Elaine Bearer

Summary

Affiliation: Brown University
Country: USA

Publications

  1. ncbi 2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Eur J Cell Biol 78:117-26. 1999
  2. ncbi Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 97:8146-50. 2000
  3. ncbi VASP protects actin filaments from gelsolin: an in vitro study with implications for platelet actin reorganizations
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Cell Motil Cytoskeleton 47:351-64. 2000
  4. ncbi 2E4/Kaptin (KPTN)--a candidate gene for the hearing loss locus, DFNA4
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Ann Hum Genet 64:189-96. 2000
  5. ncbi Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI)
    Elaine L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA
    Neuroimage 37:S37-46. 2007
  6. ncbi The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University Medical School, Providence, RI 02912, USA
    Curr Drug Targets Infect Disord 2:247-64. 2002
  7. ncbi Actin dynamics in platelets
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Int Rev Cytol 217:137-82. 2002
  8. ncbi Distribution of Xrel in the early Xenopus embryo: a cytoplasmic and nuclear gradient
    E L Bearer
    Division of Biology and Medicine, Brown University, Providence, RI 02912
    Eur J Cell Biol 63:255-68. 1994
  9. ncbi Overview of image analysis, image importing, and image processing using freeware
    E L Bearer
    Brown University, Providence, Rhode Island, USA
    Curr Protoc Mol Biol . 2003
  10. ncbi Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease
    Prasanna Satpute-Krishnan
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 2:305-18. 2003

Research Grants

  1. Molecular mechanisms of anterograde transport
    Elaine Bearer; Fiscal Year: 2007
  2. MOLECULAR MECHANISMS OF ACTIN DYNAMICS IN PLATELETS
    Elaine Bearer; Fiscal Year: 2003
  3. Using Transport to Map the Brain
    Elaine Bearer; Fiscal Year: 2009

Collaborators

Detail Information

Publications15

  1. ncbi 2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Eur J Cell Biol 78:117-26. 1999
    ....
  2. ncbi Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 97:8146-50. 2000
    ....
  3. ncbi VASP protects actin filaments from gelsolin: an in vitro study with implications for platelet actin reorganizations
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Cell Motil Cytoskeleton 47:351-64. 2000
    ..These results suggest a new concept for actin dynamics inside cells: that bundling proteins protect the actin superstructure from disassembly by severing, thereby preserving the integrity of the cytoskeleton...
  4. ncbi 2E4/Kaptin (KPTN)--a candidate gene for the hearing loss locus, DFNA4
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Ann Hum Genet 64:189-96. 2000
    ....
  5. ncbi Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI)
    Elaine L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02903, USA
    Neuroimage 37:S37-46. 2007
    ..This work provides a molecular and physiological framework for interpreting data acquired by MEMRI of circuitry in the brain...
  6. ncbi The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University Medical School, Providence, RI 02912, USA
    Curr Drug Targets Infect Disord 2:247-64. 2002
    ..Inhibition of intracellular movements provides a potential strategy to limit pathogenicity. The host cell motors and tracks, as well as the pathogen factors that interact with them, are potential targets for novel antimicrobial therapy...
  7. ncbi Actin dynamics in platelets
    E L Bearer
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Int Rev Cytol 217:137-82. 2002
    ..Morphological analysis of the distribution of these actin-binding proteins in spread platelets together with biochemical measurements of their interactions with actin lead to a model of interactions with actin that mediate shape change...
  8. ncbi Distribution of Xrel in the early Xenopus embryo: a cytoplasmic and nuclear gradient
    E L Bearer
    Division of Biology and Medicine, Brown University, Providence, RI 02912
    Eur J Cell Biol 63:255-68. 1994
    ..The presence of this putative transcription factor in the nuclei of these cells prior to mid-blastula transition suggests that Xrel-1 may be involved in programming animal cells to respond to vegetal-inducing factors...
  9. ncbi Overview of image analysis, image importing, and image processing using freeware
    E L Bearer
    Brown University, Providence, Rhode Island, USA
    Curr Protoc Mol Biol . 2003
    ....
  10. ncbi Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease
    Prasanna Satpute-Krishnan
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 2:305-18. 2003
    ..This work links fast anterograde transport of the common pathogen, HSV, with the neurodegenerative Alzheimer's disease. This novel connection should prompt new ideas for treatment and prevention strategies...
  11. ncbi Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation
    Jason M Aliotta
    Division of Hematology and Oncology, Rhode Island Hospital, 3rd Floor, George Building, 593 Eddy Street, Providence, Rhode Island 02903, USA
    Stem Cells 25:2245-56. 2007
    ..These findings demonstrate alterations of marrow cell phenotype by lung-derived microvesicles and suggest a novel mechanism for marrow cell-directed repair of injured tissue...
  12. ncbi Association of a nonmuscle myosin II with axoplasmic organelles
    Joseph A DeGiorgis
    Molecular and Cell Biology and Biochemistry Program, Brown University, Providence, RI 02912, USA
    Mol Biol Cell 13:1046-57. 2002
    ..Therefore, in addition to myosin V, this myosin is likely to be an axoplasmic organelle motor...
  13. ncbi Arp2/3 complex is required for actin polymerization during platelet shape change
    Zhi Li
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA
    Blood 99:4466-74. 2002
    ..These results suggest that activation of the Arp2/3 complex at the cortex by TRAP stimulation initiates an explosive polymerization of actin filaments that is required for all subsequent actin-dependent events...
  14. ncbi A peptide zipcode sufficient for anterograde transport within amyloid precursor protein
    Prasanna Satpute-Krishnan
    Department of Pathology and Laboratory Medicine, Brown University Medical School, 70 Ship Street, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 103:16532-7. 2006
    ..Thus, we have identified a conserved peptide zipcode sufficient to direct anterograde transport of exogenous cargo and suggest that one of APP's roles may be to recruit and activate axonal machinery for endogenous cargo transport...
  15. ncbi Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth
    Sandeep Sanga
    Department of Biomedical Engineering, University of Texas, Austin, TX 78712, USA
    Neuroimage 37:S120-34. 2007
    ..This approach further provides a means to deterministically test effects of novel and hypothetical therapy strategies on tumor behavior...

Research Grants16

  1. Molecular mechanisms of anterograde transport
    Elaine Bearer; Fiscal Year: 2007
    ..Thus, these results will yield answers to universal questions on axonal transport, specific facts about herpes pathogenesis, and fundamental new information about the role of APP in Alzheimer's disease. ..
  2. MOLECULAR MECHANISMS OF ACTIN DYNAMICS IN PLATELETS
    Elaine Bearer; Fiscal Year: 2003
    ..The applicant, Dr. Elaine Bearer, has used platelets to identify and clone a novel membrane-associated actin-binding protein, 2E4, that has the ..
  3. Using Transport to Map the Brain
    Elaine Bearer; Fiscal Year: 2009
    ..Here we propose to develop and apply this technology to map this important memory circuit in mouse models towards gaining an understanding of two frequently occurring diseases: Down syndrome and Alzheimer's disease. ..