Research Topics
| Congwu DuSummaryAffiliation: Brookhaven National Laboratory Country: USA Publications
Research Grants
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Detail Information
Publications
Optical detection of brain function: simultaneous imaging of cerebral vascular response, tissue metabolism, and cellular activity in vivoCongwu Du
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
Rev Neurosci 22:695-709. 2011..Promising results of in vivo animal brain functional studies suggest the potential of this multimodality approach for future awake animal and behavioral studies...
Differential effects of anesthetics on cocaine's pharmacokinetic and pharmacodynamic effects in brainCongwu Du
Department of Anesthesiology, State University of New York at Stony Brook, Stony Brook, NY, USA
Eur J Neurosci 30:1565-75. 2009....
Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescenceCongwu Du
Brookhaven National Laboratory, Medical Department, Upton, New York 11973 5000, USA
J Cereb Blood Flow Metab 25:1078-92. 2005....- Cocaine increases the intracellular calcium concentration in brain independently of its cerebrovascular effectsCongwu Du
Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
J Neurosci 26:11522-31. 2006..These findings support the use of calcium channel blockers as a strategy to minimize the neurotoxic effects of cocaine... - The effect of intravenous lidocaine on brain activation during non-noxious and acute noxious stimulation of the forepaw: a functional magnetic resonance imaging study in the ratZhongchi Luo
Departments of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York, USA
Anesth Analg 108:334-44. 2009..Here, we therefore characterized the effect of systemic lidocaine on the brain's response to innocuous and acute noxious stimulation in the rat using functional magnetic resonance imaging (fMRI)... - Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imagingZhongchi Luo
Departments of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 8181, USA
Opt Lett 34:1480-2. 2009..Simultaneous cerebral blood flow and oxygenation imaging at high spatiotemporal resolutions is crucial to the understanding of neural process and brain functions... - Imaging separation of neuronal from vascular effects of cocaine on rat cortical brain in vivoZhijia Yuan
Department of Biomedical Engineering, Stony Brook University, NY, NY 11794, USA
Neuroimage 54:1130-9. 2011..g., pet, fmri)... - Quantification of cocaine-induced cortical blood flow changes using laser speckle contrast imaging and Doppler optical coherence tomographyZhongchi Luo
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 8181, USA
Appl Opt 48:D247-55. 2009..g., increases in alpha-chloralose and decreases in isoflurane regimes) were quantitatively characterized, thus rendering it a potentially useful tool for imaging studies of brain functions... - Acute cocaine induces fast activation of D1 receptor and progressive deactivation of D2 receptor striatal neurons: in vivo optical microprobe [Ca2+]i imagingZhongchi Luo
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794, USA
J Neurosci 31:13180-90. 2011..We also provide direct in vivo evidence of D2R and D1R interactions in the striatal responses to acute cocaine administration... - Maternal and fetal 11C-cocaine uptake and kinetics measured in vivo by combined PET and MRI in pregnant nonhuman primatesHelene Benveniste
Medical Department, Brookhaven National Laboratory, Upton, New York 11793, USA
J Nucl Med 46:312-20. 2005..Here, we evaluate the utility of PET to measure the uptake and distribution of (11)C-cocaine in the third-trimester fetus... - Decreasing motion artifacts in calcium-dependent fluorescence transients from the perfused mouse heart using frequency filteringCongwu Du
Medical Department, Brookhaven National Laboratory, Upton, NY 11794, USA
Cell Calcium 35:141-53. 2004.... - Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortexZhongchi Luo
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 8181, USA
Opt Lett 33:1156-8. 2008..96). Quantitative LSCI of cerebral blood flow is crucial to the quantitative analyses of the spatiotemporal hemodynamics of functional brain activations and thus improved understanding of neural process... - Cerebral blood flow imaged with ultrahigh-resolution optical coherence angiography and Doppler tomographyHugang Ren
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794, USA
Opt Lett 37:1388-90. 2012..g., red and white blood cells) within the vessels; whereas, μODT permits detection of directional flow below the Brownian motion regime (e.g., laser-induced microischemia) and is, therefore, more suitable for brain functional imaging... - Anatomical and functional phenotyping of mice models of Alzheimer's disease by MR microscopyHelene Benveniste
Brookhaven National Laboratory, Medical Department, Bldg 490, 30 Bell Avenue, Upton, NY 11973, USA
Ann N Y Acad Sci 1097:12-29. 2007..We will present MRM data of brain and cardiac phenotyping in transgenic mouse models with behavioral deficits...
Research Grants
- Optical and fMRI Studies of Cocaine in the Rat BrainCongwu Du; Fiscal Year: 2007..The PI is seeking this K25 award to further extend her knowledge of the physiology, biochemistry and pharmacology underlying the brain's responses to acute and chronic administration of abused drugs. ..