Research Topics
| Lisa M MillerSummaryAffiliation: Brookhaven National Laboratory Country: USA Publications
Research Grants
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Detail Information
Publications
From structure to cellular mechanism with infrared microspectroscopyLisa M Miller
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY, USA
Curr Opin Struct Biol 20:649-56. 2010..In this manuscript, the role of synchrotron FTIRM in bridging the gap towards 'functional biology' is discussed based upon recent achievements, with a critical assessment of the contributions to biological and biomedical research...
Accretion of bone quantity and quality in the developing mouse skeletonLisa M Miller
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Bone Miner Res 22:1037-45. 2007....- Examination of bone chemical composition in osteoporosis using fluorescence-assisted synchrotron infrared microspectroscopyL M Miller
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Cell Mol Biol (Noisy-le-grand) 46:1035-44. 2000..Coupled with factors such as trabecular architecture and bone shape and size, these ultrastructural factors may play a contributing role in the increased bone fragility in osteoporosis... - A new sample substrate for imaging and correlating organic and trace metal composition in biological cells and tissuesLisa M Miller
National Synchrotron Light Source, Brookhaven National Laboratory, Bldg 725 D, 75 Brookhaven Avenue, Upton, NY 11973, USA
Anal Bioanal Chem 387:1705-15. 2007..e., 2-3 microns). The development of this new tool will be presented along with applications to paraffin-embedded metalloprotein crystals, Alzheimer's disease, and hair composition... - Chemical imaging of biological tissue with synchrotron infrared lightLisa M Miller
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
Biochim Biophys Acta 1758:846-57. 2006..In this review, we describe the development of synchrotron-based FTIRM, illustrate its advantages in many applications to biological systems, and propose some potential future directions for the technique... - Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's diseaseLisa M Miller
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY, USA
J Struct Biol 155:30-7. 2006..Thus for the first time, a strong spatial correlation has been observed between elevated beta-sheet content in Abeta plaques and accumulated Cu and Zn ions, emphasizing an association of metal ions with amyloid formation in AD... - Alterations in mineral composition observed in osteoarthritic joints of cynomolgus monkeysLisa M Miller
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Bone 35:498-506. 2004.... - In situ analysis of mineral content and crystallinity in bone using infrared micro-spectroscopy of the nu(4) PO(4)(3-) vibrationL M Miller
Albert Einstein Center for Synchrotron BioSciences, Upton, NY 11973 5000, USA
Biochim Biophys Acta 1527:11-9. 2001.... - Chemical makeup of microdamaged bone differs from undamaged boneMeghan E Ruppel
National Synchrotron Light Source, Brookhaven National Laboratory, Bldg. 725 D, Upton, NY 11973, USA
Bone 39:318-24. 2006..Even so, because microdamage results in an altered bone composition, an accumulation of microdamage might result in a long-term reduction in bone quality... - Rapid establishment of chemical and mechanical properties during lamellar bone formationB Busa
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
Calcif Tissue Int 77:386-94. 2005..83. These data indicate that lamellar bone has the ability to quickly establish its mechanical and chemical tissue properties during primary and secondary mineralization even when the skeleton experiences rapid growth... 
Acetylesterase-mediated deacetylation of pectin impairs cell elongation, pollen germination, and plant reproductionJin Ying Gou
Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Plant Cell 24:50-65. 2012....- Computed tomography of amyloid plaques in a mouse model of Alzheimer's disease using diffraction enhanced imagingDean M Connor
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
Neuroimage 46:908-14. 2009..Several anatomical structures, including hippocampal subregions and white matter tracks, were also observed. Thus, DEI has strong promise in early diagnosis of AD, as well as general studies of the mouse brain... - Imaging the material properties of bone specimens using reflection-based infrared microspectroscopyAlvin S Acerbo
Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York 11973, United States
Anal Chem 84:3607-13. 2012..It provides a unique framework for correlating bone's material and mechanical properties... - Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's diseaseAndreana C Leskovjan
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA
Neuroimage 55:32-8. 2011.... - Chemical differences are observed in children's versus adults' latent fingerprints as a function of timeKimone M Antoine
John Jay College of Criminal Justice, New York, NY, USA
J Forensic Sci 55:513-8. 2010..Thus, fingerprint composition changes with time differently in children versus adults, making it a sensitive metric to estimate the age of an individual, especially when the age of the print is known... - Metal imaging in neurodegenerative diseasesMegan W Bourassa
Department of Chemistry, Stony Brook University, Stony Brook, NY, USA
Metallomics 4:721-38. 2012..In this review, we will highlight the advances in neurodegenerative disease research facilitated by metal imaging techniques... - Compositional characterization and imaging of "wall-bound" acylesters of Populus trichocarpa reveal differential accumulation of acyl molecules in normal and reactive woodsJin Ying Gou
Department of Biology, Brookhaven National Laboratory, Upton, NY 11973, USA
Planta 229:15-24. 2008..These results indicate that different "wall-bound" acylesters play distinct roles in poplar cell wall structural construction and/or metabolism of cell wall matrix components... - A new spectroscopic approach to examining the role of disulfide bonds in the structure and unfolding of soybean trypsin inhibitorJ Tetenbaum
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973, USA
Biochemistry 40:12215-9. 2001..Thus, although the disulfide bonds are not located near the active site of STI, they play a crucial role in stabilizing the protein structure, which is necessary to sustain enzymatic activity... - In situ chemistry of osteoporosis revealed by synchrotron infrared microspectroscopyRaymond Y Huang
Department of Physiology and Biophysics, Center for Synchrotron Biosciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Bone 33:514-21. 2003..These results demonstrate that bone newly synthesized after ovariectomy is chemically different from healthy bone within specific bone regions, which may contribute to reduced bone quality in osteoporosis... - In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopyRobyn K Fuchs
Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202
Matrix Biol 27:34-41. 2008.... - Examination of interactions of oppositely charged proteins in gelsPerumal Ramasamy
Department of Materials Science and Engineering, SUNY Stony Brook, Stony Brook, New York 11794 2275, USA
Langmuir 23:2021-9. 2007.... - XANES spectroscopy: a promising tool for toxicology: a tutorialKarlene K Gunter
Neurotoxicology 23:127-46. 2002..Examples are taken from an ongoing study of manganese in brain mitochondria and neuron-like cells... - Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeletonLiqin Xie
Department of Biomedical Engineering, Psychology A, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794-2580, USA
Bone 39:1059-66. 2006.... - Following matrix metalloproteinases activity near the cell boundary by infrared micro-spectroscopySilvina Federman
Department of Structural Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
Matrix Biol 21:567-77. 2002..In addition, our spectral analysis suggests that the enzymatic proteolysis of the collagen-based matrices induces unwinding of the triple helical structures of the macromolecules within the collagen network... - Chemical imaging of microstructures of plant tissues within cellular dimension using synchrotron infrared microspectroscopyPeiqiang Yu
College of Agriculture, University of Saskatchewan, 51 Campus Drive, Saskatoon S7N 5A8, Canada
J Agric Food Chem 51:6062-7. 2003..The SR-FTIR microspectroscopic images can generate spatially localized functional group and chemical information within cellular dimensions... - Determining the oxidation states of manganese in PC12 and nerve growth factor-induced PC12 cellsKarlene K Gunter
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 575 Elmwood Avenue, Rochester, NY 14642, USA
Free Radic Biol Med 39:164-81. 2005.... - Determination of the oxidation states of manganese in brain, liver, and heart mitochondriaThomas E Gunter
Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
J Neurochem 88:266-80. 2004..While the presence of Mn3+ complexes cannot be proven in the spectrum of endogenous mitochondrial manganese, the shape of this spectrum could suggest the presence of Mn3+ near the limit of detection, probably as MnSOD... - In situ identification of protein structural changes in prion-infected tissueJanina Kneipp
Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
Biochim Biophys Acta 1639:152-8. 2003..No evidence of these structural changes was observed in normal neurons...
Research Grants
- Metals and Protein Structure in Protein-Folding DiseasesLisa Miller; Fiscal Year: 2007..Finally, we use the local structure and homogeneity of the in situ metal-protein complex to develop a possible mechanism for the complex formation and toxicity. ..
- Synchrotron-Based Infrared Microscope for Chemical Imaging of DiseaseLisa Miller; Fiscal Year: 2007..This instrument will be unique worldwide. ..