Jacob M Hooker

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 41:1044-50. 2008
  2. pmc A simple, rapid method for the preparation of [11C]formaldehyde
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 47:5989-92. 2008
  3. pmc Metabolic changes in the rodent brain after acute administration of salvinorin A
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 11:137-43. 2009
  4. pmc Modular strategies for PET imaging agents
    Jacob M Hooker
    Brookhaven National Laboratory, Medical Department, Building 555, Upton, NY 11973 5000, USA
    Curr Opin Chem Biol 14:105-11. 2010
  5. pmc One-pot, direct incorporation of [11C]CO2 into carbamates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 48:3482-5. 2009
  6. pmc Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropharmacology 57:386-91. 2009
  7. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
  8. pmc Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Bioorg Med Chem 18:7739-45. 2010
  9. doi request reprint Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography
    Matthias Schönberger
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Bioorg Med Chem Lett 20:3103-6. 2010
  10. doi request reprint [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009

Detail Information

Publications13

  1. pmc Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 41:1044-50. 2008
    ..divinorum when smoked. The effects of salvinorin A may occur at <10 mug in the human brain, emphasizing its remarkable potency...
  2. pmc A simple, rapid method for the preparation of [11C]formaldehyde
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 47:5989-92. 2008
  3. pmc Metabolic changes in the rodent brain after acute administration of salvinorin A
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 11:137-43. 2009
    ..Salvinorin A (SA) is a potent and highly selective kappa-opioid receptor (KOR) agonist with rapid kinetics and commensurate behavioral effects; however, brain regions associated with these effects have not been determined...
  4. pmc Modular strategies for PET imaging agents
    Jacob M Hooker
    Brookhaven National Laboratory, Medical Department, Building 555, Upton, NY 11973 5000, USA
    Curr Opin Chem Biol 14:105-11. 2010
    ....
  5. pmc One-pot, direct incorporation of [11C]CO2 into carbamates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 48:3482-5. 2009
    ..This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications...
  6. pmc Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropharmacology 57:386-91. 2009
    ..Our results suggest that protecting salvinorin A derivatives from metabolism will prolong duration of action, but only when administered by routes giving slow absorption...
  7. pmc Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  8. pmc Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, United States
    Bioorg Med Chem 18:7739-45. 2010
    ..However, the characterization of [(11)C]metergoline pharmacokinetics and binding in the brain and peripheral organs using PET improves our understanding of metergoline drug pharmacology...
  9. doi request reprint Synthesis of [11C]SSR149415 and preliminary imaging studies using positron emission tomography
    Matthias Schönberger
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973, USA
    Bioorg Med Chem Lett 20:3103-6. 2010
    ....
  10. doi request reprint [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
    ..A preliminary muPET-experiment demonstrates the reversible, highly specific binding of [(11)C]PR04.MZ in the brain of a male Sprague-Dawley rat...
  11. pmc Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
    ..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole...
  12. doi request reprint Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents
    Wynne K Schiffer
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 29:6176-85. 2009
    ....
  13. doi request reprint Genome-free viral capsids as carriers for positron emission tomography radiolabels
    Jacob M Hooker
    Department of Chemistry, University of California, Berkeley, CA 94720 1460, USA
    Mol Imaging Biol 10:182-91. 2008
    ..We have developed a modular synthetic strategy to append imaging agents to a viral capsid...