Dardo G Tomasi

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Striatocortical pathway dysfunction in addiction and obesity: differences and similarities
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Crit Rev Biochem Mol Biol 48:1-19. 2013
  2. pmc Resting functional connectivity of language networks: characterization and reproducibility
    D Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Laboratory of Neuroimaging, Bethesda, MD, USA
    Mol Psychiatry 17:841-54. 2012
  3. pmc Laterality patterns of brain functional connectivity: gender effects
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Cereb Cortex 22:1455-62. 2012
  4. pmc Aging and functional brain networks
    D Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Mol Psychiatry 17:471, 549-58. 2012
  5. pmc Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Biol Psychiatry 71:443-50. 2012
  6. pmc Gender differences in brain functional connectivity density
    Dardo Tomasi
    Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Hum Brain Mapp 33:849-60. 2012
  7. pmc Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasks
    D Tomasi
    Medical Department, Building 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroscience 151:1006-15. 2008
  8. pmc Association of body mass and brain activation during gastric distention: implications for obesity
    Dardo Tomasi
    National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e6847. 2009
  9. pmc Dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attention
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    PLoS ONE 4:e6102. 2009
  10. pmc Functional connectivity density mapping
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:9885-90. 2010

Research Grants

Detail Information

Publications50

  1. pmc Striatocortical pathway dysfunction in addiction and obesity: differences and similarities
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Crit Rev Biochem Mol Biol 48:1-19. 2013
    ....
  2. pmc Resting functional connectivity of language networks: characterization and reproducibility
    D Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Laboratory of Neuroimaging, Bethesda, MD, USA
    Mol Psychiatry 17:841-54. 2012
    ..Assessment of the intra-subject's reproducibility of this network and its characterization in individuals with language dysfunction is required to determine its potential as a biomarker for language disorders...
  3. pmc Laterality patterns of brain functional connectivity: gender effects
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Cereb Cortex 22:1455-62. 2012
    ..The greater lateralization of the male's brain (rightward and predominantly short-range) may underlie their greater vulnerability to disorders with disrupted brain asymmetries (schizophrenia, autism)...
  4. pmc Aging and functional brain networks
    D Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Mol Psychiatry 17:471, 549-58. 2012
    ....
  5. pmc Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Biol Psychiatry 71:443-50. 2012
    ..This neuropathology may reflect dysfunction of both attention and reward-motivation networks...
  6. pmc Gender differences in brain functional connectivity density
    Dardo Tomasi
    Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
    Hum Brain Mapp 33:849-60. 2012
    ..e., autism spectrum disorder)...
  7. pmc Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasks
    D Tomasi
    Medical Department, Building 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroscience 151:1006-15. 2008
    ..Together, these sex-specific differences in brain activation during the VA task, at different cognitive and acoustic levels suggest differences in auditory gating of the thalamus for men and women...
  8. pmc Association of body mass and brain activation during gastric distention: implications for obesity
    Dardo Tomasi
    National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e6847. 2009
    ....
  9. pmc Dopamine transporters in striatum correlate with deactivation in the default mode network during visuospatial attention
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA
    PLoS ONE 4:e6102. 2009
    ..Thus, higher striatal DAT levels, which would result in an enhanced clearance of dopamine and hence weaker dopamine signals, would be associated to lower deactivation in the DMN during an attention task...
  10. pmc Functional connectivity density mapping
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:9885-90. 2010
    ..The variability of this pattern across subjects was <36% and within subjects was 12%. The power scaling of the lFCD was consistent across research centers, suggesting that that brain networks have a "scale-free" organization...
  11. pmc Impairment of attentional networks after 1 night of sleep deprivation
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Cereb Cortex 19:233-40. 2009
    ....
  12. pmc Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e10815. 2010
    ....
  13. pmc Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls
    D Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA
    Neuroimage 54:3101-10. 2011
    ..This suggests that MPH (presumably by amplifying dopamine and noradrenergic signaling) modulates cognition in part through its effects on DAN and DMN...
  14. pmc Ultrafast method for mapping local functional connectivity hubs in the human brain
    Dardo Tomasi
    National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:4274-7. 2010
    ..In addition regions located in the paracentral lobule, cuneus, inferior parietal, and posterior cingulate cortices had localized high FCD, suggesting that these regions also include prominent functional connectivity hubs...
  15. pmc Association between functional connectivity hubs and brain networks
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Cereb Cortex 21:2003-13. 2011
    ..The significant variability among functional networks may underlie their sensitivity/resilience to neuropathology...
  16. pmc fMRI-acoustic noise alters brain activation during working memory tasks
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroimage 27:377-86. 2005
    ....
  17. pmc Functional connectivity hubs in the human brain
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Neuroimage 57:908-17. 2011
    ..Within and between-subject variability for gFCD were twice than that for lFCD (20% vs. 12% and 84% vs. 34%, respectively) suggesting that gFCD is more sensitive to individual differences in functional connectivity...
  18. ncbi request reprint Induced magnetic field gradients and forces in the human head in MRI
    Dardo G Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Magn Reson Imaging 26:1340-5. 2007
    ..To map the induced magnetic field gradients and estimate the magnetic force in the human head during magnetic resonance imaging at 4 Tesla (T)...
  19. pmc Widespread disruption in brain activation patterns to a working memory task during cocaine abstinence
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Brain Res 1171:83-92. 2007
    ..This widespread neurofunctional disruption is likely to underlie the cognitive deficits during early cocaine abstinence and to reflect involvement of dopamine as well as other neurotransmitters...
  20. ncbi request reprint Practice-induced changes of brain function during visual attention: a parametric fMRI study at 4 Tesla
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 23:1414-21. 2004
    ..Since short-term practice-effects in the prefrontal cortex may be similar to attentional load-effects, studies of attentional load need to take practice effects into account...
  21. ncbi request reprint Asymmetrical gradient coil for head imaging
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Magn Reson Med 48:707-14. 2002
    ..Magnetic field measurements and electrical parameters of coils are in good agreement with theoretical calculations...
  22. pmc Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 155:189-201. 2007
    ..The development of therapies that diminish these thalamo-cortical deficits could improve the treatment of cocaine addiction...
  23. ncbi request reprint Echo planar imaging at 4 Tesla with minimum acoustic noise
    Dardo G Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Magn Reson Imaging 18:128-30. 2003
    ..To minimize the acoustic sound pressure levels of single-shot echo planar imaging (EPI) acquisitions on high magnetic field MRI scanners...
  24. pmc Macrovascular contribution in activation patterns of working memory
    Dardo G Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 27:33-42. 2007
    ..This study suggests that the phase information embedded in the MRI signal can be used to suppress unwanted macrovascular contributions in fMRI studies...
  25. pmc Different activation patterns for working memory load and visual attention load
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave, Upton, NY 11973, USA
    Brain Res 1132:158-65. 2007
    ..Conversely, VA tasks activated more strongly an occipito-parietal network comprising the postcentral (PostCG) and the superior occipital (SOG) gyri, suggesting complex visual processing in this network...
  26. pmc Common deactivation patterns during working memory and visual attention tasks: an intra-subject fMRI study at 4 Tesla
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Hum Brain Mapp 27:694-705. 2006
    ..The task-dependent balance of activation and deactivation might allow maximization of resources for the activated network...
  27. pmc The human immunodeficiency virus reduces network capacity: acoustic noise effect
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Ann Neurol 59:419-23. 2006
    ..Increased acoustic noise (AN) during working memory leads to increased brain activation in healthy individuals and may have greater impact in human immunodeficiency virus (HIV) patients...
  28. ncbi request reprint Adaptation of the attention network in human immunodeficiency virus brain injury
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Ann Neurol 56:259-72. 2004
    ..Exceeding the brain reserve capacity may lead to attention deficits and cognitive impairment in HIV patients...
  29. pmc Methylphenidate attenuates limbic brain inhibition after cocaine-cues exposure in cocaine abusers
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland, United States of America
    PLoS ONE 5:e11509. 2010
    ..Studies to evaluate the clinical significance of methylphenidate's blunting of cue-induced limbic inhibition may help identify potential benefits of this medication in cocaine addiction...
  30. pmc Effects of low-field magnetic stimulation on brain glucose metabolism
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 51:623-8. 2010
    ..This data provides preliminary evidence that EPI sequences may affect neuronal activity and merits further investigation...
  31. pmc Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 28:8454-61. 2008
    ....
  32. pmc Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 107:16667-72. 2010
    ..neutral) cue-reactivity condition in all subjects. The clinical application of such MPH-induced brain-behavior enhancements remains to be tested...
  33. pmc Magnetic field shift due to mechanical vibration in functional magnetic resonance imaging
    Bernd U Foerster
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Magn Reson Med 54:1261-7. 2005
    ..The frequency drift correction method was tested "in vivo" and compared to the standard image realignment method. The proposed method efficiently corrects spurious motion due to magnetic field drifts during fMRI...
  34. pmc Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
    ..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability...
  35. ncbi request reprint The effect of small rotations on R2* measured with echo planar imaging
    Elisabeth C Caparelli
    Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY 11973, USA
    Neuroimage 24:1164-9. 2005
    ..Similar measurements were carried out in a human study. Rotations larger than 2 degrees changed R(2)* more than 1.5 Hz in the phantom, and indicate that even small rotations may compromise fMRI results...
  36. ncbi request reprint k-Space based summary motion detection for functional magnetic resonance imaging
    Elisabeth C Caparelli
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 20:1411-8. 2003
    ..This method makes it possible to evaluate brain motion within seconds after a scan and to decide whether a study needs to be repeated...
  37. pmc What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, NY, USA
    Emotion 7:649-59. 2007
    ....
  38. pmc Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusers
    Rita Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Drug Alcohol Depend 87:233-40. 2007
    ..These results provide for the first time evidence of restricted subjective sensitivity to gradients of reward in cocaine addiction and of the involvement of frontolimbic brain regions (including the orbitofrontal cortex) in this deficit...
  39. pmc The effect of practice on a sustained attention task in cocaine abusers
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 35:194-206. 2007
    ....
  40. pmc The MAO-A genotype does not modulate resting brain metabolism in adults
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
    Psychiatry Res 164:73-6. 2008
    ..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype...
  41. pmc Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?
    Rita Z Goldstein
    State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Am J Psychiatry 164:43-51. 2007
    ..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control...
  42. ncbi request reprint Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
    ..These findings provide evidence that the left amygdala and insula process interoceptive signals of fullness produced by gastric distention involved in the controls of food intake...
  43. pmc Dopaminergic response to drug words in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Neurosci 29:6001-6. 2009
    ..The correlation between the brief verbal fluency test, which can be easily administered (crucial for clinical studies), and fMRI cue reactivity could be used as a biomarker of neurobiological changes in addiction...
  44. pmc Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 106:9453-8. 2009
    ..Interventions to strengthen ACC reactivity or interconnectivity may be beneficial in enhancing top-down monitoring and emotion regulation as a strategy to reduce impulsive and compulsive behavior in addiction...
  45. pmc Neural mechanisms of anger regulation as a function of genetic risk for violence
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Emotion 9:385-96. 2009
    ....
  46. pmc Induced magnetic force in human heads exposed to 4 T MRI
    Ruiliang Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Magn Reson Imaging 31:815-20. 2010
    ..To map the distribution of the magnetic force induced in the human head during magnetic resonance imaging (MRI) at 4 T for a large group of healthy volunteers...
  47. pmc Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 103:15641-5. 2006
    ....
  48. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  49. pmc Hyperstimulation of striatal D2 receptors with sleep deprivation: Implications for cognitive impairment
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 45:1232-40. 2009
    ..Alternatively, these associations may reflect a compensatory striatal dopamine response (to maintain arousal) that is superimposed on a larger response to sleep deprivation...
  50. pmc Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit
    Nora D Volkow
    National Institute on Drug Abuse, NIH, Bethesda, MD 20892, USA
    Bioessays 32:748-55. 2010
    ..Upon exposure to the drug, drug cues or stress this results in unrestrained hyperactivation of the motivation/drive circuit that results in the compulsive drug intake that characterizes addiction...

Research Grants2

  1. Acoustic Interference on Attention in HIV Patients
    Dardo Tomasi; Fiscal Year: 2003
    ..More generally, this study will also improve the understanding of the neural effects of acoustic noise interference during fMRI studies in healthy populations. ..