Research Topics
Species | Rz GoldsteinSummaryAffiliation: Brookhaven National Laboratory Country: USA Publications
Research Grants
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Detail Information
Publications
Psychophysiological prediction of choice: relevance to insight and drug addictionScott J Moeller
Medical Research, Brookhaven National Laboratory, 30 Bell Ave, Bldg 490, Upton, NY 11973 5000, USA
Brain 135:3481-94. 2012..g. drug seeking in natural settings, relapse after treatment)-when insight (and self-report) is compromised...- The effect of practice on a sustained attention task in cocaine abusersRita Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Neuroimage 35:194-206. 2007.... - Neurocognitive correlates of response to treatment in formal thought disorder in patients with first-episode schizophreniaRita Z Goldstein
Brookhaven National Laboratory, Upton, New York 11973, USA
Neuropsychiatry Neuropsychol Behav Neurol 15:88-98. 2002..To examine the independent contribution of executive versus semantic function to improvement in formal thought disorder after initial stabilization in a first-episode sample... - Compromised sensitivity to monetary reward in current cocaine users: an ERP studyRita Z Goldstein
Brookhaven National Laboratory, Upton, New York 11973 5000, USA
Psychophysiology 45:705-13. 2008.... - Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaireR Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
J Psychopharmacol 24:257-66. 2010..Additional studies are required to assess the reliability of the STRAP-R in larger samples and to examine its validity in measuring the subjective value attributed to experienced reinforcers or in predicting behaviour... - Dopaminergic response to drug words in cocaine addictionRita Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Neurosci 29:6001-6. 2009..The correlation between the brief verbal fluency test, which can be easily administered (crucial for clinical studies), and fMRI cue reactivity could be used as a biomarker of neurobiological changes in addiction... - Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addictionRita Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Proc Natl Acad Sci U S A 106:9453-8. 2009..Interventions to strengthen ACC reactivity or interconnectivity may be beneficial in enhancing top-down monitoring and emotion regulation as a strategy to reduce impulsive and compulsive behavior in addiction... - The neurocircuitry of impaired insight in drug addictionRita Z Goldstein
Center for Translational Neuroimaging, Medical Research, Brookhaven National Laboratory, 30 Bell Ave Bldg 490, Upton, NY 11973 5000, USA
Trends Cogn Sci 13:372-80. 2009..We discuss implications for clinical treatment including the design of interventions to improve insight into illness severity in addiction... - Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive taskRita Z Goldstein
Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Proc Natl Acad Sci U S A 107:16667-72. 2010..neutral) cue-reactivity condition in all subjects. The clinical application of such MPH-induced brain-behavior enhancements remains to be tested... - Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implicationsRita Z Goldstein
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Nat Rev Neurosci 12:652-69. 2011..Disruption of the PFC in addiction underlies not only compulsive drug taking but also accounts for the disadvantageous behaviours that are associated with addiction and the erosion of free will... - Drug fluency: a potential marker for cocaine use disordersR Z Goldstein
Brookhaven National Laboratory, Medical Department, Upton, NY 11973 5000, United States
Drug Alcohol Depend 89:97-101. 2007..Future studies are needed to probe the exact cognitive processes and neural circuitry underlying performance on this cue-sensitive 1-min measure... - Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?Rita Z Goldstein
State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Am J Psychiatry 164:43-51. 2007..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control... - Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortexRita Z Goldstein
Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
Am J Psychiatry 159:1642-52. 2002..Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction... - The orbitofrontal cortex in methamphetamine addiction: involvement in fearRita Z Goldstein
Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
Neuroreport 13:2253-7. 2002..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction... - Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortexRita Z Goldstein
Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Neuropsychologia 42:1447-58. 2004..Obtaining valid estimates of alcohol use in cocaine addicted subjects is essential in characterizing neurocognitive functioning in individuals addicted to drugs... - Anger and depression in cocaine addiction: association with the orbitofrontal cortexRita Z Goldstein
Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Ave, Upton, NY, 11973 5000, USA
Psychiatry Res 138:13-22. 2005.... - The effect of graded monetary reward on cognitive event-related potentials and behavior in young healthy adultsRita Z Goldstein
Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Int J Psychophysiol 62:272-9. 2006..These findings suggest a difference between the P3 and CNV; the P3 is sensitive to the sustained effect of relative reward value, while the CNV does not vary with reward magnitude... - Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addictionR Z Goldstein
Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Neuroscience 144:1153-9. 2007.... - Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusersRita Z Goldstein
Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Drug Alcohol Depend 87:233-40. 2007..These results provide for the first time evidence of restricted subjective sensitivity to gradients of reward in cocaine addiction and of the involvement of frontolimbic brain regions (including the orbitofrontal cortex) in this deficit... - Brain monoamine oxidase A activity predicts trait aggressionNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Neurosci 28:5099-104. 2008..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression... - Gene x disease interaction on orbitofrontal gray matter in cocaine addictionNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Arch Gen Psychiatry 68:283-94. 2011..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability... - Insight into illness and adherence to psychotropic medications are separately associated with violence severity in a forensic sampleNelly Alia-Klein
Brookhaven National Laboratory, Upton, New York 11973 5000, USA 11973 5000 E mail
Aggress Behav 33:86-96. 2007..Treatment addressing medication adherence needs to concomitantly target substance use behaviors since the latter was responsible for a substantial increase in ODV... - Disrupted functional connectivity with dopaminergic midbrain in cocaine abusersDardo Tomasi
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 5:e10815. 2010.... - Induced magnetic force in human heads exposed to 4 T MRIRuiliang Wang
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Magn Reson Imaging 31:815-20. 2010..To map the distribution of the magnetic force induced in the human head during magnetic resonance imaging (MRI) at 4 T for a large group of healthy volunteers... - Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studiesNora D Volkow
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Neurobiol Learn Mem 78:610-24. 2002.... - Neural mechanisms of anger regulation as a function of genetic risk for violenceNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Emotion 9:385-96. 2009.... - Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perceptionDardo Tomasi
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Psychiatry Res 155:189-201. 2007..The development of therapies that diminish these thalamo-cortical deficits could improve the treatment of cocaine addiction... - What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortexNelly Alia-Klein
Brookhaven National Laboratory, Upton, NY, USA
Emotion 7:649-59. 2007.... - The MAO-A genotype does not modulate resting brain metabolism in adultsNelly Alia-Klein
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
Psychiatry Res 164:73-6. 2008..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype... - The neuropsychology of cocaine addiction: recent cocaine use masks impairmentPatricia A Woicik
Brookhaven National Laboratory, Medical Department, Upton, NY 11973 5000, USA
Neuropsychopharmacology 34:1112-22. 2009..These results call for development of pharmacological agents targeted to enhance cognition, without negatively impacting mood in individuals addicted to cocaine... - Impaired insight in cocaine addiction: laboratory evidence and effects on cocaine-seeking behaviourScott J Moeller
Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
Brain 133:1484-93. 2010..These findings suggest that interventions to enhance insight may decrease drug-seeking behaviour, especially in urine negative cocaine subjects, potentially to improve their longer-term clinical outcomes... - Category fluency in first-episode schizophreniaTania Giovannetti
Moss Rehabilitation Research Institute, Philadelphia, Pennsylvania 19141, USA
J Int Neuropsychol Soc 9:384-93. 2003..e., semantic search/access, response monitoring) or global cognitive impairment... - Incentive motivation is associated with striatal dopamine asymmetryRachel Tomer
Department of Psychology and Brain and Behavior Center, University of Haifa, Mount Carmel 31905, Israel
Biol Psychol 77:98-101. 2008..721, p=.001), suggesting that greater positive incentive motivation is associated with higher receptor availability in the left relative to the right hemisphere...
Research Grants
- Behavioral correlates of fMRI response in cocaine usersRita Goldstein; Fiscal Year: 2006..abstract_text> ..
- The prefrontal cortex in salience and control in cocaine addiction: phFMRI studyRita Goldstein; Fiscal Year: 2009..Thus, using the pharmacological functional activation and behavioral results in our study, we may be able to highlight the intervention approaches that may be most beneficial. ..
- The prefrontal cortex in salience and control in cocaine addiction: phFMRI studyRita Z Goldstein; Fiscal Year: 2010..Thus, using the pharmacological functional activation and behavioral results in our study, we may be able to highlight the intervention approaches that may be most beneficial. ..