Lisa M Miller

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. doi request reprint From structure to cellular mechanism with infrared microspectroscopy
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY, USA
    Curr Opin Struct Biol 20:649-56. 2010
  2. ncbi request reprint A new sample substrate for imaging and correlating organic and trace metal composition in biological cells and tissues
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Bldg 725 D, 75 Brookhaven Avenue, Upton, NY 11973, USA
    Anal Bioanal Chem 387:1705-15. 2007
  3. ncbi request reprint Accretion of bone quantity and quality in the developing mouse skeleton
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Bone Miner Res 22:1037-45. 2007
  4. pmc FTIR spectroscopic imaging of protein aggregation in living cells
    Lisa M Miller
    Photon Sciences Directorate, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biochim Biophys Acta 1828:2339-46. 2013
  5. ncbi request reprint Examination of bone chemical composition in osteoporosis using fluorescence-assisted synchrotron infrared microspectroscopy
    L M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Cell Mol Biol (Noisy-le-grand) 46:1035-44. 2000
  6. ncbi request reprint Chemical imaging of biological tissue with synchrotron infrared light
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biochim Biophys Acta 1758:846-57. 2006
  7. ncbi request reprint Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY, USA
    J Struct Biol 155:30-7. 2006
  8. ncbi request reprint Alterations in mineral composition observed in osteoarthritic joints of cynomolgus monkeys
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Bone 35:498-506. 2004
  9. ncbi request reprint In situ analysis of mineral content and crystallinity in bone using infrared micro-spectroscopy of the nu(4) PO(4)(3-) vibration
    L M Miller
    Albert Einstein Center for Synchrotron BioSciences, Upton, NY 11973 5000, USA
    Biochim Biophys Acta 1527:11-9. 2001
  10. pmc Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease
    Andreana C Leskovjan
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11790, USA
    Neuroimage 47:1215-20. 2009

Collaborators

Detail Information

Publications37

  1. doi request reprint From structure to cellular mechanism with infrared microspectroscopy
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY, USA
    Curr Opin Struct Biol 20:649-56. 2010
    ..In this manuscript, the role of synchrotron FTIRM in bridging the gap towards 'functional biology' is discussed based upon recent achievements, with a critical assessment of the contributions to biological and biomedical research...
  2. ncbi request reprint A new sample substrate for imaging and correlating organic and trace metal composition in biological cells and tissues
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Bldg 725 D, 75 Brookhaven Avenue, Upton, NY 11973, USA
    Anal Bioanal Chem 387:1705-15. 2007
    ..e., 2-3 microns). The development of this new tool will be presented along with applications to paraffin-embedded metalloprotein crystals, Alzheimer's disease, and hair composition...
  3. ncbi request reprint Accretion of bone quantity and quality in the developing mouse skeleton
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Bone Miner Res 22:1037-45. 2007
    ....
  4. pmc FTIR spectroscopic imaging of protein aggregation in living cells
    Lisa M Miller
    Photon Sciences Directorate, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biochim Biophys Acta 1828:2339-46. 2013
    ..This article is part of a Special Issue entitled: FTIR in membrane proteins and peptide studies. ..
  5. ncbi request reprint Examination of bone chemical composition in osteoporosis using fluorescence-assisted synchrotron infrared microspectroscopy
    L M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Cell Mol Biol (Noisy-le-grand) 46:1035-44. 2000
    ..Coupled with factors such as trabecular architecture and bone shape and size, these ultrastructural factors may play a contributing role in the increased bone fragility in osteoporosis...
  6. ncbi request reprint Chemical imaging of biological tissue with synchrotron infrared light
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biochim Biophys Acta 1758:846-57. 2006
    ..In this review, we describe the development of synchrotron-based FTIRM, illustrate its advantages in many applications to biological systems, and propose some potential future directions for the technique...
  7. ncbi request reprint Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY, USA
    J Struct Biol 155:30-7. 2006
    ..Thus for the first time, a strong spatial correlation has been observed between elevated beta-sheet content in Abeta plaques and accumulated Cu and Zn ions, emphasizing an association of metal ions with amyloid formation in AD...
  8. ncbi request reprint Alterations in mineral composition observed in osteoarthritic joints of cynomolgus monkeys
    Lisa M Miller
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Bone 35:498-506. 2004
    ....
  9. ncbi request reprint In situ analysis of mineral content and crystallinity in bone using infrared micro-spectroscopy of the nu(4) PO(4)(3-) vibration
    L M Miller
    Albert Einstein Center for Synchrotron BioSciences, Upton, NY 11973 5000, USA
    Biochim Biophys Acta 1527:11-9. 2001
    ....
  10. pmc Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease
    Andreana C Leskovjan
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11790, USA
    Neuroimage 47:1215-20. 2009
    ..These findings were in stark contrast to the high metal ion content observed in human AD plaques, further implicating the role of metal ions in human AD pathology...
  11. pmc Changes in intracortical microporosities induced by pharmaceutical treatment of osteoporosis as detected by high resolution micro-CT
    Steven M Tommasini
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
    Bone 50:596-604. 2012
    ..Together, these data demonstrate that current treatments of osteoporosis can alter the number, size, and distribution of microporosities in cortical rat lamellar bone...
  12. ncbi request reprint Chemical makeup of microdamaged bone differs from undamaged bone
    Meghan E Ruppel
    National Synchrotron Light Source, Brookhaven National Laboratory, Bldg 725 D, Upton, NY 11973, USA
    Bone 39:318-24. 2006
    ..Even so, because microdamage results in an altered bone composition, an accumulation of microdamage might result in a long-term reduction in bone quality...
  13. ncbi request reprint Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton
    Liqin Xie
    Department of Biomedical Engineering, Psychology A, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Bone 39:1059-66. 2006
    ....
  14. ncbi request reprint Rapid establishment of chemical and mechanical properties during lamellar bone formation
    B Busa
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA
    Calcif Tissue Int 77:386-94. 2005
    ..83. These data indicate that lamellar bone has the ability to quickly establish its mechanical and chemical tissue properties during primary and secondary mineralization even when the skeleton experiences rapid growth...
  15. doi request reprint Computed tomography of amyloid plaques in a mouse model of Alzheimer's disease using diffraction enhanced imaging
    Dean M Connor
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 46:908-14. 2009
    ..Several anatomical structures, including hippocampal subregions and white matter tracks, were also observed. Thus, DEI has strong promise in early diagnosis of AD, as well as general studies of the mouse brain...
  16. pmc Fourier transform infrared imaging showing reduced unsaturated lipid content in the hippocampus of a mouse model of Alzheimer's disease
    Andreana C Leskovjan
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794, USA
    Anal Chem 82:2711-6. 2010
    ....
  17. doi request reprint Assessment of the chemical changes induced in human melanoma cells by boric acid treatment using infrared imaging
    Alvin S Acerbo
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
    Analyst 134:1669-74. 2009
    ..5, 25, and 50 mM). Together, these results suggest that high concentrations of BA have an anti-proliferative effect and show signs consistent with apoptosis...
  18. pmc Acetylesterase-mediated deacetylation of pectin impairs cell elongation, pollen germination, and plant reproduction
    Jin Ying Gou
    Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Plant Cell 24:50-65. 2012
    ....
  19. pmc Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease
    Andreana C Leskovjan
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA
    Neuroimage 55:32-8. 2011
    ....
  20. pmc Imaging the material properties of bone specimens using reflection-based infrared microspectroscopy
    Alvin S Acerbo
    Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York 11973, United States
    Anal Chem 84:3607-13. 2012
    ..It provides a unique framework for correlating bone's material and mechanical properties...
  21. doi request reprint Metal imaging in neurodegenerative diseases
    Megan W Bourassa
    Department of Chemistry, Stony Brook University, Stony Brook, NY, USA
    Metallomics 4:721-38. 2012
    ..In this review, we will highlight the advances in neurodegenerative disease research facilitated by metal imaging techniques...
  22. pmc Dynamic full-field infrared imaging with multiple synchrotron beams
    Eli Stavitski
    Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York 11973, United States
    Anal Chem 85:3599-605. 2013
    ..The unique characteristics of this setup enabled the real-time study of heterogeneous chemical dynamics with diffraction-limited spatial resolution for the first time...
  23. doi request reprint Chemical differences are observed in children's versus adults' latent fingerprints as a function of time
    Kimone M Antoine
    John Jay College of Criminal Justice, New York, NY, USA
    J Forensic Sci 55:513-8. 2010
    ..Thus, fingerprint composition changes with time differently in children versus adults, making it a sensitive metric to estimate the age of an individual, especially when the age of the print is known...
  24. doi request reprint Fourier transform infrared imaging as a tool to chemically and spatially characterize matrix-mineral deposition in osteoblasts
    Meghan E Faillace
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11790, USA
    Calcif Tissue Int 92:50-8. 2013
    ..It can further be used to detect small perturbations in the osteoid and mineral deposition process...
  25. pmc Altered composition of bone as triggered by irradiation facilitates the rapid erosion of the matrix by both cellular and physicochemical processes
    Danielle E Green
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 8:e64952. 2013
    ....
  26. ncbi request reprint Examination of interactions of oppositely charged proteins in gels
    Perumal Ramasamy
    Department of Materials Science and Engineering, SUNY Stony Brook, Stony Brook, New York 11794 2275, USA
    Langmuir 23:2021-9. 2007
    ....
  27. pmc Biophysical and structural characterization of a sequence-diverse set of solute-binding proteins for aromatic compounds
    Ruth Pietri
    Photon Sciences Directorate, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Biol Chem 287:23748-56. 2012
    ..Taken together, this study shows the capability of identifying solute-binding proteins that interact with lignin degradation products using high throughput genomic and biophysical approaches, which can be extended to other organisms...
  28. doi request reprint Compositional characterization and imaging of "wall-bound" acylesters of Populus trichocarpa reveal differential accumulation of acyl molecules in normal and reactive woods
    Jin Ying Gou
    Department of Biology, Brookhaven National Laboratory, Upton, NY 11973, USA
    Planta 229:15-24. 2008
    ..These results indicate that different "wall-bound" acylesters play distinct roles in poplar cell wall structural construction and/or metabolism of cell wall matrix components...
  29. ncbi request reprint A new spectroscopic approach to examining the role of disulfide bonds in the structure and unfolding of soybean trypsin inhibitor
    J Tetenbaum
    National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973, USA
    Biochemistry 40:12215-9. 2001
    ..Thus, although the disulfide bonds are not located near the active site of STI, they play a crucial role in stabilizing the protein structure, which is necessary to sustain enzymatic activity...
  30. ncbi request reprint In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy
    Robyn K Fuchs
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5035, Indianapolis, IN 46202
    Matrix Biol 27:34-41. 2008
    ....
  31. ncbi request reprint In situ chemistry of osteoporosis revealed by synchrotron infrared microspectroscopy
    Raymond Y Huang
    Department of Physiology and Biophysics, Center for Synchrotron Biosciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Bone 33:514-21. 2003
    ..These results demonstrate that bone newly synthesized after ovariectomy is chemically different from healthy bone within specific bone regions, which may contribute to reduced bone quality in osteoporosis...
  32. ncbi request reprint In situ identification of protein structural changes in prion-infected tissue
    Janina Kneipp
    Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Biochim Biophys Acta 1639:152-8. 2003
    ..No evidence of these structural changes was observed in normal neurons...
  33. ncbi request reprint Determining the oxidation states of manganese in PC12 and nerve growth factor-induced PC12 cells
    Karlene K Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Free Radic Biol Med 39:164-81. 2005
    ....
  34. ncbi request reprint Chemical imaging of microstructures of plant tissues within cellular dimension using synchrotron infrared microspectroscopy
    Peiqiang Yu
    College of Agriculture, University of Saskatchewan, 51 Campus Drive, Saskatoon S7N 5A8, Canada
    J Agric Food Chem 51:6062-7. 2003
    ..The SR-FTIR microspectroscopic images can generate spatially localized functional group and chemical information within cellular dimensions...
  35. ncbi request reprint Following matrix metalloproteinases activity near the cell boundary by infrared micro-spectroscopy
    Silvina Federman
    Department of Structural Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Matrix Biol 21:567-77. 2002
    ..In addition, our spectral analysis suggests that the enzymatic proteolysis of the collagen-based matrices induces unwinding of the triple helical structures of the macromolecules within the collagen network...
  36. ncbi request reprint XANES spectroscopy: a promising tool for toxicology: a tutorial
    Karlene K Gunter
    Neurotoxicology 23:127-46. 2002
    ..Examples are taken from an ongoing study of manganese in brain mitochondria and neuron-like cells...
  37. ncbi request reprint Determination of the oxidation states of manganese in brain, liver, and heart mitochondria
    Thomas E Gunter
    Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurochem 88:266-80. 2004
    ..While the presence of Mn3+ complexes cannot be proven in the spectrum of endogenous mitochondrial manganese, the shape of this spectrum could suggest the presence of Mn3+ near the limit of detection, probably as MnSOD...

Research Grants6

  1. Metals and Protein Structure in Protein-Folding Diseases
    Lisa Miller; Fiscal Year: 2007
    ..Finally, we use the local structure and homogeneity of the in situ metal-protein complex to develop a possible mechanism for the complex formation and toxicity. ..
  2. Synchrotron-Based Infrared Microscope for Chemical Imaging of Disease
    Lisa Miller; Fiscal Year: 2007
    ..This instrument will be unique worldwide. ..