Joanna Fowler

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Nucl Med 46:1414-20. 2005
  2. ncbi Low monoamine oxidase B in peripheral organs in smokers
    Joanna S Fowler
    Chemistry Department and Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 100:11600-5. 2003
  3. ncbi Monoamine oxidase and cigarette smoking
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurotoxicology 24:75-82. 2003
  4. ncbi Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 43:756-63. 2008
  5. ncbi Monoamine oxidase A imaging in peripheral organs in healthy human subjects
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 49:178-87. 2003
  6. ncbi Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans
    Joanna S Fowler
    Brookhaven National Laboratory, Chemistry Department, Bldg 555, Upton, NY 11973, USA
    Nucl Med Biol 31:313-9. 2004
  7. ncbi PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, New York, USA
    J Nucl Med 48:1724-32. 2007
  8. ncbi Imaging the addicted human brain
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Sci Pract Perspect 3:4-16. 2007
  9. ncbi Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
  10. ncbi Translational neuroimaging: positron emission tomography studies of monoamine oxidase
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 7:377-87. 2005

Research Grants

  1. Addiction and the Brain: Are We Hard Wired to Abuse Drugs
    Joanna Fowler; Fiscal Year: 2007
  2. Role of Genotype and Maternal Smoking on Brain MAO A
    Joanna Fowler; Fiscal Year: 2007
  3. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2004
  4. RADIOTRACER RANDD IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2000

Detail Information

Publications93

  1. ncbi Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Nucl Med 46:1414-20. 2005
    ..Because smoking exposes peripheral organs as well as the brain to MAO A-inhibitory compounds, we determined whether smokers would also have reduced MAO A in peripheral organs...
  2. ncbi Low monoamine oxidase B in peripheral organs in smokers
    Joanna S Fowler
    Chemistry Department and Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 100:11600-5. 2003
    ....
  3. ncbi Monoamine oxidase and cigarette smoking
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurotoxicology 24:75-82. 2003
    ....
  4. ncbi Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 43:756-63. 2008
    ..The absence of significant differences between Caucasians and African Americans suggests that variables other than methamphetamine pharmacokinetics and bioavailability account for the lower abuse prevalence in African Americans...
  5. ncbi Monoamine oxidase A imaging in peripheral organs in healthy human subjects
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 49:178-87. 2003
    ....
  6. ncbi Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans
    Joanna S Fowler
    Brookhaven National Laboratory, Chemistry Department, Bldg 555, Upton, NY 11973, USA
    Nucl Med Biol 31:313-9. 2004
    ....
  7. ncbi PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, New York, USA
    J Nucl Med 48:1724-32. 2007
    ....
  8. ncbi Imaging the addicted human brain
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Sci Pract Perspect 3:4-16. 2007
    ..The authors give examples of key findings illustrating how each technique has extended and deepened our knowledge of the neurobiological bases of drug abuse and addiction, and they address potential clinical and therapeutic applications...
  9. ncbi Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 62:355-8. 2007
    ..We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects...
  10. ncbi Translational neuroimaging: positron emission tomography studies of monoamine oxidase
    Joanna S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Mol Imaging Biol 7:377-87. 2005
    ..In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs...
  11. ncbi PET imaging of monoamine oxidase B in peripheral organs in humans
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1331-8. 2002
    ..The purpose of this study was to investigate the feasibility of imaging MAO B in peripheral organs in humans with PET...
  12. ncbi Monoamine oxidase: radiotracer development and human studies
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Methods 27:263-77. 2002
    ..PET studies have been carried out to measure the effects of age, MAO inhibitor drugs, tobacco smoke exposure, and other factors on MAO activity in the human brain...
  13. ncbi [(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 28:561-72. 2001
    ..This article will summarize preclinical and clinical research with [(11)C]cocaine...
  14. ncbi Smoking a single cigarette does not produce a measurable reduction in brain MAO B in non-smokers
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Nicotine Tob Res 1:325-9. 1999
    ..These results indicate that the reduction in MAO B in smokers probably occurs gradually and requires chronic tobacco smoke exposure...
  15. ncbi Maintenance of brain monoamine oxidase B inhibition in smokers after overnight cigarette abstinence
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 157:1864-6. 2000
    ..The authors' goal was to replicate a previous finding that smokers have lower brain monoamine oxidase B (MAO-B) levels than comparison nonsmoking subjects and to determine if levels recover after overnight cigarette abstinence...
  16. ncbi Species differences in [11C]clorgyline binding in brain
    J S Fowler
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Nucl Med Biol 28:779-85. 2001
    ..This suggests a species difference in the susceptibility of MAO A to inhibition by clorgyline and represents an unusual example of where the behavior of a radiotracer in the baboon brain does not predict its behavior in the human brain...
  17. ncbi Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain
    J S Fowler
    Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Life Sci 66:PL141-6. 2000
    ..Ginkgo biloba administration did not produce significant changes in brain MAO A or MAO B suggesting that mechanisms other than MAO inhibition need to be considered as mediating some of its CNS effects...
  18. ncbi Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain
    J S Fowler
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Life Sci 68:2759-68. 2001
    ....
  19. ncbi PET imaging studies in drug abuse
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Toxicol Clin Toxicol 36:163-74. 1998
    ..Review: In this article, we will highlight some examples of the use of Positron Emission Tomography to measure drug pharmacokinetics and pharmacodynamics and their relationship to addiction and to toxicity...
  20. ncbi Non-MAO A binding of clorgyline in white matter in human brain
    J S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurochem 79:1039-46. 2001
    ..The characterization of the non-MAO A binding component of this widely used MAO A inhibitor merits further investigation...
  21. ncbi Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain
    Nora D Volkow
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Am J Psychiatry 161:1173-80. 2004
    ..These findings support educational strategies that make schoolwork more interesting as nonpharmacological interventions to treat ADHD...
  22. ncbi Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)
    Kun Eek Kil
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:153-63. 2007
    ..Here we labeled imatinib with carbon-11 as a tool for determining the drug distribution and pharmacokinetics of imatinib, and we carried out positron emission tomography (PET) studies in baboons...
  23. ncbi Synthesis and PET studies of [(11)C-cyano]letrozole (Femara), an aromatase inhibitor drug
    Kun Eek Kil
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:215-23. 2009
    ..5 nM) that has Food and Drug Administration approval for breast cancer treatment. Here we report the synthesis of carbon-11-labeled letrozole and its assessment as a radiotracer for brain aromatase in the baboon...
  24. ncbi 6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter
    Yu-Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 53:184-9. 2004
  25. ncbi Enhanced resting activity of the oral somatosensory cortex in obese subjects
    Gene-Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroreport 13:1151-5. 2002
    ....
  26. ncbi Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:531-42. 2005
    ..The focus of this work is to identify a suitable reference region or means of normalizing data for the NET ligands investigated...
  27. ncbi Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157
    Joanna S Fowler
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Neuropsychopharmacology 35:623-31. 2010
    ..These data were used to establish the dosing regimen for a current clinical efficacy trial with CX157...
  28. ncbi New-generation radiotracers for nAChR and NET
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:707-18. 2005
    ....
  29. ncbi Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease
    Lisa Mosconi
    Center for Brain Health, MHL 400, Department of Psychiatry, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Eur J Nucl Med Mol Imaging 34:1467-79. 2007
    ....
  30. ncbi Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-D-glucose cerebral uptake in rodents through time
    Douglas A Marsteller
    Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, NY 11794 8651, USA
    Nucl Med Biol 33:71-9. 2006
    ..However, the variability of within-rodent brain glucose uptake after an intraperitoneal injection across an extended time has not been measured...
  31. ncbi What is in a word? No versus Yes differentially engage the lateral orbitofrontal cortex
    Nelly Alia-Klein
    Brookhaven National Laboratory, Upton, NY, USA
    Emotion 7:649-59. 2007
    ....
  32. ncbi Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET
    Alicia E Reid
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 35:287-98. 2008
    ....
  33. ncbi Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, New York, USA
    PLoS ONE 5:e11067. 2010
    ....
  34. ncbi Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons
    Anat Biegon
    Brookhaven National Laboratory, Upton, New York, USA
    Biol Psychiatry 67:774-7. 2010
    ..We report the first in vivo primate study to determine whether there is a direct effect of nicotine administration on brain aromatase...
  35. ncbi Neural mechanisms of anger regulation as a function of genetic risk for violence
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Emotion 9:385-96. 2009
    ....
  36. ncbi One-pot, direct incorporation of [11C]CO2 into carbamates
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Angew Chem Int Ed Engl 48:3482-5. 2009
    ..This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications...
  37. ncbi Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole
    Anat Biegon
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 64:801-7. 2010
    ..These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain...
  38. ncbi Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain
    Alicia E Reid
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Nucl Med Biol 36:247-58. 2009
    ..For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition, metabolic stability and the distribution of the putative metabolite [(18)F]fluoroacetate ([(18)F]FAC)...
  39. ncbi Gastric distention activates satiety circuitry in the human brain
    Gene Jack Wang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 39:1824-31. 2008
    ..These findings provide evidence that the left amygdala and insula process interoceptive signals of fullness produced by gastric distention involved in the controls of food intake...
  40. ncbi Gene x disease interaction on orbitofrontal gray matter in cocaine addiction
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Arch Gen Psychiatry 68:283-94. 2011
    ..However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability...
  41. ncbi Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY, 11973, USA
    Proc Natl Acad Sci U S A 106:1249-54. 2009
    ..This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity...
  42. ncbi The MAO-A genotype does not modulate resting brain metabolism in adults
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, United States
    Psychiatry Res 164:73-6. 2008
    ..Here we show no changes in baseline regional brain metabolism as a function of genotype indicating that, unchallenged, corticolimbic activity is not modulated by the MAO-A genotype...
  43. ncbi A simple, rapid method for the preparation of [11C]formaldehyde
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
    Angew Chem Int Ed Engl 47:5989-92. 2008
  44. ncbi Brain monoamine oxidase A activity predicts trait aggression
    Nelly Alia-Klein
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Neurosci 28:5099-104. 2008
    ..Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression...
  45. ncbi Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase
    Sung Won Kim
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 36:323-34. 2009
    ..Herein we report the preparation and positron emission tomography (PET) studies of pure [N-methyl-(11)C]vorozole...
  46. ncbi Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
    Jacob M Hooker
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 41:1044-50. 2008
    ..divinorum when smoked. The effects of salvinorin A may occur at <10 mug in the human brain, emphasizing its remarkable potency...
  47. ncbi Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 32:521-9. 2005
    ....
  48. ncbi Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications
    Nora D Volkow
    Brookhaven National Laboratory, Upton, New York 11973, USA
    Synapse 43:181-7. 2002
    ....
  49. ncbi Exposure to appetitive food stimuli markedly activates the human brain
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 21:1790-7. 2004
    ..Here we assess the response of the human brain to the presentation of appetitive food stimuli during food presentation using PET and FDG...
  50. ncbi 2-deoxy-2-[18F]fluoro-D-glucose and alternative radiotracers for positron emission tomography imaging using the human brain as a model
    Joanna S Fowler
    Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Semin Nucl Med 34:112-21. 2004
    ..We describe studies that fall into three major areas: normal aging, neuropsychiatric disorders, and drug action...
  51. ncbi Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Am J Psychiatry 161:242-8. 2004
    ..In this study, the authors assessed whether metabolism recovers with protracted abstinence...
  52. ncbi Maternal-fetal in vivo imaging: a combined PET and MRI study
    Helene Benveniste
    Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
    J Nucl Med 44:1522-30. 2003
    ....
  53. ncbi Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Alcohol Clin Exp Res 27:909-17. 2003
    ..We compared the regional changes in brain glucose metabolism during alcohol intoxication between female and male subjects...
  54. ncbi The addicted human brain: insights from imaging studies
    Nora D Volkow
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Clin Invest 111:1444-51. 2003
  55. ncbi Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
    David L Alexoff
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Nucl Med 44:815-22. 2003
    ..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 receptor (D2R) availability...
  56. ncbi Cardiovascular effects of methylphenidate in humans are associated with increases of dopamine in brain and of epinephrine in plasma
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychopharmacology (Berl) 166:264-70. 2003
    ..However, there is some evidence that dopaminergic effects are involved in the cardiovascular actions of these drugs. Here, we evaluated this association in humans...
  57. ncbi Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies
    Nora D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Neurobiol Learn Mem 78:610-24. 2002
    ....
  58. ncbi Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine
    Wynne K Schiffer
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
    Synapse 48:35-8. 2003
    ..On the other hand, chronic selegiline treatment may improve DA deficits, which are thought to contribute to relapse through a decreased response to natural rewards...
  59. ncbi The orbitofrontal cortex in methamphetamine addiction: involvement in fear
    Rita Z Goldstein
    Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
    Neuroreport 13:2253-7. 2002
    ..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction...
  60. ncbi Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Psychiatry Res 116:163-72. 2002
    ..These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor...
  61. ncbi Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies
    Nora D Volkow
    Medical Department Brookhaven National Laboratory, Upton, NY 11973, USA
    Eur Neuropsychopharmacol 12:557-66. 2002
    ..Moreover, abuse of methylphenidate is constrained by its long half-life, which we postulate limits the frequency at which it can be administered...
  62. ncbi Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline
    Jean Logan
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 22:1367-76. 2002
    ..This method should be generalizable to other tracers and should facilitate the analysis of group differences...
  63. ncbi In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET
    Panayotis K Thanos
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1570-7. 2002
    ..MRI has been used to image brain structural changes in KO mice but, to our knowledge, the feasibility of using PET to investigate brain neurochemistry in KO mice has not been demonstrated...
  64. ncbi The role of dopamine in motivation for food in humans: implications for obesity
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Expert Opin Ther Targets 6:601-9. 2002
    ..A better understanding of the role of the DA system in the motivation for food intake will help the development of better therapeutic interventions...
  65. ncbi DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking
    Panayotis K Thanos
    Department of Medicine, Brookhaven National Laboratory, Upton, New York, USA
    Alcohol Clin Exp Res 28:720-8. 2004
    ..This overexpression of DRD2 reduced alcohol consumption in a two-bottle-choice paradigm and supported the view that high levels of DRD2 may be protective against alcohol abuse...
  66. ncbi Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 103:15641-5. 2006
    ....
  67. ncbi Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene-Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  68. ncbi Anger and depression in cocaine addiction: association with the orbitofrontal cortex
    Rita Z Goldstein
    Medical Research, Brookhaven National Laboratory, Bldg 490, 30 Bell Ave, Upton, NY, 11973 5000, USA
    Psychiatry Res 138:13-22. 2005
    ....
  69. ncbi Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primates
    Helene Benveniste
    Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
    J Nucl Med 46:312-20. 2005
    ..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus...
  70. ncbi Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review
    Gene Jack Wang
    Medical Department, Brookhaven National Laboratory, PO Box 5000, Upton, NY 11973, USA
    J Addict Dis 23:39-53. 2004
    ..Understanding the mechanism in food intake will help to suggest strategies for the treatment of obesity...
  71. ncbi Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex
    Rita Z Goldstein
    Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Neuropsychologia 42:1447-58. 2004
    ..Obtaining valid estimates of alcohol use in cocaine addicted subjects is essential in characterizing neurocognitive functioning in individuals addicted to drugs...
  72. ncbi Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration
    Yu Shin Ding
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Synapse 53:168-75. 2004
    ..These results are pertinent to the question of whether l-threo-MP contributes to the behavioral and side effect profile of MP during treatment of ADHD...
  73. ncbi The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Biol Psychiatry 57:640-6. 2005
    ..This study measures the potency and kinetics for DAT blockade by radafaxine in human brain...
  74. ncbi The use of alternative forms of graphical analysis to balance bias and precision in PET images
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Cereb Blood Flow Metab 31:535-46. 2011
    ..The variance of the four estimates can serve as a guide to the reliability of the median estimate. This may provide a general method for the generation of parametric images with little bias and good precision...
  75. ncbi Polymer-supported organotin reagent for prosthetic group labeling of biological macromolecules with radioiodine
    Andrew N Gifford
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Bioconjug Chem 22:406-12. 2011
    ..This solid-phase approach is potentially adaptable to kit-formulation for performing conjugate radiolabeling of biological macromolecules...
  76. ncbi Nuclear medicine and chemistry
    Joanna Fowler
    Brookhaven National Laboratory, NY, USA
    J Nucl Med 43:20N, 22N. 2002
  77. ncbi Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 32:1782-92. 2006
    ..Thus, the state of expectation needs to be considered as a variable modulating the reinforcing and therapeutic effects of drugs even in subjects who have no prior experience with the drug...
  78. ncbi Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction
    Nora D Volkow
    National Institute of Drug Abuse, Rockville, Maryland 20857, USA
    J Neurosci 25:3932-9. 2005
    ..It also suggests that the mesothalamic DA pathway may contribute to these processes...
  79. ncbi Low doses of alcohol substantially decrease glucose metabolism in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Neuroimage 29:295-301. 2006
    ....
  80. ncbi MicroPET imaging in an animal model of anorexia nervosa
    Nicole C Barbarich-Marsteller
    Graduate Program in Neuroscience, Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Synapse 57:85-90. 2005
    ..This is the first study to establish support for the use of microPET imaging in an animal model of anorexia nervosa as a means for studying the neurobiological changes that occur due to chronic food restriction...
  81. ncbi Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
    ..Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction...
  82. ncbi High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA
    Arch Gen Psychiatry 63:999-1008. 2006
    ..Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption...
  83. ncbi A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator
    Martine M Mirrione
    Graduate Program in Molecular and Cellular Pharmacology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Neuroimage 38:34-42. 2007
    ..Furthermore, we report unexpected activations that may underlie the tPA modulation of seizure susceptibility. The methods described here should be applicable to other mouse models of human neurological disease...
  84. ncbi Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 27:12700-6. 2007
    ....
  85. ncbi Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda MD 20892, USA National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Neuroimage 39:1266-73. 2008
    ....
  86. ncbi Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2017. 2008
    ..This would explain why methylphenidate has beneficial effects in some individuals and contexts and detrimental effects in others...
  87. ncbi Relationship between ethanol-induced changes in brain regional metabolism and its motor, behavioural and cognitive effects
    Wei Zhu
    Department of Applied Mathematics and Statistics, State University of New York, Stony Brook, NY 11794 3600, USA
    Alcohol Alcohol 39:53-8. 2004
    ..We also used canonical correlations in the polynomial space to assess for possible nonlinear relationships...
  88. ncbi Stimulant-induced enhanced sexual desire as a potential contributing factor in HIV transmission
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Rm 5274, Bethesda, MD 20892, USA
    Am J Psychiatry 164:157-60. 2007
    ..The authors investigated the effect of the stimulant drug methylphenidate (given intravenously) on sexual desire as a possible contributing factor to risky sexual behavior associated with the contraction of HIV...
  89. ncbi Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology
    Nora D Volkow
    National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 363:3191-200. 2008
    ..These neuronal circuits, which are modulated by DA, interact with one another so that disruption in one circuit can be buffered by another, which highlights the need of multiprong approaches in the treatment of addiction and obesity...
  90. ncbi Brain dopamine transporter levels in treatment and drug naïve adults with ADHD
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, MD 20892, USA
    Neuroimage 34:1182-90. 2007
    ..g., prefrontal or cingulostriatal pathways, noradrenergic neurotransmission) is necessary to account for the large differences in inattention observed between controls and ADHD subjects...
  91. ncbi Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    Biol Psychiatry 57:1410-5. 2005
    ..We postulate that these effects would improve school performance...
  92. ncbi Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 28:8454-61. 2008
    ....
  93. ncbi Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...

Research Grants10

  1. Addiction and the Brain: Are We Hard Wired to Abuse Drugs
    Joanna Fowler; Fiscal Year: 2007
    ....
  2. Role of Genotype and Maternal Smoking on Brain MAO A
    Joanna Fowler; Fiscal Year: 2007
    ..abstract_text> ..
  3. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2004
    ....
  4. RADIOTRACER RANDD IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2000
    ....