Andrew N Gifford

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi request reprint 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur J Pharmacol 307:331-8. 1996
  2. doi request reprint Polymer-supported organotin reagent for prosthetic group labeling of biological macromolecules with radioiodine
    Andrew N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Bioconjug Chem 22:406-12. 2011
  3. ncbi request reprint In vivo imaging of the brain cannabinoid receptor
    Andrew N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Chem Phys Lipids 121:65-72. 2002
  4. ncbi request reprint Effect of amphetamine-induced dopamine release on radiotracer binding to D1 and D2 receptors in rat brain striatal slices
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Naunyn Schmiedebergs Arch Pharmacol 362:413-8. 2000
  5. pmc Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, New York, NY 11973, USA
    Br J Pharmacol 131:645-50. 2000
  6. ncbi request reprint Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374)
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur J Pharmacol 383:9-14. 1999
  7. ncbi request reprint Large receptor reserve for cannabinoid actions in the central nervous system
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Pharmacol Exp Ther 288:478-83. 1999
  8. doi request reprint Biodistribution of radiolabeled ethanol in rodents
    Andrew N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NNew York 11973, USA
    Drug Metab Dispos 36:1853-8. 2008
  9. ncbi request reprint Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233
    Jasbeer Dhawan
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 60:93-101. 2006
  10. ncbi request reprint Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain
    Sherrye T Glaser
    Center for Translational Neuroimaging, Medical Department, Bldg 490, 30 Bell Ave, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Pharmacol Exp Ther 316:1088-97. 2006

Research Grants

  1. MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDS
    Andrew Gifford; Fiscal Year: 2002
  2. Animal model for inhalant abuse
    Andrew Gifford; Fiscal Year: 2004
  3. PET Studies of Alcohol Distribution and Metabolism
    Andrew Gifford; Fiscal Year: 2005

Collaborators

Detail Information

Publications23

  1. ncbi request reprint 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur J Pharmacol 307:331-8. 1996
    ..08). In in vitro binding assays with mouse hippocampal membranes, tetrahydrocannabinol inhibited binding of [123I]AM251 with an IC50 value of about 700 nM, compared with about 0.2 nM for SR141716A...
  2. doi request reprint Polymer-supported organotin reagent for prosthetic group labeling of biological macromolecules with radioiodine
    Andrew N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Bioconjug Chem 22:406-12. 2011
    ..This solid-phase approach is potentially adaptable to kit-formulation for performing conjugate radiolabeling of biological macromolecules...
  3. ncbi request reprint In vivo imaging of the brain cannabinoid receptor
    Andrew N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Chem Phys Lipids 121:65-72. 2002
    ..Although rodent studies have indicated that in vivo imaging of CB1 receptors is feasible, at the present time this receptor has still to be successful imaged in a human PET study...
  4. ncbi request reprint Effect of amphetamine-induced dopamine release on radiotracer binding to D1 and D2 receptors in rat brain striatal slices
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Naunyn Schmiedebergs Arch Pharmacol 362:413-8. 2000
    ....
  5. pmc Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, New York, NY 11973, USA
    Br J Pharmacol 131:645-50. 2000
    ..The SR 141716A-induced enhancement of ACh release can similarly be observed in hippocampal synaptosomes and is probably due to an inverse agonist action at constitutively active receptors...
  6. ncbi request reprint Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374)
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur J Pharmacol 383:9-14. 1999
    ..These results indicate that AM 374 potently inhibits endogenous amidase activity and thus facilitates access of exogenous anandamide to cannabinoid receptors in the hippocampal tissue...
  7. ncbi request reprint Large receptor reserve for cannabinoid actions in the central nervous system
    A N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Pharmacol Exp Ther 288:478-83. 1999
    ..p.), completely abolished specific [131I]AM 281 binding. These experiments suggest that behavioral effects of cannabinoids, like neurochemical effects, are produced at very low receptor occupancy...
  8. doi request reprint Biodistribution of radiolabeled ethanol in rodents
    Andrew N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, NNew York 11973, USA
    Drug Metab Dispos 36:1853-8. 2008
    ..It is thus tempting to speculate that the well documented high incidence of pancreatic disease observed in human chronic alcoholism may be related to a propensity of this organ to accumulate ethanol and/or reactive ethanol metabolites...
  9. ncbi request reprint Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233
    Jasbeer Dhawan
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 60:93-101. 2006
    ..These observations suggest that the behavioral effects of CB1 receptor agonists are manifested with a relatively small fraction of the agonist-preferring affinity state of the receptor occupied...
  10. ncbi request reprint Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain
    Sherrye T Glaser
    Center for Translational Neuroimaging, Medical Department, Bldg 490, 30 Bell Ave, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Pharmacol Exp Ther 316:1088-97. 2006
    ..This imaging method determines regionally specific FAAH inhibition and can elucidate the in vivo effects of pharmacological agents targeting anandamide inactivation...
  11. ncbi request reprint Concentration-dependent conditioned place preference to inhaled toluene vapors in rats
    Dianne E Lee
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Drug Alcohol Depend 85:87-90. 2006
    ..For the conditioned place preference experiments rats were exposed to toluene vapors at concentrations of 800, 2000, 3000 or 5000 ppm in one compartment of a three-compartment box...
  12. ncbi request reprint Effect of SA4503 on the electrically evoked release of (3)H-acetylcholine from striatal and hippocampal rat brain slices
    Bryan Horan
    Medical Department, Brookhaven National Laboratories, Upton, New York 11973, USA
    Synapse 46:1-3. 2002
    ....
  13. ncbi request reprint Study of brain uptake and biodistribution of [11C]toluene in non-human primates and mice
    M R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Life Sci 70:2811-28. 2002
    ..Taken together, our data provides insight into pharmacokinetic features possibly associated with the abuse liability of toluene...
  14. ncbi request reprint Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 61:PL 191-7. 1997
    ..However, the binding site domains which interact with AM251 and CP 55,940 may not be identical, since IC50 values for cannabinoid receptor ligands depended on whether [123I]AM251 or [3H]CP 55,940 was used as radioligand...
  15. ncbi request reprint In vitro and ex vivo autoradiographic studies of nicotinic acetylcholine receptors using [18F]fluoronochloroepibatidine in rodent and human brain
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 25:449-54. 1998
    ..However, similar Kd values close to 50 pM were calculated for all regions. These studies support the suitability of [18F]NFEP as a radioligand for PET studies of nAcChR in the living human brain...
  16. ncbi request reprint Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 146:93-100. 1999
    ..The present experiments were conducted to examine dose-occupancy and dose-effect relationships in mice for cocaine and also for methylphenidate, a dopamine uptake blocker used in pediatric psychiatry...
  17. ncbi request reprint Sensitivity of binding of high-affinity dopamine receptor radioligands to increased synaptic dopamine
    S J Gatley
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 38:483-8. 2000
    ..We suggest that the magnitude of the competition is reduced by failure of the receptor binding of high-affinity radioligands to rapidly attain equilibrium...
  18. ncbi request reprint Effects of endogenous neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in mice
    O V Rice
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuropsychopharmacology 25:679-89. 2001
    ..3H]N-methylspiperone binding to 5-HT(2A) receptors and [3H]WAY 100635 binding to 5-HT(1A) receptors appeared insensitive to changes in neurotransmitter levels...
  19. ncbi request reprint "Nonhedonic" food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 44:175-80. 2002
    ..In addition it demonstrates the ability of methylphenidate to amplify weak dopamine signals...
  20. ncbi request reprint Toluene inhalation produces a conditioned place preference in rats
    Madina R Gerasimov
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur J Pharmacol 477:45-52. 2003
    ..Thus, toluene produced a clear conditioned place preference that appears to be most evident when animals are not intoxicated. This procedure should be useful for further studies of the abuse-related effects of abused inhalants...
  21. ncbi request reprint Preparation of radioiodinated peptide nucleic acids with high specific activity
    Adriana Tovar-Salazar
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Anal Biochem 360:92-8. 2007
    ..As an example of a potential molecular biology application of the resultant (125)I-labeled PNA probe, it was used to detect mRNA for the Lcn2 gene in Northern blotting...
  22. ncbi request reprint Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice
    Onarae V Rice
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Brain Res 945:135-8. 2002
    ..CB1 receptor knockout mice developed a strong place preference to 4 and 8 mg/kg morphine, similar to that in wild-type Swiss-Webster mice. This data thus does not support a contribution of the brain cannabinoid system to morphine reward...
  23. ncbi request reprint Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor
    Hongfeng Deng
    Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, 116 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA
    J Med Chem 48:6386-92. 2005
    ..Radioiodinated 8 thus appears to be a suitable radioligand for studies of CB1 cannabinoid receptors...

Research Grants3

  1. MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDS
    Andrew Gifford; Fiscal Year: 2002
    ..Furthermore, these experiments will give information on the mode of action of cannabinoid antagonists and could suggest novel therapeutic uses for this new class of compounds. ..
  2. Animal model for inhalant abuse
    Andrew Gifford; Fiscal Year: 2004
    ..Additionally, an animal model for inhalant abuse will aid further exploration of the factors contributing to the predisposition, development and potential treatment of inhalant abuse. ..
  3. PET Studies of Alcohol Distribution and Metabolism
    Andrew Gifford; Fiscal Year: 2005
    ..abstract_text> ..