Jason M Aliotta

Summary

Affiliation: Brown University
Country: USA

Publications

  1. pmc Progenitor/stem cell fate determination: interactive dynamics of cell cycle and microvesicles
    Jason M Aliotta
    Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Stem Cells Dev 21:1627-38. 2012
  2. pmc Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation
    Jason M Aliotta
    Division of Hematology and Oncology, Rhode Island Hospital, 3rd Floor, George Building, 593 Eddy Street, Providence, Rhode Island 02903, USA
    Stem Cells 25:2245-56. 2007
  3. pmc Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension
    Jason M Aliotta
    Division of Hematology and Oncology, Sleep, and Critical Care Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Stem Cells Dev 18:773-82. 2009
  4. pmc Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice
    Jason M Aliotta
    Division of Hematology Oncology, Department of Medicine, Rhode Island Hospital, Providence, RI 02908, USA
    Cardiovasc Res 100:354-62. 2013
  5. doi request reprint Conversion potential of marrow cells into lung cells fluctuates with cytokine-induced cell cycle
    Mark S Dooner
    Department of Medical Oncology Research, Center for Stem Cell Biology Research, Rhode Island Hospital, Providence, RI 02903, USA
    Stem Cells Dev 17:207-19. 2008
  6. pmc Bone marrow production of lung cells: the impact of G-CSF, cardiotoxin, graded doses of irradiation, and subpopulation phenotype
    Jason M Aliotta
    Roger Williams Medical Center, Center for Stem Cell Biology, Providence, RI 02908, USA
    Exp Hematol 34:230-41. 2006
  7. pmc Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription
    Jason M Aliotta
    Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, Providence, RI 02903, USA
    Exp Hematol 38:233-45. 2010
  8. doi request reprint Marrow cell genetic phenotype change induced by human lung cancer cells
    Michael Del Tatto
    Department of Medicine, Division of Hematology Oncology, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, USA
    Exp Hematol 39:1072-80. 2011
  9. ncbi request reprint The stem cell continuum: cell cycle, injury, and phenotype lability
    Peter J Quesenberry
    Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, George 3, Providence, RI 02903, USA
    Ann N Y Acad Sci 1106:20-9. 2007
  10. pmc Cellular phenotype switching and microvesicles
    Peter J Quesenberry
    Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, USA
    Adv Drug Deliv Rev 62:1141-8. 2010

Collaborators

Detail Information

Publications21

  1. pmc Progenitor/stem cell fate determination: interactive dynamics of cell cycle and microvesicles
    Jason M Aliotta
    Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Stem Cells Dev 21:1627-38. 2012
    ..These data demonstrate that microvesicle modification of progenitor/stem cells is influenced by cell cycle and the treatment of the originator lung tissue...
  2. pmc Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation
    Jason M Aliotta
    Division of Hematology and Oncology, Rhode Island Hospital, 3rd Floor, George Building, 593 Eddy Street, Providence, Rhode Island 02903, USA
    Stem Cells 25:2245-56. 2007
    ..These findings demonstrate alterations of marrow cell phenotype by lung-derived microvesicles and suggest a novel mechanism for marrow cell-directed repair of injured tissue...
  3. pmc Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension
    Jason M Aliotta
    Division of Hematology and Oncology, Sleep, and Critical Care Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Stem Cells Dev 18:773-82. 2009
    ..In conclusion, WBM alone appears to increase RVPP and RV/BW in normal mice but the combination of WBM and TBI attenuates MCT-induced PH...
  4. pmc Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice
    Jason M Aliotta
    Division of Hematology Oncology, Department of Medicine, Rhode Island Hospital, Providence, RI 02908, USA
    Cardiovasc Res 100:354-62. 2013
    ..In this study, we sought to determine whether LEV or plasma-derived EV (PEV) alter pulmonary vascular endothelial or marrow progenitor cell phenotype to induce pulmonary vascular remodelling...
  5. doi request reprint Conversion potential of marrow cells into lung cells fluctuates with cytokine-induced cell cycle
    Mark S Dooner
    Department of Medical Oncology Research, Center for Stem Cell Biology Research, Rhode Island Hospital, Providence, RI 02903, USA
    Stem Cells Dev 17:207-19. 2008
    ..The present study indicates that marrow stem cell production of nonhematopoietic cells also fluctuates on a continuum...
  6. pmc Bone marrow production of lung cells: the impact of G-CSF, cardiotoxin, graded doses of irradiation, and subpopulation phenotype
    Jason M Aliotta
    Roger Williams Medical Center, Center for Stem Cell Biology, Providence, RI 02908, USA
    Exp Hematol 34:230-41. 2006
    ..Previous studies have demonstrated the production of various types of lung cells from marrow cells under diverse experimental conditions. Our aim was to identify some of the variables that influence conversion in the lung...
  7. pmc Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription
    Jason M Aliotta
    Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, Providence, RI 02903, USA
    Exp Hematol 38:233-45. 2010
    ..The present studies establish that entry of lung-derived microvesicles into marrow cells is a prerequisite for marrow expression of pulmonary epithelial cell-derived mRNA...
  8. doi request reprint Marrow cell genetic phenotype change induced by human lung cancer cells
    Michael Del Tatto
    Department of Medicine, Division of Hematology Oncology, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, USA
    Exp Hematol 39:1072-80. 2011
    ..They also suggest that the tissue environment may alter cancer cell gene expression...
  9. ncbi request reprint The stem cell continuum: cell cycle, injury, and phenotype lability
    Peter J Quesenberry
    Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, George 3, Providence, RI 02903, USA
    Ann N Y Acad Sci 1106:20-9. 2007
    ..Altogether, marrow appears to represent a highly flexible ever-changing cell system with the capacity to respond to products of injured cells and top repair a broad range of tissues...
  10. pmc Cellular phenotype switching and microvesicles
    Peter J Quesenberry
    Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, USA
    Adv Drug Deliv Rev 62:1141-8. 2010
    ..Additionally, vesicles have promise in the clinical arenas of disease biomarkers, tissue restoration and control of neoplastic cell growth...
  11. pmc Fate and effects of adult bone marrow cells in lungs of normoxic and hyperoxic newborn mice
    James A Fritzell
    Women and Infants Hospital, Dept of Pathology, 101 Dudley Street, Providence, RI 02905, USA
    Am J Respir Cell Mol Biol 40:575-87. 2009
    ....
  12. pmc Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells
    Ming Li
    Department of Medicine, Rhode Island and Miriam Hospitals, Warren Alpert Medical School of Brown University, Providence, RI, USA
    Proteomics 12:2203-11. 2012
    ....
  13. ncbi request reprint Stem cells and pulmonary metamorphosis: new concepts in repair and regeneration
    Jason M Aliotta
    Roger Williams Medical Center, Center for Stem Cell Biology, Providence, RI 02908, USA
    J Cell Physiol 204:725-41. 2005
    ....
  14. pmc Stem cell plasticity revisited: the continuum marrow model and phenotypic changes mediated by microvesicles
    Peter J Quesenberry
    Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Exp Hematol 38:581-92. 2010
    ..We further propose a stem cell population model in which the individual cell phenotypes continually change, but the population phenotype is relatively stable. This, in turn, is modulated by microvesicle and microenvironmental influences...
  15. pmc Intercellular transfer of proteins as identified by stable isotope labeling of amino acids in cell culture
    Ming Li
    Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Biol Chem 285:6285-97. 2010
    ..SILAC-generated data sets offer a valuable tool to identify and validate potential paracrine networks that may impact relevant biologic processes associated with phenotypic and genotypic signatures of health and disease...
  16. doi request reprint The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles
    Peter J Quesenberry
    Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    Stem Cell Rev 4:137-47. 2008
    ..We propose that there is an interactive triangulated Venn diagram with continuously changing stem cells interacting with continuously changing areas of influence, both being modulated by transfer of genetic information by microvesicles...
  17. pmc Cellular phenotype and extracellular vesicles: basic and clinical considerations
    Peter J Quesenberry
    1 Department of Medicine, Rhode Island Hospital, Providence, Rhode Island
    Stem Cells Dev 23:1429-36. 2014
    ..Extracellular vesicles offer an intriguing strategy for treating a number of diseases characterized by tissue injury. ..
  18. pmc Partial anomalous pulmonary venous return presenting with adult-onset pulmonary hypertension
    Edmund H Sears
    Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Pulm Circ 2:250-5. 2012
    ..The diagnosis and treatment of PAPVR and its role in pulmonary vascular disease is discussed. Cardiac and pulmonary physicians should be aware of this entity and its diagnosis and management options...
  19. ncbi request reprint Update on idiopathic pulmonary fibrosis: the role of gamma interferon and cytokines
    Napoleon A Puente
    Roger Williams Medical Center, Providence, RI, 02908, USA
    Med Health R I 90:43-5. 2007
  20. ncbi request reprint Differentiation hotspots: the deterioration of hierarchy and stochasm
    Gerald A Colvin
    Department of Research, Roger Williams Medical Center, Providence, RI 02908, USA
    Blood Cells Mol Dis 32:34-41. 2004
    ..This data inaugurates the end of a pure stochastic model. This work complements existing scientific work without discounting it and adds an additional dimension of complexity (or simplicity) to the process of hematopoiesis...