuing neuronal cells from the adverse effects of chronic gestational exposure to ethanol. ..
  5. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2004
    ..These investigations could lead to new approaches for rescuing neuronal cells from the adverse effects of chronic gestational exposure to ethanol. ..
  6. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2009
    ....
  7. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne M de la Monte; Fiscal Year: 2010
    ....
  8. Midcareer Investigator Award in Alcohol-Related Human Disease Research
    Suzanne de la Monte; Fiscal Year: 2007
    ..The information included in this application demonstrates a productive career in human and translational research, and demonstrates Dr. De la Monte's commitment to continuing this type of work while mentoring scientists for the future. ..
  9. Effects of Ethanol on Insulin Signaling in the Brain
    Suzanne de la Monte; Fiscal Year: 2006
    ..These investigations could lead to new approaches for rescuing neuronal cells from the adverse effects of chronic gestational exposure to ethanol. ..