J Logan

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi request reprint A consideration of the dopamine D2 receptor monomer-dimer equilibrium and the anomalous binding properties of the dopamine D2 receptor ligand, N-methyl spiperone
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Neural Transm 108:279-86. 2001
  2. ncbi request reprint A review of graphical methods for tracer studies and strategies to reduce bias
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 30:833-44. 2003
  3. ncbi request reprint Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 22:1367-76. 2002
  4. ncbi request reprint Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 27:43-9. 2000
  5. ncbi request reprint Graphical analysis of PET data applied to reversible and irreversible tracers
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 27:661-70. 2000
  6. ncbi request reprint Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Am J Psychiatry 156:19-26. 1999
  7. ncbi request reprint Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:1325-31. 1998
  8. ncbi request reprint Measuring dopamine transporter occupancy by cocaine in vivo: radiotracer considerations
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 28:111-6. 1998
  9. ncbi request reprint Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
  10. ncbi request reprint Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:344-9. 1998

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint A consideration of the dopamine D2 receptor monomer-dimer equilibrium and the anomalous binding properties of the dopamine D2 receptor ligand, N-methyl spiperone
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Neural Transm 108:279-86. 2001
    ..If increasing DA favors cluster with fewer receptors, an increase in NMSP binding sites may also occur under some circumstances with an increase in DA...
  2. ncbi request reprint A review of graphical methods for tracer studies and strategies to reduce bias
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 30:833-44. 2003
    ..One problem in the use of these methods particularly the method for reversible tracers is the bias generated due to the presence of statistical noise. Some recently proposed techniques for reducing the noise are considered...
  3. ncbi request reprint Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 22:1367-76. 2002
    ..This method should be generalizable to other tracers and should facilitate the analysis of group differences...
  4. ncbi request reprint Reproducibility of repeated measures of deuterium substituted [11C]L-deprenyl ([11C]L-deprenyl-D2) binding in the human brain
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 27:43-9. 2000
    ..84 +/- 7.07%. Linear regression applied to values of lambda k3 from the LIN and NLLSQ methods validated the use of the linear method for calculating lambda k3...
  5. ncbi request reprint Graphical analysis of PET data applied to reversible and irreversible tracers
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 27:661-70. 2000
    ..Smoothing techniques may minimize this problem and retain the model independence. In any case graphical techniques can provide insight into the binding kinetics of tracers in a visual way...
  6. ncbi request reprint Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Am J Psychiatry 156:19-26. 1999
    ..To assess whether increasing dopamine would reverse these metabolic decrements, they measured the effects of methylphenidate, a drug that increases dopamine, on brain glucose metabolism in 20 cocaine abusers...
  7. ncbi request reprint Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:1325-31. 1998
    ..This study measured, for the first time, dopamine transporter occupancy by orally administered methylphenidate in the human brain and its rate of uptake in the brain...
  8. ncbi request reprint Measuring dopamine transporter occupancy by cocaine in vivo: radiotracer considerations
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 28:111-6. 1998
    ..We conclude that in vivo measurements of DAT occupancy by rapidly clearing drugs like cocaine requires the use of radiotracers having similar kinetics to the drug itself...
  9. ncbi request reprint Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
    ..Moreover, they suggest a participation of thalamic dopamine pathways in cocaine addiction, a possibility that merits further investigation...
  10. ncbi request reprint Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 155:344-9. 1998
    ..This study assessed the relation between measures of brain dopamine activity and indexes of motor and cognitive function in healthy individuals...
  11. ncbi request reprint Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y 11973, USA
    Am J Psychiatry 154:50-5. 1997
    ..The authors' goals were to determine whether baseline dopamine activity contributes to response to methylphenidate and to assess the pattern of metabolic responses associated with enhanced dopamine activity...
  12. ncbi request reprint Species differences in [11C]clorgyline binding in brain
    J S Fowler
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 28:779-85. 2001
    ..This suggests a species difference in the susceptibility of MAO A to inhibition by clorgyline and represents an unusual example of where the behavior of a radiotracer in the baboon brain does not predict its behavior in the human brain...
  13. ncbi request reprint Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, N Y, USA
    Am J Psychiatry 156:1440-3. 1999
    ..This study assessed whether brain dopamine D2 receptor levels, which show significant intersubject variability, predict reinforcing responses to psychostimulants in humans...
  14. ncbi request reprint Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 146:93-100. 1999
    ..The present experiments were conducted to examine dose-occupancy and dose-effect relationships in mice for cocaine and also for methylphenidate, a dopamine uptake blocker used in pediatric psychiatry...
  15. ncbi request reprint Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:59-66. 1999
    ....
  16. ncbi request reprint Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain
    N D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 65:PL7-12. 1999
    ..Other variables i.e. longer duration of methylphenidate's side effects may counterbalance its reinforcing effects...
  17. ncbi request reprint Concentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET
    J Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA
    Synapse 27:347-56. 1997
    ..The average Bmax may, however, provide an estimate of the expected concentration in humans. (2) The DVR can be used as a measure of DAT occupancy without applying an explicit model...
  18. ncbi request reprint Non-MAO A binding of clorgyline in white matter in human brain
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurochem 79:1039-46. 2001
    ..The characterization of the non-MAO A binding component of this widely used MAO A inhibitor merits further investigation...
  19. ncbi request reprint Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:75-80. 2000
    ..This study investigates the relationship between measures of brain dopamine D(2) receptors (molecules that transmit dopamine signals) and regional brain glucose metabolism (a marker of brain function) in healthy individuals...
  20. ncbi request reprint Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 68:2759-68. 2001
    ....
  21. ncbi request reprint Smoking a single cigarette does not produce a measurable reduction in brain MAO B in non-smokers
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Nicotine Tob Res 1:325-9. 1999
    ..These results indicate that the reduction in MAO B in smokers probably occurs gradually and requires chronic tobacco smoke exposure...
  22. pmc Brain monoamine oxidase A inhibition in cigarette smokers
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 93:14065-9. 1996
    ..This suggests that MAO A inhibition needs to be considered as a potential contributing variable in the high rate of smoking in depression and in the development of more effective strategies for smoking cessation...
  23. ncbi request reprint Dopamine receptor-mediated regulation of striatal cholinergic activity: positron emission tomography studies with norchloro[18F]fluoroepibatidine
    Y S Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Neurochem 74:1514-21. 2000
    ..However, both the D1 agonist and antagonist had no significant effect. This suggests that under physiological conditions the predominant influence of endogenous dopamine on striatal ACh output is dopamine D2, not D1, receptor-mediated...
  24. ncbi request reprint Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain
    J S Fowler
    Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Life Sci 66:PL141-6. 2000
    ..Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects...
  25. ncbi request reprint [18F]haloperidol binding in baboon brain in vivo
    K A Yousef
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 23:47-52. 1996
    ..Haloperidol increased the clearance rate from all brain regions. These results indicate that the binding profile of [18F]haloperidol does not permit the selective examination of either dopamine D2 or sigma sites using PET...
  26. ncbi request reprint Maintenance of brain monoamine oxidase B inhibition in smokers after overnight cigarette abstinence
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:1864-6. 2000
    ..The authors' goal was to replicate a previous finding that smokers have lower brain monoamine oxidase B (MAO-B) levels than comparison nonsmoking subjects and to determine if levels recover after overnight cigarette abstinence...
  27. ncbi request reprint Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 158:2015-21. 2001
    ..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers...
  28. ncbi request reprint Chiral drugs: comparison of the pharmacokinetics of [11C]d-threo and L-threo-methylphenidate in the human and baboon brain
    Y S Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Psychopharmacology (Berl) 131:71-8. 1997
    ..These results indicate that pharmacological specificity of MP resides entirely in the d-threo isomer and directly show that binding of the l-isomer in human brain is mostly nonspecific...
  29. ncbi request reprint Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain
    N D Volkow
    Medical Department, Upton, NY 11973, USA
    Life Sci 67:1507-15. 2000
    ..The faster time course for the subjective effects for smoked than intravenous and for intravenous than for intranasal cocaine highlights the importance of the speed of cocaine's delivery into the brain on its reinforcing effects...
  30. ncbi request reprint Comparative studies of epibatidine derivatives [18F]NFEP and [18F]N-methyl-NFEP: kinetics, nicotine effect, and toxicity
    Y S Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Nucl Med Biol 26:139-48. 1999
    ..Our results suggest that although the binding characteristics of [18F]NFEP and [18F]N-Me-NFEP appear to be ideally suited for PET imaging studies of the human brain, their relatively small safety margin will limit their use in humans...
  31. ncbi request reprint Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
    N D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:9414-8. 2001
    ..These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals...
  32. ncbi request reprint Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors
    N D Volkow
    Brookhaven National Laboratory, Upton, New York, USA
    J Pharmacol Exp Ther 291:409-15. 1999
    ....
  33. ncbi request reprint Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain
    Nora D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Am J Psychiatry 161:1173-80. 2004
    ..The objective of this study was to assess if methylphenidate, by increasing dopamine (neurotransmitter involved in motivation) in brain, would enhance the saliency of an academic task, making it more interesting...
  34. pmc Decreased dopamine activity predicts relapse in methamphetamine abusers
    G J Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Psychiatry 17:918-25. 2012
    ..Detection of the extent of DA dysfunction may be helpful in predicting therapeutic outcomes...
  35. ncbi request reprint Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain
    N D Volkow
    Departments of Medical and Chemistry, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 21:RC121. 2001
    ..Alternatively methylphenidate-induced increases in DA, a neurotransmitter involved with motivation and reward, could enhance the salience of the task facilitating the "interest that it elicits" and thus improving performance...
  36. ncbi request reprint A strategy for removing the bias in the graphical analysis method
    J Logan
    Chemistry and Medical Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 21:307-20. 2001
    ..The DVR generated directly from the model (DVR(FL)) was compared with DVR(FG) (determined from a "smoothed" uptake curve as for DV(FG)) using the graphical method...
  37. ncbi request reprint [(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 28:561-72. 2001
    ..This article will summarize preclinical and clinical research with [(11)C]cocaine...
  38. ncbi request reprint A novel strategy for the treatment of cocaine addiction
    S L Dewey
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Synapse 30:119-29. 1998
    ..Human trials with GVG are currently being developed to directly examine the utility of this novel strategy for the treatment of cocaine addiction...
  39. ncbi request reprint Distribution of tracer levels of cocaine in the human brain as assessed with averaged [11C]cocaine images
    F W Telang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 31:290-6. 1999
    ..Further work is required to characterize the binding properties of cocaine in these brain areas and to elucidate their role in the reinforcing and addictive properties of cocaine...
  40. ncbi request reprint Brain dopamine and obesity
    G J Wang
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    Lancet 357:354-7. 2001
    ..To test the hypothesis that obese individuals have abnormalities in brain dopamine activity we measured the availability of dopamine D2 receptors in brain...
  41. ncbi request reprint Mapping catechol-O-methyltransferase in vivo: initial studies with [18F]Ro41-0960
    Y S Ding
    Chemistry Dept, Brookhaven National Laboratory, Upton, NY, USA
    Life Sci 58:195-208. 1996
    ..They also provide the first example of a positron emitter labeled radiotracer for COMT, and provide initial encouraging evidence that [18F]Ro41-0960 may be used to examine COMT in peripheral organs in vivo...
  42. ncbi request reprint Increased activity of the temporal insula in subjects with bradycardia
    N D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 67:2213-20. 2000
    ..The temporal insula is interconnected with limbic brain region and autonomic centers and suggests that this may be a mechanism by which emotional responses regulate heart rate...
  43. ncbi request reprint Inhibition of monoamine oxidase B in the brains of smokers
    J S Fowler
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 379:733-6. 1996
    ..We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking...
  44. ncbi request reprint Synthesis and evaluation of inhaled [11C]butane and intravenously injected [11C]acetone as potential radiotracers for studying inhalant abuse
    Madina R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:201-8. 2005
    ..These data provide insight into the pharmacokinetic features possibly associated with the abuse liability of toluene, acetone and butane...
  45. ncbi request reprint Therapeutic doses of amphetamine or methylphenidate differentially increase synaptic and extracellular dopamine
    W K Schiffer
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 59:243-51. 2006
    ..The similar potencies of MP and AMP to alter synaptic DA, despite their different potencies in raising ECF DA, could reflect their different molecular mechanisms...
  46. ncbi request reprint 6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 53:184-9. 2004
  47. ncbi request reprint Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:667-79. 2007
    ..Quantification methods were determined from test/retest studies, and sensitivity to pharmacological blockade was tested with different doses of atomoxetine (ATX), a drug that binds to the NET with high affinity (K(i)=2-5 nM)...
  48. pmc Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability
    E Shumay
    Brookhaven National Laboratory, Medical Department, Center for Translational Neuroimaging, Upton, NY 11973, USA
    Transl Psychiatry 2:e86. 2012
    ..01). Taken together, these results provide preliminary evidence for the role of the PER2 gene in regulating striatal D2R availability in the human brain and in vulnerability for cocaine addiction...
  49. ncbi request reprint Study of brain uptake and biodistribution of [11C]toluene in non-human primates and mice
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 70:2811-28. 2002
    ..Taken together, our data provides insight into pharmacokinetic features possibly associated with the abuse liability of toluene...
  50. pmc Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Neuropsychopharmacology 35:623-31. 2010
    ..These data were used to establish the dosing regimen for a current clinical efficacy trial with CX157...
  51. ncbi request reprint Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers
    N D Volkow
    Department of Psychiatry, State University of New York at Stony Brook, USA
    Am J Psychiatry 158:383-9. 2001
    ..The authors measured regional brain glucose metabolism, which serves as a marker of brain function, to assess if there is evidence of functional changes in methamphetamine abusers in regions other than those innervated by dopamine cells...
  52. ncbi request reprint Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers
    N D Volkow
    Department of Psychiatry, State University of New York at Stony Brook, USA
    Am J Psychiatry 158:377-82. 2001
    ..The authors evaluated if similar changes occur in humans and assessed if they were functionally significant...
  53. ncbi request reprint Simplifications in analyzing positron emission tomography data: effects on outcome measures
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:743-56. 2007
    ..The ultimate solution to the problem of arterial sampling may be a wrist scanner, which acts as a small PET camera for imaging the arteries in the wrist. This is currently under development...
  54. ncbi request reprint Translational neuroimaging: positron emission tomography studies of monoamine oxidase
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 7:377-87. 2005
    ..In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs...
  55. pmc Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
    ..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects...
  56. pmc Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 43:756-63. 2008
    ..The absence of significant differences between Caucasians and African Americans suggests that variables other than methamphetamine pharmacokinetics and bioavailability account for the lower abuse prevalence in African Americans...
  57. ncbi request reprint Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Nucl Med 46:1414-20. 2005
    ..Because smoking exposes peripheral organs as well as the brain to MAO A-inhibitory compounds, we determined whether smokers would also have reduced MAO A in peripheral organs...
  58. ncbi request reprint Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisox
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurochem 94:337-51. 2005
    ..Thus, to our knowledge (S,S)-[11C]MRB remains by far the most promising NET ligand for PET studies...
  59. ncbi request reprint Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:531-42. 2005
    ..The focus of this work is to identify a suitable reference region or means of normalizing data for the NET ligands investigated...
  60. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
    ..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...
  61. pmc The use of alternative forms of graphical analysis to balance bias and precision in PET images
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 31:535-46. 2011
    ..The variance of the four estimates can serve as a guide to the reliability of the median estimate. This may provide a general method for the generation of parametric images with little bias and good precision...
  62. pmc The MAO-A genotype does not modulate resting brain metabolism in adults
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
    Psychiatry Res 164:73-6. 2008
    ..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype...
  63. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  64. pmc Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET
    Alicia E Reid
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 35:287-98. 2008
    ....
  65. pmc Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain
    Alicia E Reid
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Nucl Med Biol 36:247-58. 2009
    ..For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition, metabolic stability and the distribution of the putative metabolite [(18)F]fluoroacetate ([(18)F]FAC)...
  66. pmc PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, New York, USA
    J Nucl Med 48:1724-32. 2007
    ....
  67. pmc Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial alpha7 nicotinic cholinergic agonist drug
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:541-51. 2007
    ..One of its two major demethylated metabolites, 4-OH-GTS-21, has been suggested to contribute to its therapeutic effects...
  68. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  69. ncbi request reprint PET imaging of norepinephrine transporters
    Yu Shin Ding
    Chemistry and Medical Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
    Curr Pharm Des 12:3831-45. 2006
    ..Thus, to our knowledge, (S, S)-[(11)C]MRB remains by far the most promising NET ligand for PET studies...
  70. ncbi request reprint Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:521-9. 2005
    ....
  71. pmc Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging
    Wynne K Schiffer
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, NY 11794 5230, USA
    J Neurosci Methods 144:25-34. 2005
    ..0 and 3.5 pmol/ml, around which the measured BP can be compromised by system sensitivity, endogenous DA, or excessive competition with unlabeled compound...
  72. ncbi request reprint Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
    David L Alexoff
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Nucl Med 44:815-22. 2003
    ..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability...
  73. ncbi request reprint Brain dopamine is associated with eating behaviors in humans
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Int J Eat Disord 33:136-42. 2003
    ..We investigate the role of dopamine (DA), a neurotransmitter involved with food motivation, in these variables...
  74. ncbi request reprint Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 166:264-70. 2003
    ..However, there is some evidence that dopaminergic effects are involved in the cardiovascular actions of these drugs. Here, we evaluated this association in humans...
  75. ncbi request reprint Monoamine oxidase and cigarette smoking
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurotoxicology 24:75-82. 2003
    ....
  76. ncbi request reprint Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 116:163-72. 2002
    ..These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor...
  77. ncbi request reprint In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET
    Panayotis K Thanos
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1570-7. 2002
    ..MRI has been used to image brain structural changes in KO mice but, to our knowledge, the feasibility of using PET to investigate brain neurochemistry in KO mice has not been demonstrated...
  78. ncbi request reprint PET imaging of monoamine oxidase B in peripheral organs in humans
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1331-8. 2002
    ..The purpose of this study was to investigate the feasibility of imaging MAO B in peripheral organs in humans with PET...
  79. ncbi request reprint Brain DA D2 receptors predict reinforcing effects of stimulants in humans: replication study
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 46:79-82. 2002
    ..These results replicate our previous findings and provide further evidence that striatal DA D2 receptors modulate reinforcing responses to stimulants in humans and may underlie predisposition for drug self-administration...
  80. ncbi request reprint Monoamine oxidase: radiotracer development and human studies
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Methods 27:263-77. 2002
    ..PET studies have been carried out to measure the effects of age, MAO inhibitor drugs, tobacco smoke exposure, and other factors on MAO activity in the human brain...
  81. ncbi request reprint Effect of vehicle on brain uptake of [11C]toluene
    Madina R Gerasimov
    Brookhaven National Laboratory, Department of Chemistry, Upton, NY 11973, USA
    Nucl Med Biol 29:607-12. 2002
    ..Present results clearly demonstrate that the choice of a vehicle has a significant effect on tracer uptake and should be considered as a potential factor contributing to the pharmacokinetic measurements...
  82. ncbi request reprint "Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 44:175-80. 2002
    ..In addition it demonstrates the ability of methylphenidate to amplify weak dopamine signals...
  83. ncbi request reprint Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications
    Nora D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 43:181-7. 2002
    ....
  84. ncbi request reprint Monoamine oxidase A imaging in peripheral organs in healthy human subjects
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 49:178-87. 2003
    ....
  85. ncbi request reprint Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine
    Wynne K Schiffer
    SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA
    Neuropsychopharmacology 28:2192-8. 2003
    ..5%, consistent with a competitive interaction at the DAT. These results suggest that PCP may be exerting some direct effects through the DAT and that GABA partially modulates NMDA-antagonist-induced increases in striatal DA...
  86. ncbi request reprint Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 161:242-8. 2004
    ..In this study, the authors assessed whether metabolism recovers with protracted abstinence...
  87. ncbi request reprint The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 57:640-6. 2005
    ..This study measures the potency and kinetics for DAT blockade by radafaxine in human brain...
  88. ncbi request reprint Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates
    Helene Benveniste
    Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
    J Nucl Med 46:312-20. 2005
    ..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus...
  89. pmc Low monoamine oxidase B in peripheral organs in smokers
    Joanna S Fowler
    Chemistry Department and Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 100:11600-5. 2003
    ....
  90. ncbi request reprint Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  91. ncbi request reprint Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 50:345-52. 2003
    ..These studies demonstrate that the use of (S,S)-[11C]MRB would allow a better understanding of the role that NET plays in living systems...
  92. ncbi request reprint Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans
    Joanna S Fowler
    Brookhaven National Laboratory, Chemistry Department, Bldg 555, Upton, NY 11973, USA
    Nucl Med Biol 31:313-9. 2004
    ....
  93. ncbi request reprint Imaging dopamine receptors in the rat striatum with the MicroPET R4: kinetic analysis of [11C]raclopride binding using graphical methods
    David L Alexoff
    Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973, USA
    Methods Enzymol 385:213-28. 2004
  94. ncbi request reprint PET imaging in clinical drug abuse research
    S John Gatley
    Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973, USA
    Curr Pharm Des 11:3203-19. 2005
    ....
  95. pmc Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 28:8454-61. 2008
    ....
  96. ncbi request reprint Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
  97. ncbi request reprint High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA
    Arch Gen Psychiatry 63:999-1008. 2006
    ..Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption...
  98. pmc Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2017. 2008
    ..This would explain why methylphenidate has beneficial effects in some individuals and contexts and detrimental effects in others...
  99. ncbi request reprint Brain dopamine transporter levels in treatment and drug naïve adults with ADHD
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 34:1182-90. 2007
    ..g., prefrontal or cingulostriatal pathways, noradrenergic neurotransmission) is necessary to account for the large differences in inattention observed between controls and ADHD subjects...
  100. pmc Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda MD 20892, USA National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Neuroimage 39:1266-73. 2008
    ....
  101. ncbi request reprint Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 27:12700-6. 2007
    ....