Sung Won Kim

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial alpha7 nicotinic cholinergic agonist drug
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:541-51. 2007
  2. pmc Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
  3. pmc Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)
    Kun Eek Kil
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:153-63. 2007
  4. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
  5. pmc Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug
    Kun Eek Kil
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:215-23. 2009
  6. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
  7. ncbi request reprint Synthesis, enantiomeric resolution, F-18 labeling and biodistribution of reboxetine analogs: promising radioligands for imaging the norepinephrine transporter with positron emission tomography
    Kuo Shyan Lin
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 32:415-22. 2005
  8. pmc Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Bioorg Med Chem 18:7739-45. 2010
  9. doi request reprint [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
  10. doi request reprint Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography
    Matthias Schönberger
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Bioorg Med Chem Lett 20:3103-6. 2010

Collaborators

Detail Information

Publications12

  1. pmc Synthesis and positron emission tomography studies of C-11-labeled isotopomers and metabolites of GTS-21, a partial alpha7 nicotinic cholinergic agonist drug
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:541-51. 2007
    ..One of its two major demethylated metabolites, 4-OH-GTS-21, has been suggested to contribute to its therapeutic effects...
  2. pmc Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
    ..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole...
  3. pmc Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)
    Kun Eek Kil
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:153-63. 2007
    ..Here we labeled imatinib with carbon-11 as a tool for determining the drug distribution and pharmacokinetics of imatinib, and we carried out positron emission tomography (PET) studies in baboons...
  4. pmc Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
    ..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...
  5. pmc Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug
    Kun Eek Kil
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:215-23. 2009
    ..5 nM) that has Food and Drug Administration approval for breast cancer treatment. Here we report the synthesis of carbon-11-labeled letrozole and its assessment as a radiotracer for brain aromatase in the baboon...
  6. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  7. ncbi request reprint Synthesis, enantiomeric resolution, F-18 labeling and biodistribution of reboxetine analogs: promising radioligands for imaging the norepinephrine transporter with positron emission tomography
    Kuo Shyan Lin
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 32:415-22. 2005
    ..Positron emission tomography studies in baboon brain also showed that (S,S)-[(18)F]FRB-D(4) may be a potentially useful ligand for imaging NET with PET...
  8. pmc Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Bioorg Med Chem 18:7739-45. 2010
    ..However, the characterization of [(11)C]metergoline pharmacokinetics and binding in the brain and peripheral organs using PET improves our understanding of metergoline drug pharmacology...
  9. doi request reprint [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
    ..A preliminary muPET-experiment demonstrates the reversible, highly specific binding of [(11)C]PR04.MZ in the brain of a male Sprague-Dawley rat...
  10. doi request reprint Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography
    Matthias Schönberger
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Bioorg Med Chem Lett 20:3103-6. 2010
    ....
  11. pmc Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain
    Alicia E Reid
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Nucl Med Biol 36:247-58. 2009
    ..For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition, metabolic stability and the distribution of the putative metabolite [(18)F]fluoroacetate ([(18)F]FAC)...
  12. doi request reprint Carbon-11 radiolabeling of iron-oxide nanoparticles for dual-modality PET/MR imaging
    Ramesh Sharma
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Nanoscale 5:7476-83. 2013
    ..The proof-of-concept dual-modality PET/MR imaging using the radiolabeled SPIO NPs was demonstrated in an in vivo experiment. ..