Research Topics
| Pk ThanosSummaryAffiliation: Brookhaven National Laboratory Country: USA Publications
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Detail Information
Publications
Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cuesPanayotis K Thanos
Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
Synapse 67:171-8. 2013....- Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatementPanayotis K Thanos
Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism NIH, Bethesda, MD 20892, USA
Behav Brain Res 239:8-14. 2013.... - Gastric bypass increases ethanol and water consumption in diet-induced obese ratsPanayotis K Thanos
Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA
Obes Surg 22:1884-92. 2012..The purpose of our study was to examine the effects of a RYGB on ethanol intake in diet-induced obese rats (high-fat diet)... - A non-invasive method for detecting the metabolic stress response in rodents: characterization and disruption of the circadian corticosterone rhythmP K Thanos
Brookhaven National Laboratory, Medical Department, Upton, NY, USA
Physiol Res 58:219-28. 2009..This can benefit research that requires long-term glucocorticoid assessment (e.g. stress mechanisms underlying health)... - D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in ratsPanayotis K Thanos
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Synapse 62:481-6. 2008..Thus strategies aimed at increasing D2R expression in NAc may be beneficial in treating cocaine abuse and addiction... - Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regionsPanayotis K Thanos
Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Lab, Upton, NY 11973, USA
Synapse 62:637-42. 2008..These results are consistent with prior findings showing increased levels of endogenous cannabinoids in the Ob rats corroborating the regulation of cannabinoid signaling by leptin... - D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c micePanayotis K Thanos
Neuroimaging Lab, NIAAA Intramural Program, NIH, Bethesda, MD, USA
Behav Brain Res 199:345-9. 2009..Thus, studies evaluating the beneficial therapeutic effects of DCS should assess not only the short-term effects but also the potential of longer lasting undesirable effects... - Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptorsP K Thanos
Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA
J Psychopharmacol 24:897-904. 2010..Thus, individuals with D4 receptor polymorphisms might show enhanced reinforcing responses to MP and AMPH and attenuated locomotor response to AMPH... - Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination TaskPanayotis K Thanos
Laboratory of Neuroimaging, NIAAA, NIH, Dept of Health and Human Services, Bethesda, MD 20892, USA
Pharmacol Biochem Behav 94:374-9. 2010.... - Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocainePanayotis K Thanos
Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, MD, USA
Behav Brain Res 207:508-11. 2010..Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine... - Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis ratsPanayotis K Thanos
Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, United States
Behav Brain Res 215:77-82. 2010..We also corroborate a gender-specific sensitivity to the reinforcing effects of cocaine, highlighting the need to consider gender-tailored exercise interventions for drug abuse prevention... - Obesity-resistant S5B rats showed greater cocaine conditioned place preference than the obesity-prone OM ratsPanayotis K Thanos
Laboratory of Neuroimaging, NIAAA, NIH, Department of Health and Human Services, Bethesda, MD, United States
Physiol Behav 101:713-8. 2010.... - Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumptionPanayotis K Thanos
Department of Health and Human Services, Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, Maryland, USA
Alcohol Clin Exp Res 35:19-27. 2011.... - Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant ratsPanayotis K Thanos
Laboratory of Neuroimaging, NIAAA, NIH, Department of Health and Human Services, Bethesda, MD, USA
Behav Brain Res 217:165-70. 2011.... - D-cycloserine facilitates extinction of cocaine self-administration in C57 micePanayotis K Thanos
Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, USA
Synapse 65:1099-105. 2011..Since cues delay extinction here, we evaluated the effects d-cycloserine in extinction with and without the presence of cues... - The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesityPanayotis K Thanos
Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Pharmacol Biochem Behav 89:499-507. 2008..These results suggest that along with its involvement in seeking behavior for drugs of abuse, the D(3) dopamine receptor may also be involved in seeking behavior for natural reinforcers such as food... - The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout micePanayotis K Thanos
Behavioral Neuropharmacology Lab, Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
Synapse 62:319-24. 2008..The greater baseline metabolism in DAT(-/-) than DAT(+/+) mice in cerebellum (brain region mostly devoid of DAT) suggests that dopamine indirectly regulates activity of these brain regions... 
Overexpression of dopamine D2 receptors reduces alcohol self-administrationP K Thanos
Department of Medicine, Brookhaven National Laboratory, Upton, New York, USA
J Neurochem 78:1094-103. 2001..This is the first evidence that overexpression of DRD2 reduces alcohol intake and suggests that high levels of DRD2 may be protective against alcohol abuse...- In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPETPanayotis K Thanos
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Nucl Med 43:1570-7. 2002..MRI has been used to image brain structural changes in KO mice but, to our knowledge, the feasibility of using PET to investigate brain neurochemistry in KO mice has not been demonstrated... - DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinkingPanayotis K Thanos
Department of Medicine, Brookhaven National Laboratory, Upton, New York, USA
Alcohol Clin Exp Res 28:720-8. 2004..This overexpression of DRD2 reduced alcohol consumption in a two-bottle-choice paradigm and supported the view that high levels of DRD2 may be protective against alcohol abuse... - Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinkingPanayotis K Thanos
Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Life Sci 77:130-9. 2005..Significant deviations in D2R levels from this range could impact alcohol consumption, and could help to explain possible individual variations in alcohol response, metabolism, sensitivity and consumption... - The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) ratsPanayotis K Thanos
Behavioral Neuropharmacology Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Pharmacol Biochem Behav 81:190-7. 2005.... - Ethanol self-administration and ethanol conditioned place preference are reduced in mice lacking cannabinoid CB1 receptorsPanayotis K Thanos
Behavioral Pharmacology Lab, Department of Medicine, Brookhaven National Laboratory, Building 490, 30 Bell Avenue, Upton, NY 11973 5000, USA
Behav Brain Res 164:206-13. 2005..Thus, medications targeting the CB1 receptors may be beneficial for the treatment of alcoholism... - Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiographyPanayotis K Thanos
Behavioral Neuropharmacology Laboratory, Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
Synapse 62:50-61. 2008..Here we assess DA D2 receptors (D2R) in a genetic rodent obesity model characterized by leptin-receptor deficiency and assess the influence of food restriction on these receptors... - Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodentsPanayotis K Thanos
Behavioral Neuropharmacology and Neuroimaging Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973 5000, United States
Pharmacol Biochem Behav 87:426-33. 2007.... - Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesityLisa M Davis
Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Neuroendocrinology 89:152-62. 2009.... - Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring miceK Yaragudri Vinod
Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
Synapse 62:574-81. 2008..Innate differences in the CB(1) receptor function might be one of the contributing factors for higher ethanol drinking behavior. The antagonists of the CB(1) receptor may have therapeutic potential in the treatment of ethanol dependence... - Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidateMichael Michaelides
Behavioral Neuropharmacology and Neuroimaging Laboratory, 30 Bell Avenue, Medical Department, Brookhaven National Laboratory, Upton, NY, USA
Eur J Neurosci 32:668-76. 2010..The differential response to MP as a function of genotype could explain differences in brain functional responses to MP between patients with ADHD and healthy controls and between patients with ADHD with different D(4) polymorphisms... - Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activityDavid L Alexoff
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Nucl Med 44:815-22. 2003..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability... - Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administrationYu Shin Ding
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
Synapse 53:168-75. 2004..These results are pertinent to the question of whether l-threo-MP contributes to the behavioral and side effect profile of MP during treatment of ADHD... - Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept reviewGene Jack Wang
Medical Department, Brookhaven National Laboratory, PO Box 5000, Upton, NY 11973, USA
J Addict Dis 23:39-53. 2004..Understanding the mechanism in food intake will help to suggest strategies for the treatment of obesity... - Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulationGene Jack Wang
Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
Proc Natl Acad Sci U S A 106:1249-54. 2009..This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity... - Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitryGene Jack Wang
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Proc Natl Acad Sci U S A 103:15641-5. 2006.... - Gastric distention activates satiety circuitry in the human brainGene Jack Wang
Brookhaven National Laboratory, Upton, NY 11973, USA
Neuroimage 39:1824-31. 2008..These findings provide evidence that the left amygdala and insula process interoceptive signals of fullness produced by gastric distention involved in the controls of food intake... - Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson diseaseJosé A Rodríguez-Gómez
Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Porter Neuroscience Research Center, National Institute of Health, Bethesda, Maryland 20892, USA
Stem Cells 25:918-28. 2007..This work supports continued interest in ES cells as a source of functional DA neurons... - D-cycloserine facilitates extinction of cocaine self-administration in ratsPanayotis K Thanos
Neuroimaging Lab, NIAAA Intramural Program, NIH, Bethesda, Maryland, USA
Synapse 65:938-44. 2011..These results provide further support for the potential of DCS as a treatment strategy for addiction... - Inverse association between BMI and prefrontal metabolic activity in healthy adultsNora D Volkow
National Institute on Drug Abuse, Bethesda, Maryland, USA
Obesity (Silver Spring) 17:60-5. 2009..These results further highlight the urgency to institute public health interventions to prevent obesity... - The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidenceChristian A Heidbreder
Centre of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, 37135 Verona, Italy
Brain Res Brain Res Rev 49:77-105. 2005..Provided these results can be extrapolated to human drug addicts, they suggest that selective DA D3 receptor antagonists may prove effective as potential pharmacotherapeutic agents to manage drug dependence and addiction... - Role of dopamine D3 receptors in the addictive properties of ethanolChristian A Heidbreder
Center of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, Via A Fleming 4, 37135 Verona, Italy
Drugs Today (Barc) 40:355-65. 2004..The present review is intended to highlight a new, promising area in alcohol research that focuses on the role of the dopamine D(3) receptor in the addictive properties of ethanol...