Pk Thanos

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cues
    Panayotis K Thanos
    Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    Synapse 67:171-8. 2013
  2. pmc Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement
    Panayotis K Thanos
    Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism NIH, Bethesda, MD 20892, USA
    Behav Brain Res 239:8-14. 2013
  3. pmc Gastric bypass increases ethanol and water consumption in diet-induced obese rats
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA
    Obes Surg 22:1884-92. 2012
  4. pmc A non-invasive method for detecting the metabolic stress response in rodents: characterization and disruption of the circadian corticosterone rhythm
    P K Thanos
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Physiol Res 58:219-28. 2009
  5. pmc D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats
    Panayotis K Thanos
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 62:481-6. 2008
  6. pmc Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Lab, Upton, NY 11973, USA
    Synapse 62:637-42. 2008
  7. pmc D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice
    Panayotis K Thanos
    Neuroimaging Lab, NIAAA Intramural Program, NIH, Bethesda, MD, USA
    Behav Brain Res 199:345-9. 2009
  8. pmc Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors
    P K Thanos
    Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA
    J Psychopharmacol 24:897-904. 2010
  9. pmc Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA, NIH, Dept of Health and Human Services, Bethesda, MD 20892, USA
    Pharmacol Biochem Behav 94:374-9. 2010
  10. pmc Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, MD, USA
    Behav Brain Res 207:508-11. 2010

Detail Information

Publications39

  1. pmc Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cues
    Panayotis K Thanos
    Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    Synapse 67:171-8. 2013
    ....
  2. pmc Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement
    Panayotis K Thanos
    Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism NIH, Bethesda, MD 20892, USA
    Behav Brain Res 239:8-14. 2013
    ....
  3. pmc Gastric bypass increases ethanol and water consumption in diet-induced obese rats
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA
    Obes Surg 22:1884-92. 2012
    ..The purpose of our study was to examine the effects of a RYGB on ethanol intake in diet-induced obese rats (high-fat diet)...
  4. pmc A non-invasive method for detecting the metabolic stress response in rodents: characterization and disruption of the circadian corticosterone rhythm
    P K Thanos
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Physiol Res 58:219-28. 2009
    ..This can benefit research that requires long-term glucocorticoid assessment (e.g. stress mechanisms underlying health)...
  5. pmc D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats
    Panayotis K Thanos
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 62:481-6. 2008
    ..Thus strategies aimed at increasing D2R expression in NAc may be beneficial in treating cocaine abuse and addiction...
  6. pmc Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Lab, Upton, NY 11973, USA
    Synapse 62:637-42. 2008
    ..These results are consistent with prior findings showing increased levels of endogenous cannabinoids in the Ob rats corroborating the regulation of cannabinoid signaling by leptin...
  7. pmc D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice
    Panayotis K Thanos
    Neuroimaging Lab, NIAAA Intramural Program, NIH, Bethesda, MD, USA
    Behav Brain Res 199:345-9. 2009
    ..Recently, it was shown that D-cycloserine (DCS, a NMDA partial agonist) facilitated extinction of fear as well as cocaine conditioned place preference (CPP) in rats...
  8. pmc Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors
    P K Thanos
    Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, MD, USA
    J Psychopharmacol 24:897-904. 2010
    ..Thus, individuals with D4 receptor polymorphisms might show enhanced reinforcing responses to MP and AMPH and attenuated locomotor response to AMPH...
  9. pmc Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA, NIH, Dept of Health and Human Services, Bethesda, MD 20892, USA
    Pharmacol Biochem Behav 94:374-9. 2010
    ....
  10. pmc Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, MD, USA
    Behav Brain Res 207:508-11. 2010
    ..Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine...
  11. pmc Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats
    Panayotis K Thanos
    Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, United States
    Behav Brain Res 215:77-82. 2010
    ..We also corroborate a gender-specific sensitivity to the reinforcing effects of cocaine, highlighting the need to consider gender-tailored exercise interventions for drug abuse prevention...
  12. pmc Obesity-resistant S5B rats showed greater cocaine conditioned place preference than the obesity-prone OM rats
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA, NIH, Department of Health and Human Services, Bethesda, MD, United States
    Physiol Behav 101:713-8. 2010
    ....
  13. pmc Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption
    Panayotis K Thanos
    Department of Health and Human Services, Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, Maryland, USA
    Alcohol Clin Exp Res 35:19-27. 2011
    ....
  14. pmc Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant rats
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Behav Brain Res 217:165-70. 2011
    ....
  15. pmc D-cycloserine facilitates extinction of cocaine self-administration in C57 mice
    Panayotis K Thanos
    Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, USA
    Synapse 65:1099-105. 2011
    ..Since cues delay extinction here, we evaluated the effects d-cycloserine in extinction with and without the presence of cues...
  16. pmc The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Pharmacol Biochem Behav 89:499-507. 2008
    ..These results suggest that along with its involvement in seeking behavior for drugs of abuse, the D(3) dopamine receptor may also be involved in seeking behavior for natural reinforcers such as food...
  17. pmc The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice
    Panayotis K Thanos
    Behavioral Neuropharmacology Lab, Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Synapse 62:319-24. 2008
    ..The greater baseline metabolism in DAT(-/-) than DAT(+/+) mice in cerebellum (brain region mostly devoid of DAT) suggests that dopamine indirectly regulates activity of these brain regions...
  18. ncbi request reprint Overexpression of dopamine D2 receptors reduces alcohol self-administration
    P K Thanos
    Department of Medicine, Brookhaven National Laboratory, Upton, New York, USA
    J Neurochem 78:1094-103. 2001
    ..This is the first evidence that overexpression of DRD2 reduces alcohol intake and suggests that high levels of DRD2 may be protective against alcohol abuse...
  19. ncbi request reprint In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET
    Panayotis K Thanos
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1570-7. 2002
    ..MRI has been used to image brain structural changes in KO mice but, to our knowledge, the feasibility of using PET to investigate brain neurochemistry in KO mice has not been demonstrated...
  20. ncbi request reprint DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking
    Panayotis K Thanos
    Department of Medicine, Brookhaven National Laboratory, Upton, New York, USA
    Alcohol Clin Exp Res 28:720-8. 2004
    ..This overexpression of DRD2 reduced alcohol consumption in a two-bottle-choice paradigm and supported the view that high levels of DRD2 may be protective against alcohol abuse...
  21. ncbi request reprint Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking
    Panayotis K Thanos
    Department of Medicine, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Life Sci 77:130-9. 2005
    ..Significant deviations in D2R levels from this range could impact alcohol consumption, and could help to explain possible individual variations in alcohol response, metabolism, sensitivity and consumption...
  22. ncbi request reprint The selective dopamine D3 receptor antagonist SB-277011-A attenuates ethanol consumption in ethanol preferring (P) and non-preferring (NP) rats
    Panayotis K Thanos
    Behavioral Neuropharmacology Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Pharmacol Biochem Behav 81:190-7. 2005
    ....
  23. ncbi request reprint Ethanol self-administration and ethanol conditioned place preference are reduced in mice lacking cannabinoid CB1 receptors
    Panayotis K Thanos
    Behavioral Pharmacology Lab, Department of Medicine, Brookhaven National Laboratory, Building 490, 30 Bell Avenue, Upton, NY 11973 5000, USA
    Behav Brain Res 164:206-13. 2005
    ..Thus, medications targeting the CB1 receptors may be beneficial for the treatment of alcoholism...
  24. ncbi request reprint Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography
    Panayotis K Thanos
    Behavioral Neuropharmacology Laboratory, Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Synapse 62:50-61. 2008
    ..Here we assess DA D2 receptors (D2R) in a genetic rodent obesity model characterized by leptin-receptor deficiency and assess the influence of food restriction on these receptors...
  25. ncbi request reprint Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents
    Panayotis K Thanos
    Behavioral Neuropharmacology and Neuroimaging Lab, Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973 5000, United States
    Pharmacol Biochem Behav 87:426-33. 2007
    ....
  26. pmc Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity
    Lisa M Davis
    Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Neuroendocrinology 89:152-62. 2009
    ....
  27. pmc Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice
    K Yaragudri Vinod
    Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Synapse 62:574-81. 2008
    ..Innate differences in the CB(1) receptor function might be one of the contributing factors for higher ethanol drinking behavior. The antagonists of the CB(1) receptor may have therapeutic potential in the treatment of ethanol dependence...
  28. pmc Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate
    Michael Michaelides
    Behavioral Neuropharmacology and Neuroimaging Laboratory, 30 Bell Avenue, Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Eur J Neurosci 32:668-76. 2010
    ..The differential response to MP as a function of genotype could explain differences in brain functional responses to MP between patients with ADHD and healthy controls and between patients with ADHD with different D(4) polymorphisms...
  29. ncbi request reprint Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
    David L Alexoff
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Nucl Med 44:815-22. 2003
    ..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability...
  30. ncbi request reprint Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Synapse 53:168-75. 2004
    ..These results are pertinent to the question of whether l-threo-MP contributes to the behavioral and side effect profile of MP during treatment of ADHD...
  31. ncbi request reprint Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, PO Box 5000, Upton, NY 11973, USA
    J Addict Dis 23:39-53. 2004
    ..Understanding the mechanism in food intake will help to suggest strategies for the treatment of obesity...
  32. pmc Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
    Proc Natl Acad Sci U S A 106:1249-54. 2009
    ..This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity...
  33. pmc Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 103:15641-5. 2006
    ....
  34. ncbi request reprint Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
    ..These findings provide evidence that the left amygdala and insula process interoceptive signals of fullness produced by gastric distention involved in the controls of food intake...
  35. ncbi request reprint Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease
    José A Rodríguez-Gómez
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Porter Neuroscience Research Center, National Institute of Health, Bethesda, Maryland 20892, USA
    Stem Cells 25:918-28. 2007
    ..This work supports continued interest in ES cells as a source of functional DA neurons...
  36. pmc D-cycloserine facilitates extinction of cocaine self-administration in rats
    Panayotis K Thanos
    Neuroimaging Lab, NIAAA Intramural Program, NIH, Bethesda, Maryland, USA
    Synapse 65:938-44. 2011
    ..These results provide further support for the potential of DCS as a treatment strategy for addiction...
  37. pmc Inverse association between BMI and prefrontal metabolic activity in healthy adults
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland, USA
    Obesity (Silver Spring) 17:60-5. 2009
    ..These results further highlight the urgency to institute public health interventions to prevent obesity...
  38. pmc The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence
    Christian A Heidbreder
    Centre of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, 37135 Verona, Italy
    Brain Res Brain Res Rev 49:77-105. 2005
    ..Provided these results can be extrapolated to human drug addicts, they suggest that selective DA D3 receptor antagonists may prove effective as potential pharmacotherapeutic agents to manage drug dependence and addiction...
  39. ncbi request reprint Role of dopamine D3 receptors in the addictive properties of ethanol
    Christian A Heidbreder
    Center of Excellence for Drug Discovery in Psychiatry, GlaxoSmithKline Pharmaceuticals, Via A Fleming 4, 37135 Verona, Italy
    Drugs Today (Barc) 40:355-65. 2004
    ..The present review is intended to highlight a new, promising area in alcohol research that focuses on the role of the dopamine D(3) receptor in the addictive properties of ethanol...