Research Topics
Species | Barry W ConnorsSummaryAffiliation: Brown University Country: USA Publications
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Publications
Electrical synapses in the mammalian brainBarry W Connors
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
Annu Rev Neurosci 27:393-418. 2004..Electrical synapses are a ubiquitous yet underappreciated feature of neural circuits in the mammalian brain...- Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applicationsYoon Kyu Song
Division of Engineering, Brown University, Providence, RI 02912, USA
IEEE Trans Neural Syst Rehabil Eng 13:220-6. 2005..An alternative power delivery scheme using photovoltaic power converter, and an encapsulation strategy for chronic implantation are also discussed... 
A microelectrode array incorporating an optical waveguide device for stimulation and spatiotemporal electrical recording of neural activityJiayi Zhang
Department of Physics, Brown University, Providence, RI 02912, USA
Conf Proc IEEE Eng Med Biol Soc 2009:2046-9. 2009..Specifically, epileptiform events were reliably optically triggered by the optrode and their spatiotemporal patterns were simultaneously recorded by the multi-electrode array...- Long-term modulation of electrical synapses in the mammalian thalamusCarole E Landisman
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
Science 310:1809-13. 2005.... - Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortexScott J Cruikshank
Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
Nat Neurosci 10:462-8. 2007..These results demonstrate the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing... - Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4Jay R Gibson
Dept. of Neuroscience, Box 1953, Brown University, Providence, RI 02912, USA
J Neurophysiol 93:467-80. 2005..Our results suggest that electrical synapses among inhibitory interneurons are most readily described as low-pass linear filters that promote firing synchrony... 
Electrical and chemical synapses between relay neurons in developing thalamusSeung Chan Lee
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
J Physiol 588:2403-15. 2010..Our results demonstrate that thalamic relay neurons communicate primarily via electrical synapses during early postnatal development, and then lose their electrical coupling as a chemical synapse-mediated inhibitory circuit matures...- The roles of somatostatin-expressing (GIN) and fast-spiking inhibitory interneurons in UP-DOWN states of mouse neocortexErika E Fanselow
Department of Neuroscience, Brown University, Providence, Rhode Island, USA
J Neurophysiol 104:596-606. 2010..These results suggest that there is a division of labor between FS and GIN cells as the UP-state progresses and suggest that GIN cells could be important in the termination of UP-states... - Abrupt maturation of a spike-synchronizing mechanism in neocortexMichael A Long
Division of Biology and Medicine, Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 25:7309-16. 2005..The developmental transformation of LTS interneurons into a synchronous, oscillatory network overlaps with the onset of active somatosensory exploration, suggesting a potential role for this synchronizing system in sensory processing... - Small clusters of electrically coupled neurons generate synchronous rhythms in the thalamic reticular nucleusMichael A Long
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 24:341-9. 2004..The results suggest that electrical synapses can coordinate spindle-frequency rhythms among small clusters of mGluR-activated TRN cells... - Stability of electrical coupling despite massive developmental changes of intrinsic neuronal physiologyPhilip R L Parker
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 29:9761-70. 2009..Our results demonstrate that certain central neurons may maintain or even increase their gap junctional communication as they mature... - Semiconductor ultra-violet light-emitting diodes for flash photolysisSowmya Venkataramani
Department of Physics, Brown University, Providence, RI 02912, United States
J Neurosci Methods 160:5-9. 2007.... - Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissueJiayi Zhang
Department of Physics, Brown University, Providence, RI 02912, USA
J Neural Eng 6:055007. 2009..Specifically, epileptiform events were reliably optically triggered by the optrode and their spatiotemporal patterns were simultaneously recorded by the multi-electrode array... - Electrical synapses coordinate activity in the suprachiasmatic nucleusMichael A Long
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
Nat Neurosci 8:61-6. 2005..We suggest that electrical synapses in the SCN help to synchronize its spiking activity, and that such synchrony is necessary for normal circadian behavior... - Rhythmicity without synchrony in the electrically uncoupled inferior oliveMichael A Long
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 22:10898-905. 2002..We conclude that electrical coupling is not necessary for the generation of spontaneous subthreshold oscillations in single IO neurons, but that coupling can serve to synchronize rhythmic activity among IO neurons... - Short-term dynamics of thalamocortical and intracortical synapses onto layer 6 neurons in neocortexMichael Beierlein
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurophysiol 88:1924-32. 2002..We conclude that layer 6 neurons integrate a variety of inputs with distinct temporal dynamics that are determined by the presynaptic cell type... - Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axonsScott J Cruikshank
Department of Neuroscience, Brown University, Providence, RI 02912, USA
Neuron 65:230-45. 2010..Thus, a major difference between thalamocortical and corticothalamic processing was the extent to which feedforward inhibitory neurons were themselves engaged by feedforward inhibition... - Synchronization of electrically coupled pairs of inhibitory interneurons in neocortexJaime G Mancilla
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 27:2058-73. 2007..Electrical coupling between cortical interneurons of the same type maintained robust synchronous firing of cell pairs for up to approximately 10% heterogeneity in their intrinsic frequencies... - Two dynamically distinct inhibitory networks in layer 4 of the neocortexMichael Beierlein
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurophysiol 90:2987-3000. 2003..Because of their unique dynamic properties, each inhibitory network will be recruited by different temporal patterns of cortical activity... - Widely integrative properties of layer 5 pyramidal cells support a role for processing of extralaminar synaptic inputs in rat neocortexAlbert E Telfeian
Department of Neuroscience, Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
Neurosci Lett 343:121-4. 2003..However, layers 2/3 cells rarely responded to stimuli delivered to isolated deeper layers, while layer 5 neurons were often excited by horizontal inputs from isolated layers 2/3 and 4... - Initiation, propagation, and termination of epileptiform activity in rodent neocortex in vitro involve distinct mechanismsDavid J Pinto
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 25:8131-40. 2005..These results suggest that the phenomenological stages of epileptiform events correspond to distinct mechanistic stages... - Electrical synapses in the thalamic reticular nucleusCarole E Landisman
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 22:1002-9. 2002..When combined with recent observations from the cerebral cortex, our results imply that electrical synapses are a common mechanism for generating synchrony within networks of inhibitory neurons in the mammalian forebrain... - VPM and PoM nuclei of the rat somatosensory thalamus: intrinsic neuronal properties and corticothalamic feedbackCarole E Landisman
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
Cereb Cortex 17:2853-65. 2007..These findings suggest that despite the exclusively excitatory nature of corticothalamic fibers, activation of cortex can trigger excitation or inhibition in thalamic relay neurons... - Potent block of Cx36 and Cx50 gap junction channels by mefloquineScott J Cruikshank
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 101:12364-9. 2004..Thus, mefloquine is expected to be a useful tool to study the functional roles of Cx36 and Cx50... - The spatial dimensions of electrically coupled networks of interneurons in the neocortexYael Amitai
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 22:4142-52. 2002..These quantitative results have important implications for the effects of electrical coupling on the dynamic behavior of interneuron networks... - Thalamic control of layer 1 circuits in prefrontal cortexScott J Cruikshank
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 32:17813-23. 2012.... - A microelectrode/microelectronic hybrid device for brain implantable neuroprosthesis applicationsWilliam R Patterson
Division of Engineering, Brown University, Providence, RI 02912, USA
IEEE Trans Biomed Eng 51:1845-53. 2004..5 mV and a period ranging 80-120 ms. The results suggest that the hybrid integrated neuroport can form a prime platform for the development of a next level microminiaturized neural interface to the brain in a single implantable unit... - Electrophysiological and morphological properties of neurons in layer 5 of the rat postrhinal cortexJoseph B Sills
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
Hippocampus 22:1912-22. 2012..We conclude that POR includes at least two major classes of neocortical inhibitory interneurons, but has a functionally restricted cohort of pyramidal cells... - High temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampusJennifer A Kim
Department of Neuroscience, Brown University, Providence RI, USA
Front Cell Neurosci 6:27. 2012..Our results suggest that hyperthermia increases hippocampal excitability, particularly in seizure-prone area CA3, by altering the intrinsic membrane properties of pyramidal cells and interneurons... - Neuroscience: State-sanctioned synchronyScott J Cruikshank
Nature 454:839-40. 2008 - Bypassing interneurons: inhibition in neocortexBarry W Connors
Nat Neurosci 10:808-10. 2007 - Single-neuron mnemonicsBarry W Connors
Nature 420:133-4. 2002