T Ernst

Summary

Affiliation: Brookhaven National Laboratory
Country: USA

Publications

  1. ncbi request reprint The effects of tamoxifen and estrogen on brain metabolism in elderly women
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Natl Cancer Inst 94:592-7. 2002
  2. ncbi request reprint Effect of aging on brain metabolism in antiretroviral-naive HIV patients
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    AIDS 18:S61-7. 2004
  3. ncbi request reprint Increased glial metabolites predict increased working memory network activation in HIV brain injury
    T Ernst
    Medical Department, Brookhaven National Laboratory, Building 490, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 19:1686-93. 2003
  4. ncbi request reprint Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients
    T Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurology 59:1343-9. 2002
  5. ncbi request reprint Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: A coregistered (1)H MRS and SPECT study
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 12:859-65. 2000
  6. ncbi request reprint Neural correlates of attention and working memory deficits in HIV patients
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Neurology 57:1001-7. 2001
  7. ncbi request reprint Cerebral metabolites in HIV-infected children followed for 10 months with 1H-MRS
    M A Keller
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 66:874-9. 2006
  8. ncbi request reprint Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats
    L Chang
    Department of Neurology, Harbor UCLA Medical Center, Torrance, Calif 90509, USA
    Arch Neurol 55:305-11. 1998
  9. pmc Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasks
    D Tomasi
    Medical Department, Building 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroscience 151:1006-15. 2008
  10. pmc Different activation patterns for working memory load and visual attention load
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave, Upton, NY 11973, USA
    Brain Res 1132:158-65. 2007

Detail Information

Publications56

  1. ncbi request reprint The effects of tamoxifen and estrogen on brain metabolism in elderly women
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    J Natl Cancer Inst 94:592-7. 2002
    ..Consequently, we assessed the effects of tamoxifen and estrogen on the brain chemistry of elderly women...
  2. ncbi request reprint Effect of aging on brain metabolism in antiretroviral-naive HIV patients
    Thomas Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    AIDS 18:S61-7. 2004
    ..The goal of this pilot study was to evaluate the interaction between aging and HIV infection in the brain using proton magnetic resonance spectroscopy (H-MRS)...
  3. ncbi request reprint Increased glial metabolites predict increased working memory network activation in HIV brain injury
    T Ernst
    Medical Department, Brookhaven National Laboratory, Building 490, P O Box 5000, Upton, NY 11973 5000, USA
    Neuroimage 19:1686-93. 2003
    ..The same mechanism may also contribute to cognitive dysfunction in other brain diseases that involve inflammation...
  4. ncbi request reprint Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients
    T Ernst
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neurology 59:1343-9. 2002
    ..The current study aims to determine whether patients who are HIV-1 positive and have normal cognitive function also show increased brain activation on fMRI...
  5. ncbi request reprint Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: A coregistered (1)H MRS and SPECT study
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 12:859-65. 2000
    ..This finding suggests that metabolite concentrations on (1)H MRS are better surrogate markers than rCBF measurements with SPECT for the evaluation of brain injury in early HIV-CMC. J. Magn. Reson. Imaging 2000;12:859-865...
  6. ncbi request reprint Neural correlates of attention and working memory deficits in HIV patients
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Neurology 57:1001-7. 2001
    ..To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1...
  7. ncbi request reprint Cerebral metabolites in HIV-infected children followed for 10 months with 1H-MRS
    M A Keller
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 66:874-9. 2006
    ..0 years +/- 3.7 years) and repeated the MR spectroscopy at 24.1 +/- 3.7 weeks and 42.2 +/- 3.5 weeks following the entry time with repeated neuropsychological testing...
  8. ncbi request reprint Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats
    L Chang
    Department of Neurology, Harbor UCLA Medical Center, Torrance, Calif 90509, USA
    Arch Neurol 55:305-11. 1998
    ....
  9. pmc Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasks
    D Tomasi
    Medical Department, Building 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroscience 151:1006-15. 2008
    ..Together, these sex-specific differences in brain activation during the VA task, at different cognitive and acoustic levels suggest differences in auditory gating of the thalamus for men and women...
  10. pmc Different activation patterns for working memory load and visual attention load
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave, Upton, NY 11973, USA
    Brain Res 1132:158-65. 2007
    ..Conversely, VA tasks activated more strongly an occipito-parietal network comprising the postcentral (PostCG) and the superior occipital (SOG) gyri, suggesting complex visual processing in this network...
  11. ncbi request reprint Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 10:521-6. 1999
    ..However, the usage-related increase in MI suggests that exposure to MDMA, even at recreational doses, may cause increased glial content. J. Magn. Reson. Imaging 1999;10:521-526...
  12. ncbi request reprint Brain N-acetyl aspartate concentrations measured by H MRS are reduced in adult male rats subjected to perinatal stress: preliminary observations and hypothetical implications for neurodevelopmental disorders
    R E Poland
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    J Psychiatr Res 33:41-51. 1999
    ..particularly in relation to NAA. For hypothesis-generating purposes, the possible relevance of stress and NAA to the neurodevelopmental hypothesis of schizophrenia is discussed in greater detail...
  13. pmc fMRI-acoustic noise alters brain activation during working memory tasks
    D Tomasi
    Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
    Neuroimage 27:377-86. 2005
    ....
  14. ncbi request reprint Gender effects on persistent cerebral metabolite changes in the frontal lobes of abstinent cocaine users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
    Am J Psychiatry 156:716-22. 1999
    ..The aim of this study was to investigate persistent neurochemical changes in the frontal lobes of subjects with a history of crack cocaine dependence and to determine whether these changes are different in male and female users...
  15. ncbi request reprint Brain proton magnetic resonance spectroscopy and imaging in children exposed to cocaine in utero
    L M Smith
    Department of Pediatrics, Harbor University of California, Los Angeles Medical Center, Torrance, CA 90502, USA
    Pediatrics 107:227-31. 2001
    ..The purpose of this study was to examine the possible neurotoxic effects of prenatal cocaine exposure on the developing brain using (1)H-MRS...
  16. ncbi request reprint Correlation of regional cerebral blood flow from perfusion MRI and spect in normal subjects
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Magn Reson Imaging 17:349-54. 1999
    ..pMRI is a reliable noninvasive method for rCBF measurements...
  17. ncbi request reprint Altered neurometabolite development in HIV-infected children: correlation with neuropsychological tests
    M A Keller
    Harbor UCLA Research and Education Institute, Torrance, CA, USA
    Neurology 62:1810-7. 2004
    ..HIV-infected children have abnormal cerebral metabolites, measured by proton MR spectroscopy ((1)H-MRS), but how these abnormalities relate to brain function is unclear...
  18. ncbi request reprint Automatic scan prescription for brain MRI
    L Itti
    Harbor UCLA Research and Education Institute, University of California Los Angeles, Torrance, California, USA
    Magn Reson Med 45:486-94. 2001
    ..Magn Reson Med 45:486-494, 2001...
  19. ncbi request reprint Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, B 4, Torrance, CA 90509, USA
    Psychiatry Res 98:15-28. 2000
    ....
  20. ncbi request reprint Biexponential modeling of multigradient-echo MRI data of the brain
    O Speck
    Department of Neurology, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, California, USA
    Magn Reson Med 45:1116-21. 2001
    ..The activation-induced parameter changes are detected with a sensitivity equal to that of a monoexponential method. The resulting T2* and DeltaT2* values describe the experimental data more accurately...
  21. ncbi request reprint Practice-induced changes of brain function during visual attention: a parametric fMRI study at 4 Tesla
    D Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 23:1414-21. 2004
    ..Since short-term practice-effects in the prefrontal cortex may be similar to attentional load-effects, studies of attentional load need to take practice effects into account...
  22. ncbi request reprint Evidence for long-term neurotoxicity associated with methamphetamine abuse: A 1H MRS study
    T Ernst
    Department of Neurology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 54:1344-9. 2000
    ..To determine whether proton MRS (1H MRS) can detect long-term metabolite abnormalities in abstinent methamphetamine users...
  23. ncbi request reprint Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero
    L M Smith
    Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance 90502, USA
    Neurology 57:255-60. 2001
    ..To examine the possible neurotoxic effects of prenatal methamphetamine exposure on the developing brain using 1H-MRS...
  24. ncbi request reprint HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosis
    M Issakhanian
    Department of Neurology, University of California, Los Angeles (UCLA) School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA
    J Neuroimaging 11:212-6. 2001
    ..The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis...
  25. ncbi request reprint Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease
    C C Cloak
    Medical Department, Brookhaven National Laboratory, Buliding 490, Upton, NY, USA
    J Neuroimmunol 147:16-20. 2004
    ..The decreased glutamate in FIV cats normalized with MA exposure. FIV and MA both affect brain metabolites individually and combined. 1HMRS is useful for evaluating the effects of FIV and drug abuse in the brain...
  26. pmc Selegiline and oxidative stress in HIV-associated cognitive impairment
    G Schifitto
    University of Rochester, NY, USA
    Neurology 73:1975-81. 2009
    ....
  27. ncbi request reprint Cerebral perfusion abnormalities in abstinent cocaine abusers: a perfusion MRI and SPECT study
    T Ernst
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 100 West Carson Street, B 4, 90509, Torrance, CA, USA
    Psychiatry Res 99:63-74. 2000
    ..The hypoperfusion in the cortex and deep gray matter of the cocaine users is consistent with previous results. The increased rCBF in the white matter of cocaine users may be due to the presence of reactive glia...
  28. pmc The human immunodeficiency virus reduces network capacity: acoustic noise effect
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Ann Neurol 59:419-23. 2006
    ..Increased acoustic noise (AN) during working memory leads to increased brain activation in healthy individuals and may have greater impact in human immunodeficiency virus (HIV) patients...
  29. ncbi request reprint Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu 96813, USA
    Biol Psychiatry 57:967-74. 2005
    ....
  30. ncbi request reprint Unified structural equation modeling approach for the analysis of multisubject, multivariate functional MRI data
    Jieun Kim
    Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, New York, USA
    Hum Brain Mapp 28:85-93. 2007
    ....
  31. pmc Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?
    Rita Z Goldstein
    State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
    Am J Psychiatry 164:43-51. 2007
    ..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control...
  32. ncbi request reprint Structural and metabolic brain changes in the striatum associated with methamphetamine abuse
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Addiction 102:16-32. 2007
    ..To review structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine, as well as in children with prenatal methamphetamine exposure...
  33. pmc Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controls
    Cheuk Y Tang
    Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
    BMC Psychiatry 7:25. 2007
    ..DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions...
  34. pmc Brain metabolite abnormalities in the white matter of elderly schizophrenic subjects: implication for glial dysfunction
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, Honolulu, Hawaii 96813, USA
    Biol Psychiatry 62:1396-404. 2007
    ....
  35. ncbi request reprint Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study
    Giovanni Schifitto
    University of Rochester, Rochester, New York 14620, USA
    AIDS 21:1877-86. 2007
    ..To assess the safety and efficacy of memantine, an uncompetitive antagonist of the N-methyl-D-aspartate receptor as treatment of HIV-associated cognitive impairment...
  36. ncbi request reprint Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificity
    Robert H Paul
    Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
    J Neuropsychiatry Clin Neurosci 19:283-92. 2007
    ..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy...
  37. pmc Common deactivation patterns during working memory and visual attention tasks: an intra-subject fMRI study at 4 Tesla
    Dardo Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Hum Brain Mapp 27:694-705. 2006
    ..The task-dependent balance of activation and deactivation might allow maximization of resources for the activated network...
  38. ncbi request reprint A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia
    Ned Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Magn Reson Imaging 21:325-33. 2005
    ..To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia...
  39. ncbi request reprint Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalities
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, 1356 Lusitana St, 7th Floor, Honolulu, HI 96813, USA
    Am J Psychiatry 162:361-9. 2005
    ..The authors sought to determine whether HIV and a history of chronic methamphetamine use might have additive or interactive effects on brain metabolite abnormalities...
  40. ncbi request reprint Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    Neuroimage 17:1638-48. 2002
    ..Metabolite concentrations, rather than metabolite ratios, should be measured since [CR], a commonly used reference for metabolite ratios, varies with disease severity in both frontal lobe and basal ganglia...
  41. ncbi request reprint Identification of HIV-associated progressive multifocal leukoencephalopathy: magnetic resonance imaging and spectroscopy
    Robin A Hurley
    Mental Health Care Line, Houston Veterans Affairs Medical Center, Houston, Texas, USA
    J Neuropsychiatry Clin Neurosci 15:1-6. 2003
  42. ncbi request reprint Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders
    Linda Chang
    Brookhaven National Laboratory, Upton, NY 11973, USA
    J Clin Psychiatry 64:7-14. 2003
    ..Examples of such a rational therapeutic approach include anticonvulsants that elevate brain GABA levels and are effective for the treatment of epilepsy and anxiety disorder...
  43. ncbi request reprint A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis
    Patricia Lani Lee
    NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
    J Magn Reson Imaging 17:625-33. 2003
    ....
  44. ncbi request reprint Echo planar imaging at 4 Tesla with minimum acoustic noise
    Dardo G Tomasi
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Magn Reson Imaging 18:128-30. 2003
    ..To minimize the acoustic sound pressure levels of single-shot echo planar imaging (EPI) acquisitions on high magnetic field MRI scanners...
  45. ncbi request reprint k-Space based summary motion detection for functional magnetic resonance imaging
    Elisabeth C Caparelli
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Neuroimage 20:1411-8. 2003
    ..This method makes it possible to evaluate brain motion within seconds after a scan and to decide whether a study needs to be repeated...
  46. ncbi request reprint Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Antivir Ther 8:17-26. 2003
    ..We aimed to evaluate whether brain abnormalities will improve 3 months after HAART...
  47. ncbi request reprint Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai, Honolulu, HI, USA
    Antivir Ther 9:431-40. 2004
    ..The relationships between neurometabolites and macrophage chemoattractant protein (MCP-1) in serum and cerebrospinal fluid (CSF) were evaluated in HIV patients before and after antiretroviral treatment...
  48. ncbi request reprint The effect of small rotations on R2* measured with echo planar imaging
    Elisabeth C Caparelli
    Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY 11973, USA
    Neuroimage 24:1164-9. 2005
    ..Similar measurements were carried out in a human study. Rotations larger than 2 degrees changed R(2)* more than 1.5 Hz in the phantom, and indicate that even small rotations may compromise fMRI results...
  49. ncbi request reprint Smaller subcortical volumes and cognitive deficits in children with prenatal methamphetamine exposure
    Linda Chang
    Department of Medicine, John A Burns School of Medicine, University of Hawai i, HI 96813, USA
    Psychiatry Res 132:95-106. 2004
    ..These preliminary findings suggest prenatal Meth exposure may be neurotoxic to the developing brain...
  50. ncbi request reprint Regional patterns of brain metabolites in AIDS dementia complex
    Constantin T Yiannoutsos
    Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
    Neuroimage 23:928-35. 2004
    ..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age...
  51. ncbi request reprint Localized in vivo human 1H MRS at very short echo times
    Kai Zhong
    Medical Department, Brookhaven National Laboratory, Upton, New York, USA
    Magn Reson Med 52:898-901. 2004
    ..These improvements should result in more accurate quantitation of these metabolites...
  52. ncbi request reprint Decreased brain dopaminergic transporters in HIV-associated dementia patients
    Gene Jack Wang
    Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
    Brain 127:2452-8. 2004
    ..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals...
  53. ncbi request reprint Adaptation of the attention network in human immunodeficiency virus brain injury
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Upton, NY, USA
    Ann Neurol 56:259-72. 2004
    ..Exceeding the brain reserve capacity may lead to attention deficits and cognitive impairment in HIV patients...
  54. ncbi request reprint Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users
    Linda Chang
    Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY, 11973 5000, USA
    Psychiatry Res 114:65-79. 2002
    ..These findings suggest that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function...
  55. pmc Regional variations and the effects of age and gender on glutamate concentrations in the human brain
    Napapon Sailasuta
    Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Magn Reson Imaging 26:667-75. 2008
    ..Our results also highlight the importance of brain region, age and gender matching in clinical studies...
  56. ncbi request reprint Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjects
    Joseph I Friedman
    Schizophr Res 100:356-8. 2008