Elena Shumay

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Epigenetics 7:1151-60. 2012
  2. pmc Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability
    E Shumay
    Brookhaven National Laboratory, Medical Department, Center for Translational Neuroimaging, Upton, NY 11973, USA
    Transl Psychiatry 2:e86. 2012
  3. pmc Identification and characterization of putative methylation targets in the MAOA locus using bioinformatic approaches
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Epigenetics 5:325-42. 2010
  4. pmc Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, New York, USA
    PLoS ONE 5:e11067. 2010
  5. pmc Genotype and ancestry modulate brain's DAT availability in healthy humans
    Elena Shumay
    Brookhaven National Laboratory, Department of Medicine, Upton, New York, United States of America
    PLoS ONE 6:e22754. 2011
  6. pmc Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
  7. pmc Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence
    Scott J Moeller
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    J Neurosci 33:10027-36. 2013
  8. pmc Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Neuropsychopharmacology 35:623-31. 2010
  9. pmc Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain
    Alicia E Reid
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Nucl Med Biol 36:247-58. 2009
  10. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008

Detail Information

Publications10

  1. pmc Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Epigenetics 7:1151-60. 2012
    ..Therefore, the status of MAOA methylation observed in healthy males merits consideration as a variable contributing to interindividual differences in behavior...
  2. pmc Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability
    E Shumay
    Brookhaven National Laboratory, Medical Department, Center for Translational Neuroimaging, Upton, NY 11973, USA
    Transl Psychiatry 2:e86. 2012
    ..01). Taken together, these results provide preliminary evidence for the role of the PER2 gene in regulating striatal D2R availability in the human brain and in vulnerability for cocaine addiction...
  3. pmc Identification and characterization of putative methylation targets in the MAOA locus using bioinformatic approaches
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Epigenetics 5:325-42. 2010
    ....
  4. pmc Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, New York, USA
    PLoS ONE 5:e11067. 2010
    ....
  5. pmc Genotype and ancestry modulate brain's DAT availability in healthy humans
    Elena Shumay
    Brookhaven National Laboratory, Department of Medicine, Upton, New York, United States of America
    PLoS ONE 6:e22754. 2011
    ....
  6. pmc Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
    ..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability...
  7. pmc Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence
    Scott J Moeller
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
    J Neurosci 33:10027-36. 2013
    ..Because drug cues contribute to relapse, our results identify the DAT1R 9R-allele as a vulnerability allele for relapse especially during early abstinence (e.g., detoxification)...
  8. pmc Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Neuropsychopharmacology 35:623-31. 2010
    ..These data were used to establish the dosing regimen for a current clinical efficacy trial with CX157...
  9. pmc Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain
    Alicia E Reid
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Nucl Med Biol 36:247-58. 2009
    ..For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition, metabolic stability and the distribution of the putative metabolite [(18)F]fluoroacetate ([(18)F]FAC)...
  10. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...