S P David

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation
    Sean P David
    Brown University Center for Primary Care and Prevention, Pawtucket, Rhode Island, USA
    Pharmacogenetics 12:265-8. 2002
  2. doi request reprint Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses
    Sean P David
    Department of Family Medicine, Center for Primary Care and Prevention, The Warren Alpert Medical School of Brown University, 111 Brewster Street, Pawtucket, RI 02806, USA
    Drug Alcohol Depend 98:77-85. 2008
  3. pmc Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials
    Sean P David
    Brown University Center for Primary Care and Prevention, Primary Care Genetics and Translational Research Center, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA
    Nicotine Tob Res 9:1251-7. 2007
  4. pmc Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation
    Sean P David
    Brown University Center for Primary Care and Prevention, Providence, RI 02860, USA
    Nicotine Tob Res 9:821-33. 2007
  5. pmc Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch
    S P David
    Brown Medical School Memorial Hospital of Rhode Island, Pawtucket, RI, USA
    Pharmacogenomics J 8:122-8. 2008
  6. pmc The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial
    Sean P David
    Center for Primary Care and Prevention, Brown Medical School Memorial Hospital of Rhode Island, Pawtucket, RI 02960, USA
    Nicotine Tob Res 9:225-31. 2007
  7. pmc Building a successful research enterprise in family medicine: the Brown experience
    Sean P David
    Brown Medical School, USA
    Med Health R I 89:281-4. 2006
  8. ncbi request reprint Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: a functional magnetic resonance imaging study
    Sean P David
    Cancer Research United Kingdom General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, UK
    Biol Psychiatry 58:488-94. 2005
  9. ncbi request reprint Envisaging and applying a unifying three-dimensional theoretical framework for generalist physicians
    Sean P David
    Brown University Center for Primary Care and Prevention, Pawtucket, RI 02860, USA
    Med Health R I 87:336-40. 2004
  10. ncbi request reprint Should we prescribe antibiotics for acute conjunctivitis?
    Sean P David
    Brown Medical School, Providence, Rhode Island, USA
    Am Fam Physician 66:1649-50. 2002

Research Grants

Detail Information

Publications27

  1. ncbi request reprint No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation
    Sean P David
    Brown University Center for Primary Care and Prevention, Pawtucket, Rhode Island, USA
    Pharmacogenetics 12:265-8. 2002
    ..These data suggest that the COMT 1947A>G polymorphism is not associated with smoking initiation, smoking persistence or smoking cessation...
  2. doi request reprint Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses
    Sean P David
    Department of Family Medicine, Center for Primary Care and Prevention, The Warren Alpert Medical School of Brown University, 111 Brewster Street, Pawtucket, RI 02806, USA
    Drug Alcohol Depend 98:77-85. 2008
    ..However, the possibility remains that other variants in these or other 5-HT genes may influence NRT efficacy for smoking cessation in treatment seeking smokers...
  3. pmc Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials
    Sean P David
    Brown University Center for Primary Care and Prevention, Primary Care Genetics and Translational Research Center, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA
    Nicotine Tob Res 9:1251-7. 2007
    ..These data suggest that bupropion may be effective for smoking cessation only in a subgroup of smokers with the DRD2 Taq1 A2/A2 genotype...
  4. pmc Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation
    Sean P David
    Brown University Center for Primary Care and Prevention, Providence, RI 02860, USA
    Nicotine Tob Res 9:821-33. 2007
    ....
  5. pmc Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch
    S P David
    Brown Medical School Memorial Hospital of Rhode Island, Pawtucket, RI, USA
    Pharmacogenomics J 8:122-8. 2008
    ....
  6. pmc The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial
    Sean P David
    Center for Primary Care and Prevention, Brown Medical School Memorial Hospital of Rhode Island, Pawtucket, RI 02960, USA
    Nicotine Tob Res 9:225-31. 2007
    ....
  7. pmc Building a successful research enterprise in family medicine: the Brown experience
    Sean P David
    Brown Medical School, USA
    Med Health R I 89:281-4. 2006
  8. ncbi request reprint Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: a functional magnetic resonance imaging study
    Sean P David
    Cancer Research United Kingdom General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, UK
    Biol Psychiatry 58:488-94. 2005
    ..Converging evidence from several theories of the development of incentive-sensitization to smoking-related environmental stimuli suggests that the ventral striatum plays an important role in the processing of smoking-related cue reactivity...
  9. ncbi request reprint Envisaging and applying a unifying three-dimensional theoretical framework for generalist physicians
    Sean P David
    Brown University Center for Primary Care and Prevention, Pawtucket, RI 02860, USA
    Med Health R I 87:336-40. 2004
  10. ncbi request reprint Should we prescribe antibiotics for acute conjunctivitis?
    Sean P David
    Brown Medical School, Providence, Rhode Island, USA
    Am Fam Physician 66:1649-50. 2002
  11. ncbi request reprint Pharmacogenetics
    Sean P David
    Department of Family Medicine, Brown Medical School, Brown University Center for Primary Care and Prevention, Primary Care Genetics Laboratory, Translational Research Center, Memorial Hospital of Rhode Island USA
    Prim Care 31:543-59, ix. 2004
    ....
  12. ncbi request reprint Should we use multiple risk factor interventions for the primary prevention of coronary heart disease?
    Sean P David
    Brown Medical School, Pawtucket, Rhode Island, USA
    Am Fam Physician 66:245-6. 2002
  13. ncbi request reprint Does the DRD2-Taq1 A polymorphism influence treatment response to bupropion hydrochloride for reduction of the nicotine withdrawal syndrome?
    Sean P David
    Center for Primary Care and Prevention, Brown University Medical School, Providence, RI 02860, USA
    Nicotine Tob Res 5:935-42. 2003
    ..These data suggest that bupropion attenuates specific symptoms of the nicotine withdrawal syndrome and that this effect may be modified by genotype for the dopamine D2 receptor...
  14. ncbi request reprint Should we offer routine breast cancer screening with mammography?
    Sean P David
    Brown Medical School, Pawtucket, Rhode Island, USA
    Am Fam Physician 68:260-2. 2003
  15. pmc Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial
    Elaine C Johnstone
    Department of Clinical Pharmacology, University of Oxford, Oxford, United Kingdom
    Cancer Epidemiol Biomarkers Prev 16:1065-9. 2007
    ....
  16. pmc Effects of nicotine withdrawal on verbal working memory and associated brain response
    Lawrence H Sweet
    Department of Psychiatry, Alpert Medical School of Brown University, Providence, RI 02906, United States
    Psychiatry Res 183:69-74. 2010
    ....
  17. pmc A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans
    Sean P David
    Department of Clinical Pharmacology, Cancer Research United Kingdom General Practice Research Group, University of Oxford, Oxford OX2 6HE, United Kingdom
    J Neurosci 25:2586-90. 2005
    ..The results may offer a plausible physiological mechanism underlying the association between 5-HTTLPR genotype, behavioral traits, and mood states...
  18. ncbi request reprint Fellowship training in family medicine at Brown: adding depth to breadth
    Rick Long
    Department of Family Medicine, Brown Medical School, USA
    Med Health R I 89:274-5. 2006
    ....
  19. doi request reprint Genetic variation in the dopamine pathway and smoking cessation
    Sean P David
    Brown University Center for Primary Care and Prevention, Department of Family Medicine, The Warren Alpert Medical School of Brown University, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA
    Pharmacogenomics 9:1307-21. 2008
    ....
  20. ncbi request reprint Are family physicians willing to use pharmacogenetics for smoking cessation therapy?
    Michael J Stamp
    Fam Med 35:83. 2003
  21. pmc Chronic cigarette smoking and the microstructural integrity of white matter in healthy adults: a diffusion tensor imaging study
    Robert H Paul
    Department of Psychology, Behavioral Neuroscience, University of Missouri, St Louis, MO 63121, USA
    Nicotine Tob Res 10:137-47. 2008
    ..Additional studies are needed to further explore differences in white matter integrity between smokers and nonsmokers...
  22. pmc A cost-effectiveness analysis of genetic testing of the DRD2 Taq1A polymorphism to aid treatment choice for smoking cessation
    Nicky J Welton
    Primary Care, Department, Community Based Medicine, University of Bristol, Bristol, UK
    Nicotine Tob Res 10:231-40. 2008
    ..In addition, single-gene tests are unlikely to be cost-effective, partly because the predictive value of these tests is likely to be modest...
  23. pmc Smoking cessation in primary care
    Sean P David
    BMJ 336:1200-1. 2008
  24. pmc Molecular genetics of successful smoking cessation: convergent genome-wide association study results
    George R Uhl
    Molecular Neurobiology Research Branch, National Institutes of Health Intramural Research Program, National Institute on Drug Abuse, 333 Cassell Dr, Ste 3510, Baltimore, MD 21224, USA
    Arch Gen Psychiatry 65:683-93. 2008
    ..Smoking remains a major public health problem. Twin studies indicate that the ability to quit smoking is substantially heritable, with genetics that overlap modestly with the genetics of vulnerability to dependence on addictive substances...
  25. pmc Smoking cessation
    Kate E Koplan
    Harvard Medical School, Brigham and Women s Hospital, Boston, MA 01225, USA
    BMJ 336:217. 2008
  26. ncbi request reprint Comment on "The public health implications of smoking-induced decreased serum and red blood cell folate levels"
    Sean P David
    Nicotine Tob Res 5:397-9. 2003
  27. pmc Successful Latino community partnership program for smoking cessation
    Sean P David
    Am J Public Health 97:1348-9; author reply 1349. 2007

Research Grants2

  1. Primary Care Genetics Cancer Prevention Conference
    Sean David; Fiscal Year: 2003
    ..abstract_text> ..
  2. Psychobiological /Genetic Determinants-Smoking Cessation
    Sean David; Fiscal Year: 2006
    ....