G J Wang

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi request reprint The role of dopamine in motivation for food in humans: implications for obesity
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Expert Opin Ther Targets 6:601-9. 2002
  2. ncbi request reprint Brain dopamine and obesity
    G J Wang
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    Lancet 357:354-7. 2001
  3. ncbi request reprint Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Am J Psychiatry 156:19-26. 1999
  4. ncbi request reprint Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:1325-31. 1998
  5. ncbi request reprint Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
  6. ncbi request reprint Measuring dopamine transporter occupancy by cocaine in vivo: radiotracer considerations
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 28:111-6. 1998
  7. ncbi request reprint Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:75-80. 2000
  8. ncbi request reprint Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:344-9. 1998
  9. ncbi request reprint Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y 11973, USA
    Am J Psychiatry 154:50-5. 1997
  10. ncbi request reprint Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA
    Synapse 27:347-56. 1997

Research Grants

  1. PHARMACOKINETICS OF PSYCHOSTIMULANTS AND REINFORCEMENT
    Gene Jack Wang; Fiscal Year: 2002
  2. PET in Obese Monkeys: A Developmental (R21) Application
    Gene Jack Wang; Fiscal Year: 2005
  3. Brain Dopamine Function in Adults with ADHD
    Gene Jack Wang; Fiscal Year: 2007
  4. PET Studies of Brain Dopamine in Stimulant Abusers
    Gene Jack Wang; Fiscal Year: 2006
  5. DOPAMINERGIC BRAIN FUNCTION IN ALCOHOLICS
    Gene Jack Wang; Fiscal Year: 2007
  6. PET Studies of Brain Dopamine in Stimulant Abusers
    Gene Jack Wang; Fiscal Year: 2007
  7. Studies in Cocaine Abuse
    Gene Jack Wang; Fiscal Year: 2010
  8. Studies in Cocaine Abuse
    Gene Jack Wang; Fiscal Year: 2004
  9. Studies in Cocaine Abuse
    Gene Jack Wang; Fiscal Year: 2010

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint The role of dopamine in motivation for food in humans: implications for obesity
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Expert Opin Ther Targets 6:601-9. 2002
    ..A better understanding of the role of the DA system in the motivation for food intake will help the development of better therapeutic interventions...
  2. ncbi request reprint Brain dopamine and obesity
    G J Wang
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    Lancet 357:354-7. 2001
    ..To test the hypothesis that obese individuals have abnormalities in brain dopamine activity we measured the availability of dopamine D2 receptors in brain...
  3. ncbi request reprint Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Am J Psychiatry 156:19-26. 1999
    ..To assess whether increasing dopamine would reverse these metabolic decrements, they measured the effects of methylphenidate, a drug that increases dopamine, on brain glucose metabolism in 20 cocaine abusers...
  4. ncbi request reprint Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:1325-31. 1998
    ..This study measured, for the first time, dopamine transporter occupancy by orally administered methylphenidate in the human brain and its rate of uptake in the brain...
  5. ncbi request reprint Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
    ..Moreover, they suggest a participation of thalamic dopamine pathways in cocaine addiction, a possibility that merits further investigation...
  6. ncbi request reprint Measuring dopamine transporter occupancy by cocaine in vivo: radiotracer considerations
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 28:111-6. 1998
    ..We conclude that in vivo measurements of DAT occupancy by rapidly clearing drugs like cocaine requires the use of radiotracers having similar kinetics to the drug itself...
  7. ncbi request reprint Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:75-80. 2000
    ..This study investigates the relationship between measures of brain dopamine D(2) receptors (molecules that transmit dopamine signals) and regional brain glucose metabolism (a marker of brain function) in healthy individuals...
  8. ncbi request reprint Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:344-9. 1998
    ..This study assessed the relation between measures of brain dopamine activity and indexes of motor and cognitive function in healthy individuals...
  9. ncbi request reprint Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y 11973, USA
    Am J Psychiatry 154:50-5. 1997
    ..The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assess the pattern of metabolic responses associated with enhanced dopamine activity...
  10. ncbi request reprint Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA
    Synapse 27:347-56. 1997
    ..The average Bmax may, however, provide an estimate of the expected concentration in humans. (2) The DVR can be used as a measure of DAT occupancy without applying an explicit model...
  11. pmc Brain monoamine oxidase A inhibition in cigarette smokers
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 93:14065-9. 1996
    ..This suggests that MAO A inhibition needs to be considered as a potential contributing variable in the high rate of smoking in depression and in the development of more effective strategies for smoking cessation...
  12. ncbi request reprint Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain
    N D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 65:PL7-12. 1999
    ..Other variables i.e. longer duration of methylphenidate's side effects may counterbalance its reinforcing effects...
  13. ncbi request reprint Smoking a single cigarette does not produce a measurable reduction in brain MAO B in non-smokers
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Nicotine Tob Res 1:325-9. 1999
    ..These results indicate that the reduction in MAO B in smokers probably occurs gradually and requires chronic tobacco smoke exposure...
  14. ncbi request reprint Evaluation of gender difference in regional brain metabolic responses to lorazepam
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 82:37-46. 1998
    ....
  15. ncbi request reprint Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y, USA
    Am J Psychiatry 156:1440-3. 1999
    ..This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans...
  16. ncbi request reprint Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 68:2759-68. 2001
    ....
  17. pmc Decreased dopamine activity predicts relapse in methamphetamine abusers
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Psychiatry 17:918-25. 2012
    ..Detection of the extent of DA dysfunction may be helpful in predicting therapeutic outcomes...
  18. ncbi request reprint Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions
    N D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 66:PL161-7. 2000
    ..Analysis of the regional measures showed that cocaine abusers had a blunted response to alcohol in limbic regions, cingulate gyrus, medial frontal and orbitofrontal cortices...
  19. ncbi request reprint Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain
    J S Fowler
    Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Life Sci 66:PL141-6. 2000
    ..Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects...
  20. ncbi request reprint Species differences in [11C]clorgyline binding in brain
    J S Fowler
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 28:779-85. 2001
    ..This suggests a species difference in the susceptibility of MAO A to inhibition by clorgyline and represents an unusual example of where the behavior of a radiotracer in the baboon brain does not predict its behavior in the human brain...
  21. ncbi request reprint Regional brain metabolic activation during craving elicited by recall of previous drug experiences
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 64:775-84. 1999
    ....
  22. ncbi request reprint Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:59-66. 1999
    ....
  23. ncbi request reprint Non-MAO A binding of clorgyline in white matter in human brain
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurochem 79:1039-46. 2001
    ..The characterization of the non-MAO A binding component of this widely used MAO A inhibitor merits further investigation...
  24. ncbi request reprint Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:9414-8. 2001
    ..These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals...
  25. ncbi request reprint Chiral drugs: comparison of the pharmacokinetics of [11C]d-threo and L-threo-methylphenidate in the human and baboon brain
    Y S Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Psychopharmacology (Berl) 131:71-8. 1997
    ..These results indicate that pharmacological specificity of MP resides entirely in the d-threo isomer and directly show that binding of the l-isomer in human brain is mostly nonspecific...
  26. ncbi request reprint Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers...
  27. ncbi request reprint Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors
    N D Volkow
    Brookhaven National Laboratory, Upton, New York, USA
    J Pharmacol Exp Ther 291:409-15. 1999
    ....
  28. pmc Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire
    R Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Psychopharmacol 24:257-66. 2010
    ..Additional studies are required to assess the reliability of the STRAP-R in larger samples and to examine its validity in measuring the subjective value attributed to experienced reinforcers or in predicting behaviour...
  29. ncbi request reprint Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 27:43-9. 2000
    ..84 +/- 7.07%. Linear regression applied to values of lambda k3 from the LIN and NLLSQ methods validated the use of the linear method for calculating lambda k3...
  30. ncbi request reprint Maintenance of brain monoamine oxidase B inhibition in smokers after overnight cigarette abstinence
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:1864-6. 2000
    ..The authors' goal was to replicate a previous finding that smokers have lower brain monoamine oxidase B (MAO-B) levels than comparison nonsmoking subjects and to determine if levels recover after overnight cigarette abstinence...
  31. ncbi request reprint Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain
    N D Volkow
    Medical Department, Upton, NY 11973, USA
    Life Sci 67:1507-15. 2000
    ..The faster time course for the subjective effects for smoked than intravenous and for intravenous than for intranasal cocaine highlights the importance of the speed of cocaine's delivery into the brain on its reinforcing effects...
  32. ncbi request reprint Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans
    N D Volkow
    Department of Medicine, Brookhaven National Laboratory, Upton, New York, NY 11973, USA
    J Psychopharmacol 13:337-45. 1999
    ..Thus, strategies to enhance DA brain function in ways that mimic physiological DA activity may be of help in overcoming cocaine addiction...
  33. ncbi request reprint Enhanced sensitivity to benzodiazepines in active cocaine-abusing subjects: a PET study
    N D Volkow
    Medical Department, Brookhaven National Laboratory, NY 11973, USA
    Am J Psychiatry 155:200-6. 1998
    ..Because cocaine enhances dopamine brain activity and dopamine signals are transferred through gamma-aminobutyric acid pathways, the authors hypothesized GABA-ergic disruption in cocaine-abusing subjects. This study tests this hypothesis...
  34. ncbi request reprint Differences in regional brain metabolic responses between single and repeated doses of methylphenidate
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 83:29-36. 1998
    ..This indicates that methylphenidate's metabolic effects vary with acute previous exposure and highlights the importance of studying drugs after single and repeated administration...
  35. ncbi request reprint [(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 28:561-72. 2001
    ..This article will summarize preclinical and clinical research with [(11)C]cocaine...
  36. ncbi request reprint Regional brain metabolism during alcohol intoxication
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Alcohol Clin Exp Res 24:822-9. 2000
    ..The results were compared with those we previously published in a different group of 16 normal male subjects who received intravenous lorazepam, a benzodiazepine drug that also enhances GABA neurotransmission...
  37. ncbi request reprint Distribution of tracer levels of cocaine in the human brain as assessed with averaged [11C]cocaine images
    F W Telang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:290-6. 1999
    ..Further work is required to characterize the binding properties of cocaine in these brain areas and to elucidate their role in the reinforcing and addictive properties of cocaine...
  38. ncbi request reprint Brain glucose metabolism in violent psychiatric patients: a preliminary study
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 61:243-53. 1995
    ..These regions have been implicated as substrates for aggression and impulsivity, and their dysfunction may have contributed to the patients' violent behavior...
  39. ncbi request reprint Imaging the neurochemistry of nicotine actions: studies with positron emission tomography
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nicotine Tob Res 1:S127-32; discussion S139-40. 1999
    ....
  40. ncbi request reprint Increased activity of the temporal insula in subjects with bradycardia
    N D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 67:2213-20. 2000
    ..The temporal insula is interconnected with limbic brain region and autonomic centers and suggests that this may be a mechanism by which emotional responses regulate heart rate...
  41. pmc Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability
    E Shumay
    Brookhaven National Laboratory, Medical Department, Center for Translational Neuroimaging, Upton, NY 11973, USA
    Transl Psychiatry 2:e86. 2012
    ..01). Taken together, these results provide preliminary evidence for the role of the PER2 gene in regulating striatal D2R availability in the human brain and in vulnerability for cocaine addiction...
  42. ncbi request reprint Resting brain metabolic activity in a 4 tesla magnetic field
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Magn Reson Med 44:701-5. 2000
    ..We conclude that a static magnetic field of 4 T does not in itself affect this fairly sensitive measure of brain activity...
  43. ncbi request reprint Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Behav Pharmacol 13:355-66. 2002
    ....
  44. ncbi request reprint Inhibition of monoamine oxidase B in the brains of smokers
    J S Fowler
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 379:733-6. 1996
    ..We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking...
  45. ncbi request reprint A strategy for removing the bias in the graphical analysis method
    J Logan
    Chemistry and Medical Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 21:307-20. 2001
    ..The DVR generated directly from the model (DVR(FL)) was compared with DVR(FG) (determined from a "smoothed" uptake curve as for DV(FG)) using the graphical method...
  46. pmc Addiction changes orbitofrontal gyrus function: involvement in response inhibition
    R Z Goldstein
    Brookhaven National Laboratory, Medical Research, Bldg. 490, 30 Bell Ave, Upton, NY 11973, USA
    Neuroreport 12:2595-9. 2001
    ....
  47. pmc Differences in response to food stimuli in a rat model of obesity: in-vivo assessment of brain glucose metabolism
    P K Thanos
    Department of Medicine, Behavioral Neuropharmacology and Neuroimaging Laboratory, Brookhaven National Laboratory, Upton, NY, USA
    Int J Obes (Lond) 32:1171-9. 2008
    ..In this study, we measured brain glucose utilization to an olfactory stimulus (bacon scent), and we examined the role of food restriction and genetic predisposition to obesity on such brain metabolic activity...
  48. pmc Impairment of attentional networks after 1 night of sleep deprivation
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Cereb Cortex 19:233-40. 2009
    ....
  49. pmc Simultaneous TMS-fMRI of the Visual Cortex Reveals Functional Network, Even in Absence of Phosphene Sensation
    E C Caparelli
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Open Neuroimag J 4:100-10. 2010
    ....
  50. ncbi request reprint Translational neuroimaging: positron emission tomography studies of monoamine oxidase
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 7:377-87. 2005
    ..In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs...
  51. ncbi request reprint Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
  52. ncbi request reprint Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 34:1467-79. 2007
    ....
  53. ncbi request reprint Stimulant-induced enhanced sexual desire as a potential contributing factor in HIV transmission
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Rm 5274, Bethesda, MD 20892, USA
    Am J Psychiatry 164:157-60. 2007
    ..The authors investigated the effect of the stimulant drug methylphenidate (given intravenously) on sexual desire as a possible contributing factor to risky sexual behavior associated with the contraction of HIV...
  54. pmc Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
    ..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects...
  55. ncbi request reprint Brain dopamine transporter levels in treatment and drug naïve adults with ADHD
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 34:1182-90. 2007
    ..g., prefrontal or cingulostriatal pathways, noradrenergic neurotransmission) is necessary to account for the large differences in inattention observed between controls and ADHD subjects...
  56. pmc Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 103:15641-5. 2006
    ....
  57. ncbi request reprint Low doses of alcohol substantially decrease glucose metabolism in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Neuroimage 29:295-301. 2006
    ....
  58. ncbi request reprint Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
    ..Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction...
  59. ncbi request reprint Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Nucl Med 46:1414-20. 2005
    ..Because smoking exposes peripheral organs as well as the brain to MAO A-inhibitory compounds, we determined whether smokers would also have reduced MAO A in peripheral organs...
  60. ncbi request reprint Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 32:1782-92. 2006
    ..Thus, the state of expectation needs to be considered as a variable modulating the reinforcing and therapeutic effects of drugs even in subjects who have no prior experience with the drug...
  61. ncbi request reprint PET imaging in clinical drug abuse research
    S John Gatley
    Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973, USA
    Curr Pharm Des 11:3203-19. 2005
    ....
  62. pmc What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, NY, USA
    Emotion 7:649-59. 2007
    ....
  63. pmc Incentive motivation is associated with striatal dopamine asymmetry
    Rachel Tomer
    Department of Psychology and Brain and Behavior Center, University of Haifa, Mount Carmel 31905, Israel
    Biol Psychol 77:98-101. 2008
    ..721, p=.001), suggesting that greater positive incentive motivation is associated with higher receptor availability in the left relative to the right hemisphere...
  64. ncbi request reprint High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA
    Arch Gen Psychiatry 63:999-1008. 2006
    ..Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption...
  65. pmc Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 28:8454-61. 2008
    ....
  66. pmc Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
    Nora D Volkow
    National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 363:3191-200. 2008
    ..These neuronal circuits, which are modulated by DA, interact with one another so that disruption in one circuit can be buffered by another, which highlights the need of multiprong approaches in the treatment of addiction and obesity...
  67. pmc Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Lab, Upton, NY 11973, USA
    Synapse 62:637-42. 2008
    ..These results are consistent with prior findings showing increased levels of endogenous cannabinoids in the Ob rats corroborating the regulation of cannabinoid signaling by leptin...
  68. pmc Compromised sensitivity to monetary reward in current cocaine users: an ERP study
    Rita Z Goldstein
    Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Psychophysiology 45:705-13. 2008
    ....
  69. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  70. pmc Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2017. 2008
    ..This would explain why methylphenidate has beneficial effects in some individuals and contexts and detrimental effects in others...
  71. pmc The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Pharmacol Biochem Behav 89:499-507. 2008
    ..These results suggest that along with its involvement in seeking behavior for drugs of abuse, the D(3) dopamine receptor may also be involved in seeking behavior for natural reinforcers such as food...
  72. pmc Moderate doses of alcohol disrupt the functional organization of the human brain
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Rockville, MD 20852, USA
    Psychiatry Res 162:205-13. 2008
    ..The widespread nature of the changes induced by a moderate dose of alcohol is likely to contribute to the marked disruption of alcohol on behavior, mood, cognition and motor activity...
  73. ncbi request reprint Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
    ..These findings provide evidence that the left amygdala and insula process interoceptive signals of fullness produced by gastric distention involved in the controls of food intake...
  74. pmc Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda MD 20892, USA National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Neuroimage 39:1266-73. 2008
    ....
  75. ncbi request reprint Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 27:12700-6. 2007
    ....
  76. ncbi request reprint Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography
    Panayotis K Thanos
    Behavioral Neuropharmacology Laboratory, Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Synapse 62:50-61. 2008
    ..Here we assess DA D2 receptors (D2R) in a genetic rodent obesity model characterized by leptin-receptor deficiency and assess the influence of food restriction on these receptors...
  77. ncbi request reprint Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    Biol Psychiatry 57:1410-5. 2005
    ..We postulate that these effects would improve school performance...
  78. ncbi request reprint Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction
    Nora D Volkow
    National Institute of Drug Abuse, Rockville, Maryland 20857, USA
    J Neurosci 25:3932-9. 2005
    ..It also suggests that the mesothalamic DA pathway may contribute to these processes...
  79. ncbi request reprint Positron emission tomography and single-photon emission computed tomography in substance abuse research
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Semin Nucl Med 33:114-28. 2003
    ..This article highlights recent advances in the use of PET and SPECT imaging to measure the pharmacokinetic and pharmacodynamic effects of drugs of abuse on the human brain...
  80. pmc The addicted human brain: insights from imaging studies
    Nora D Volkow
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Clin Invest 111:1444-51. 2003
  81. ncbi request reprint Brain dopamine is associated with eating behaviors in humans
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Int J Eat Disord 33:136-42. 2003
    ..We investigate the role of dopamine (DA), a neurotransmitter involved with food motivation, in these variables...
  82. ncbi request reprint Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 166:264-70. 2003
    ..However, there is some evidence that dopaminergic effects are involved in the cardiovascular actions of these drugs. Here, we evaluated this association in humans...
  83. ncbi request reprint Monoamine oxidase and cigarette smoking
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurotoxicology 24:75-82. 2003
    ....
  84. ncbi request reprint Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Neurobiol Learn Mem 78:610-24. 2002
    ....
  85. pmc The orbitofrontal cortex in methamphetamine addiction: involvement in fear
    Rita Z Goldstein
    Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
    Neuroreport 13:2253-7. 2002
    ..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction...
  86. ncbi request reprint Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 116:163-72. 2002
    ..These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor...
  87. ncbi request reprint Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 22:1367-76. 2002
    ..This method should be generalizable to other tracers and should facilitate the analysis of group differences...
  88. ncbi request reprint PET imaging of monoamine oxidase B in peripheral organs in humans
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1331-8. 2002
    ..The purpose of this study was to investigate the feasibility of imaging MAO B in peripheral organs in humans with PET...
  89. ncbi request reprint Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 46:79-82. 2002
    ..These results replicate our previous findings and provide further evidence that striatal DA D2 receptors modulate reinforcing responses to stimulants in humans and may underlie predisposition for drug self-administration...
  90. ncbi request reprint Monoamine oxidase: radiotracer development and human studies
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Methods 27:263-77. 2002
    ..PET studies have been carried out to measure the effects of age, MAO inhibitor drugs, tobacco smoke exposure, and other factors on MAO activity in the human brain...
  91. ncbi request reprint Enhanced resting activity of the oral somatosensory cortex in obese subjects
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroreport 13:1151-5. 2002
    ....
  92. ncbi request reprint "Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 44:175-80. 2002
    ..In addition it demonstrates the ability of methylphenidate to amplify weak dopamine signals...
  93. ncbi request reprint Monoamine oxidase A imaging in peripheral organs in healthy human subjects
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 49:178-87. 2003
    ....
  94. ncbi request reprint Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Alcohol Clin Exp Res 27:909-17. 2003
    ..We compared the regional changes in brain glucose metabolism during alcohol intoxication between female and male subjects...
  95. ncbi request reprint The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 57:640-6. 2005
    ..This study measures the potency and kinetics for DAT blockade by radafaxine in human brain...
  96. ncbi request reprint Anger and depression in cocaine addiction: association with the orbitofrontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Ave, Upton, NY, 11973 5000, USA
    Psychiatry Res 138:13-22. 2005
    ....
  97. ncbi request reprint Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  98. ncbi request reprint Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, PO Box 5000, Upton, NY 11973, USA
    J Addict Dis 23:39-53. 2004
    ..Understanding the mechanism in food intake will help to suggest strategies for the treatment of obesity...
  99. ncbi request reprint Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex
    Rita Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuropsychologia 42:1447-58. 2004
    ..Obtaining valid estimates of alcohol use in cocaine addicted subjects is essential in characterizing neurocognitive functioning in individuals addicted to drugs...
  100. ncbi request reprint 6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 53:184-9. 2004
  101. ncbi request reprint Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain
    Nora D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Am J Psychiatry 161:1173-80. 2004
    ..The objective of this study was to assess if methylphenidate, by increasing dopamine (neurotransmitter involved in motivation) in brain, would enhance the saliency of an academic task, making it more interesting...

Research Grants25

  1. PHARMACOKINETICS OF PSYCHOSTIMULANTS AND REINFORCEMENT
    Gene Jack Wang; Fiscal Year: 2002
    ....
  2. PET in Obese Monkeys: A Developmental (R21) Application
    Gene Jack Wang; Fiscal Year: 2005
    ..In particular, this would allow us to address the hypothesis that weight reduction is associated with increases in D2 receptor levels to the normal range ..
  3. Brain Dopamine Function in Adults with ADHD
    Gene Jack Wang; Fiscal Year: 2007
    ..abstract_text> ..
  4. PET Studies of Brain Dopamine in Stimulant Abusers
    Gene Jack Wang; Fiscal Year: 2006
    ..e Parkinson's disease). Such knowledge should help guide the management of the METH abuser and the development of medications that may help ameliorate the DA deficits. ..
  5. DOPAMINERGIC BRAIN FUNCTION IN ALCOHOLICS
    Gene Jack Wang; Fiscal Year: 2007
    ..understanding of the neurobiological mechanisms underlying protective and predisposing factors in alcoholism would allow development of better preventive interventions and may help in the design of corrective therapeutic strategies ..
  6. PET Studies of Brain Dopamine in Stimulant Abusers
    Gene Jack Wang; Fiscal Year: 2007
    ..e Parkinson's disease). Such knowledge should help guide the management of the METH abuser and the development of medications that may help ameliorate the DA deficits. ..
  7. Studies in Cocaine Abuse
    Gene Jack Wang; Fiscal Year: 2010
    ....
  8. Studies in Cocaine Abuse
    Gene Jack Wang; Fiscal Year: 2004
    ..abstract_text> ..
  9. Studies in Cocaine Abuse
    Gene Jack Wang; Fiscal Year: 2010
    ....