Rz Goldstein

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. pmc Psychophysiological prediction of choice: relevance to insight and drug addiction
    Scott J Moeller
    Medical Research, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Brain 135:3481-94. 2012
  2. pmc The effect of practice on a sustained attention task in cocaine abusers
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 35:194-206. 2007
  3. ncbi request reprint Neurocognitive correlates of response to treatment in formal thought disorder in patients with first-episode schizophrenia
    Rita Z Goldstein
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Neuropsychiatry Neuropsychol Behav Neurol 15:88-98. 2002
  4. pmc Compromised sensitivity to monetary reward in current cocaine users: an ERP study
    Rita Z Goldstein
    Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Psychophysiology 45:705-13. 2008
  5. pmc Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire
    R Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Psychopharmacol 24:257-66. 2010
  6. pmc Dopaminergic response to drug words in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Neurosci 29:6001-6. 2009
  7. pmc Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 106:9453-8. 2009
  8. pmc The neurocircuitry of impaired insight in drug addiction
    Rita Z Goldstein
    Center for Translational Neuroimaging, Medical Research, Brookhaven National Laboratory, 30 Bell Ave Bldg 490, Upton, NY 11973 5000, USA
    Trends Cogn Sci 13:372-80. 2009
  9. pmc Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 107:16667-72. 2010
  10. pmc Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
    Rita Z Goldstein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nat Rev Neurosci 12:652-69. 2011

Detail Information

Publications33

  1. pmc Psychophysiological prediction of choice: relevance to insight and drug addiction
    Scott J Moeller
    Medical Research, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Brain 135:3481-94. 2012
    ..g. drug seeking in natural settings, relapse after treatment)--when insight (and self-report) is compromised...
  2. pmc The effect of practice on a sustained attention task in cocaine abusers
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 35:194-206. 2007
    ....
  3. ncbi request reprint Neurocognitive correlates of response to treatment in formal thought disorder in patients with first-episode schizophrenia
    Rita Z Goldstein
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Neuropsychiatry Neuropsychol Behav Neurol 15:88-98. 2002
    ..To examine the independent contribution of executive versus semantic function to improvement in formal thought disorder after initial stabilization in a first-episode sample...
  4. pmc Compromised sensitivity to monetary reward in current cocaine users: an ERP study
    Rita Z Goldstein
    Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Psychophysiology 45:705-13. 2008
    ....
  5. pmc Liking and wanting of drug and non-drug rewards in active cocaine users: the STRAP-R questionnaire
    R Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Psychopharmacol 24:257-66. 2010
    ..Additional studies are required to assess the reliability of the STRAP-R in larger samples and to examine its validity in measuring the subjective value attributed to experienced reinforcers or in predicting behaviour...
  6. pmc Dopaminergic response to drug words in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Neurosci 29:6001-6. 2009
    ..The correlation between the brief verbal fluency test, which can be easily administered (crucial for clinical studies), and fMRI cue reactivity could be used as a biomarker of neurobiological changes in addiction...
  7. pmc Anterior cingulate cortex hypoactivations to an emotionally salient task in cocaine addiction
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 106:9453-8. 2009
    ..Interventions to strengthen ACC reactivity or interconnectivity may be beneficial in enhancing top-down monitoring and emotion regulation as a strategy to reduce impulsive and compulsive behavior in addiction...
  8. pmc The neurocircuitry of impaired insight in drug addiction
    Rita Z Goldstein
    Center for Translational Neuroimaging, Medical Research, Brookhaven National Laboratory, 30 Bell Ave Bldg 490, Upton, NY 11973 5000, USA
    Trends Cogn Sci 13:372-80. 2009
    ..We discuss implications for clinical treatment including the design of interventions to improve insight into illness severity in addiction...
  9. pmc Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task
    Rita Z Goldstein
    Department of Medical Research, Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Proc Natl Acad Sci U S A 107:16667-72. 2010
    ..neutral) cue-reactivity condition in all subjects. The clinical application of such MPH-induced brain-behavior enhancements remains to be tested...
  10. pmc Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
    Rita Z Goldstein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nat Rev Neurosci 12:652-69. 2011
    ..Disruption of the PFC in addiction underlies not only compulsive drug taking but also accounts for the disadvantageous behaviours that are associated with addiction and the erosion of free will...
  11. pmc Drug fluency: a potential marker for cocaine use disorders
    R Z Goldstein
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973 5000, United States
    Drug Alcohol Depend 89:97-101. 2007
    ..Future studies are needed to probe the exact cognitive processes and neural circuitry underlying performance on this cue-sensitive 1-min measure...
  12. pmc Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?
    Rita Z Goldstein
    State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Am J Psychiatry 164:43-51. 2007
    ..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control...
  13. pmc Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
    Am J Psychiatry 159:1642-52. 2002
    ..Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction...
  14. pmc The orbitofrontal cortex in methamphetamine addiction: involvement in fear
    Rita Z Goldstein
    Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
    Neuroreport 13:2253-7. 2002
    ..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction...
  15. ncbi request reprint Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex
    Rita Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuropsychologia 42:1447-58. 2004
    ..Obtaining valid estimates of alcohol use in cocaine addicted subjects is essential in characterizing neurocognitive functioning in individuals addicted to drugs...
  16. ncbi request reprint Anger and depression in cocaine addiction: association with the orbitofrontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Ave, Upton, NY, 11973 5000, USA
    Psychiatry Res 138:13-22. 2005
    ....
  17. pmc The effect of graded monetary reward on cognitive event-related potentials and behavior in young healthy adults
    Rita Z Goldstein
    Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Int J Psychophysiol 62:272-9. 2006
    ..These findings suggest a difference between the P3 and CNV; the P3 is sensitive to the sustained effect of relative reward value, while the CNV does not vary with reward magnitude...
  18. pmc Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction
    R Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroscience 144:1153-9. 2007
    ....
  19. pmc Subjective sensitivity to monetary gradients is associated with frontolimbic activation to reward in cocaine abusers
    Rita Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Drug Alcohol Depend 87:233-40. 2007
    ..These results provide for the first time evidence of restricted subjective sensitivity to gradients of reward in cocaine addiction and of the involvement of frontolimbic brain regions (including the orbitofrontal cortex) in this deficit...
  20. pmc Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  21. pmc Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
    ..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability...
  22. ncbi request reprint Insight into illness and adherence to psychotropic medications are separately associated with violence severity in a forensic sample
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, New York 11973 5000, USA 11973 5000 E mail
    Aggress Behav 33:86-96. 2007
    ..Treatment addressing medication adherence needs to concomitantly target substance use behaviors since the latter was responsible for a substantial increase in ODV...
  23. pmc Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers
    Dardo Tomasi
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 5:e10815. 2010
    ....
  24. pmc Induced magnetic force in human heads exposed to 4 T MRI
    Ruiliang Wang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Magn Reson Imaging 31:815-20. 2010
    ..To map the distribution of the magnetic force induced in the human head during magnetic resonance imaging (MRI) at 4 T for a large group of healthy volunteers...
  25. ncbi request reprint Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Neurobiol Learn Mem 78:610-24. 2002
    ....
  26. pmc Neural mechanisms of anger regulation as a function of genetic risk for violence
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Emotion 9:385-96. 2009
    ....
  27. pmc Thalamo-cortical dysfunction in cocaine abusers: implications in attention and perception
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 155:189-201. 2007
    ..The development of therapies that diminish these thalamo-cortical deficits could improve the treatment of cocaine addiction...
  28. pmc What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, NY, USA
    Emotion 7:649-59. 2007
    ....
  29. pmc The MAO-A genotype does not modulate resting brain metabolism in adults
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
    Psychiatry Res 164:73-6. 2008
    ..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype...
  30. pmc The neuropsychology of cocaine addiction: recent cocaine use masks impairment
    Patricia A Woicik
    Brookhaven National Laboratory, Medical Department, Upton, NY 11973 5000, USA
    Neuropsychopharmacology 34:1112-22. 2009
    ..These results call for development of pharmacological agents targeted to enhance cognition, without negatively impacting mood in individuals addicted to cocaine...
  31. pmc Impaired insight in cocaine addiction: laboratory evidence and effects on cocaine-seeking behaviour
    Scott J Moeller
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Brain 133:1484-93. 2010
    ..These findings suggest that interventions to enhance insight may decrease drug-seeking behaviour, especially in urine negative cocaine subjects, potentially to improve their longer-term clinical outcomes...
  32. ncbi request reprint Category fluency in first-episode schizophrenia
    Tania Giovannetti
    Moss Rehabilitation Research Institute, Philadelphia, Pennsylvania 19141, USA
    J Int Neuropsychol Soc 9:384-93. 2003
    ..e., semantic search/access, response monitoring) or global cognitive impairment...
  33. pmc Incentive motivation is associated with striatal dopamine asymmetry
    Rachel Tomer
    Department of Psychology and Brain and Behavior Center, University of Haifa, Mount Carmel 31905, Israel
    Biol Psychol 77:98-101. 2008
    ..721, p=.001), suggesting that greater positive incentive motivation is associated with higher receptor availability in the left relative to the right hemisphere...

Research Grants5

  1. Behavioral correlates of fMRI response in cocaine users
    Rita Goldstein; Fiscal Year: 2006
    ..abstract_text> ..
  2. The prefrontal cortex in salience and control in cocaine addiction: phFMRI study
    Rita Goldstein; Fiscal Year: 2009
    ..Thus, using the pharmacological functional activation and behavioral results in our study, we may be able to highlight the intervention approaches that may be most beneficial. ..
  3. The prefrontal cortex in salience and control in cocaine addiction: phFMRI study
    Rita Z Goldstein; Fiscal Year: 2010
    ..Thus, using the pharmacological functional activation and behavioral results in our study, we may be able to highlight the intervention approaches that may be most beneficial. ..