K Boekelheide

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Predicting later-life outcomes of early-life exposures
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Environ Health Perspect 120:1353-61. 2012
  2. doi request reprint SOT/EUROTOX debate: biomarkers from blood and urine will replace traditional histopathological evaluation to determine adverse responses
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02818, USA
    Toxicol Sci 129:249-55. 2012
  3. pmc Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting
    Sara E Pacheco
    Department of Pathology and Laboratory Medicine, Brown University, Box G E5, Providence, RI 02912, USA
    J Androl 33:811-6. 2012
  4. pmc Induction and persistence of abnormal testicular germ cells following gestational exposure to di-(n-butyl) phthalate in p53-null mice
    Camelia M Saffarini
    Department of Pathology and Laboratory Medicine and the Center for Statistical Sciences, Brown University, Providence, RI, USA
    J Androl 33:505-13. 2012
  5. pmc Dose-dependent effects on cell proliferation, seminiferous tubules, and male germ cells in the fetal rat testis following exposure to di(n-butyl) phthalate
    Kim Boekelheide
    Brown University, Providence, Rhode Island 02912, USA
    Microsc Res Tech 72:629-38. 2009
  6. ncbi request reprint Gonadotropin-releasing hormone antagonist (Cetrorelix) therapy fails to protect nonhuman primates (Macaca arctoides) from radiation-induced spermatogenic failure
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Box G E504, Providence, RI 02912, USA
    J Androl 26:222-34. 2005
  7. ncbi request reprint Cracking the nut
    Kim Boekelheide
    Toxicol Sci 81:1-2. 2004
  8. pmc Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Toxicol Sci 114:20-4. 2010
  9. ncbi request reprint Role of Sertoli cells in injury-associated testicular germ cell apoptosis
    K Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Proc Soc Exp Biol Med 225:105-15. 2000
  10. ncbi request reprint 2,5-hexanedione-induced testicular injury
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Pharmacol Toxicol 43:125-47. 2003

Collaborators

Detail Information

Publications55

  1. pmc Predicting later-life outcomes of early-life exposures
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Environ Health Perspect 120:1353-61. 2012
    ..In utero exposure of the fetus to a stressor can lead to disease in later life. Epigenetic mechanisms are likely mediators of later-life expression of early-life events...
  2. doi request reprint SOT/EUROTOX debate: biomarkers from blood and urine will replace traditional histopathological evaluation to determine adverse responses
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02818, USA
    Toxicol Sci 129:249-55. 2012
    ..The ultimate purpose of this discussion is to help researchers and regulators understand the challenges they face in the development and integration of new and existing biomarkers to determine adverse responses...
  3. pmc Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting
    Sara E Pacheco
    Department of Pathology and Laboratory Medicine, Brown University, Box G E5, Providence, RI 02912, USA
    J Androl 33:811-6. 2012
    ..A filterlysis protocol was optimized to purify rat testicular homogenates for automated HRSH counts. Automated counting systems yield unbiased data and can be applied to detect changes in the testis after low-dose toxicant exposure...
  4. pmc Induction and persistence of abnormal testicular germ cells following gestational exposure to di-(n-butyl) phthalate in p53-null mice
    Camelia M Saffarini
    Department of Pathology and Laboratory Medicine and the Center for Statistical Sciences, Brown University, Providence, RI, USA
    J Androl 33:505-13. 2012
    ..This unique model identified a role for p53 in the perinatal apoptosis of DBP-induced MNGs and provided insight into the long-term effects of gestational DBP exposure within a p53-null environment...
  5. pmc Dose-dependent effects on cell proliferation, seminiferous tubules, and male germ cells in the fetal rat testis following exposure to di(n-butyl) phthalate
    Kim Boekelheide
    Brown University, Providence, Rhode Island 02912, USA
    Microsc Res Tech 72:629-38. 2009
    ..Cell proliferation and apoptosis are key processes regulating development of the testis, and alterations in these processes may underlie testicular dysgenesis...
  6. ncbi request reprint Gonadotropin-releasing hormone antagonist (Cetrorelix) therapy fails to protect nonhuman primates (Macaca arctoides) from radiation-induced spermatogenic failure
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Box G E504, Providence, RI 02912, USA
    J Androl 26:222-34. 2005
    ..Species differences exist in the testicular response to radiation, GnRH antagonist therapy, or both, so that rescue protocols that were successful in rodents might not work in primates...
  7. ncbi request reprint Cracking the nut
    Kim Boekelheide
    Toxicol Sci 81:1-2. 2004
  8. pmc Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Toxicol Sci 114:20-4. 2010
    ..Similar to an accident, predisposing "latent failures" identified within categories of the toxicant response database will be associated with the "active failure" of an adverse effect...
  9. ncbi request reprint Role of Sertoli cells in injury-associated testicular germ cell apoptosis
    K Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Proc Soc Exp Biol Med 225:105-15. 2000
    ..The different models of Sertoli cell injury indicate that spermatogenesis is susceptible to disruption, and that targeting critical Sertoli cell functions can lead to rapid and massive germ cell death...
  10. ncbi request reprint 2,5-hexanedione-induced testicular injury
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Pharmacol Toxicol 43:125-47. 2003
    ..The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research...
  11. ncbi request reprint Expression of Fas system-related genes in the testis during development and after toxicant exposure
    K Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Toxicol Lett 102:503-8. 1998
    ....
  12. ncbi request reprint A mechanistic redefinition of adverse effects - a key step in the toxicity testing paradigm shift
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02901, USA
    ALTEX 27:243-52. 2010
    ....
  13. ncbi request reprint Continuously proliferative stem germ cells partially repopulate the aged, atrophic rat testis after gonadotropin-releasing hormone agonist therapy
    H A Schoenfeld
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biol Reprod 64:1273-82. 2001
    ..An increase in the ratio of soluble to membrane stem cell factor mRNA levels was present in aged rats and partially reversed following leuprolide therapy...
  14. ncbi request reprint Multiple cadherin superfamily members with unique expression profiles are produced in rat testis
    K J Johnson
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Endocrinology 141:675-83. 2000
    ..The large number and variety of cadherin superfamily members found in testis supports a critical function for cadherin-mediated cell-cell adhesion in spermatogenesis...
  15. ncbi request reprint Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium
    Mary L Hixon
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island
    J Androl 24:891-8. 2003
    ..Further analysis demonstrated this staining to be associated with the Golgi complex in both germ and Sertoli cells...
  16. ncbi request reprint Spermatogenesis by Sisyphus: proliferating stem germ cells fail to repopulate the testis after 'irreversible' injury
    K Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Adv Exp Med Biol 500:421-8. 2001
    ..Ongoing experiments are designed to address the role of the Leydig cell in post-injury recovery, and to further characterize the molecular events contributing to the different states of persistent atrophy...
  17. ncbi request reprint Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity
    Stephanie A Beall
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA
    J Androl 26:529-38. 2005
    ..Collectively, these data indicate that celsr cadherins have a cell type-specific expression pattern, and celsr2 may mediate Sertoli cell-germ cell adhesion outside of classic cadherin-based adhesion junctions...
  18. ncbi request reprint 2,5-hexanedione and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules
    Robert J Markelewicz
    Department of Pathology and Laboratory Medicine, Brown University, 175 Meeting Street, Providence, Rhode Island 02912, USA
    Toxicol Sci 80:92-100. 2004
    ....
  19. pmc Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction
    Jan Klysik
    Department of Molecular Biology Cell Biology and Biochemistry, Brown University, Providence, RI 02912, United States
    Cell Signal 20:1-9. 2008
    ..In this review, the role of RKIP-1 in cellular signaling, and especially its functions revealed using a mouse knockout model, are discussed...
  20. ncbi request reprint gamma-Tubulin overexpression in Sertoli cells in vivo: I. Localization to sites of spermatid head attachment and alterations in Sertoli cell microtubule distribution
    Shawna L Fleming
    Departments of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biol Reprod 69:310-21. 2003
    ....
  21. ncbi request reprint gamma-Tubulin overexpression in Sertoli cells in vivo. II: Retention of spermatids, residual bodies, and germ cell apoptosis
    Shawna L Fleming
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biol Reprod 69:322-30. 2003
    ....
  22. pmc Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat
    Bronwyn H Bryant
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02903, USA
    Toxicol Pathol 36:552-9. 2008
    ..There was no evidence of other histopathological alterations. These data identify RSH as a sensitive histopathological marker of testicular toxicity for subacute HD exposure...
  23. ncbi request reprint Dynamic testicular adhesion junctions are immunologically unique. II. Localization of classic cadherins in rat testis
    Kamin J Johnson
    Department of Pathology and Laboratory Medicine, Brown University, 175 Meeting Street, Providence, Rhode Island 02912, USA
    Biol Reprod 66:992-1000. 2002
    ..These data show that the various testicular cell-cell junctions are molecularly unique and dynamic complexes...
  24. ncbi request reprint Dynamic testicular adhesion junctions are immunologically unique. I. Localization of p120 catenin in rat testis
    Kamin J Johnson
    Department of Pathology and Laboratory Medicine, Brown University, 175 Meeting Street, Providence, Rhode Island 02912, USA
    Biol Reprod 66:983-91. 2002
    ..From these data, we conclude that p120 is a component of most, if not all, desmosome-like junctions, and that desmosome-like junctions between different cell types contain a unique molecular composition...
  25. pmc A tumorigenic murine Sertoli cell line that is temperature-sensitive for differentiation
    K Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912
    Am J Pathol 143:1159-68. 1993
    ..The murine S14-1 Sertoli cell line should be useful for both in vitro studies of Sertoli cell function and in vivo studies of Sertoli cell malignancy...
  26. ncbi request reprint Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis
    Jeffrey S Moffit
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Toxicol Pathol 35:719-27. 2007
    ..In addition, this work is fundamental to a planned investigation of the histopathologic and gene expression changes associated with testicular toxicant co-exposures, which may occur both occupationally and environmentally...
  27. ncbi request reprint Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury
    Jeffrey S Moffit
    Brown University, Department of Molecular Biology Cell Biology and Biochemistry, Division of Biology and Medicine, 70 Ship Street, Providence, RI 02912, USA
    J Androl 28:883-90. 2007
    ..Overall, these studies indicate an important role for RKIP in reproduction as a modulator of capacitation but not in the regulation of testicular injury...
  28. ncbi request reprint Cloning and characterization of the 5' flanking region of the stem cell factor gene in rat Sertoli cells
    C Jiang
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Gene 185:285-90. 1997
    ....
  29. ncbi request reprint Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis
    Michelle Embree-Ku
    Department of Pathology and Laboratory Medicine, Brown University, 171 Meeting Street, Providence, Rhode Island 02912, USA
    Biol Reprod 66:1456-61. 2002
    ..These results indicate that apoptosis and up-regulation of Fas following radiation are both p53-dependent events. Although Fas is necessary, in part, for radiation-induced p53-dependent apoptosis, FasL is not...
  30. ncbi request reprint FasL deficiency enhances the development of tumors in p53+/- mice
    Michelle Embree-Ku
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Toxicol Pathol 30:705-13. 2002
    ..Given the reduced life span and increased incidence of lymphoma in FasL -/- p53 +/- mice, these mice could be useful in carcinogenicity testing, particularly for understanding mechanisms of compounds that are nongenotoxic...
  31. pmc Expression of a K48R mutant ubiquitin protects mouse testis from cryptorchid injury and aging
    Reza J Rasoulpour
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Am J Pathol 163:2595-603. 2003
    ..These results demonstrate a resistance to testicular injury conferred by the K48R mutation, suggesting that ubiquitin-mediated protein degradation is involved in the processing or modulation of testicular insults...
  32. ncbi request reprint NF-kappaB activation elicited by ionizing radiation is proapoptotic in testis
    Reza J Rasoulpour
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02903, USA
    Biol Reprod 76:279-85. 2007
    ..These data indicate that, despite acting in an antiapoptotic manner in many tissue types, NF-kappaB is proapoptotic in modulating the germ cell response to ionizing radiation...
  33. ncbi request reprint The Sycp1-Cre transgenic mouse and male germ cell inhibition of NF-kappa b
    Reza J Rasoulpour
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA
    J Androl 27:729-33. 2006
    ..Taken together, these data demonstrate a need for early spermatogonial expression of Cre recombinase, as an alternative to meiotic Cre expression, for the creation of germ cell-specific knockout mice...
  34. doi request reprint Functional modulation of choroid plexus epithelial clusters in vitro for tissue repair applications
    C G Thanos
    CytoSolv, Inc, Providence, RI 02905, USA
    Cell Transplant 20:1659-72. 2011
    ....
  35. ncbi request reprint Transmembrane versus soluble stem cell factor expression in human testis
    R A Fox
    Department of Pathology and Laboratory Medicine, Brown University School of Medicine, Providence, Rhode Island 02912, USA
    J Androl 21:579-85. 2000
    ..A significant correlation (r(s) = 0.665, P < .02, n = 16) was found between testosterone levels and percent soluble SCF, which suggests that, in humans, there may be a regulatory interaction between soluble SCF and testosterone...
  36. ncbi request reprint Time-dependent changes in post-mortem testis histopathology in the rat
    Bronwyn H Bryant
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Toxicol Pathol 35:665-71. 2007
    ..These findings will aid in ensuring proficient histopathological analysis of testes in toxicity studies...
  37. ncbi request reprint Absence of p53 and FasL has sexually dimorphic effects on both development and reproduction
    Michelle Embree-Ku
    Department of Pathology and Laboratory Medicine, Brown University, 171 Meeting Street, Providence, RI 02912, USA
    Exp Biol Med (Maywood) 227:545-53. 2002
    ..In this report, we suggest a potential mechanism involving corpora luteal regression to explain this defect in parturition in FasL-/-p53-/- female mice...
  38. ncbi request reprint NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane
    Kim Boekelheide
    Brown University, Providence, RI, USA
    Reprod Toxicol 18:189-217. 2004
  39. pmc Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death
    Erin Paul
    Division of Biology and Medicine, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship St, Providence, RI 02903, USA
    Mamm Genome 20:92-108. 2009
    ..Together, these data indicate that Supv3L1 is important for the maintenance of the skin barrier. In addition, loss of Supv3L1 function leads to accelerated aging-like phenotypes...
  40. ncbi request reprint Testicular microlithiasis in association with pseudoxanthoma elasticum
    Robert S Bercovitch
    Brown Medical School, Providence, RI, USA
    Radiology 237:550-4. 2005
    ..To determine the presence of testicular microlithiasis in male subjects with pseudoxanthoma elasticum (PXE)...
  41. ncbi request reprint NF-kappaB is activated in the rat testis following exposure to mono-(2-ethylhexyl) phthalate
    Reza J Rasoulpour
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biol Reprod 72:479-86. 2005
    ..These results suggest that NF-kappaB is involved in the testicular response to MEHP-induced injury...
  42. ncbi request reprint Extensive neuroprotection by choroid plexus transplants in excitotoxin lesioned monkeys
    Dwaine F Emerich
    LCT BioPharma, Providence, RI 02906, USA
    Neurobiol Dis 23:471-80. 2006
    ..43% in controls) and striatum volume (10% decrease vs. 40% in controls). These data indicate that CP transplants might be useful for preventing the degeneration of neurons in HD...
  43. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isodecyl phthalate
    Robert Kavlock
    National Health and Environmental Effects, Research Laboratory USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:655-78. 2002
  44. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:679-708. 2002
  45. pmc The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
    Michael W McBurney
    Ottawa Regional Cancer Centre and Department of Medicine, University of Ottawa, Ontario K1H 1C4, Canada
    Mol Cell Biol 23:38-54. 2003
    ..The phenotype of the sir2alpha null animals suggests that the SIR2alpha protein is essential for normal embryogenesis and for normal reproduction in both sexes...
  46. ncbi request reprint NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate
    Robert Kavlock
    US Environmental Agency, Research Triangle Park, NC, USA
    Reprod Toxicol 22:291-399. 2006
  47. ncbi request reprint Exposure in utero to di(n-butyl) phthalate alters the vimentin cytoskeleton of fetal rat Sertoli cells and disrupts Sertoli cell-gonocyte contact
    Elena Kleymenova
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 73:482-90. 2005
    ..Our data indicate that fetal Sertoli cells are targeted by exposure in utero to DBP and suggest that abnormal interactions between Sertoli and germ cells during fetal life play a role in the development of MNG...
  48. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:721-34. 2002
  49. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of butyl benzyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:453-87. 2002
  50. ncbi request reprint Fetal mouse phthalate exposure shows that Gonocyte multinucleation is not associated with decreased testicular testosterone
    Kevin W Gaido
    The Hamner Institutes for Health Sciences Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Sci 97:491-503. 2007
    ..This response in the mouse occurs without a measurable decrease in testicular testosterone, suggesting that altered seminiferous cord formation and gonocyte multinucleation may not be mechanistically linked to lowered testosterone...
  51. doi request reprint NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
    Robert E Chapin
    Pfizer, Inc, Groton, CT, USA
    Birth Defects Res B Dev Reprod Toxicol 83:157-395. 2008
  52. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-hexyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:709-19. 2002
  53. pmc The mouse polyubiquitin gene Ubb is essential for meiotic progression
    Kwon Yul Ryu
    Department of Biological Sciences, Bio X Program, Stanford University, Stanford, California 94305, USA
    Mol Cell Biol 28:1136-46. 2008
    ....
  54. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:529-653. 2002
  55. ncbi request reprint NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate
    Robert Kavlock
    National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC, USA
    Reprod Toxicol 16:489-527. 2002

Research Grants24

  1. Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine Disruption
    Kim Boekelheide; Fiscal Year: 2010
    ..This project will develop a xenograft bioassay consisting of fetal testes implanted in a rodent host to directly assess human susceptibility to endocrine disrupting chemicals, including the plasticizer di-n-butyl phthalate. ..
  2. SERTOLI CELL TOXICITY IN VIVO--MICROTUBULE DISRUPTION
    Kim Boekelheide; Fiscal Year: 2001
    ..Together, these complimentary approaches will critically examine key steps in the pathogenetic sequence by which microtubule disrupters alter the supportive capacity of Sertoli cells resulting in loss of germ cells and infertility. ..
  3. ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURY
    Kim Boekelheide; Fiscal Year: 2003
    ..Together, these complimentary approaches will elucidate the key molecular mechanisms responsible for irreversible testicular injury. ..
  4. PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53
    Kim Boekelheide; Fiscal Year: 2007
    ....
  5. ENVIRONMENTAL/INDUSTRIAL TOXICANTS & TESTICULAR INJURY
    Kim Boekelheide; Fiscal Year: 1992
    ..Tissue culture and immunologic techniques will be developed to allow early assessment of additional compounds which may induce testicular atrophy by Sertoli cell cytoskeletal disruption...
  6. ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURY
    Kim Boekelheide; Fiscal Year: 1993
    ....
  7. Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine Disruption
    Kim Boekelheide; Fiscal Year: 2011
    ..This project will develop a xenograft bioassay consisting of fetal testes implanted in a rodent host to directly assess human susceptibility to endocrine disrupting chemicals, including the plasticizer di-n-butyl phthalate. ..