A Chodobski

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
    Chris Pickering
    Uppsala University, Department of Neuroscience, Functional Pharmacology, BMC, Box 593, SE 75124, Uppsala, Sweden
    BMC Neurosci 9:97. 2008
  2. ncbi request reprint Vasopressin mediates the inhibitory effect of central angiotensin II on cerebrospinal fluid formation
    A Chodobski
    Department of Clinical Neurosciences, Brown University Rhode Island Hospital, Providence 02903, USA
    Eur J Pharmacol 347:205-9. 1998
  3. pmc Expression of junctional proteins in choroid plexus epithelial cell lines: a comparative study
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Cerebrospinal Fluid Res 4:11. 2007
  4. ncbi request reprint Choroid plexus: target for polypeptides and site of their synthesis
    A Chodobski
    Department of Clinical Neurosciences, Brown University Medical School, Providence, Rhode Island 02903, USA
    Microsc Res Tech 52:65-82. 2001
  5. ncbi request reprint Early neutrophilic expression of vascular endothelial growth factor after traumatic brain injury
    A Chodobski
    Department of Clinical Neurosciences, Brown University School of Medicine, Aldrich Building, Room 405, 593 Eddy Street, Providence, RI 02903, USA
    Neuroscience 122:853-67. 2003
  6. ncbi request reprint Angiotensin II regulates choroid plexus blood flow by interacting with the sympathetic nervous system and nitric oxide
    A Chodobski
    Program in Neurosurgery, Department of Clinical Neurosciences, Brown University Rhode Island Hospital, Aldrich Bldg, Rm 403, 593 Eddy Street, Providence, RI 02903
    Brain Res 816:518-26. 1999
  7. ncbi request reprint Traumatic brain injury results in a concomitant increase in neocortical expression of vasopressin and its V1a receptor
    C L Pascale
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI 02903, USA
    J Physiol Pharmacol 57:161-7. 2006
  8. pmc Vasopressin amplifies the production of proinflammatory mediators in traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Neurotrauma 27:1449-61. 2010
  9. pmc Multiple sites of vasopressin synthesis in the injured brain
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 31:47-51. 2011
  10. pmc The role of the choroid plexus in neutrophil invasion after traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 29:1503-16. 2009

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
    Chris Pickering
    Uppsala University, Department of Neuroscience, Functional Pharmacology, BMC, Box 593, SE 75124, Uppsala, Sweden
    BMC Neurosci 9:97. 2008
    ..We also identified a Drosophila sequence, DmCG15744, which shares a common ancestor with the entire Group III of Adhesion GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125...
  2. ncbi request reprint Vasopressin mediates the inhibitory effect of central angiotensin II on cerebrospinal fluid formation
    A Chodobski
    Department of Clinical Neurosciences, Brown University Rhode Island Hospital, Providence 02903, USA
    Eur J Pharmacol 347:205-9. 1998
    ..Our observations indicate, therefore, that vasopressin mediates the inhibitory effect of central angiotensin II on CSF formation...
  3. pmc Expression of junctional proteins in choroid plexus epithelial cell lines: a comparative study
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Cerebrospinal Fluid Res 4:11. 2007
    ..Accordingly, in the present study, we sought to characterize the expression of these junctional proteins in these three cell lines...
  4. ncbi request reprint Choroid plexus: target for polypeptides and site of their synthesis
    A Chodobski
    Department of Clinical Neurosciences, Brown University Medical School, Providence, Rhode Island 02903, USA
    Microsc Res Tech 52:65-82. 2001
    ..Therefore, it is proposed that the CP plays an integral role not only in normal brain functioning, but also in the recovery from the injury. This review attempts to critically analyze the available data to support the above hypothesis...
  5. ncbi request reprint Early neutrophilic expression of vascular endothelial growth factor after traumatic brain injury
    A Chodobski
    Department of Clinical Neurosciences, Brown University School of Medicine, Aldrich Building, Room 405, 593 Eddy Street, Providence, RI 02903, USA
    Neuroscience 122:853-67. 2003
    ..Therefore, these findings suggest that VEGF plays an important role in promoting the formation of post-traumatic brain edema...
  6. ncbi request reprint Angiotensin II regulates choroid plexus blood flow by interacting with the sympathetic nervous system and nitric oxide
    A Chodobski
    Program in Neurosurgery, Department of Clinical Neurosciences, Brown University Rhode Island Hospital, Aldrich Bldg, Rm 403, 593 Eddy Street, Providence, RI 02903
    Brain Res 816:518-26. 1999
    ..The AII-mediated stimulation of sympathetic nerves also results in the beta-adrenoceptor-dependent relaxation of choroidal blood vessels. In addition, choroidal vasodilatory actions of AII are NO-mediated...
  7. ncbi request reprint Traumatic brain injury results in a concomitant increase in neocortical expression of vasopressin and its V1a receptor
    C L Pascale
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI 02903, USA
    J Physiol Pharmacol 57:161-7. 2006
    ....
  8. pmc Vasopressin amplifies the production of proinflammatory mediators in traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Neurotrauma 27:1449-61. 2010
    ..These data demonstrate that AVP plays an important role in exacerbating the brain inflammatory response to injury...
  9. pmc Multiple sites of vasopressin synthesis in the injured brain
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 31:47-51. 2011
    ..In the cortex, vasopressin was predominantly produced by activated microglia/macrophages, and, to a lesser extent, by the cerebrovascular endothelium. These data further support the pathophysiological role of vasopressin in brain injury...
  10. pmc The role of the choroid plexus in neutrophil invasion after traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 29:1503-16. 2009
    ..This is the first detailed analysis of the BCSFB function related to neutrophil trafficking. Our observations support the role of this barrier in posttraumatic neutrophil invasion...
  11. ncbi request reprint Chronic hypernatremia increases the expression of vasopressin and voltage-gated Na channels in the rat choroid plexus
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA
    Neuroendocrinology 84:339-45. 2006
    ..It is also suggested that the increased expression of voltage-gated Na(+) channels found in the hypothalamus and CP after salt loading may play a role in the adaptation of AVP-producing cells to chronic hypernatremia...
  12. doi request reprint Emerging concepts in the pathophysiology of traumatic brain injury
    Brian J Zink
    Department of Emergency Medicine, Alpert Medical School of Brown, University Rhode Island Hospital and The Miriam Hospital, 593 Eddy Street, Claverick 2, Providence, RI 02903, USA
    Psychiatr Clin North Am 33:741-56. 2010
    ..Hopefully, improved knowledge of these elements of pathophysiology will provide the mechanistic clues that lead to improved treatment of TBI...
  13. ncbi request reprint Expression of two membrane fusion proteins, synaptosome-associated protein of 25 kDa and vesicle-associated membrane protein, in choroid plexus epithelium
    I Chung
    Department of Clinical Neurosciences, Brown University School of Medicine, Aldrich Building, Room 403, 593 Eddy Street, Providence, RI 02903, USA
    Neuroscience 116:349-57. 2003
    ....
  14. ncbi request reprint Altered formation and bulk absorption of cerebrospinal fluid in FGF-2-induced hydrocephalus
    C E Johanson
    Program in Neurosurgery, Brown University Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Am J Physiol 277:R263-71. 1999
    ..The FGF-2-induced ventriculomegaly is interpreted as an ex vacuuo hydrocephalus brought about by an altered neuropil and interstitium of the brain...
  15. ncbi request reprint Increased expression of vasopressin v1a receptors after traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Neurotrauma 21:1090-102. 2004
    ..It is suggested that the increased expression of V1a receptors plays an important role in the vasopressin-mediated formation of edema in the injured brain...
  16. ncbi request reprint Distribution of fibroblast growth factor receptors and their co-localization with vasopressin in the choroid plexus epithelium
    Joanna Szmydynger-Chodobska
    Department of Clinical Neurosciences, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Neuroreport 13:257-9. 2002
    ..These observations are in line with the possible mediatory role of VP in the FGF2-dependent inhibition of CSF secretion and the induction of dark epithelial cells...
  17. ncbi request reprint Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury
    J Frederick Harrington
    Department of Neurosurgery, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Neurotrauma 22:919-28. 2005
    ..It is concluded that the shedding of TNFR1 receptor may represent an important post-traumatic physiological response aimed at reducing the proapoptotic effect of TNF-alpha...
  18. ncbi request reprint The choroid plexus-cerebrospinal fluid system: from development to aging
    Zoran B Redzic
    Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD United Kingdom
    Curr Top Dev Biol 71:1-52. 2005
    ..The understanding of the mechanisms that underlie the dysfunction of the CP-CSF system in the elderly may help discover the treatments needed to reverse the negative effects of aging that lead to global CNS failure...

Research Grants11

  1. Role of the BBB and Choroid Plexus in VP-mediated Edema
    Adam Chodobski; Fiscal Year: 2007
    ..The results obtained may have important implications for designing novel therapeutic strategies for intervening in such CNS disorders as TBI, ischemic stroke, and intracerebral hemorrhage. ..
  2. 7th International Cerebral Vascular Biology Conference
    Adam Chodobski; Fiscal Year: 2007
    ..The key accent of this meeting will be on translational research - advancing from fundamental mechanistic discoveries through pre-clinical development to clinical applications. ..
  3. Role of the BBB and Choroid Plexus in VP-mediated Edema
    Adam Chodobski; Fiscal Year: 2007
    ..The results obtained may have important implications for designing novel therapeutic strategies for intervening in such CNS disorders as TBI, ischemic stroke, and intracerebral hemorrhage. ..
  4. EXTRAHYPOTHALAMIC AVP: SYNTHESIS AND SECRETION
    Adam Chodobski; Fiscal Year: 2002
    ..These studies will form the basis for development of pathological models and, consequently, effective therapies for the treatment of CNS disorders, such as trauma, SAH, and stroke. ..