G J Wang

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder
    Gene Jack Wang
    Department of Radiology, Stony Brook University, Stony Brook, New York, USA
    PLoS ONE 8:e63023. 2013
  2. pmc Decreased dopamine activity predicts relapse in methamphetamine abusers
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Psychiatry 17:918-25. 2012
  3. pmc Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 103:15641-5. 2006
  4. ncbi request reprint The role of dopamine in motivation for food in humans: implications for obesity
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Expert Opin Ther Targets 6:601-9. 2002
  5. ncbi request reprint Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
  6. ncbi request reprint Regional brain metabolic activation during craving elicited by recall of previous drug experiences
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 64:775-84. 1999
  7. pmc Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
    Proc Natl Acad Sci U S A 106:1249-54. 2009
  8. ncbi request reprint Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, PO Box 5000, Upton, NY 11973, USA
    J Addict Dis 23:39-53. 2004
  9. pmc Enhanced striatal dopamine release during food stimulation in binge eating disorder
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Obesity (Silver Spring) 19:1601-8. 2011
  10. ncbi request reprint Regional brain metabolism during alcohol intoxication
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Alcohol Clin Exp Res 24:822-9. 2000

Detail Information

Publications121 found, 100 shown here

  1. pmc Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder
    Gene Jack Wang
    Department of Radiology, Stony Brook University, Stony Brook, New York, USA
    PLoS ONE 8:e63023. 2013
    ..However while the acute increases in dopamine induced by stimulant medications have been associated with symptom improvement in ADHD the chronic effects have not been investigated...
  2. pmc Decreased dopamine activity predicts relapse in methamphetamine abusers
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Psychiatry 17:918-25. 2012
    ..Detection of the extent of DA dysfunction may be helpful in predicting therapeutic outcomes...
  3. pmc Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 103:15641-5. 2006
    ....
  4. ncbi request reprint The role of dopamine in motivation for food in humans: implications for obesity
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Expert Opin Ther Targets 6:601-9. 2002
    ..A better understanding of the role of the DA system in the motivation for food intake will help the development of better therapeutic interventions...
  5. ncbi request reprint Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
    ..These findings provide evidence that the left amygdala and insula process interoceptive signals of fullness produced by gastric distention involved in the controls of food intake...
  6. ncbi request reprint Regional brain metabolic activation during craving elicited by recall of previous drug experiences
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 64:775-84. 1999
    ....
  7. pmc Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
    Proc Natl Acad Sci U S A 106:1249-54. 2009
    ..This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity...
  8. ncbi request reprint Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, PO Box 5000, Upton, NY 11973, USA
    J Addict Dis 23:39-53. 2004
    ..Understanding the mechanism in food intake will help to suggest strategies for the treatment of obesity...
  9. pmc Enhanced striatal dopamine release during food stimulation in binge eating disorder
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Obesity (Silver Spring) 19:1601-8. 2011
    ..The lack of correlation between BMI and dopamine changes suggests that dopamine release per se does not predict BMI within a group of obese individuals but that it predicts binge eating...
  10. ncbi request reprint Regional brain metabolism during alcohol intoxication
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Alcohol Clin Exp Res 24:822-9. 2000
    ..The results were compared with those we previously published in a different group of 16 normal male subjects who received intravenous lorazepam, a benzodiazepine drug that also enhances GABA neurotransmission...
  11. ncbi request reprint Evaluation of gender difference in regional brain metabolic responses to lorazepam
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 82:37-46. 1998
    ....
  12. ncbi request reprint Exposure to appetitive food stimuli markedly activates the human brain
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 21:1790-7. 2004
    ..Here we assess the response of the human brain to the presentation of appetitive food stimuli during food presentation using PET and FDG...
  13. ncbi request reprint Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Alcohol Clin Exp Res 27:909-17. 2003
    ..We compared the regional changes in brain glucose metabolism during alcohol intoxication between female and male subjects...
  14. ncbi request reprint Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 161:242-8. 2004
    ..In this study, the authors assessed whether metabolism recovers with protracted abstinence...
  15. ncbi request reprint Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Am J Psychiatry 156:19-26. 1999
    ..To assess whether increasing dopamine would reverse these metabolic decrements, they measured the effects of methylphenidate, a drug that increases dopamine, on brain glucose metabolism in 20 cocaine abusers...
  16. ncbi request reprint Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:1325-31. 1998
    ..This study measured, for the first time, dopamine transporter occupancy by orally administered methylphenidate in the human brain and its rate of uptake in the brain...
  17. ncbi request reprint Measuring dopamine transporter occupancy by cocaine in vivo: radiotracer considerations
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 28:111-6. 1998
    ..We conclude that in vivo measurements of DAT occupancy by rapidly clearing drugs like cocaine requires the use of radiotracers having similar kinetics to the drug itself...
  18. ncbi request reprint Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
    ..Moreover, they suggest a participation of thalamic dopamine pathways in cocaine addiction, a possibility that merits further investigation...
  19. ncbi request reprint Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y 11973, USA
    Am J Psychiatry 154:50-5. 1997
    ..The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assess the pattern of metabolic responses associated with enhanced dopamine activity...
  20. ncbi request reprint Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:344-9. 1998
    ..This study assessed the relation between measures of brain dopamine activity and indexes of motor and cognitive function in healthy individuals...
  21. ncbi request reprint Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y, USA
    Am J Psychiatry 156:1440-3. 1999
    ..This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans...
  22. ncbi request reprint Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:75-80. 2000
    ..This study investigates the relationship between measures of brain dopamine D(2) receptors (molecules that transmit dopamine signals) and regional brain glucose metabolism (a marker of brain function) in healthy individuals...
  23. ncbi request reprint Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:9414-8. 2001
    ..These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals...
  24. ncbi request reprint Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA
    Synapse 27:347-56. 1997
    ..The average Bmax may, however, provide an estimate of the expected concentration in humans. (2) The DVR can be used as a measure of DAT occupancy without applying an explicit model...
  25. ncbi request reprint Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain
    N D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 65:PL7-12. 1999
    ..Other variables i.e. longer duration of methylphenidate's side effects may counterbalance its reinforcing effects...
  26. pmc Brain monoamine oxidase A inhibition in cigarette smokers
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 93:14065-9. 1996
    ..This suggests that MAO A inhibition needs to be considered as a potential contributing variable in the high rate of smoking in depression and in the development of more effective strategies for smoking cessation...
  27. ncbi request reprint Smoking a single cigarette does not produce a measurable reduction in brain MAO B in non-smokers
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Nicotine Tob Res 1:325-9. 1999
    ..These results indicate that the reduction in MAO B in smokers probably occurs gradually and requires chronic tobacco smoke exposure...
  28. ncbi request reprint Cocaine abusers show a blunted response to alcohol intoxication in limbic brain regions
    N D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 66:PL161-7. 2000
    ..Analysis of the regional measures showed that cocaine abusers had a blunted response to alcohol in limbic regions, cingulate gyrus, medial frontal and orbitofrontal cortices...
  29. ncbi request reprint Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 68:2759-68. 2001
    ....
  30. ncbi request reprint Brain dopamine and obesity
    G J Wang
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    Lancet 357:354-7. 2001
    ..To test the hypothesis that obese individuals have abnormalities in brain dopamine activity we measured the availability of dopamine D2 receptors in brain...
  31. pmc Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire
    R Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Psychopharmacol 24:257-66. 2010
    ..Additional studies are required to assess the reliability of the STRAP-R in larger samples and to examine its validity in measuring the subjective value attributed to experienced reinforcers or in predicting behaviour...
  32. ncbi request reprint Non-MAO A binding of clorgyline in white matter in human brain
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurochem 79:1039-46. 2001
    ..The characterization of the non-MAO A binding component of this widely used MAO A inhibitor merits further investigation...
  33. ncbi request reprint Species differences in [11C]clorgyline binding in brain
    J S Fowler
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 28:779-85. 2001
    ..This suggests a species difference in the susceptibility of MAO A to inhibition by clorgyline and represents an unusual example of where the behavior of a radiotracer in the baboon brain does not predict its behavior in the human brain...
  34. ncbi request reprint Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers...
  35. ncbi request reprint Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:59-66. 1999
    ....
  36. ncbi request reprint Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain
    J S Fowler
    Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Life Sci 66:PL141-6. 2000
    ..Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects...
  37. ncbi request reprint Chiral drugs: comparison of the pharmacokinetics of [11C]d-threo and L-threo-methylphenidate in the human and baboon brain
    Y S Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Psychopharmacology (Berl) 131:71-8. 1997
    ..These results indicate that pharmacological specificity of MP resides entirely in the d-threo isomer and directly show that binding of the l-isomer in human brain is mostly nonspecific...
  38. pmc Differences in response to food stimuli in a rat model of obesity: in-vivo assessment of brain glucose metabolism
    P K Thanos
    Department of Medicine, Behavioral Neuropharmacology and Neuroimaging Laboratory, Brookhaven National Laboratory, Upton, NY, USA
    Int J Obes (Lond) 32:1171-9. 2008
    ..In this study, we measured brain glucose utilization to an olfactory stimulus (bacon scent), and we examined the role of food restriction and genetic predisposition to obesity on such brain metabolic activity...
  39. ncbi request reprint Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain
    Nora D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Am J Psychiatry 161:1173-80. 2004
    ..The objective of this study was to assess if methylphenidate, by increasing dopamine (neurotransmitter involved in motivation) in brain, would enhance the saliency of an academic task, making it more interesting...
  40. ncbi request reprint Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors
    N D Volkow
    Brookhaven National Laboratory, Upton, New York, USA
    J Pharmacol Exp Ther 291:409-15. 1999
    ....
  41. ncbi request reprint Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans
    N D Volkow
    Department of Medicine, Brookhaven National Laboratory, Upton, New York, NY 11973, USA
    J Psychopharmacol 13:337-45. 1999
    ..Thus, strategies to enhance DA brain function in ways that mimic physiological DA activity may be of help in overcoming cocaine addiction...
  42. ncbi request reprint Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 27:43-9. 2000
    ..84 +/- 7.07%. Linear regression applied to values of lambda k3 from the LIN and NLLSQ methods validated the use of the linear method for calculating lambda k3...
  43. ncbi request reprint Differences in regional brain metabolic responses between single and repeated doses of methylphenidate
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 83:29-36. 1998
    ..This indicates that methylphenidate's metabolic effects vary with acute previous exposure and highlights the importance of studying drugs after single and repeated administration...
  44. ncbi request reprint Maintenance of brain monoamine oxidase B inhibition in smokers after overnight cigarette abstinence
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:1864-6. 2000
    ..The authors' goal was to replicate a previous finding that smokers have lower brain monoamine oxidase B (MAO-B) levels than comparison nonsmoking subjects and to determine if levels recover after overnight cigarette abstinence...
  45. ncbi request reprint [(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 28:561-72. 2001
    ..This article will summarize preclinical and clinical research with [(11)C]cocaine...
  46. ncbi request reprint Increased activity of the temporal insula in subjects with bradycardia
    N D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 67:2213-20. 2000
    ..The temporal insula is interconnected with limbic brain region and autonomic centers and suggests that this may be a mechanism by which emotional responses regulate heart rate...
  47. ncbi request reprint Enhanced sensitivity to benzodiazepines in active cocaine-abusing subjects: a PET study
    N D Volkow
    Medical Department, Brookhaven National Laboratory, NY 11973, USA
    Am J Psychiatry 155:200-6. 1998
    ..Because cocaine enhances dopamine brain activity and dopamine signals are transferred through gamma-aminobutyric acid pathways, the authors hypothesized GABA-ergic disruption in cocaine-abusing subjects. This study tests this hypothesis...
  48. ncbi request reprint Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain
    N D Volkow
    Medical Department, Upton, NY 11973, USA
    Life Sci 67:1507-15. 2000
    ..The faster time course for the subjective effects for smoked than intravenous and for intravenous than for intranasal cocaine highlights the importance of the speed of cocaine's delivery into the brain on its reinforcing effects...
  49. ncbi request reprint A strategy for removing the bias in the graphical analysis method
    J Logan
    Chemistry and Medical Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 21:307-20. 2001
    ..The DVR generated directly from the model (DVR(FL)) was compared with DVR(FG) (determined from a "smoothed" uptake curve as for DV(FG)) using the graphical method...
  50. ncbi request reprint Brain glucose metabolism in violent psychiatric patients: a preliminary study
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 61:243-53. 1995
    ..These regions have been implicated as substrates for aggression and impulsivity, and their dysfunction may have contributed to the patients' violent behavior...
  51. ncbi request reprint Distribution of tracer levels of cocaine in the human brain as assessed with averaged [11C]cocaine images
    F W Telang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:290-6. 1999
    ..Further work is required to characterize the binding properties of cocaine in these brain areas and to elucidate their role in the reinforcing and addictive properties of cocaine...
  52. pmc Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability
    E Shumay
    Brookhaven National Laboratory, Medical Department, Center for Translational Neuroimaging, Upton, NY 11973, USA
    Transl Psychiatry 2:e86. 2012
    ..01). Taken together, these results provide preliminary evidence for the role of the PER2 gene in regulating striatal D2R availability in the human brain and in vulnerability for cocaine addiction...
  53. ncbi request reprint Resting brain metabolic activity in a 4 tesla magnetic field
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Magn Reson Med 44:701-5. 2000
    ..We conclude that a static magnetic field of 4 T does not in itself affect this fairly sensitive measure of brain activity...
  54. ncbi request reprint Imaging the neurochemistry of nicotine actions: studies with positron emission tomography
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nicotine Tob Res 1:S127-32; discussion S139-40. 1999
    ....
  55. pmc Impairment of attentional networks after 1 night of sleep deprivation
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Cereb Cortex 19:233-40. 2009
    ....
  56. ncbi request reprint Enhanced resting activity of the oral somatosensory cortex in obese subjects
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroreport 13:1151-5. 2002
    ....
  57. ncbi request reprint Inhibition of monoamine oxidase B in the brains of smokers
    J S Fowler
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 379:733-6. 1996
    ..We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking...
  58. ncbi request reprint Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Behav Pharmacol 13:355-66. 2002
    ....
  59. pmc Addiction changes orbitofrontal gyrus function: involvement in response inhibition
    R Z Goldstein
    Brookhaven National Laboratory, Medical Research, Bldg. 490, 30 Bell Ave, Upton, NY 11973, USA
    Neuroreport 12:2595-9. 2001
    ....
  60. pmc Effect of combined naltrexone and bupropion therapy on the brain's reactivity to food cues
    G J Wang
    1 Department of Bioscience, Brookhaven National Laboratory, Upton, NY, USA 2 Department of Radiology, Stony Brook University, Stony Brook, NY, USA
    Int J Obes (Lond) 38:682-8. 2014
    ..We assessed changes in brain reactivity to food cues before and after NB32 treatment...
  61. pmc Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors
    P K Thanos
    Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA
    J Psychopharmacol 24:897-904. 2010
    ..Thus, individuals with D4 receptor polymorphisms might show enhanced reinforcing responses to MP and AMPH and attenuated locomotor response to AMPH...
  62. ncbi request reprint Gender differences in cerebellar metabolism: test-retest reproducibility
    N D Volkow
    Department of Psychiatry, State University of New York at Stony Brook, USA
    Am J Psychiatry 154:119-21. 1997
    ..The purpose of this study was to evaluate gender differences in baseline measures of regional brain metabolism and to assess their reproducibility...
  63. ncbi request reprint Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers
    N D Volkow
    Department of Psychiatry, State University of New York at Stony Brook, USA
    Am J Psychiatry 158:377-82. 2001
    ..The authors evaluated if similar changes occur in humans and assessed if they were functionally significant...
  64. ncbi request reprint Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers
    N D Volkow
    Department of Psychiatry, State University of New York at Stony Brook, USA
    Am J Psychiatry 158:383-9. 2001
    ..The authors measured regional brain glucose metabolism, which serves as a marker of brain function, to assess if there is evidence of functional changes in methamphetamine abusers in regions other than those innervated by dopamine cells...
  65. pmc Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls
    D Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Neuroimage 54:3101-10. 2011
    ..This suggests that MPH (presumably by amplifying dopamine and noradrenergic signaling) modulates cognition in part through its effects on DAN and DMN...
  66. ncbi request reprint PET imaging of monoamine oxidase B in peripheral organs in humans
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1331-8. 2002
    ..The purpose of this study was to investigate the feasibility of imaging MAO B in peripheral organs in humans with PET...
  67. pmc What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, NY, USA
    Emotion 7:649-59. 2007
    ....
  68. ncbi request reprint Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 22:1367-76. 2002
    ..This method should be generalizable to other tracers and should facilitate the analysis of group differences...
  69. ncbi request reprint Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 116:163-72. 2002
    ..These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor...
  70. ncbi request reprint Translational neuroimaging: positron emission tomography studies of monoamine oxidase
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 7:377-87. 2005
    ..In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs...
  71. ncbi request reprint Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography
    Panayotis K Thanos
    Behavioral Neuropharmacology Laboratory, Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Synapse 62:50-61. 2008
    ..Here we assess DA D2 receptors (D2R) in a genetic rodent obesity model characterized by leptin-receptor deficiency and assess the influence of food restriction on these receptors...
  72. pmc The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Pharmacol Biochem Behav 89:499-507. 2008
    ..These results suggest that along with its involvement in seeking behavior for drugs of abuse, the D(3) dopamine receptor may also be involved in seeking behavior for natural reinforcers such as food...
  73. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  74. pmc The addicted human brain: insights from imaging studies
    Nora D Volkow
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Clin Invest 111:1444-51. 2003
  75. pmc Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
    ..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects...
  76. pmc Compromised sensitivity to monetary reward in current cocaine users: an ERP study
    Rita Z Goldstein
    Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Psychophysiology 45:705-13. 2008
    ....
  77. pmc Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Lab, Upton, NY 11973, USA
    Synapse 62:637-42. 2008
    ..These results are consistent with prior findings showing increased levels of endogenous cannabinoids in the Ob rats corroborating the regulation of cannabinoid signaling by leptin...
  78. ncbi request reprint Monoamine oxidase: radiotracer development and human studies
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Methods 27:263-77. 2002
    ..PET studies have been carried out to measure the effects of age, MAO inhibitor drugs, tobacco smoke exposure, and other factors on MAO activity in the human brain...
  79. ncbi request reprint "Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 44:175-80. 2002
    ..In addition it demonstrates the ability of methylphenidate to amplify weak dopamine signals...
  80. ncbi request reprint Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 46:79-82. 2002
    ..These results replicate our previous findings and provide further evidence that striatal DA D2 receptors modulate reinforcing responses to stimulants in humans and may underlie predisposition for drug self-administration...
  81. ncbi request reprint Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Nucl Med 46:1414-20. 2005
    ..Because smoking exposes peripheral organs as well as the brain to MAO A-inhibitory compounds, we determined whether smokers would also have reduced MAO A in peripheral organs...
  82. ncbi request reprint Brain dopamine is associated with eating behaviors in humans
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Int J Eat Disord 33:136-42. 2003
    ..We investigate the role of dopamine (DA), a neurotransmitter involved with food motivation, in these variables...
  83. pmc The orbitofrontal cortex in methamphetamine addiction: involvement in fear
    Rita Z Goldstein
    Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
    Neuroreport 13:2253-7. 2002
    ..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction...
  84. ncbi request reprint Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Neurobiol Learn Mem 78:610-24. 2002
    ....
  85. ncbi request reprint 2-deoxy-2-[18F]fluoro-D-glucose and alternative radiotracers for positron emission tomography imaging using the human brain as a model
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Semin Nucl Med 34:112-21. 2004
    ..We describe studies that fall into three major areas: normal aging, neuropsychiatric disorders, and drug action...
  86. ncbi request reprint Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex
    Rita Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuropsychologia 42:1447-58. 2004
    ..Obtaining valid estimates of alcohol use in cocaine addicted subjects is essential in characterizing neurocognitive functioning in individuals addicted to drugs...
  87. ncbi request reprint Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans
    Joanna S Fowler
    Brookhaven National Laboratory, Chemistry Department, Bldg 555, Upton, NY 11973, USA
    Nucl Med Biol 31:313-9. 2004
    ....
  88. ncbi request reprint Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications
    Nora D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 43:181-7. 2002
    ....
  89. ncbi request reprint Monoamine oxidase and cigarette smoking
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurotoxicology 24:75-82. 2003
    ....
  90. ncbi request reprint Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 23:11461-8. 2003
    ..The enhanced cerebellar activation with expectation may reflect conditioned responses that are not linked to conscious responses...
  91. ncbi request reprint Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  92. pmc Low monoamine oxidase B in peripheral organs in smokers
    Joanna S Fowler
    Chemistry Department and Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 100:11600-5. 2003
    ....
  93. ncbi request reprint Monoamine oxidase A imaging in peripheral organs in healthy human subjects
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 49:178-87. 2003
    ....
  94. ncbi request reprint The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 57:640-6. 2005
    ..This study measures the potency and kinetics for DAT blockade by radafaxine in human brain...
  95. ncbi request reprint Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 166:264-70. 2003
    ..However, there is some evidence that dopaminergic effects are involved in the cardiovascular actions of these drugs. Here, we evaluated this association in humans...
  96. ncbi request reprint DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking
    Panayotis K Thanos
    Department of Medicine, Brookhaven National Laboratory, Upton, New York, USA
    Alcohol Clin Exp Res 28:720-8. 2004
    ..This overexpression of DRD2 reduced alcohol consumption in a two-bottle-choice paradigm and supported the view that high levels of DRD2 may be protective against alcohol abuse...
  97. ncbi request reprint Anger and depression in cocaine addiction: association with the orbitofrontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Ave, Upton, NY, 11973 5000, USA
    Psychiatry Res 138:13-22. 2005
    ....
  98. ncbi request reprint Hippocampal formation glucose metabolism and volume losses in MCI and AD
    S De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA
    Neurobiol Aging 22:529-39. 2001
    ..These cross-sectional data show that in MCI hippocampal formation changes exist without significant neocortical changes. Neocortical changes best characterize AD. In both MCI and AD, metabolism reductions exceed volume losses...
  99. ncbi request reprint PET imaging in clinical drug abuse research
    S John Gatley
    Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973, USA
    Curr Pharm Des 11:3203-19. 2005
    ....
  100. ncbi request reprint Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:667-79. 2007
    ..Quantification methods were determined from test/retest studies, and sensitivity to pharmacological blockade was tested with different doses of atomoxetine (ATX), a drug that binds to the NET with high affinity (K(i)=2-5 nM)...
  101. ncbi request reprint Positron emission tomography and single-photon emission computed tomography in substance abuse research
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Semin Nucl Med 33:114-28. 2003
    ..This article highlights recent advances in the use of PET and SPECT imaging to measure the pharmacokinetic and pharmacodynamic effects of drugs of abuse on the human brain...