Jean Logan

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 223:447-55. 2012
  2. ncbi request reprint Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:531-42. 2005
  3. ncbi request reprint Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:521-9. 2005
  4. pmc The use of alternative forms of graphical analysis to balance bias and precision in PET images
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 31:535-46. 2011
  5. ncbi request reprint Simplifications in analyzing positron emission tomography data: effects on outcome measures
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:743-56. 2007
  6. ncbi request reprint Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain
    Nora D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Am J Psychiatry 161:1173-80. 2004
  7. ncbi request reprint Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisox
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurochem 94:337-51. 2005
  8. ncbi request reprint Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Nucl Med 46:1414-20. 2005
  9. ncbi request reprint Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 50:345-52. 2003
  10. ncbi request reprint Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans
    Joanna S Fowler
    Brookhaven National Laboratory, Chemistry Department, Bldg 555, Upton, NY 11973, USA
    Nucl Med Biol 31:313-9. 2004

Detail Information

Publications66

  1. pmc Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [¹¹C]GSK189254 in anesthetized baboon
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 223:447-55. 2012
    ....
  2. ncbi request reprint Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:531-42. 2005
    ..The focus of this work is to identify a suitable reference region or means of normalizing data for the NET ligands investigated...
  3. ncbi request reprint Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:521-9. 2005
    ....
  4. pmc The use of alternative forms of graphical analysis to balance bias and precision in PET images
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 31:535-46. 2011
    ..The variance of the four estimates can serve as a guide to the reliability of the median estimate. This may provide a general method for the generation of parametric images with little bias and good precision...
  5. ncbi request reprint Simplifications in analyzing positron emission tomography data: effects on outcome measures
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:743-56. 2007
    ..The ultimate solution to the problem of arterial sampling may be a wrist scanner, which acts as a small PET camera for imaging the arteries in the wrist. This is currently under development...
  6. ncbi request reprint Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain
    Nora D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Am J Psychiatry 161:1173-80. 2004
    ..The objective of this study was to assess if methylphenidate, by increasing dopamine (neurotransmitter involved in motivation) in brain, would enhance the saliency of an academic task, making it more interesting...
  7. ncbi request reprint Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisox
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurochem 94:337-51. 2005
    ..Thus, to our knowledge (S,S)-[11C]MRB remains by far the most promising NET ligand for PET studies...
  8. ncbi request reprint Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Nucl Med 46:1414-20. 2005
    ..Because smoking exposes peripheral organs as well as the brain to MAO A-inhibitory compounds, we determined whether smokers would also have reduced MAO A in peripheral organs...
  9. ncbi request reprint Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 50:345-52. 2003
    ..These studies demonstrate that the use of (S,S)-[11C]MRB would allow a better understanding of the role that NET plays in living systems...
  10. ncbi request reprint Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans
    Joanna S Fowler
    Brookhaven National Laboratory, Chemistry Department, Bldg 555, Upton, NY 11973, USA
    Nucl Med Biol 31:313-9. 2004
    ....
  11. pmc Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial alpha7 nicotinic cholinergic agonist drug
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:541-51. 2007
    ..One of its two major demethylated metabolites, 4-OH-GTS-21, has been suggested to contribute to its therapeutic effects...
  12. ncbi request reprint Brain dopamine is associated with eating behaviors in humans
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Int J Eat Disord 33:136-42. 2003
    ..We investigate the role of dopamine (DA), a neurotransmitter involved with food motivation, in these variables...
  13. ncbi request reprint Monoamine oxidase A imaging in peripheral organs in healthy human subjects
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 49:178-87. 2003
    ....
  14. pmc Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET
    Alicia E Reid
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 35:287-98. 2008
    ....
  15. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
    ..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...
  16. ncbi request reprint 6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 53:184-9. 2004
  17. ncbi request reprint Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates
    Helene Benveniste
    Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
    J Nucl Med 46:312-20. 2005
    ..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus...
  18. pmc Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 43:756-63. 2008
    ..The absence of significant differences between Caucasians and African Americans suggests that variables other than methamphetamine pharmacokinetics and bioavailability account for the lower abuse prevalence in African Americans...
  19. ncbi request reprint Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:667-79. 2007
    ..Quantification methods were determined from test/retest studies, and sensitivity to pharmacological blockade was tested with different doses of atomoxetine (ATX), a drug that binds to the NET with high affinity (K(i)=2-5 nM)...
  20. pmc Low monoamine oxidase B in peripheral organs in smokers
    Joanna S Fowler
    Chemistry Department and Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 100:11600-5. 2003
    ....
  21. ncbi request reprint Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 22:1367-76. 2002
    ..This method should be generalizable to other tracers and should facilitate the analysis of group differences...
  22. ncbi request reprint PET imaging of monoamine oxidase B in peripheral organs in humans
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1331-8. 2002
    ..The purpose of this study was to investigate the feasibility of imaging MAO B in peripheral organs in humans with PET...
  23. pmc PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, New York, USA
    J Nucl Med 48:1724-32. 2007
    ....
  24. pmc Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
    ..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects...
  25. ncbi request reprint The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 57:640-6. 2005
    ..This study measures the potency and kinetics for DAT blockade by radafaxine in human brain...
  26. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  27. ncbi request reprint Synthesis and evaluation of inhaled [11C]butane and intravenously injected [11C]acetone as potential radiotracers for studying inhalant abuse
    Madina R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:201-8. 2005
    ..These data provide insight into the pharmacokinetic features possibly associated with the abuse liability of toluene, acetone and butane...
  28. ncbi request reprint Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 166:264-70. 2003
    ..However, there is some evidence that dopaminergic effects are involved in the cardiovascular actions of these drugs. Here, we evaluated this association in humans...
  29. ncbi request reprint In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET
    Panayotis K Thanos
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1570-7. 2002
    ..MRI has been used to image brain structural changes in KO mice but, to our knowledge, the feasibility of using PET to investigate brain neurochemistry in KO mice has not been demonstrated...
  30. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  31. ncbi request reprint Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  32. pmc The MAO-A genotype does not modulate resting brain metabolism in adults
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
    Psychiatry Res 164:73-6. 2008
    ..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype...
  33. ncbi request reprint Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 116:163-72. 2002
    ..These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor...
  34. ncbi request reprint "Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 44:175-80. 2002
    ..In addition it demonstrates the ability of methylphenidate to amplify weak dopamine signals...
  35. ncbi request reprint Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 161:242-8. 2004
    ..In this study, the authors assessed whether metabolism recovers with protracted abstinence...
  36. ncbi request reprint Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine
    Wynne K Schiffer
    SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA
    Neuropsychopharmacology 28:2192-8. 2003
    ..5%, consistent with a competitive interaction at the DAT. These results suggest that PCP may be exerting some direct effects through the DAT and that GABA partially modulates NMDA-antagonist-induced increases in striatal DA...
  37. ncbi request reprint Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
    David L Alexoff
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Nucl Med 44:815-22. 2003
    ..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability...
  38. ncbi request reprint Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 46:79-82. 2002
    ..These results replicate our previous findings and provide further evidence that striatal DA D2 receptors modulate reinforcing responses to stimulants in humans and may underlie predisposition for drug self-administration...
  39. ncbi request reprint Translational neuroimaging: positron emission tomography studies of monoamine oxidase
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 7:377-87. 2005
    ..In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs...
  40. pmc Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Neuropsychopharmacology 35:623-31. 2010
    ..These data were used to establish the dosing regimen for a current clinical efficacy trial with CX157...
  41. ncbi request reprint Monoamine oxidase: radiotracer development and human studies
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Methods 27:263-77. 2002
    ..PET studies have been carried out to measure the effects of age, MAO inhibitor drugs, tobacco smoke exposure, and other factors on MAO activity in the human brain...
  42. ncbi request reprint PET imaging in clinical drug abuse research
    S John Gatley
    Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973, USA
    Curr Pharm Des 11:3203-19. 2005
    ....
  43. pmc Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, NY, USA
    Epigenetics 7:1151-60. 2012
    ..Therefore, the status of MAOA methylation observed in healthy males merits consideration as a variable contributing to interindividual differences in behavior...
  44. pmc Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    J Neurosci 32:6711-7. 2012
    ....
  45. pmc Enhanced striatal dopamine release during food stimulation in binge eating disorder
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Obesity (Silver Spring) 19:1601-8. 2011
    ..The lack of correlation between BMI and dopamine changes suggests that dopamine release per se does not predict BMI within a group of obese individuals but that it predicts binge eating...
  46. ncbi request reprint Therapeutic doses of buspirone block D3 receptors in the living primate brain
    Sung Won Kim
    Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Upton, NY, USA
    Int J Neuropsychopharmacol 17:1257-67. 2014
    ..Nonetheless, based on previous clinical studies, these doses would be safe and well tolerated. ..
  47. ncbi request reprint Monoamine oxidase and cigarette smoking
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurotoxicology 24:75-82. 2003
    ....
  48. ncbi request reprint Imaging dopamine receptors in the rat striatum with the MicroPET R4: kinetic analysis of [11C]raclopride binding using graphical methods
    David L Alexoff
    Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973, USA
    Methods Enzymol 385:213-28. 2004
  49. pmc Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder
    Gene Jack Wang
    Department of Radiology, Stony Brook University, Stony Brook, New York, USA
    PLoS ONE 8:e63023. 2013
    ..However while the acute increases in dopamine induced by stimulant medications have been associated with symptom improvement in ADHD the chronic effects have not been investigated...
  50. pmc Predominance of D2 receptors in mediating dopamine's effects in brain metabolism: effects of alcoholism
    Nora D Volkow
    National Institute of Drug Abuse, Rockville, Maryland 20857, USA
    J Neurosci 33:4527-35. 2013
    ..These findings are consistent with a predominant inhibitory effect of dopamine in the human brain that is likely mediated by the prominence of dopamine D2/D3 receptors...
  51. ncbi request reprint Effect of vehicle on brain uptake of [11C]toluene
    Madina R Gerasimov
    Brookhaven National Laboratory, Department of Chemistry, Upton, NY 11973, USA
    Nucl Med Biol 29:607-12. 2002
    ..Present results clearly demonstrate that the choice of a vehicle has a significant effect on tracer uptake and should be considered as a potential factor contributing to the pharmacokinetic measurements...
  52. ncbi request reprint PET imaging of norepinephrine transporters
    Yu Shin Ding
    Chemistry and Medical Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    Curr Pharm Des 12:3831-45. 2006
    ..Thus, to our knowledge, (S, S)-[(11)C]MRB remains by far the most promising NET ligand for PET studies...
  53. ncbi request reprint A review of graphical methods for tracer studies and strategies to reduce bias
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 30:833-44. 2003
    ..One problem in the use of these methods particularly the method for reversible tracers is the bias generated due to the presence of statistical noise. Some recently proposed techniques for reducing the noise are considered...
  54. pmc Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging
    Wynne K Schiffer
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 144:25-34. 2005
    ..0 and 3.5 pmol/ml, around which the measured BP can be compromised by system sensitivity, endogenous DA, or excessive competition with unlabeled compound...
  55. pmc Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain
    Alicia E Reid
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Nucl Med Biol 36:247-58. 2009
    ..For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition, metabolic stability and the distribution of the putative metabolite [(18)F]fluoroacetate ([(18)F]FAC)...
  56. ncbi request reprint Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications
    Nora D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 43:181-7. 2002
    ....
  57. ncbi request reprint Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
    ..Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction...
  58. ncbi request reprint High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA
    Arch Gen Psychiatry 63:999-1008. 2006
    ..Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption...
  59. ncbi request reprint Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
  60. pmc Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 28:8454-61. 2008
    ....
  61. ncbi request reprint Brain dopamine transporter levels in treatment and drug naïve adults with ADHD
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 34:1182-90. 2007
    ..g., prefrontal or cingulostriatal pathways, noradrenergic neurotransmission) is necessary to account for the large differences in inattention observed between controls and ADHD subjects...
  62. pmc Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda MD 20892, USA National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Neuroimage 39:1266-73. 2008
    ....
  63. ncbi request reprint Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 27:12700-6. 2007
    ....
  64. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  65. pmc Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2017. 2008
    ..This would explain why methylphenidate has beneficial effects in some individuals and contexts and detrimental effects in others...
  66. ncbi request reprint Seeing what Alzheimer saw
    Mony J de Leon
    Nat Med 13:129-31. 2007