Weibiao Cao

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi request reprint Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis
    Weibiao Cao
    Dept of Medicine, Brown Medical School and Rhode Island Hospital, 593 Eddy St, SWP 510, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 286:G833-43. 2004
  2. ncbi request reprint Production of IL-1beta, hydrogen peroxide, and nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis
    Weibiao Cao
    Dept of Medicine, Brown Medical School and Rhode Island Hospital, 55 Claverick St, Rm 337, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 289:C1408-16. 2005
  3. ncbi request reprint NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon
    Weibiao Cao
    Department of Medicine, Brown Medical School and Rhode Island Hospital, 55 Claverick Street, Room 337, Providence, RI 02903, USA
    J Pharmacol Exp Ther 317:1349-55. 2006
  4. pmc Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Cancer Res 70:1247-55. 2010
  5. ncbi request reprint STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells
    Jin Si
    Department of Medicine, Brown Medical School and Rhode Island Hospital, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 294:G174-83. 2008
  6. ncbi request reprint NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells
    Jin Si
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    J Biol Chem 282:16244-55. 2007
  7. ncbi request reprint Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle
    Ling Cheng
    Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Pharmacol Exp Ther 319:117-26. 2006
  8. pmc Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, 02903, USA
    Am J Physiol Gastrointest Liver Physiol 299:G697-706. 2010
  9. pmc Role of Rac1 in regulation of NOX5-S function in Barrett's esophageal adenocarcinoma cells
    Jie Hong
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 301:C413-20. 2011
  10. ncbi request reprint Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis
    Weibiao Cao
    Department of Surgery, Brown Medical School and Rhode Island Hospital, 2 Dudley St, Suite 470, Providence, RI 02905, USA
    J Pharmacol Exp Ther 311:60-70. 2004

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis
    Weibiao Cao
    Dept of Medicine, Brown Medical School and Rhode Island Hospital, 593 Eddy St, SWP 510, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 286:G833-43. 2004
    ..We conclude that H(2)O(2) may contribute to reduction of NKA-induced Ca(2+) release from intracellular Ca(2+) stores in UC and contribute to the observed colonic motor dysfunction...
  2. ncbi request reprint Production of IL-1beta, hydrogen peroxide, and nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis
    Weibiao Cao
    Dept of Medicine, Brown Medical School and Rhode Island Hospital, 55 Claverick St, Rm 337, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 289:C1408-16. 2005
    ..Sodium nitroprusside inhibited NKA but not the caffeine-induced Ca2+ signal. We conclude that in UC the mucosa releases IL-1beta, H2O2, and NO, which may contribute to the impaired Ca2+ release and altered sigmoid muscle contractility...
  3. ncbi request reprint NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon
    Weibiao Cao
    Department of Medicine, Brown Medical School and Rhode Island Hospital, 55 Claverick Street, Room 337, Providence, RI 02903, USA
    J Pharmacol Exp Ther 317:1349-55. 2006
    ..In ulcerative colitis patients, spontaneous phasic contractions are decreased, and this decrease may be in part due to overproduction of hydrogen peroxide affecting sigmoid circular muscle...
  4. pmc Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Cancer Res 70:1247-55. 2010
    ....
  5. ncbi request reprint STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells
    Jin Si
    Department of Medicine, Brown Medical School and Rhode Island Hospital, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 294:G174-83. 2008
    ....
  6. ncbi request reprint NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells
    Jin Si
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    J Biol Chem 282:16244-55. 2007
    ..COX2-derived PGE2 production may contribute to NOX5-S-mediated cell proliferation in SEG1 cells...
  7. ncbi request reprint Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle
    Ling Cheng
    Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    J Pharmacol Exp Ther 319:117-26. 2006
    ....
  8. pmc Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, 02903, USA
    Am J Physiol Gastrointest Liver Physiol 299:G697-706. 2010
    ....
  9. pmc Role of Rac1 in regulation of NOX5-S function in Barrett's esophageal adenocarcinoma cells
    Jie Hong
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 301:C413-20. 2011
    ..We conclude that Rac1 may be important in activation of NOX5-S in FLO EA cells...
  10. ncbi request reprint Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis
    Weibiao Cao
    Department of Surgery, Brown Medical School and Rhode Island Hospital, 2 Dudley St, Suite 470, Providence, RI 02905, USA
    J Pharmacol Exp Ther 311:60-70. 2004
    ..IL-1beta reproduces these changes, possibly by production of H(2)O(2) via sequential activation of MAPKs (ERK1/ERK2) and cPLA(2)...
  11. pmc Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells
    Jie Ma
    Rhode Island Hospital, Gastrointestinal Motor Function Research Laboratory, 55 Claverick Street, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 298:G233-40. 2010
    ..Thus epithelial cells produce PAF in response to TRPV1-mediated calcium elevation...
  12. ncbi request reprint H(2)O(2): a mediator of esophagitis-induced damage to calcium-release mechanisms in cat lower esophageal sphincter
    Weibiao Cao
    Dept of Medicine, Brown Medical School and Rhode Island Hospital, Gastrointestinal Motor Function Research Laboratory, 55 Claverick St, Rm 333, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1170-8. 2005
    ..We conclude that H(2)O(2) may be at least partly responsible for impairment of Ca(2+) release in acute experimental esophagitis by inhibiting Ca(2+) uptake and refilling Ca(2+) stores...
  13. pmc Signaling in H2O2-induced increase in cell proliferation in Barrett's esophageal adenocarcinoma cells
    Xiaoxu Zhou
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Pharmacol Exp Ther 339:218-27. 2011
    ..We conclude that a low dose of H(2)O(2) increases cell proliferation. H(2)O(2)-induced increase in cell proliferation may depend on sequential activation of ERK2 MAPK, NF-κB1 p50, and NOX5-S...
  14. ncbi request reprint HCl-induced inflammatory mediators in cat esophageal mucosa and inflammatory mediators in esophageal circular muscle in an in vitro model of esophagitis
    Ling Cheng
    Department of Medicine, Rhode Island Hospital and Brown University, Providence, 02903, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1307-17. 2006
    ..H(2)O(2) causes formation of IL-1beta that may induce production of PAF in the muscle, possibly closing a self-sustaining cycle of production of inflammatory mediators...
  15. pmc Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Gut 59:170-80. 2010
    ..Bile acids may have an important role in this progression. This study aimed at examining the role of NADPH oxidase NOX5-S and a novel bile acid receptor TGR5 in taurodeoxycholic acid (TDCA)-induced increase in cell proliferation...
  16. ncbi request reprint In vitro model of acute esophagitis in the cat
    Ling Cheng
    Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 289:G860-9. 2005
    ..IL-1beta appears to remain in the mucosa. In contrast, IL-6 is produced and released by the mucosa, eventually resulting in the production of H2O2 by the circular muscle, with this affecting circular muscle contraction...
  17. ncbi request reprint Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis
    Ling Cheng
    Rhode Island Hospital, Providence, RI, USA
    Am J Physiol Gastrointest Liver Physiol 289:G418-28. 2005
    ..IL-6 causes production of H2O2, PAF, and other unidentified inflammatory mediators...
  18. pmc NADPH oxidase NOX5-S and nuclear factor κB1 mediate acid-induced microsomal prostaglandin E synthase-1 expression in Barrett's esophageal adenocarcinoma cells
    Xiaoxu Zhou
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Mol Pharmacol 83:978-90. 2013
    ..Acid-induced mPGES1 expression depends on activation of NOX5-S and NF-κB1 p50. Microsomal PGES1 may be a potential target to prevent or treat EA...
  19. pmc HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells
    Jie Ma
    Department of Medicine, Rhode Island Hospital, Providence, Rhode Island, USA
    Am J Physiol Gastrointest Liver Physiol 303:G635-45. 2012
    ..The data support the validity of HET-1A cells as a model of the response of the human esophageal mucosa in GERD...
  20. ncbi request reprint IL-1beta signaling in cat lower esophageal sphincter circular muscle
    Weibiao Cao
    Dept of Medicine, Brown Medical School and Rhode Island Hospital, 55 Claverick St, Rm 336, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 291:G672-80. 2006
    ..Both H(2)O(2) and PGE(2) production depend on sequential activation of p38 MAPK and cPLA(2). cPLA(2) activates NADPH oxidases, producing H(2)O(2), and may produce arachidonic acid, converted to PGE(2) via COX-2...
  21. pmc HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa
    Ling Cheng
    Department of Medicine, Rhode Island Hospital and Brown University, Providence, Rhode Island, USA
    Am J Physiol Gastrointest Liver Physiol 297:G135-43. 2009
    ..We conclude that HCl-induced activation of TRPV1 receptors in esophageal mucosa causes release of substance P and CGRP from neurons and release of PAF from epithelial cells...
  22. ncbi request reprint Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines
    Matthew D Vrees
    Department of Surgery, Rhode Island Hospital and Brown University School of Medicine, 593 Eddy St, Providence, RI 02903, USA
    Arch Surg 137:439-45; discussion 445-6. 2002
    ..We propose that IL-1 beta may also be elevated in the circular muscle layer of the colon and may be partially responsible for the motility dysfunction observed in patients with UC...
  23. ncbi request reprint Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis
    Ling Cheng
    Division of Gastroenterology, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA
    Gastroenterology 129:1675-85. 2005
    ..Now, for the first time, we have obtained a human LES specimen with esophagitis (E-LES) and characterized its pathophysiologic mechanical and inflammatory profiles...
  24. ncbi request reprint Proinflammatory cytokines alter/reduce esophageal circular muscle contraction in experimental cat esophagitis
    Weibiao Cao
    Department of Medicine, Rhode Island Hospital and Brown University, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1131-9. 2004
    ..The data suggest that the proinflammatory cytokines IL-1beta and IL-6 contribute to reduced esophageal contraction by inhibiting release of ACh from myenteric neurons...
  25. pmc Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells
    Dan Li
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island and
    Am J Physiol Gastrointest Liver Physiol 306:G863-72. 2014
    ..It is possible that in BE acid reflux increases intracellular calcium, activates NOX5-S, and increases ROS production, which causes DNA damage, thereby contributing to the progression from BE to EA...
  26. ncbi request reprint Inflammation induced changes in arachidonic acid metabolism in cat LES circular muscle
    Ling Cheng
    G I Motility Research Laboratory, Rhode Island Hospital and Brown Univ, 55 Claverick St, Room 333, Providence RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 288:G787-97. 2005
    ..The data suggest that, in esophagitis, IL-1beta causes production of H(2)O(2). H(2)O(2) increases PGE(2), which relaxes the LES, and 8-iso-F(2alpha), which blocks PGF(2alpha)-mediated contraction...
  27. ncbi request reprint MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle
    Weibiao Cao
    Department of Medicine, Rhode Island Hospital and Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 285:G86-95. 2003
    ..These data suggest that PKC-dependent contraction in ESO and LES is mediated by the following two distinct MAPK pathways: ERK1/2 and HSP27-linked p38 MAPK...
  28. pmc Role of NADPH oxidase NOX5-S, NF-κB, and DNMT1 in acid-induced p16 hypermethylation in Barrett's cells
    Jie Hong
    Department of Medicine, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island
    Am J Physiol Cell Physiol 305:C1069-79. 2013
    ..Acid-induced DNMT1 expression may depend on sequential activation of NOX5-S and NF-κB1 p50...
  29. ncbi request reprint Nongenomic effects of progesterone on the contraction of muscle cells from the guinea pig colon
    Zuo Liang Xiao
    Division of Gastroenterology, APC 406, Rhode Island Hospital Brown University Medical School, 593 Eddy St, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1008-15. 2006
    ..This effect does not appear to be specific to PG because other steroid hormones such as aldosterone and testosterone can also induce it...
  30. pmc Expression of bile acid receptor TGR5 in gastric adenocarcinoma
    Weibiao Cao
    Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 304:G322-7. 2013
    ..Bile acids increase cell proliferation via activation of TGR5 receptors and G(q)α and Gα(i-3) proteins...
  31. ncbi request reprint Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles
    Karen M Harnett
    Gastrointestinal Motility Research, Rhode Island Hospital, 55 Claverick Street, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 288:G407-16. 2005
    ..This shift in signal-transduction pathways between initial and sustained contraction has been recently reported in intestinal smooth muscle...
  32. ncbi request reprint cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells
    Xiaoying Fu
    Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island 02903, USA
    J Biol Chem 281:20368-82. 2006
    ..Acid-induced NOX5-S expression depends on an increase in intracellular Ca(2+) and activation of CREB. NOX5-S contributes to increased cell proliferation and decreased apoptosis...
  33. ncbi request reprint PGF(2alpha)-induced contraction of cat esophageal and lower esophageal sphincter circular smooth muscle
    Weibiao Cao
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA
    Am J Physiol Gastrointest Liver Physiol 283:G282-91. 2002
    ..At low concentrations, PGF(2alpha) activates PKC. At high concentration, it activates both a PKC- and a calmodulin-dependent pathway...
  34. ncbi request reprint Distinct kinases are involved in contraction of cat esophageal and lower esophageal sphincter smooth muscles
    Nayoung Kim
    Department of Medicine, Seoul National University, Bundang Hospital, Seoungnam, Gyeronggi Do 463 707, Korea
    Am J Physiol Cell Physiol 287:C384-94. 2004
    ..We conclude that phosphatase inhibition potentiates the effects of MLCK in LES but not in ESO. Contraction of ESO is mediated by activation of PKCepsilon, MEK, ERK1/2, and ILK...

Research Grants6

  1. Signal transduction in progression of Barretts esophagus
    Weibiao Cao; Fiscal Year: 2002
    ..4. Determine signaling pathways involved in the upregulation of COX-2 following acid exposure. 5. Determine whether IL-lb induces production of IL-6. ..
  2. CONTRACTILE SIGNAL TRANSDUCTION IN ULCERATIVE COLITIS
    Weibiao Cao; Fiscal Year: 2004
    ..Examining the relationship between inflammatory mechanisms and changes in motor function may help in understanding the functional disturbances associated with ulcerative colitis and identifying new targets for therapeutic intervention. ..
  3. NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2007
    ....
  4. NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2009
    ..This project is designed to find potential therapeutic targets to prevent this progression. ..
  5. NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2010
    ..This project is designed to find potential therapeutic targets to prevent this progression. ..