Barry W Connors

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Electrical synapses in the mammalian brain
    Barry W Connors
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Neurosci 27:393-418. 2004
  2. ncbi request reprint Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications
    Yoon Kyu Song
    Division of Engineering, Brown University, Providence, RI 02912, USA
    IEEE Trans Neural Syst Rehabil Eng 13:220-6. 2005
  3. doi request reprint A microelectrode array incorporating an optical waveguide device for stimulation and spatiotemporal electrical recording of neural activity
    Jiayi Zhang
    Department of Physics, Brown University, Providence, RI 02912, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2046-9. 2009
  4. ncbi request reprint Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
    Scott J Cruikshank
    Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:462-8. 2007
  5. ncbi request reprint Long-term modulation of electrical synapses in the mammalian thalamus
    Carole E Landisman
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Science 310:1809-13. 2005
  6. pmc Electrical and chemical synapses between relay neurons in developing thalamus
    Seung Chan Lee
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Physiol 588:2403-15. 2010
  7. pmc The roles of somatostatin-expressing (GIN) and fast-spiking inhibitory interneurons in UP-DOWN states of mouse neocortex
    Erika E Fanselow
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    J Neurophysiol 104:596-606. 2010
  8. ncbi request reprint Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4
    Jay R Gibson
    Dept of Neuroscience, Box 1953, Brown University, Providence, RI 02912, USA
    J Neurophysiol 93:467-80. 2005
  9. ncbi request reprint Abrupt maturation of a spike-synchronizing mechanism in neocortex
    Michael A Long
    Division of Biology and Medicine, Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 25:7309-16. 2005
  10. pmc Stability of electrical coupling despite massive developmental changes of intrinsic neuronal physiology
    Philip R L Parker
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 29:9761-70. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Electrical synapses in the mammalian brain
    Barry W Connors
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Neurosci 27:393-418. 2004
    ..Electrical synapses are a ubiquitous yet underappreciated feature of neural circuits in the mammalian brain...
  2. ncbi request reprint Development of a chipscale integrated microelectrode/microelectronic device for brain implantable neuroengineering applications
    Yoon Kyu Song
    Division of Engineering, Brown University, Providence, RI 02912, USA
    IEEE Trans Neural Syst Rehabil Eng 13:220-6. 2005
    ..An alternative power delivery scheme using photovoltaic power converter, and an encapsulation strategy for chronic implantation are also discussed...
  3. doi request reprint A microelectrode array incorporating an optical waveguide device for stimulation and spatiotemporal electrical recording of neural activity
    Jiayi Zhang
    Department of Physics, Brown University, Providence, RI 02912, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2046-9. 2009
    ..Specifically, epileptiform events were reliably optically triggered by the optrode and their spatiotemporal patterns were simultaneously recorded by the multi-electrode array...
  4. ncbi request reprint Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
    Scott J Cruikshank
    Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:462-8. 2007
    ..These results demonstrate the importance of selective synaptic targeting and precise timing in the initial stages of neocortical processing...
  5. ncbi request reprint Long-term modulation of electrical synapses in the mammalian thalamus
    Carole E Landisman
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Science 310:1809-13. 2005
    ....
  6. pmc Electrical and chemical synapses between relay neurons in developing thalamus
    Seung Chan Lee
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Physiol 588:2403-15. 2010
    ..Our results demonstrate that thalamic relay neurons communicate primarily via electrical synapses during early postnatal development, and then lose their electrical coupling as a chemical synapse-mediated inhibitory circuit matures...
  7. pmc The roles of somatostatin-expressing (GIN) and fast-spiking inhibitory interneurons in UP-DOWN states of mouse neocortex
    Erika E Fanselow
    Department of Neuroscience, Brown University, Providence, Rhode Island, USA
    J Neurophysiol 104:596-606. 2010
    ..These results suggest that there is a division of labor between FS and GIN cells as the UP-state progresses and suggest that GIN cells could be important in the termination of UP-states...
  8. ncbi request reprint Functional properties of electrical synapses between inhibitory interneurons of neocortical layer 4
    Jay R Gibson
    Dept of Neuroscience, Box 1953, Brown University, Providence, RI 02912, USA
    J Neurophysiol 93:467-80. 2005
    ..Our results suggest that electrical synapses among inhibitory interneurons are most readily described as low-pass linear filters that promote firing synchrony...
  9. ncbi request reprint Abrupt maturation of a spike-synchronizing mechanism in neocortex
    Michael A Long
    Division of Biology and Medicine, Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 25:7309-16. 2005
    ..The developmental transformation of LTS interneurons into a synchronous, oscillatory network overlaps with the onset of active somatosensory exploration, suggesting a potential role for this synchronizing system in sensory processing...
  10. pmc Stability of electrical coupling despite massive developmental changes of intrinsic neuronal physiology
    Philip R L Parker
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 29:9761-70. 2009
    ..Our results demonstrate that certain central neurons may maintain or even increase their gap junctional communication as they mature...
  11. ncbi request reprint Small clusters of electrically coupled neurons generate synchronous rhythms in the thalamic reticular nucleus
    Michael A Long
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 24:341-9. 2004
    ..The results suggest that electrical synapses can coordinate spindle-frequency rhythms among small clusters of mGluR-activated TRN cells...
  12. pmc Thalamic control of layer 1 circuits in prefrontal cortex
    Scott J Cruikshank
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 32:17813-23. 2012
    ....
  13. pmc Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue
    Jiayi Zhang
    Department of Physics, Brown University, Providence, RI 02912, USA
    J Neural Eng 6:055007. 2009
    ..Specifically, epileptiform events were reliably optically triggered by the optrode and their spatiotemporal patterns were simultaneously recorded by the multi-electrode array...
  14. ncbi request reprint Electrical synapses coordinate activity in the suprachiasmatic nucleus
    Michael A Long
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 8:61-6. 2005
    ..We suggest that electrical synapses in the SCN help to synchronize its spiking activity, and that such synchrony is necessary for normal circadian behavior...
  15. pmc Rhythmicity without synchrony in the electrically uncoupled inferior olive
    Michael A Long
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 22:10898-905. 2002
    ..We conclude that electrical coupling is not necessary for the generation of spontaneous subthreshold oscillations in single IO neurons, but that coupling can serve to synchronize rhythmic activity among IO neurons...
  16. ncbi request reprint Semiconductor ultra-violet light-emitting diodes for flash photolysis
    Sowmya Venkataramani
    Department of Physics, Brown University, Providence, RI 02912, United States
    J Neurosci Methods 160:5-9. 2007
    ....
  17. pmc Electrophysiological and morphological properties of neurons in layer 5 of the rat postrhinal cortex
    Joseph B Sills
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Hippocampus 22:1912-22. 2012
    ..We conclude that POR includes at least two major classes of neocortical inhibitory interneurons, but has a functionally restricted cohort of pyramidal cells...
  18. doi request reprint Temporal and mosaic Tsc1 deletion in the developing thalamus disrupts thalamocortical circuitry, neural function, and behavior
    Elizabeth A Normand
    Department of Neuroscience, Division of Biology and Medicine, Brown University, 70 Ship Street, Providence, RI 02903, USA
    Neuron 78:895-909. 2013
    ..Our findings demonstrate that abnormalities in a discrete population of neurons can cause global brain dysfunction and that phenotype severity depends on developmental timing and degree of genetic mosaicism...
  19. ncbi request reprint Synchronization of electrically coupled pairs of inhibitory interneurons in neocortex
    Jaime G Mancilla
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 27:2058-73. 2007
    ..Electrical coupling between cortical interneurons of the same type maintained robust synchronous firing of cell pairs for up to approximately 10% heterogeneity in their intrinsic frequencies...
  20. ncbi request reprint Short-term dynamics of thalamocortical and intracortical synapses onto layer 6 neurons in neocortex
    Michael Beierlein
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurophysiol 88:1924-32. 2002
    ..We conclude that layer 6 neurons integrate a variety of inputs with distinct temporal dynamics that are determined by the presynaptic cell type...
  21. pmc Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axons
    Scott J Cruikshank
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 65:230-45. 2010
    ..Thus, a major difference between thalamocortical and corticothalamic processing was the extent to which feedforward inhibitory neurons were themselves engaged by feedforward inhibition...
  22. ncbi request reprint Widely integrative properties of layer 5 pyramidal cells support a role for processing of extralaminar synaptic inputs in rat neocortex
    Albert E Telfeian
    Department of Neuroscience, Brown University, Division of Biology and Medicine, Providence, RI 02912, USA
    Neurosci Lett 343:121-4. 2003
    ..However, layers 2/3 cells rarely responded to stimuli delivered to isolated deeper layers, while layer 5 neurons were often excited by horizontal inputs from isolated layers 2/3 and 4...
  23. ncbi request reprint Two dynamically distinct inhibitory networks in layer 4 of the neocortex
    Michael Beierlein
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurophysiol 90:2987-3000. 2003
    ..Because of their unique dynamic properties, each inhibitory network will be recruited by different temporal patterns of cortical activity...
  24. ncbi request reprint Electrical synapses in the thalamic reticular nucleus
    Carole E Landisman
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 22:1002-9. 2002
    ..When combined with recent observations from the cerebral cortex, our results imply that electrical synapses are a common mechanism for generating synchrony within networks of inhibitory neurons in the mammalian forebrain...
  25. ncbi request reprint Initiation, propagation, and termination of epileptiform activity in rodent neocortex in vitro involve distinct mechanisms
    David J Pinto
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 25:8131-40. 2005
    ..These results suggest that the phenomenological stages of epileptiform events correspond to distinct mechanistic stages...
  26. pmc Potent block of Cx36 and Cx50 gap junction channels by mefloquine
    Scott J Cruikshank
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 101:12364-9. 2004
    ..Thus, mefloquine is expected to be a useful tool to study the functional roles of Cx36 and Cx50...
  27. ncbi request reprint VPM and PoM nuclei of the rat somatosensory thalamus: intrinsic neuronal properties and corticothalamic feedback
    Carole E Landisman
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Cereb Cortex 17:2853-65. 2007
    ..These findings suggest that despite the exclusively excitatory nature of corticothalamic fibers, activation of cortex can trigger excitation or inhibition in thalamic relay neurons...
  28. ncbi request reprint The spatial dimensions of electrically coupled networks of interneurons in the neocortex
    Yael Amitai
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 22:4142-52. 2002
    ..These quantitative results have important implications for the effects of electrical coupling on the dynamic behavior of interneuron networks...
  29. ncbi request reprint A microelectrode/microelectronic hybrid device for brain implantable neuroprosthesis applications
    William R Patterson
    Division of Engineering, Brown University, Providence, RI 02912, USA
    IEEE Trans Biomed Eng 51:1845-53. 2004
    ..5 mV and a period ranging 80-120 ms. The results suggest that the hybrid integrated neuroport can form a prime platform for the development of a next level microminiaturized neural interface to the brain in a single implantable unit...
  30. pmc High temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampus
    Jennifer A Kim
    Department of Neuroscience, Brown University, Providence RI, USA
    Front Cell Neurosci 6:27. 2012
    ..Our results suggest that hyperthermia increases hippocampal excitability, particularly in seizure-prone area CA3, by altering the intrinsic membrane properties of pyramidal cells and interneurons...
  31. ncbi request reprint Bypassing interneurons: inhibition in neocortex
    Barry W Connors
    Nat Neurosci 10:808-10. 2007
  32. doi request reprint Neuroscience: State-sanctioned synchrony
    Scott J Cruikshank
    Nature 454:839-40. 2008
  33. ncbi request reprint Single-neuron mnemonics
    Barry W Connors
    Nature 420:133-4. 2002