Wynne K Schiffer

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi request reprint Imaging addiction with PET: is insight in sight?
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Drug Discov Today 10:547-62. 2005
  2. ncbi request reprint Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-D-glucose cerebral uptake in rodents through time
    Douglas A Marsteller
    Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, NY 11794 8651, USA
    Nucl Med Biol 33:71-9. 2006
  3. ncbi request reprint Serial microPET measures of the metabolic reaction to a microdialysis probe implant
    Wynne K Schiffer
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 155:272-84. 2006
  4. ncbi request reprint Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animals
    Wynne K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 186:159-67. 2006
  5. ncbi request reprint Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York, New York 11973, USA
    J Nucl Med 48:277-87. 2007
  6. ncbi request reprint Targeting the treatment of drug abuse with molecular imaging
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:833-47. 2007
  7. ncbi request reprint Therapeutic doses of amphetamine or methylphenidate differentially increase synaptic and extracellular dopamine
    W K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 59:243-51. 2006
  8. pmc Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging
    Wynne K Schiffer
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 144:25-34. 2005
  9. ncbi request reprint Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine
    Wynne K Schiffer
    SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA
    Neuropsychopharmacology 28:2192-8. 2003
  10. ncbi request reprint Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Psychopharmacology (Berl) 168:339-43. 2003

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Imaging addiction with PET: is insight in sight?
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Drug Discov Today 10:547-62. 2005
    ..Thus, with this tool and the knowledge it provides, the potential for developing novel drugs and treatment strategies for drug addiction is now close at hand...
  2. ncbi request reprint Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-D-glucose cerebral uptake in rodents through time
    Douglas A Marsteller
    Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, NY 11794 8651, USA
    Nucl Med Biol 33:71-9. 2006
    ..However, the variability of within-rodent brain glucose uptake after an intraperitoneal injection across an extended time has not been measured...
  3. ncbi request reprint Serial microPET measures of the metabolic reaction to a microdialysis probe implant
    Wynne K Schiffer
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 155:272-84. 2006
    ..Despite the extent and persistence of these reductions, 11C-raclopride binding and ECF DA concentrations remained stable...
  4. ncbi request reprint Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animals
    Wynne K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 186:159-67. 2006
    ..Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism...
  5. ncbi request reprint Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York, New York 11973, USA
    J Nucl Med 48:277-87. 2007
    ....
  6. ncbi request reprint Targeting the treatment of drug abuse with molecular imaging
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:833-47. 2007
    ..Imaging can also give some insights into potential pharmacotherapeutic targets to manage the reinforcing effects of addictive compounds, as well as into protective strategies to minimize their toxic consequences...
  7. ncbi request reprint Therapeutic doses of amphetamine or methylphenidate differentially increase synaptic and extracellular dopamine
    W K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 59:243-51. 2006
    ..The similar potencies of MP and AMP to alter synaptic DA, despite their different potencies in raising ECF DA, could reflect their different molecular mechanisms...
  8. pmc Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging
    Wynne K Schiffer
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 144:25-34. 2005
    ..0 and 3.5 pmol/ml, around which the measured BP can be compromised by system sensitivity, endogenous DA, or excessive competition with unlabeled compound...
  9. ncbi request reprint Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine
    Wynne K Schiffer
    SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA
    Neuropsychopharmacology 28:2192-8. 2003
    ..5%, consistent with a competitive interaction at the DAT. These results suggest that PCP may be exerting some direct effects through the DAT and that GABA partially modulates NMDA-antagonist-induced increases in striatal DA...
  10. ncbi request reprint Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA
    Psychopharmacology (Berl) 168:339-43. 2003
    ..gamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism...
  11. ncbi request reprint Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
    Synapse 48:35-8. 2003
    ..On the other hand, chronic selegiline treatment may improve DA deficits, which are thought to contribute to relapse through a decreased response to natural rewards...
  12. doi request reprint Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 29:6176-85. 2009
    ....
  13. doi request reprint Racemic gamma vinyl-GABA (R,S-GVG) blocks methamphetamine-triggered reinstatement of conditioned place preference
    Amy DeMarco
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 63:87-94. 2009
    ..Given that drug re-exposure may potentiate relapse to drug-seeking behavior, the ability of R,S-GVG to block METH-triggered reinstatement offers further support for its use in the successful management of METH dependence...
  14. doi request reprint Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animals
    Vinal D Patel
    Medical Department, Brookhaven National Laboratory, Upton NY 11973, USA
    Neuroimage 41:1051-66. 2008
    ..This imaging strategy extends the applicability of small animal PET to include functional neurotransmitter imaging and the neurochemical correlates of behavioral tasks...
  15. pmc A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator
    Martine M Mirrione
    Graduate Program in Molecular and Cellular Pharmacology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Neuroimage 38:34-42. 2007
    ..Furthermore, we report unexpected activations that may underlie the tPA modulation of seizure susceptibility. The methods described here should be applicable to other mouse models of human neurological disease...
  16. ncbi request reprint Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex
    Douglas A Marsteller
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropsychopharmacology 27:163-70. 2002
    ..These findings suggest that persistent alterations in mesocorticolimbic DA-ergic activity are induced by a short exposure to restraint stress as evidenced by the altered response to MP challenge...
  17. pmc Metabolic changes in the rodent brain after acute administration of salvinorin A
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 11:137-43. 2009
    ..Salvinorin A (SA) is a potent and highly selective kappa-opioid receptor (KOR) agonist with rapid kinetics and commensurate behavioral effects; however, brain regions associated with these effects have not been determined...
  18. ncbi request reprint Toluene inhalation produces regionally specific changes in extracellular dopamine
    Madina R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Drug Alcohol Depend 65:243-51. 2002
    ..As further evidence of specific effects, our results indicate regionally specific changes in dopaminergic transmission following toluene exposure...
  19. ncbi request reprint Concentration-dependent conditioned place preference to inhaled toluene vapors in rats
    Dianne E Lee
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Drug Alcohol Depend 85:87-90. 2006
    ..For the conditioned place preference experiments rats were exposed to toluene vapors at concentrations of 800, 2000, 3000 or 5000 ppm in one compartment of a three-compartment box...
  20. ncbi request reprint Gamma-vinyl GABA (vigabatrin) blocks the expression of toluene-induced conditioned place preference (CPP)
    Dianne E Lee
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 54:183-5. 2004
  21. doi request reprint Subchronic racemic gamma vinyl-GABA produces weight loss in Sprague Dawley and Zucker fatty rats
    Amy DeMarco
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 62:870-2. 2008
    ....
  22. pmc Differential effects of anesthetics on cocaine's pharmacokinetic and pharmacodynamic effects in brain
    Congwu Du
    Department of Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY, USA
    Eur J Neurosci 30:1565-75. 2009
    ....
  23. ncbi request reprint PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy
    Martine M Mirrione
    Graduate Program in Molecular and Cellular Pharmacology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Synapse 59:119-21. 2006
    ..These studies provide a foundation upon which we can begin to identify genetic contributions to the metabolic signature of TLE in mice, since many transgenics are in the C57Bl/6 background strain...
  24. ncbi request reprint Quantitative imaging with the micro-PET small-animal PET tomograph
    Paul Vaska
    Medical Department and Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973, USA
    Int Rev Neurobiol 73:191-218. 2006
  25. ncbi request reprint Regional brain metabolism in a murine systemic lupus erythematosus model
    An Vo
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, USA
    J Cereb Blood Flow Metab 34:1315-20. 2014
    ..These findings suggest that local metabolic alterations in this model take place through different mechanisms with distinct time courses, with important implications for the interpretation of imaging data in SLE subjects. ..
  26. doi request reprint Initial comparison of ntPET with microdialysis measurements of methamphetamine-induced dopamine release in rats: support for estimation of dopamine curves from PET data
    Evan D Morris
    Biomedical Engineering Department, Indiana University Purdue University, Indianapolis, IN, USA
    Mol Imaging Biol 10:67-73. 2008
    ..The method is entirely translatable to human PET imaging...
  27. ncbi request reprint Gamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male rats
    Eliot L Gardner
    Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    Synapse 46:240-50. 2002
    ....
  28. pmc Metabolic and behavioral deficits following a routine surgical procedure in rats
    David B Frumberg
    Cornell University, Ithaca NY 14853, USA
    Brain Res 1144:209-18. 2007
    ..Probe implantation in the striatum results in a widespread and long-lasting decline in cortical glucose metabolism together with a persistent, injury-related deficit in the performance of a cognitive (object recognition) task in rats...

Research Grants1

  1. Neurochemistry of Nicotine Dependence in Schizophrenia
    Wynne Schiffer; Fiscal Year: 2004
    ..Or increase inhibitory activity with the GABA agonist, gamma-vinyl GABA, prior to the nicotine challenge. We hope to guide the development of novel therapies for dual-diagnosis schizophrenia. ..